Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1424 products of "Autophagy"
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STO-609 acetate
CAS:<p>STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for the</p>Formula:C19H10N2O3·C2H4O2Purity:99.75%Color and Shape:SolidMolecular weight:374.35TH152
CAS:<p>TH152 is a general reversible ligand for LC3/GABARAP with a dissociation constant (KD) of 2 µM. LC3/GABARAP is a protein associated with autophagy.</p>Formula:C22H23ClN4O4S2Color and Shape:SolidMolecular weight:507.03Fumagilin-105
CAS:<p>Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.</p>Formula:C46H60N2O9Color and Shape:SolidMolecular weight:784.98SQA1
CAS:<p>SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.</p>Formula:C22H26N4O5Color and Shape:SolidMolecular weight:426.47TRAF6 peptide
CAS:<p>TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.</p>Formula:C145H238N34O44Color and Shape:SolidMolecular weight:3161.64PBA-1105b
CAS:<p>PBA-1105b, a longer PEGylated derivative of PBA-1105, is an autophagy-targeting chimeric compound (AUTOTAC) that can induce self-oligomerization of p62. It enhances the autophagic flux of Ub-bound aggregates.</p>Formula:C47H64N2O10Color and Shape:SolidMolecular weight:817.02Microcolin H
CAS:<p>Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].</p>Formula:C38H63N5O9Color and Shape:SolidMolecular weight:733.93LC3in-C42
<p>LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.</p>Color and Shape:Odour SolidPHTPP-1304
CAS:<p>PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.</p>Formula:C51H50F6N4O7Color and Shape:SolidMolecular weight:944.96Erlotinib-13C6
CAS:<p>Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.</p>Formula:C22H23N3O4Color and Shape:SolidMolecular weight:399.397Polyphemusin II-Derived Peptide
CAS:<p>T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.</p>Formula:C90H141N33O18S2Color and Shape:SolidMolecular weight:2037.42cGMP-HTL
<p>cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.</p>Formula:C31H51ClN7O14PSColor and Shape:SolidMolecular weight:844.27Beclin1-Bcl-2 interaction inhibitor 1
<p>Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].</p>Color and Shape:Odour SolidALA-A2 peptide
<p>ALA-A2, a cancer peptide found in α-lactalbumin, selectively kills cancer cells by inducing autophagy (Autophagy). It possesses cell-penetrating properties, allowing it to enter cells effectively without relying on membrane solubilization effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. This peptide shows promise for research in cancer treatment and autophagy regulation.</p>Formula:C67H111N21O19SColor and Shape:SolidMolecular weight:1546.79Hoechst 33342 analog trihydrochloride
CAS:<p>Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating the</p>Formula:C32H38Cl3N7Color and Shape:SolidMolecular weight:627.05Corydalmine hydrochloride
CAS:<p>Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.</p>Formula:C20H24ClNO4Color and Shape:SolidMolecular weight:377.86Cy5.5-SE (DIPEA)
<p>Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.</p>Formula:C53H66N4O16S4Color and Shape:SolidMolecular weight:1143.37Zn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Formula:C115H145ClN18O31S2Zn2Color and Shape:SolidMolecular weight:2505.83Biotin-11-dCTP
<p>Biotin-11-dCTP is a fluorescent dye for DNA labeling [1] .</p>Formula:C28H43Li3N7O16P3SColor and Shape:SolidMolecular weight:879.49Flavopiridol
CAS:<p>Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.</p>Formula:C21H20ClNO5Purity:97.74% - 99.86%Color and Shape:SolidMolecular weight:401.84
