Wnt/beta-catenin
Wnt/beta-catenin inhibitors are compounds that target and inhibit the Wnt/beta-catenin signaling pathway, which is crucial for the regulation of embryonic development, cell proliferation, and stem cell maintenance. Dysregulation of this pathway is linked to various cancers and degenerative diseases. Inhibitors of Wnt/beta-catenin signaling are valuable in research focused on understanding the role of this pathway in disease and developing targeted therapies. At CymitQuimica, we offer Wnt/beta-catenin inhibitors to support your research in stem cell biology, developmental biology, and cancer research.
Found 62 products of "Wnt/beta-catenin"
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KY1220
CAS:KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.Formula:C14H10N4O3SPurity:99.9%Color and Shape:SolidMolecular weight:314.32Ref: TM-T15677
2mg34.00€5mg66.00€10mg101.00€25mg200.00€50mg319.00€100mg515.00€200mg702.00€1mL*10mM (DMSO)70.00€CCT251545
CAS:CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).Formula:C23H24ClN5OPurity:98.29% - 98.69%Color and Shape:SolidMolecular weight:421.92CWP232228
CAS:CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.Formula:C33H34N7Na2O7PPurity:98.87%Color and Shape:SolidMolecular weight:717.63TNIK-IN-5
CAS:TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.Formula:C22H17N3O3Purity:99.58%Color and Shape:SolidMolecular weight:371.39JW74
CAS:JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).Formula:C24H20N6O2SPurity:95.00%Color and Shape:SolidMolecular weight:456.52Vantictumab
CAS:Vantictumab (OMP-18R5) is a humanized anti-FZD1/2/5/7/8 monoclonal antibody that inhibits Wnt pathway signaling.Purity:99% (SDS-PAGE); 97.7% (SEC-HPLC) - 99% (SDS-PAGE); 97.7% (SEC-HPLC)Color and Shape:LiquidMolecular weight:142.69 kDaBML-286
CAS:BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.Formula:C22H18N2O4Purity:98.44%Color and Shape:SolidMolecular weight:374.391(R),2(S)-epoxy Cannabidiol
CAS:1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.Formula:C21H30O3Color and Shape:SolidMolecular weight:330.46Foxy-5 Ammonium Salt
Foxy-5 Ammonium Salt, a WNT5A mimetic, blocks epithelial cancer cell migration without β-catenin impact and curbs prostate cancer spread.Formula:C26H46N7O12S2Purity:97.70%Color and Shape:SolidMolecular weight:712.26Ref: TM-TP1565L1
1mg90.00€5mg288.00€10mg430.00€25mg705.00€50mg982.00€100mg1,324.00€1mL*10mM (DMSO)309.00€Foxy-5 acetate
Foxy-5 acetate: Wnt 5A agonist, inhibits cancer cell migration/invasion, boosts calcium signaling, doesn't activate β-catenin.Formula:C28H46N6O14S2Purity:98%Color and Shape:SolidMolecular weight:754.83YW2036
CAS:YW2036 is an inhibitor of Wnt signaling pathway.Formula:C20H16N4OPurity:99.94%Color and Shape:SoildMolecular weight:328.37β-catenin peptide
CAS:β-catenin peptide,(βCATp) is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes.Formula:C49H76N12O15Purity:98%Color and Shape:SolidMolecular weight:1073.2Blosozumab
CAS:Blosozumab (LY2541546) is a monoclonal antibody targeting sclerostin that promotes bone formation, used in the research of osteoporosis.Purity:98.7% (SEC-HPLC) - 99.53% (SEC-HPLC)Color and Shape:LiquidMolecular weight:144.88 kDaTabituximab
CAS:BMS-986148 is a CHO-expressed humanized antibody-drug coupling targeting mesothelin-expressing cells for cytotoxic load delivery.Purity:98.7% (SDS-PAGE); 96.4% (SEC-HPLC) - 98.7% (SDS-PAGE); 96.4% (SEC-HPLC)Color and Shape:LiquidMolecular weight:145.5 kDaCCT 031374 hydrobromide
CAS:CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.Formula:C23H20BrN3OPurity:99.50%Color and Shape:SolidMolecular weight:434.33Ref: TM-T21685
1mg38.00€5mg71.00€10mg105.00€25mg207.00€50mg329.00€100mg472.00€200mg620.00€1mL*10mM (DMSO)87.00€Foxy-5
CAS:Foxy-5 is a wnt5a peptide mimeticFormula:C26H42N6O12S2Purity:98%Color and Shape:SolidMolecular weight:694.77NLS-StAx-h
Wnt inhibitor; halts cancer cell growth & spread by blocking β-catenin, IC50=1.4μM, cell-permeable.Formula:C161H275N55O29Purity:98%Color and Shape:SolidMolecular weight:3445.26Wnt/β-catenin agonist 3
CAS:Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.
Formula:C16H15ClN4O2Purity:99.52%Color and Shape:SolidMolecular weight:330.77LP-922056
CAS:LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
Formula:C11H9ClN2O2S2Purity:99.84%Color and Shape:SolidMolecular weight:300.78F7H
CAS:F7H is an FZD7 antagonist, a potent ligand for the FZD7 transmembrane domain (TMD), with potential antitumor and bacteriostatic activities.
Formula:C24H18FN3O2S2Purity:99.85%Color and Shape:SoildMolecular weight:463.55β-catenin modulator IIa-661
CAS:β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.Formula:C19H23ClN2O3SPurity:99.58%Color and Shape:SoildMolecular weight:394.92WIC1
CAS:2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.
Formula:C22H23N3O3Purity:99.82%Color and Shape:SoildMolecular weight:377.44ABC99
CAS:ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.Formula:C22H21ClN4O5Purity:99.89%Color and Shape:SoildMolecular weight:456.88Ref: TM-T23602
1mg114.00€2mg155.00€5mg222.00€10mg334.00€25mg595.00€50mg893.00€100mg1,243.00€200mg1,674.00€1mL*10mM (DMSO)224.00€IWP-3
CAS:IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α [1] [2].Formula:C22H17FN4O2S3Purity:98%Color and Shape:SolidMolecular weight:484.59MSAB
CAS:MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.Formula:C15H15NO4SPurity:99.76%Color and Shape:SolidMolecular weight:305.35Ref: TM-T8710
1mg34.00€2mg47.00€5mg70.00€10mg113.00€25mg222.00€50mg334.00€100mg507.00€500mg1,063.00€1mL*10mM (DMSO)78.00€Cardiogenol C
CAS:Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.Formula:C13H16N4O2Purity:98.46%Color and Shape:SolidMolecular weight:260.29Cardiogenol C hydrochloride
CAS:Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).Formula:C13H17ClN4O2Purity:99.89% - 99.94%Color and Shape:SolidMolecular weight:296.75IWR-1
CAS:IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).Formula:C25H19N3O3Purity:99.19% - 99.82%Color and Shape:SolidMolecular weight:409.44LF3
CAS:LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)Formula:C20H24N4O2S2Purity:99.63%Color and Shape:SolidMolecular weight:416.56SKL2001
CAS:SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.Formula:C14H14N4O3Purity:97.46% - 99.99%Color and Shape:SolidMolecular weight:286.29Ref: TM-T6989
5mg38.00€10mg57.00€25mg102.00€50mg175.00€100mg321.00€200mg484.00€500mg755.00€1mL*10mM (DMSO)63.00€Adavivint
CAS:Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.
Formula:C29H24FN7OPurity:98.27% - 98.6%Color and Shape:SolidMolecular weight:505.55Wnt-C59
CAS:Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.Formula:C25H21N3OPurity:99.56% - 99.95%Color and Shape:SolidMolecular weight:379.45Teplinovivint
CAS:Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathyFormula:C25H26N6O2Purity:97.21%Color and Shape:SolidMolecular weight:442.51iCRT 14
CAS:iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).Formula:C21H17N3O2SPurity:99.8% - 99.97%Color and Shape:SolidMolecular weight:375.44BML-284
CAS:BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.Formula:C19H18N4O3Purity:99.91% - 99.921%Color and Shape:SolidMolecular weight:350.37Ref: TM-T3144
5mg60.00€10mg88.00€25mg140.00€50mg253.00€100mg427.00€200mg615.00€500mg938.00€1mL*10mM (DMSO)66.00€KY02111
CAS:KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.Formula:C18H17ClN2O3SPurity:97.71% - 98.3%Color and Shape:SolidMolecular weight:376.86β-catenin-IN-2
CAS:β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.Formula:C15H14FN3Purity:99.93%Color and Shape:SolidMolecular weight:255.29Ref: TM-T9696
1mg96.00€5mg227.00€10mg359.00€25mg607.00€50mg868.00€100mg1,169.00€500mg2,365.00€1mL*10mM (DMSO)264.00€exo-IWR-1
CAS:exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin
Formula:C25H19N3O3Purity:97.41%Color and Shape:SolidMolecular weight:409.44Wnt pathway activator 1
CAS:Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM.Formula:C18H16O4Purity:99.93%Color and Shape:SolidMolecular weight:296.32Ref: TM-T17256
2mg33.00€5mg49.00€10mg75.00€25mg124.00€50mg200.00€100mg299.00€200mg430.00€1mL*10mM (DMSO)50.00€WAY 316606
CAS:WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.Formula:C18H19F3N2O4S2Purity:99.65%Color and Shape:SolidMolecular weight:448.48IWP-O1
CAS:IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Formula:C26H20N6OPurity:99.12%Color and Shape:SolidMolecular weight:432.48Ref: TM-T5342
2mg39.00€5mg64.00€10mg101.00€25mg163.00€50mg226.00€100mg320.00€200mg459.00€1mL*10mM (DMSO)70.00€Tegatrabetan
CAS:Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.Formula:C28H36N4O6S2Purity:98.01% - 99.18%Color and Shape:SolidMolecular weight:588.74Ref: TM-T5642
1mg40.00€2mg52.00€5mg85.00€10mg124.00€25mg210.00€50mg334.00€100mg565.00€1mL*10mM (DMSO)96.00€Fz7-21
CAS:Fz7-21, a peptide antagonist of FZD7, inhibits Wnt/β-catenin signaling (IC50=50-100nM) in cells with WNT3A.Formula:C83H114N18O23S2Purity:99.8%Color and Shape:SolidMolecular weight:1796.03KYA1797K
CAS:KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.Formula:C17H11N2O6S2·KPurity:97.57% - 99.33%Color and Shape:SolidMolecular weight:442.51Ref: TM-T6868
2mg39.00€5mg56.00€10mg92.00€25mg178.00€50mg301.00€100mg485.00€200mg690.00€1mL*10mM (DMSO)62.00€Pyrvinium pamoate
CAS:Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drugFormula:C26H28N3C23H14O6Purity:99.76% - >99.99%Color and Shape:SolidMolecular weight:575.71BML-284 hydrochloride
CAS:BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.Formula:C19H19ClN4O3Purity:99.80%Color and Shape:SolidMolecular weight:386.84Ref: TM-T8820
1mg34.00€5mg64.00€10mg84.00€25mg142.00€50mg253.00€100mg439.00€200mg615.00€500mg964.00€1mL*10mM (DMSO)94.00€WAY-262611
CAS:WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.Formula:C20H22N4Purity:98.09% - 99.09%Color and Shape:SolidMolecular weight:318.42IQ 1
CAS:IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions.
Formula:C21H22N4O2Purity:98.57% - ≥95%Color and Shape:SolidMolecular weight:362.42IWP-4
CAS:IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.Formula:C23H20N4O3S3Purity:98% - 99.59%Color and Shape:SolidMolecular weight:496.62PRI-724
CAS:PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.Cost-effective and quality-assured.
Formula:C33H35N6O7PPurity:98.25% - 99.11%Color and Shape:SoildMolecular weight:658.64
