Cysteine Protease
Cysteine Protease inhibitors are compounds that target and inhibit cysteine proteases, a class of enzymes that break down proteins by cleaving peptide bonds in which a cysteine residue acts as the nucleophile. These enzymes are involved in various physiological processes, including apoptosis, immune response, and protein turnover. Cysteine protease inhibitors are crucial for studying diseases such as cancer, neurodegenerative disorders, and parasitic infections. At CymitQuimica, we provide cysteine protease inhibitors to aid your research in proteolysis, cellular regulation, and drug discovery.
Found 143 products for "Cysteine Protease".
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PMSF
CAS:PMSF (Phenylmethylsulfonyl fluoride) is an irreversible inhibitor of serine/cysteine protease , preparation of cell lysates. High-Quality, Low-Cost!Formula:C7H7FO2SPurity:97.75% - 99.88%Color and Shape:White SolidMolecular weight:174.193N-CBZ-Phe-Arg-AMC
CAS:Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.Formula:C33H37ClN6O6Purity:98%Color and Shape:SolidMolecular weight:649.136Cathepsin D/E Substrate, Fluorogenic
CathepsinD/E Substrate, Fluorogenic, is an 11-amino acid peptide specifically designed as a substrate for cathepsins D and E, demonstrating selectivity by not acting as a substrate for cathepsins B, H, or L.Formula:C83H119N21O18Color and Shape:SolidMolecular weight:1697.9042Z-Phe-Tyr(tBu)-diazomethylketone
CAS:Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.Formula:C31H34N4O5Color and Shape:SolidMolecular weight:542.636RO5461111
CAS:RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.Formula:C27H24F6N4O4SColor and Shape:SolidMolecular weight:614.56FGA139
FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.Formula:C48H58BF2N7O5Color and Shape:SolidMolecular weight:861.456056,6′-Dihydroxythiobinupharidine
CAS:6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-foldFormula:C30H42N2O4SColor and Shape:SolidMolecular weight:526.73Leupeptin
CAS:Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.Formula:C20H38N6O4Purity:98%Color and Shape:SolidMolecular weight:426.562FGA146
FGA146 is a selective inhibitor of Mpro and human Cathepsin L, with Ki values of 2.19 μM for Mal-Mpro, 0.96 μM for pET21-Mpro, and 0.87 μM for Cathepsin L. It exhibits antiviral activity against SARS-CoV-2.Formula:C24H31N5O6Molecular weight:485.22743CTSL/CAPN1-IN-1
CTSL/CAPN1-IN-1 (compound 14a) is an orally active inhibitor targeting CTSL and CAPN1, with IC50 values of 3.34 nM and 375.1 nM, respectively. It exhibits both anti-coronavirus and anti-inflammatory activities.Formula:C34H33FN4O6Color and Shape:SolidMolecular weight:612.23841Cathepsin L-IN-3 TFA
CathepsinL-IN-3 (Compound cat L inh. 7) TFA is a selective, non-covalent inhibitor of cathepsin L, with a Ki value of 4.3 nM.Acetyl-Calpastatin (184-210)(human) acetate
Acetyl-Calpastatin acetate inhibits µ-calpain (Ki=0.2nM) and cathepsin L (Ki=6μM) selectively and reversibly.Formula:C144H234N36O46SPurity:98.16% - 99.05%Color and Shape:SolidMolecular weight:3237.68FGA145
FGA145 is a dual inhibitor of Mpro and human Cathepsin L, with Ki values of 3.71 μM for Mal-Mpro, 9.82 μM for pET21-Mpro, and 53 nM for Cathepsin L. Additionally, FGA145 exhibits multi-target antiviral activity.Formula:C23H30N4O5Molecular weight:442.22162Protease Inhibitor Library
A unique collection of xnum protease and proteasome inhibitors for research in chemical genomics, and drug screening;Color and Shape:Odour SolidZ-L(D-Val)G-CHN2
Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase.Formula:C22H31N5O5Purity:98%Color and Shape:SolidMolecular weight:445.51N-CBZ-Phe-Arg-AMC TFA
N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.Formula:C35H37F3N6O8Purity:99.88%Color and Shape:White SolidMolecular weight:726.7SARS-CoV-2-IN-77
SARS-CoV-2-IN-77 (compound 11e) is an inhibitor of cathepsin L and cathepsin S, with Ki values of 111 nM and 103 nM, respectively. It effectively inhibits SARS-CoV-2 in Calu-3 cells with an EC50 value of 38.4 nM and does not exhibit cytotoxicity.Formula:C23H25Cl2N3O3Molecular weight:461.1273Cathepsin C-IN-6
Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastaseFormula:C24H35N5O4·xC2HF3O2Color and Shape:SolidSmCB1-IN-1
SmCB1-IN-1 (Compound 2h) is an inhibitor of the Schistosoma mansoni cathepsin B1 (SmCB1) with a Ki of 0.05 μM. It demonstrates selectivity towards non-target human proteases, showing inhibition rates of 29% for CatB and 37% for CatL at 20 μM. At 1 μM, SmCB1-IN-1 inhibits 68% of Schistosoma mansoni.Formula:C26H25NO6SColor and Shape:SolidMolecular weight:479.14026Relacatib
CAS:Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.Formula:C27H32N4O6SColor and Shape:SolidMolecular weight:540.631
