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Trk receptor

Trk receptor

Trk receptor inhibitors target the Tropomyosin receptor kinases (Trk), a family of receptor tyrosine kinases that play a significant role in the development and function of the nervous system. Trk receptors are involved in neurotrophin signaling, which is essential for the survival, differentiation, and growth of neurons. Dysregulation of Trk signaling is associated with neurological disorders and certain cancers. At CymitQuimica, we offer Trk receptor inhibitors to support your research in neurobiology, oncology, and neurodegenerative diseases.

Found 59 products of "Trk receptor"

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  • CG 428
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    CG 428

    CAS:
    <p>CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM.</p>
    Formula:C43H43FN10O6
    Purity:99.83%
    Color and Shape:Solid
    Molecular weight:814.86

    Ref: TM-T41224

  • CymitQuimica logo
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    Type II TRK inhibitor 1

    CAS:
    <p>Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type.</p>
    Formula:C35H33F3N8O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:670.68

    Ref: TM-T72289

  • ENT-C225
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    ENT-C225

    CAS:
    <p>ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.</p>
    Formula:C26H40N4O5
    Purity:99.36% - 99.36%
    Color and Shape:Solid
    Molecular weight:488.62

    Ref: TM-T73397

  • PF-06733804
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    PF-06733804

    CAS:
    <p>PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.</p>
    Formula:C20H19F5N4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:474.38

    Ref: TM-T13207

  • TRK-IN-24
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    TRK-IN-24

    CAS:
    <p>TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L,</p>
    Formula:C39H45N7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:659.82

    Ref: TM-T79706

  • AZ-23
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    AZ-23

    CAS:
    <p>AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C.</p>
    Formula:C17H19ClFN7O
    Purity:99.4%
    Color and Shape:Solid
    Molecular weight:391.83

    Ref: TM-T14363

  • TRK-IN-28
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    TRK-IN-28

    CAS:
    <p>TRK-IN-28 (compound 30f) functions as a TRK inhibitor, displaying potencies with IC 50 values of 0.55 nM for TRK WT, 25.1 nM for TRK G595R, and 5.4 nM for TRK G667C. Another TRK inhibitor, TRK-IN-2, exhibits antiproliferative effects with IC 50 values against multiple cell lines: 9.5 nM for Ba/F3-ETV6-TRKA WT, 3.7 nM for Ba/F3-ETV6-TRKB WT, 205.0 nM for Ba/F3-LMNA-TRK G595R, and 48.3 nM for Ba/F3-LMNA-TRKA G667C [1].</p>
    Formula:C27H25F2N7
    Color and Shape:Solid
    Molecular weight:485.53

    Ref: TM-T87570

  • TRK-IN-26
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    TRK-IN-26

    CAS:
    <p>TRK-IN-26 (compound 12), a TRK inhibitor, holds potential for use in cancer research [1].</p>
    Formula:C30H22F2N6O4
    Color and Shape:Solid
    Molecular weight:568.53

    Ref: TM-T87569

  • TrkA-IN-7
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    TrkA-IN-7

    CAS:
    <p>TrkA-IN-7 (Compound 4) is an inhibitor of tropomyosin receptor kinase A (TrkA), with a Kd value of 40 μM.</p>
    Formula:C16H13N3O3
    Color and Shape:Solid
    Molecular weight:295.293

    Ref: TM-T204489

  • TrkA-IN-8
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    TrkA-IN-8

    CAS:
    <p>TrkA-IN-8 (Compound 2) is a TrkA inhibitor with a Kd value of 3.3 µM. RTKs-IN-1 demonstrates a concentration-dependent inhibitory effect on the proliferation of lung cancer cell lines and holds potential for research in non-small cell lung cancer.</p>
    Formula:C20H16N4
    Color and Shape:Solid
    Molecular weight:312.368

    Ref: TM-T205511

  • TrkA-IN-9
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    TrkA-IN-9

    CAS:
    <p>TrkA-IN-9 (VMD-928) is an orally active and selective inhibitor of tropomyosin receptor kinase A (TrkA). It disrupts downstream signaling pathways activated by nerve growth factor (NGF) binding to TrkA, thereby inhibiting cell proliferation and invasion, and promoting cancer cell death. TrkA-IN-9 shows potential for research in various cancers, including prostate cancer, thymic carcinoma, mesothelioma, head and neck squamous cell carcinoma, lung cancer, ovarian cancer, and hepatocellular carcinoma.</p>
    Formula:C31H32N4O4
    Color and Shape:Solid
    Molecular weight:524.61

    Ref: TM-T206381

  • PF-06273340
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    PF-06273340

    CAS:
    <p>PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。</p>
    Formula:C23H22ClN7O3
    Purity:98% - 98.00%
    Color and Shape:Solid
    Molecular weight:479.92

    Ref: TM-T19649

  • NMS-P626
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    NMS-P626

    CAS:
    <p>NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.</p>
    Formula:C28H35F2N7O4S
    Color and Shape:Solid
    Molecular weight:603.68

    Ref: TM-T200149

  • BNN-20
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    BNN-20

    CAS:
    <p>BNN-20 is a synthetic micro-neurotrophic factor that mimics Brain-Derived Neurotrophic Factor (BDNF) and exhibits region-specific neuroprotective and neurogenesis-promoting effects. It is applicable in research related to Parkinson's disease.</p>
    Formula:C20H30O2
    Color and Shape:Solid
    Molecular weight:302.45

    Ref: TM-T201864

  • TrkC-IN-1
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    TrkC-IN-1

    CAS:
    <p>TrkC-IN-1 (Compound 6c) is an inhibitor of TrkC, with IC50 values of 3.3-7.1 and 7.3-10.2 μΜ for EBC-1 and HT-29 cells, respectively. This compound shows potential for research in the field of cancer therapeutics.</p>
    Formula:C28H20BrN5O2
    Color and Shape:Solid
    Molecular weight:538.395

    Ref: TM-T206472

  • ONO-7579
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    ONO-7579

    CAS:
    <p>ONO-7579, an orally active TRKA inhibitor, effectively suppresses tumor growth by inhibiting TRKA phosphorylation. In KM12 colorectal cancer cells, it exhibits an EC 50 of 17.6 ng/g, indicating that a concentration of 17.6 ng per gram of tumor tissue reduces the activity of phosphorylated TRKA by 50%. This compound is utilized in cancer research.</p>
    Formula:C24H18ClF3N6O4S
    Color and Shape:Solid
    Molecular weight:578.95

    Ref: TM-T200301

  • HS-345
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    HS-345

    CAS:
    <p>HS-345, a TrkA/Akt inhibitor, exhibits potent anti-pancreatic cancer properties. This compound inhibits the growth and proliferation of pancreatic cancer cells by blocking the TrkA/Akt signaling pathway and induces cell apoptosis (Apoptosis). Additionally, HS-345 inhibits angiogenesis by reducing the expression of HIF-1α and VEGF. It holds promise for use in pancreatic cancer research.</p>
    Formula:C19H18N6O2S
    Color and Shape:Solid
    Molecular weight:394.45

    Ref: TM-T200230

  • Trk-IN-4
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    Trk-IN-4

    CAS:
    <p>Trk-IN-4 (PF-6683324) is a potent pan-Trk inhibitor and antinociceptive. It is also a selective type II PTK6 inhibitor antitumor.</p>
    Formula:C24H23F4N5O4
    Purity:98.13%
    Color and Shape:Solid
    Molecular weight:521.46

    Ref: TM-T17169

    1mg
    Discontinued
    2mg
    Discontinued
    Discontinued product
  • TrkB-IN-1
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    TrkB-IN-1

    CAS:
    <p>TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties.</p>
    Formula:C19H16N2O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:368.34

    Ref: TM-T79011

    ne
    Discontinued
    5mg
    Discontinued
    50mg
    Discontinued
    Discontinued product