Fibroblast Growth Factor Receptor (FGFR)
FGFR inhibitors are targeted therapies that block the activity of fibroblast growth factor receptors (FGFRs), which are involved in cell proliferation, differentiation, and angiogenesis. FGFR signaling contributes to the formation of new blood vessels in tumors, promoting their growth and survival. Inhibiting FGFR can therefore reduce angiogenesis and tumor progression. At CymitQuimica, we provide a range of high-quality FGFR inhibitors to support your research in cancer, developmental biology, and angiogenesis.
Found 180 products of "Fibroblast Growth Factor Receptor (FGFR)"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Irpagratinib
CAS:Irpagratinib (ABSK011) is an FGFR4 antagonist with anticancer activity, inhibiting FGFR4 autophosphorylation and blocking downstream signaling pathways.Formula:C28H32F2N6O5Purity:99.08% - 99.38%Color and Shape:SolidMolecular weight:570.59CP-547632 TFA
CAS:CP-547632 TFA, an oral VEGFR-2 and FGF inhibitor, IC50: VEGFR-2 at 11 nM, FGF at 9 nM, shows antitumor activity.Formula:C22H25BrF5N5O5SPurity:98%Color and Shape:SolidMolecular weight:646.43TYRA-300
CAS:TYRA-300 is an oral and selective FGFR3 inhibito, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.Formula:C25H24Cl2N6O3SPurity:99.66%Color and Shape:SolidMolecular weight:559.47Ref: TM-T88841
1mg382.00€5mg696.00€10mg947.00€25mg1,554.00€50mg2,034.00€100mg2,749.00€1mL*10mM (DMSO)856.00€Sulfatinib
CAS:Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 toFormula:C24H28N6O3SPurity:99.21% - >99.99%Color and Shape:SolidMolecular weight:480.58FGFR3-IN-7
CAS:FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1].Formula:C25H24FN9OPurity:98%Color and Shape:SolidMolecular weight:485.52FGFR-IN-11
CAS:FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (Formula:C28H29ClN4O4Purity:98%Color and Shape:SolidMolecular weight:521.01Infigratinib-Boc
CAS:Infigratinib-Boc, a derivative of the ATP-competitive pan-FGFR inhibitor Infigratinib, incorporates a Boc (t-Butyloxy carbonyl) group [1].Formula:C29H35Cl2N7O5Color and Shape:SolidMolecular weight:632.54FGFR4-IN-8
CAS:FGFR4-IN-8 is a selective, ATP-competitive FGFR4 inhibitor with IC50s as low as 0.25 nM, halting growth of Hep3B cells at 29 nM and showing in vivo efficacy.Formula:C32H34Cl2FN7O3Purity:98%Color and Shape:SolidMolecular weight:654.56FIIN-1
CAS:FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3,Formula:C32H39Cl2N7O4Purity:98.75%Color and Shape:SolidMolecular weight:656.6Ref: TM-T37426
1mg74.00€2mg98.00€5mg192.00€10mg313.00€25mg520.00€50mg742.00€100mg982.00€500mg2,008.00€FGFR4-IN-4
CAS:FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.Formula:C28H32Cl2N6O5Purity:98%Color and Shape:SolidMolecular weight:603.5FGFR1 inhibitor-16
CAS:FGFR1inhibitor-16 (Compound 89) functions as an FGFR1 inhibitor, demonstrating an inhibition rate of 53.00% at a concentration of 50 μM and 24.95% at 10 μM. It is utilized in tumor research.Formula:C16H9N5O3SColor and Shape:SolidMolecular weight:351.339FGFR-IN-6
CAS:FGFR-IN-6 (Compound 5) is an FGFR inhibitor.Formula:C23H22N6O3Color and Shape:SolidMolecular weight:430.46FGFR4-IN-6
FGFR4-IN-6: covalent, reversible FGFR4 blocker, 5.4 nM IC50, good oral bioavailability, reduces Hep3B2.1-7 tumors in mice, low toxicity.Formula:C31H33N7O4Color and Shape:SolidMolecular weight:567.64FGFR4-IN-9
FGFR4-IN-9 is a selective inhibitor of FGFR4 (IC50: 75.3 nM) that effectively inhibits the growth and angiogenesis of hepatocellular carcinoma cells.Formula:C24H22ClF3N4O4Color and Shape:SolidMolecular weight:522.9PNU-145156E
CAS:PNU-145156E is a noncytotoxic molecule inhibiting growth and angiogenic factors, suppress tumor angiogenesis, support anti-angiogenic research strategies.Formula:C45H40N10O17S4Color and Shape:SolidMolecular weight:1121.12FGFR-IN-5
CAS:FGFR-IN-5 is a potent inhibitor of FGFR. FGFR-IN-5 has potential for research in cancer diseases.Formula:C25H22N6O3Color and Shape:SolidMolecular weight:454.48Lucitanib dihydrochloride
CAS:Lucitanib dihydrochloride (E-3810 dihydrochloride) is an efficient VEGFR1-3, FGFR1-3, and PDGFRalpha/β inhibitor, used in metastatic breast cancer research.Formula:C26H27Cl2N3O4Color and Shape:SolidMolecular weight:516.42E7090 succinate
CAS:E7090 succinate inhibits FGFR1, FGFR2, and FGFR3 with IC50: 0.71, 0.50, 1.2 nM; less so FGFR4 at 120 nM.Formula:C76H92N10O24Color and Shape:SolidMolecular weight:1529.60FGFR3-IN-4
CAS:FGFR3-IN-4 is a selective inhibitor targeting FGFR3, demonstrating an IC50 value of under 50 nM.Formula:C26H24ClN7OColor and Shape:SolidMolecular weight:485.97FGFR1 inhibitor-6
FGFR1 inhibitor-6, IC50: 16.31 nM, blocks cell cycle at pro-G1/G2/M and induces apoptosis.Formula:C27H19N5O4S2Color and Shape:SolidMolecular weight:541.6FGFR1 inhibitor-15
CAS:FGFR1inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC50 value of 27 μM, useful for tumor research.Formula:C17H13FN4OColor and Shape:SolidMolecular weight:308.31CEP-11981
CAS:CEP-11981 is an orally active TIE2/pan-VEGFR inhibitor with broad tyrosine kinase inhibitory activity, antitumour and anti-angiogenic, refractory solid tumours.Formula:C28H27N7OPurity:99.58%Color and Shape:SolidMolecular weight:477.56Fanregratinib
CAS:Fanregratinib is a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.Formula:C27H33ClN6O2Color and Shape:SolidMolecular weight:509.04FGFR4-IN-10
FGFR4-IN-10 (compound 5a) is a potent, selective FGFR4 inhibitor with IC50 of 70.7 nM, sparing FGFR1-3.Formula:C20H19F3N6O3Color and Shape:SolidMolecular weight:448.4FGFR-IN-15
FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.Formula:C22H23N5O5SColor and Shape:SolidMolecular weight:469.51FGFR1 inhibitor-17
CAS:FGFR1inhibitor-17 (Compound 92) is a potent inhibitor of FGFR1, with promising applications in cancer research.Formula:C16H13ClN2O3Color and Shape:SolidMolecular weight:316.739FGFR-IN-16
CAS:FGFR-IN-16 (compound 7N) is a potent inhibitor of FGFR1, FGFR2, and FGFR4, exhibiting IC50 values of 8 nM, 4 nM, and 3.8 nM respectively. It plays a crucial role in cancer research.Formula:C30H27Cl2N7O4Color and Shape:SolidMolecular weight:620.49FGFR2/3-IN-2
CAS:FGFR2/3-IN-2 (compound 10) is an orally active inhibitor targeting FGFR2 and FGFR3. It exhibits IC50 values of 3.7 nM for FGFR2 and 31.2 nM for FGFR3, with a pre-incubation time of 1 hour. FGFR2/3-IN-2 demonstrates selectivity over FGFR1/4 and other kinases, and does not cause diarrhea or increased serum phosphate in vivo. In the SNU-16 gastric cancer model, FGFR2/3-IN-2 can induce tumor stasis or regression.Formula:C29H23FN6O3Color and Shape:SolidMolecular weight:522.53AZ8010
CAS:AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.Formula:C27H34N4O3Color and Shape:SolidMolecular weight:462.58FGFR1 inhibitor-10
CAS:FGFR1 inhibitor-10 (Compound 4i), with an IC50 of 28 nM, effectively inhibits FGFR1 phosphorylation.
Formula:C26H30F3N7O2SPurity:98%Color and Shape:SolidMolecular weight:561.62
