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c-RET

c-RET

c-RET inhibitors target the RET (Rearranged during Transfection) proto-oncogene, which encodes a receptor tyrosine kinase involved in cell growth, differentiation, and survival. Abnormal activation of RET signaling can lead to uncontrolled cell proliferation and resistance to apoptosis, contributing to the development of cancers such as medullary thyroid carcinoma and non-small cell lung cancer. Inhibiting c-RET can induce apoptosis in cancer cells and is a promising approach in targeted cancer therapy. At CymitQuimica, we offer a variety of high-quality c-RET inhibitors to support your research in oncology, signal transduction, and apoptosis.

Found 51 products of "c-RET"

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  • Selpercatinib
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    Selpercatinib

    CAS:
    <p>"Selpercatinib (LOXO-292) is a RET tyrosine kinase inhibitor with IC50s of 14.0, 24.1, 530.7 nM for different RET mutations."</p>
    Formula:C29H31N7O3
    Purity:99.89% - >99.99%
    Color and Shape:Solid
    Molecular weight:525.6

    Ref: TM-T8222

  • Pyrazoloadenine
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    Pyrazoloadenine

    CAS:
    <p>Pyrazoloadenine (4-Aminopyrazolo[3,4-d]pyrimidine) is the inhibitor of human xanthine oxidase.</p>
    Formula:C5H5N5
    Purity:99.02%
    Color and Shape:Beige Powder
    Molecular weight:135.13

    Ref: TM-T9366

  • BBT594
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    BBT594

    CAS:
    <p>BBT594 (NVP-BBT594)(NVP-BBT594) is a potent inhibitor of receptor tyrosine kinase RET,Treatment of cancer.</p>
    Formula:C28H30F3N7O3
    Purity:99.57%
    Color and Shape:Solid
    Molecular weight:569.58

    Ref: TM-T7418

  • SPP-86
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    SPP-86

    CAS:
    <p>SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.</p>
    Formula:C16H15N5
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:277.32

    Ref: TM-T16923

  • RET V804M-IN-1
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    RET V804M-IN-1

    CAS:
    <p>RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).</p>
    Formula:C19H16N6O
    Purity:97.94% - 99.62%
    Color and Shape:Solid
    Molecular weight:344.37

    Ref: TM-T8467

  • WHI-P180 hydrochloride
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    WHI-P180 hydrochloride

    CAS:
    <p>WHI-P180 (Janex 3) inhibits RET, KDR and EGFR with IC50 values of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 is a multi-kinase inhibitor.</p>
    Formula:C16H16ClN3O3
    Color and Shape:Solid
    Molecular weight:333.77

    Ref: TM-T61007

  • RET-IN-22
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    RET-IN-22

    CAS:
    <p>RET-IN-22 (compound 17b) is a potent, selective, and orally active inhibitor of RET, exhibiting IC50 values of 20.9 nM for wild-type RET and 18.3 nM for RET-</p>
    Formula:C29H31F3N6O4
    Color and Shape:Solid
    Molecular weight:584.59

    Ref: TM-T78683

  • RET-IN-15
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    RET-IN-15

    CAS:
    <p>RET-IN-15 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.</p>
    Formula:C27H28N8O2
    Color and Shape:Solid
    Molecular weight:496.56

    Ref: TM-T63358

  • RET-IN-6
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    RET-IN-6

    CAS:
    <p>RET-IN-6 is a potent inhibitor of RET (IC50: 4.57 nM).</p>
    Formula:C30H29N7
    Color and Shape:Solid
    Molecular weight:487.6

    Ref: TM-T63249

  • DUN73423
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    DUN73423

    CAS:
    <p>DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.</p>
    Formula:C19H16N6O
    Purity:98.09%
    Color and Shape:Solid
    Molecular weight:344.37

    Ref: TM-T69644

  • RET-IN-8
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    RET-IN-8

    CAS:
    <p>RET-IN-8 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.</p>
    Formula:C27H30N6O3
    Color and Shape:Solid
    Molecular weight:486.57

    Ref: TM-T63230

  • TRK II-IN-1
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    TRK II-IN-1

    CAS:
    <p>TRK II-IN-1: potent type II TRK inhibitor; IC50s: TRKA (3.3 nM), TRKB (6.4 nM), TRKC (4.3 nM), TRKA G667C (9.4 nM); also targets FLT3, RET, VEGFR2.</p>
    Formula:C29H31F3N8O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:564.6

    Ref: TM-T73033

  • RET-IN-16
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    RET-IN-16

    CAS:
    <p>RET-IN-16: Selective RET inhibitor, IC50s 3.98-15.05 nM for various RET mutations; anticancer properties.</p>
    Formula:C31H29F3N8O2
    Color and Shape:Solid
    Molecular weight:602.61

    Ref: TM-T73256

  • RET-IN-12
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    RET-IN-12

    CAS:
    <p>RET-IN-12 is a RET inhibitor capable of acting on RET(WT) (IC50: 0.3 nM) and RET(V804M) (IC50: 1 nM).</p>
    Formula:C30H30F3N5O4
    Color and Shape:Solid
    Molecular weight:581.59

    Ref: TM-T64103

  • RET-IN-23
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    RET-IN-23

    CAS:
    <p>RET-IN-23 is an orally available and highly potent RET inhibitor with significant antitumor activity for the study of non-small cell lung cancer.</p>
    Formula:C28H28FN11
    Purity:97.46%
    Color and Shape:Solid
    Molecular weight:537.59

    Ref: TM-T79099

  • RET-IN-3
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    RET-IN-3

    CAS:
    <p>RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.</p>
    Formula:C18H21N5O2
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:339.39

    Ref: TM-T9673

  • RET-IN-25
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    RET-IN-25

    CAS:
    <p>RET-IN-25 (compound 6b) is an anticancer RET kinase inhibitor that demonstrates efficacy against medullary thyroid carcinoma (MTC), exhibiting half-maximal</p>
    Formula:C22H17N3O5S
    Color and Shape:Solid
    Molecular weight:435.45

    Ref: TM-T79726

  • RET-IN-17
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    RET-IN-17

    CAS:
    <p>RET-IN-17 inhibits RET kinase; may help in IBS pain and RET-activated cancers.</p>
    Formula:C27H28F4N4O4
    Color and Shape:Solid
    Molecular weight:548.53

    Ref: TM-T63877

  • Vepafestinib
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    Vepafestinib

    CAS:
    <p>Vepafestinib is a RET inhibitor with potential antineoplastic activity[1].</p>
    Formula:C26H30N6O3
    Purity:98.56%
    Color and Shape:Solid
    Molecular weight:474.55

    Ref: TM-T9445

  • RET-IN-24
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    RET-IN-24

    CAS:
    <p>RET-IN-24 (Compound 26) is a selective inhibitor of RET tyrosine kinase, demonstrating antitumor activity [1].</p>
    Formula:C27H26F2N8O
    Color and Shape:Solid
    Molecular weight:516.55

    Ref: TM-T79163