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c-RET

c-RET

c-RET inhibitors target the RET (Rearranged during Transfection) proto-oncogene, which encodes a receptor tyrosine kinase involved in cell growth, differentiation, and survival. Abnormal activation of RET signaling can lead to uncontrolled cell proliferation and resistance to apoptosis, contributing to the development of cancers such as medullary thyroid carcinoma and non-small cell lung cancer. Inhibiting c-RET can induce apoptosis in cancer cells and is a promising approach in targeted cancer therapy. At CymitQuimica, we offer a variety of high-quality c-RET inhibitors to support your research in oncology, signal transduction, and apoptosis.

Found 51 products of "c-RET"

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  • RET-IN-5
    Targetmol
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    RET-IN-5

    CAS:
    <p>RET-IN-5 is a potent inhibitor of RET (IC50: 4.57 nM).</p>
    Formula:C29H26FN9O
    Color and Shape:Solid
    Molecular weight:535.57

    Ref: TM-T63772

  • FHND5071
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    FHND5071

    CAS:
    <p>FHND5071, a potent and selective RET kinase inhibitor, exerts antitumor effects through the inhibition of RET autophosphorylation and may be utilized for tumor</p>
    Formula:C30H30D3N9O
    Color and Shape:Solid
    Molecular weight:538.66

    Ref: TM-T78797

  • NSC194598
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    NSC194598

    CAS:
    <p>NSC194598 is a p53 DNA-binding inhibitor, demonstrating an in vitro IC50 of 180 nM and an in vivo range of 2-40 μM.</p>
    Formula:C20H19N3O
    Color and Shape:Solid
    Molecular weight:317.38

    Ref: TM-T78203

  • FLT3/ITD-IN-4
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    FLT3/ITD-IN-4

    CAS:
    <p>FLT3/ITD-IN-4 inhibits FLT3-ITD mutations in acute myeloid leukemia (IC50: 2.3 nM).</p>
    Formula:C25H22N4O5
    Color and Shape:Solid
    Molecular weight:458.47

    Ref: TM-T62863

  • RET-IN-13
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    RET-IN-13

    CAS:
    <p>RET-IN-13: potent quinoline RET inhibitor; IC50 = 0.5 nM (WT), 0.9 nM (V804M); potential for RET-related tumor/intestinal disease research.</p>
    Formula:C32H33F4N5O3
    Color and Shape:Solid
    Molecular weight:611.63

    Ref: TM-T73248

  • RET-IN-10
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    RET-IN-10

    CAS:
    <p>RET-IN-10: Potent RET inhibitor, may treat congenital megacolon and tumors (Patent WO2021135938A1, compound 18).</p>
    Formula:C29H28N8OS
    Color and Shape:Solid
    Molecular weight:536.65

    Ref: TM-T63782

  • RET-IN-7
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    RET-IN-7

    CAS:
    <p>RET-IN-7 exhibits strong inhibitory effects against RET kinase in vitro and shows significant efficacy in treating RET-driven tumor xenografts in mice through</p>
    Formula:C22H24ClFN6O2
    Color and Shape:Solid
    Molecular weight:458.92

    Ref: TM-T62877

  • RET-IN-1
    Targetmol
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    RET-IN-1

    CAS:
    <p>RET-IN-1 is a RET kinase inhibitor (IC50s: 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively).</p>
    Formula:C29H31N9O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:553.61

    Ref: TM-T16735

  • CymitQuimica logo
    Targetmol
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    WF-47-JS03

    <p>WF-47-JS03: RET kinase inhibitor, crosses blood-brain barrier, 500x more selective for KDR, IC50: 1.7 nM in Ba/F3 cells, 5.3 nM in LC-2/ad lung cancer cells.</p>
    Formula:C30H38N6O2
    Color and Shape:Solid
    Molecular weight:514.66

    Ref: TM-T63573

  • RET-IN-9
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    RET-IN-9

    CAS:
    <p>RET-IN-9 is a potent RET kinase inhibitor, potentially useful for studying RET-related diseases, including lung and thyroid cancer.</p>
    Formula:C26H27N9O
    Color and Shape:Solid
    Molecular weight:481.55

    Ref: TM-T63183

  • Enbezotinib
    Targetmol
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    Enbezotinib

    CAS:
    <p>Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.</p>
    Formula:C21H21FN6O3
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:424.43

    Ref: TM-T62285