c-RET
c-RET inhibitors target the RET (Rearranged during Transfection) proto-oncogene, which encodes a receptor tyrosine kinase involved in cell growth, differentiation, and survival. Abnormal activation of RET signaling can lead to uncontrolled cell proliferation and resistance to apoptosis, contributing to the development of cancers such as medullary thyroid carcinoma and non-small cell lung cancer. Inhibiting c-RET can induce apoptosis in cancer cells and is a promising approach in targeted cancer therapy. At CymitQuimica, we offer a variety of high-quality c-RET inhibitors to support your research in oncology, signal transduction, and apoptosis.
Found 61 products for "c-RET".
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BBT594
CAS:BBT594 (NVP-BBT594)(NVP-BBT594) is a potent inhibitor of receptor tyrosine kinase RET,Treatment of cancer.Formula:C28H30F3N7O3Purity:99.57%Color and Shape:White SolidMolecular weight:569.58RET V804M-IN-1
CAS:RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).Formula:C19H16N6OPurity:97.94% - 99.62%Color and Shape:White SolidMolecular weight:344.37Ref: TM-T8467
1mg35.00€2mg50.00€5mg74.00€1mL*10mM (DMSO)82.00€10mg90.00€25mg157.00€50mg236.00€100mg334.00€200mg495.00€TPX-0046
CAS:TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib.Formula:C21H21FN6O3Purity:99.95%Color and Shape:SolidMolecular weight:424.43Selpercatinib
CAS:"Selpercatinib (LOXO-292) is a RET tyrosine kinase inhibitor with IC50s of 14.0, 24.1, 530.7 nM for different RET mutations."Formula:C29H31N7O3Purity:99.87% - >99.99%Color and Shape:White SolidMolecular weight:525.6Ref: TM-T8222
2mg34.00€5mg49.00€1mL*10mM (DMSO)56.00€10mg84.00€25mg166.00€50mg259.00€100mg477.00€200mg692.00€500mg1,035.00€Pyrazoloadenine
CAS:Pyrazoloadenine (4-Aminopyrazolo[3,4-d]pyrimidine) is the inhibitor of human xanthine oxidase.Formula:C5H5N5Purity:99.02%Color and Shape:SolidMolecular weight:135.13GSK3179106
CAS:GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nMFormula:C22H21F4N3O4Purity:99.8% - 99.90%Color and Shape:SolidMolecular weight:467.41Treprostinil Sodium
CAS:Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).Formula:C23H33NaO5Purity:99.67% - >99.99%Color and Shape:SolidMolecular weight:412.5SPP-86
CAS:SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.Formula:C16H15N5Purity:99.53%Color and Shape:SolidMolecular weight:277.32Ref: TM-T16923
1mg46.00€5mg90.00€1mL*10mM (DMSO)90.00€10mg144.00€25mg281.00€50mg447.00€100mg650.00€500mg1,369.00€WHI-P180 hydrochloride
CAS:WHI-P180 (Janex 3) inhibits RET, KDR and EGFR with IC50 values of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 is a multi-kinase inhibitor.Formula:C16H16ClN3O3Color and Shape:SolidMolecular weight:333.77AD80
CAS:AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.Formula:C22H19F4N7OPurity:99.49% - 99.75%Color and Shape:SolidMolecular weight:473.43Ref: TM-T4301
1mg44.00€1mL*10mM (DMSO)90.00€5mg96.00€10mg138.00€25mg268.00€50mg439.00€100mg645.00€500mg1,333.00€RET-IN-16
CAS:RET-IN-16: Selective RET inhibitor, IC50s 3.98-15.05 nM for various RET mutations; anticancer properties.Formula:C31H29F3N8O2Color and Shape:SolidMolecular weight:602.61RET-IN-15
CAS:RET-IN-15 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.Formula:C27H28N8O2Color and Shape:SolidMolecular weight:496.56RET-IN-8
CAS:RET-IN-8 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.Formula:C27H30N6O3Color and Shape:SolidMolecular weight:486.57RET-IN-12
CAS:RET-IN-12 is a RET inhibitor capable of acting on RET(WT) (IC50: 0.3 nM) and RET(V804M) (IC50: 1 nM).Formula:C30H30F3N5O4Color and Shape:SolidMolecular weight:581.59RET-IN-6
CAS:RET-IN-6 is a potent inhibitor of RET (IC50: 4.57 nM).Formula:C30H29N7Color and Shape:SolidMolecular weight:487.6RET-IN-22
CAS:RET-IN-22 (compound 17b) is a potent, selective, and orally active inhibitor of RET, exhibiting IC50 values of 20.9 nM for wild-type RET and 18.3 nM for RET-Formula:C29H31F3N6O4Color and Shape:SolidMolecular weight:584.59XMD15-44
CAS:XMD15-44, a RET kinase inhibitor, demonstrates potent growth-inhibitory effects on RAT1 cells transformed by RET/C634R and RET/M918T, with IC50 values of 11.5 nM and 8.3 nM, respectively. It effectively inhibits RET kinase activity and signaling in human thyroid cancer cell lines harboring oncogenic RET alleles, thereby reducing cell proliferation.Formula:C29H29F3N4OColor and Shape:SolidMolecular weight:506.56DUN73423
CAS:DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.Formula:C19H16N6OPurity:98.03%Color and Shape:SolidMolecular weight:344.37TRK II-IN-1
CAS:TRK II-IN-1: potent type II TRK inhibitor; IC50s: TRKA (3.3 nM), TRKB (6.4 nM), TRKC (4.3 nM), TRKA G667C (9.4 nM); also targets FLT3, RET, VEGFR2.Formula:C29H31F3N8OPurity:98%Color and Shape:SolidMolecular weight:564.6RET-IN-3
CAS:RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.Formula:C18H21N5O2Purity:99.83%Color and Shape:SolidMolecular weight:339.39Ref: TM-T9673
1mg70.00€5mg149.00€1mL*10mM (DMSO)165.00€10mg227.00€25mg427.00€50mg675.00€100mg1,035.00€200mg1,395.00€
