Cysteine Protease
Cysteine Protease inhibitors are compounds that target and inhibit cysteine proteases, a class of enzymes that break down proteins by cleaving peptide bonds in which a cysteine residue acts as the nucleophile. These enzymes are involved in various physiological processes, including apoptosis, immune response, and protein turnover. Cysteine protease inhibitors are crucial for studying diseases such as cancer, neurodegenerative disorders, and parasitic infections. At CymitQuimica, we provide cysteine protease inhibitors to aid your research in proteolysis, cellular regulation, and drug discovery.
Found 96 products of "Cysteine Protease"
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Cathepsin Inhibitor 4
<p>Cathepsin Inhibitor 4 (Compound 45) is a selective inhibitor of Cathepsin S, with a Ki value of 0.04 nM.</p>Formula:C24H35N3O5Molecular weight:445.25767Cathepsin K inhibitor 7
<p>Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.</p>Color and Shape:Odour SolidCathepsin C-IN-6
<p>Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastase</p>Formula:C24H35N5O4·xC2HF3O2Color and Shape:SolidLeupeptin
CAS:<p>Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.</p>Formula:C20H38N6O4Purity:98%Color and Shape:SolidMolecular weight:426.562PD150606
CAS:<p>PD150606 is a calpain inhibitor with neuroprotective activity that inhibits μ-calpains and interferes with excitotoxicity-dependent motor neuron death.</p>Formula:C9H7IO2SPurity:98.19%Color and Shape:SolidMolecular weight:306.12Z-FG-NHO-Bz
CAS:<p>Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].</p>Formula:C26H25N3O6Color and Shape:SolidMolecular weight:475.49VK13
<p>VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) and SARS-CoV-2 3CLpro (3CL-PR), with Ki values of 2.6 nM and 0.55 nM, respectively. It also exhibits activity against CoV-2, with an EC50 value of 1.25 μM.</p>Formula:C24H28N4O5Color and Shape:SolidMolecular weight:452.503Cathepsin D and E FRET Substrate
CAS:<p>Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.</p>Formula:C85H122N22O19Color and Shape:SolidMolecular weight:1756.046Tacalcitol monohydrate
CAS:<p>Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis.</p>Formula:C27H46O4Purity:99.93%Color and Shape:SolidMolecular weight:434.65Z-Phe-Tyr(tBu)-diazomethylketone
CAS:<p>Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.</p>Formula:C31H34N4O5Color and Shape:SolidMolecular weight:542.636Z-L(D-Val)G-CHN2
<p>Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase.</p>Formula:C22H31N5O5Purity:98%Color and Shape:SolidMolecular weight:445.51Relacatib
CAS:<p>Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.</p>Formula:C27H32N4O6SColor and Shape:SolidMolecular weight:540.64Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Color and Shape:Odour SolidN-CBZ-Phe-Arg-AMC TFA
<p>N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.</p>Formula:C35H37F3N6O8Purity:99.88%Color and Shape:SolidMolecular weight:726.7Dazcapistat
CAS:<p>Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.</p>Formula:C21H18FN3O4Purity:99.11%Color and Shape:SolidMolecular weight:395.38Ac-PLVE-FMK
CAS:<p>Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl fluoromethylketone (FMKs), serves as a cathepsin inhibitor. It is utilized in cancer research [1].</p>Formula:C25H41FN4O7Purity:98%Color and Shape:SolidMolecular weight:528.61FGA139
<p>FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.</p>Formula:C48H58BF2N7O5Color and Shape:SolidMolecular weight:861.45605Mpro/Cathepsin L-IN-1
<p>Mpro/Cathepsin L-IN-1 (Compound 4d) is an inhibitor of SARS-CoV-2 Mpro and hCatL, with Ki values of 5.54 μM and 0.701 μM, respectively.</p>Formula:C24H32FN3O4Molecular weight:445.237686,6′-Dihydroxythiobinupharidine
CAS:<p>6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold</p>Formula:C30H42N2O4SColor and Shape:SolidMolecular weight:526.73Cathepsin L-IN-3
CAS:<p>Cathepsin L-IN-3, a tripeptide-sized inhibitor of cathepsin L, effectively targets this specific enzyme.</p>Formula:C41H49N7O4SColor and Shape:SolidMolecular weight:735.94Z-Leu-Tyr-Chloromethylketone
CAS:<p>Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].</p>Formula:C24H29ClN2O5Color and Shape:SolidMolecular weight:460.95N-CBZ-Phe-Arg-AMC
CAS:<p>Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.</p>Formula:C33H36N6O6Purity:98%Color and Shape:White To Off-White PowderMolecular weight:612.68Gallinamide A TFA
CAS:<p>Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].</p>Formula:C33H53F3N4O9Color and Shape:SolidMolecular weight:706.79Z-Arg-Arg-βNA acetate
CAS:<p>Z-Arg-Arg-βNA acetate serves as a sensitive dipeptide substrate for Cathepsin B protease, while demonstrating resistance to proteases H and L. This compound is crucial for differentiating non-Cathepsin B type proteins.</p>Formula:C32H43N9O6Color and Shape:SolidMolecular weight:649.74Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
<p>Fluorogenic substrate for cathepsins D & E; cleaves at Phe-Phe bond; not for B, H, L. Useful for assays and studies.</p>Color and Shape:Odour SolidHepcidin-1 (mouse)
CAS:<p>Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion.</p>Formula:C111H169N31O35S8Color and Shape:SolidMolecular weight:2754.24LN5P45
<p>LN5P45, an OTUB2 inhibitor (IC50: 2.3 μM), promotes monoubiquitination of OTUB2 at lysine 31 and is utilized in the study of tumor progression and metastasis [1</p>Formula:C13H15ClN2O2Color and Shape:SolidMolecular weight:266.72L-006235
CAS:<p>L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.</p>Formula:C24H30N6O2SPurity:99.37%Color and Shape:SolidMolecular weight:466.6CA-074 methyl ester
CAS:<p>CA-074 methyl ester (Cathepsin B Inhibitor IV) is a selective inhibitor of Cathepsin B (IC50=36.3 nM). neuroprotective effect. High-Quality, Low-Cost!</p>Formula:C19H31N3O6Purity:97.26% - 99.58%Color and Shape:SolidMolecular weight:397.47Odanacatib
CAS:<p>Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.</p>Formula:C25H27F4N3O3SPurity:98.53% - 99.53%Color and Shape:SolidMolecular weight:525.56LY 3000328
CAS:<p>LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S.Cost-effective and quality-assured.</p>Formula:C25H29FN4O5Purity:97.83% - 99.54%Color and Shape:SolidMolecular weight:484.52E-64
CAS:<p>E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.</p>Formula:C15H27N5O5Purity:98% - 99.95%Color and Shape:White SolidMolecular weight:357.41MDL-28170
CAS:<p>MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.</p>Formula:C22H26N2O4Purity:95.06%Color and Shape:SolidMolecular weight:382.45JTE-607
CAS:<p>JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.</p>Formula:C25H33Cl4N3O5Purity:97.88%Color and Shape:SolidMolecular weight:597.36KGP94
CAS:<p>KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.</p>Formula:C14H12BrN3OSPurity:99.6%Color and Shape:SolidMolecular weight:350.23Balicatib
CAS:<p>Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.</p>Formula:C23H33N5O2Purity:97.78% - 98.17%Color and Shape:White To Off-White Solid PowderMolecular weight:411.542-Cyanopyrimidine
CAS:<p>2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)</p>Formula:C5H3N3Purity:99.27%Color and Shape:Crystalline SolidMolecular weight:105.1(1S,2R)-Alicapistat
CAS:<p>(1S,2R)-Alicapistat inhibits calpains 1 and 2, shows promise for Alzheimer's, and has an IC50 of 395 nM.</p>Formula:C25H27N3O4Purity:99.60%Color and Shape:SoildMolecular weight:433.5Cathepsin Inhibitor 1
CAS:<p>Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.</p>Formula:C20H24ClN5O2Purity:99.78%Color and Shape:SolidMolecular weight:401.89Calpain Inhibitor XII
CAS:<p>Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a calpain I inhibitor that inhibits calpain II and cathepsin B.</p>Formula:C26H34N4O5Color and Shape:SolidMolecular weight:482.57LmCPB-IN-1
CAS:<p>LmCPB-IN-1, compound 35, is a reversible inhibitor of LmCPB with strong binding (pKi 9.7).</p>Formula:C18H30N6O2Color and Shape:SolidMolecular weight:362.47DTS
CAS:<p>DTS is a selective and isoform-specific RSK1 kinase inhibitor. It also has broad cancer therapeutic potential.</p>Formula:C14H14S3Purity:98%Color and Shape:SolidMolecular weight:278.46Cathepsin L/S-IN-1
<p>Cathepsin L/S-IN-1 inhibits Cathepsin L & S (IC50: 4.10 & 1.79 μM) and reduces metastasis in pancreatic cancer cells.</p>Formula:C29H33BrN4O4SColor and Shape:SolidMolecular weight:613.57JPM-OEt
CAS:<p>JPM-OEt: broad-spectrum, covalent cysteine cathepsin inhibitor with antitumor effects.</p>Formula:C20H28N2O6Purity:98%Color and Shape:SolidMolecular weight:392.45GSK-2793660
CAS:<p>GSK-2793660, an oral, irreversible CTSC inhibitor, aids bronchiectasis research.</p>Formula:C20H27N3O3Purity:98%Color and Shape:SolidMolecular weight:357.45Gü1303
CAS:<p>Gü1303 is a highly potent and reversible inhibitor of Cathepsin K (CatK), with a Ki value of 0.91 nM for mature CatK (mCatK).</p>Formula:C20H22N4O3Color and Shape:SolidMolecular weight:366.41Cysteine Protease inhibitor
CAS:<p>Cysteine protease inhibitors are inhibitors of cysteine proteases. Target: Cysteine Protease</p>Formula:C18H14N4OPurity:98%Color and Shape:SolidMolecular weight:302.33GSK2793660 HCl
CAS:<p>GSK2793660 is a irreversible covalent α,β-unsaturated amide based DPP1 inhibitor.</p>Formula:C22H32ClN3O3Color and Shape:SolidMolecular weight:421.96JNJ-10329670
CAS:<p>JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.</p>Formula:C30H34ClF3N6O3SColor and Shape:SolidMolecular weight:651.14Gü2602
CAS:<p>Gü2602 inhibits the cathepsin K zymogen autocatalytic activation that is a potent, reversible inhibitor of cathepsin K (CatK) with a Ki of 0.013 nM for mature</p>Formula:C16H22N4O3Color and Shape:SolidMolecular weight:318.37VEL-0230
CAS:<p>VEL-0230 (NC-2300) is a cathespin K inhibitor boosting bone growth and reducing loss, targeting bone diseases and developed by Velcura Therapeutics.</p>Formula:C14H24NNaO5Color and Shape:SolidMolecular weight:309.33ASPER-29
CAS:<p>ASPER-29, an Asperphenamate analog, inhibits cathepsins L/S with IC50s of 6.03/5.02 μM, useful in cancer migration/invasion research.</p>Formula:C31H29BrN2O5SColor and Shape:SolidMolecular weight:621.54L-873724
CAS:<p>L-873724: Selective, reversible cathepsin K inhibitor; IC50s—cat K: 0.2 nM, cat S: 178 nM, cat L: 264 nM, cat B: 5239 nM; inhibits bone resorption.</p>Formula:C23H26F3N3O3SPurity:98%Color and Shape:SolidMolecular weight:481.53CAA0225
CAS:<p>CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.</p>Formula:C28H29N3O5Color and Shape:SolidMolecular weight:487.55MDL 27399
CAS:<p>MDL 27399 suppresses human neutrophil cathepsin G.</p>Formula:C26H36N4O8Color and Shape:SolidMolecular weight:532.59AM 4299 B
CAS:<p>AM 4299 B is a novel inhibitor of a thiol protease.</p>Formula:C16H27N3O7Purity:98%Color and Shape:SolidMolecular weight:373.4Cysteine Protease inhibitor hydrochloride
CAS:<p>Cysteine Protease inhibitor hydrochloride is a cysteine protease inhibitor.</p>Formula:C18H15ClN4OPurity:98%Color and Shape:SolidMolecular weight:338.79NAAA-IN-2
CAS:<p>NAAA-IN-2, a selective inhibitor with 50 nM IC50, targets NAAA, an enzyme hydrolyzing PEA/OEA, and may aid inflammation and pain studies.</p>Formula:C11H13N3O2SColor and Shape:SolidMolecular weight:251.3SSAA09E1
CAS:<p>SSAA09E1 blocks SARS-CoV entry, lowers ACE2-mediated HEK293T cell infection (EC50 = 6.7 μM), and inhibits cathepsin L (IC50 = 5.33 μM).</p>Formula:C7H9N3S2Color and Shape:SolidMolecular weight:199.3SQ 32602
CAS:<p>SQ 32602 is a cathepsin E inhibitor.</p>Formula:C32H52N3O7PColor and Shape:SolidMolecular weight:621.74Dutacatib
CAS:<p>Dutacatib is an inhibitor of SARS-CoV-2 3CLpro and cathepsin K, offering antiviral properties and potential benefits in treating cancer-induced bone disease.</p>Formula:C23H31N7OColor and Shape:SolidMolecular weight:421.54Cysteine protease inhibitor-2
CAS:<p>Cysteine protease inhibitor from US20070032499A1; halts DCT116 at 6.5μM, PC3 at 4.4μM.</p>Formula:C13H5N5OPurity:98%Color and Shape:SolidMolecular weight:247.21Kgp-IN-1
CAS:<p>Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.</p>Formula:C19H24F4N4O3Purity:98%Color and Shape:SolidMolecular weight:432.41LHVS
CAS:<p>LHVS effectively blocks T.</p>Formula:C28H37N3O5SPurity:98%Color and Shape:SolidMolecular weight:527.68CA 074
CAS:<p>CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates</p>Formula:C18H29N3O6Purity:97.80%Color and Shape:SolidMolecular weight:383.44Cathepsin X-IN-1
CAS:<p>Cathepsin X-IN-1 (compound 25) reduces the migration of PC-3 cell with low cytotoxic that is a potent inhibitor of Cathepsin X (IC 50 = 7.13 μM) [1].</p>Formula:C15H13N3O3SPurity:99.34%Color and Shape:SolidMolecular weight:315.35JNJ-10311795
CAS:<p>JNJ-10311795 (RWJ-355871) is an inhibitor of neutrophil elastase G and mast cell chymase, demonstrating significant anti-inflammatory effects.</p>Formula:C40H35N2O6PPurity:97.43%Color and Shape:SolidMolecular weight:670.69SPR38
<p>SPR38: SARS-CoV-2 protease inhibitor with Ki 0.260 μM; also blocks hCatL (Ki 1.92 μM) and hCatB (Ki 11.1 μM).</p>Formula:C24H33N3O5Color and Shape:SolidMolecular weight:443.54Cathepsin K inhibitor 3
CAS:<p>Cathepsin K inhibitor 3: Selective, IC50 of 0.5 nM, good pharmacokinetics, potential for OA research.</p>Formula:C30H31FN4O4SColor and Shape:SolidMolecular weight:562.65ABP 25
CAS:<p>ABP 25 is a highly potent and selective activity-based probe (ABP) for cathepsin K imaging.</p>Formula:C55H66ClN5O3Color and Shape:SolidMolecular weight:880.6SQ 32056
CAS:<p>SQ 32056 is a cathepsin E inhibitor.</p>Formula:C37H56N4O5Purity:98%Color and Shape:SolidMolecular weight:636.86Cathepsin Inhibitor 2
CAS:<p>Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).</p>Formula:C19H21F6N3OPurity:98%Color and Shape:SolidMolecular weight:421.38MPI8
CAS:<p>MPI8 is a SARS-CoV-2 Protease inhibitor (IC50 = 105 nM).</p>Formula:C32H48N4O7Color and Shape:SolidMolecular weight:600.75Z-DEVD-CMK
CAS:<p>Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].</p>Formula:C27H35ClN4O12Color and Shape:SolidMolecular weight:643.04Petesicatib
CAS:<p>Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.</p>Formula:C25H23F6N5O4SPurity:99.76%Color and Shape:SolidMolecular weight:603.54MeOSuc-AAPV-CMK
CAS:<p>MeOSuc-AAPV-CMK (Elastase Inhibitor III) serves as an inhibitor of elastase, as well as cathepsin G and proteinase 3, and impedes leukocyte elastase-mediated</p>Formula:C22H35ClN4O7Color and Shape:SolidMolecular weight:502.99Z-FG-NHO-BzOME
CAS:<p>Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S,</p>Formula:C27H27N3O7Color and Shape:SolidMolecular weight:505.52SID 26681509
CAS:<p>SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).</p>Formula:C27H33N5O5SPurity:98.16%Color and Shape:SolidMolecular weight:539.65MK-0674
CAS:<p>MK-0674 is a cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S for metabolism-related diseases.</p>Formula:C26H27F6N3O2Purity:97.3% - 99.91%Color and Shape:SolidMolecular weight:527.5VBY-825
CAS:<p>VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.</p>Formula:C23H29F4N3O5SPurity:99.91%Color and Shape:SolidMolecular weight:535.55GB111-NH2
CAS:<p>GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].</p>Formula:C33H39N3O6Color and Shape:SolidMolecular weight:573.68Verducatib
CAS:<p>Verducatib is an inhibitor of cathepsins (cathepsin).</p>Formula:C31H35FN4O3Color and Shape:SolidMolecular weight:530.633Cathepsin K inhibitor 2
CAS:<p>Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.</p>Formula:C30H33F4N5O3Color and Shape:SolidMolecular weight:587.61BI-1915
CAS:<p>BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.</p>Formula:C21H37N5O3Color and Shape:SolidMolecular weight:407.55Cathepsin C-IN-3
<p>Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).</p>Formula:C28H21F3N6OSColor and Shape:SolidMolecular weight:546.57RO5461111
CAS:<p>RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.</p>Formula:C27H24F6N4O4SColor and Shape:SolidMolecular weight:614.56SID 26681509 quarterhydrate
<p>SID 26681509 is a selective inhibitor of cathepsin L (IC50: 56 nM) and blocks Plasmodium falciparum (IC50: 15.4 μM) and Leishmania major (IC50: 12.5 μM).</p>Formula:C27H35N5O6SColor and Shape:SolidMolecular weight:544.16Dual Cathepsin L/JAK-IN-1
CAS:<p>DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).</p>Formula:C19H18ClN5Color and Shape:SolidMolecular weight:351.833Cathepsin C-IN-5
CAS:<p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>Formula:C21H17ClN6OSColor and Shape:SolidMolecular weight:436.92Z-FY-CHO
CAS:<p>Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.</p>Formula:C26H26N2O5Purity:95.88%Color and Shape:SolidMolecular weight:446.5CTSL/CAPN1-IN-2
CAS:<p>CTSL/CAPN1-IN-2 (Compound 14b) serves as an orally active inhibitor targeting both CTSL and CAPN1, manifesting IC50 values of 6.88 nM for CTSL and 347.6 nM for CAPN1 respectively. This compound not only displays anti-inflammatory attributes but also features favorable pharmacokinetic properties. Moreover, CTSL/CAPN1-IN-2 shows extensive antiviral effects against coronaviruses by inhibiting viral entry [1].</p>Formula:C34H40N4O6Color and Shape:SolidMolecular weight:600.7CatD-IN-1
CAS:<p>CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.</p>Formula:C18H18Cl2N4O5Color and Shape:SolidMolecular weight:441.265Cathepsin C-IN-4
<p>Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).</p>Formula:C21H14ClF3N4SColor and Shape:SolidMolecular weight:446.88MIV-247
CAS:<p>MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.</p>Formula:C17H24F3N3O4Purity:99.27%Color and Shape:SolidMolecular weight:391.39PD 151746
CAS:<p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>Formula:C11H8FNO2SPurity:98.63% - ≥95%Color and Shape:SolidMolecular weight:237.25ALLM
CAS:<p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>Formula:C19H35N3O4SPurity:98%Color and Shape:White PowderMolecular weight:401.56
