Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1489 products of "Autophagy"
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MRT 67307 dihydrochloride
CAS:<p>MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.</p>Formula:C26H38Cl2N6O2Purity:99.75%Color and Shape:SoildMolecular weight:537.53Cy5.5-SE (DIPEA)
Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.Formula:C53H66N4O16S4Color and Shape:SolidMolecular weight:1143.37Atorvastatin Sodium
CAS:Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors onFormula:C33H34FN2NaO5Purity:99.88% - >99.99%Color and Shape:SolidMolecular weight:580.63Valproic acid sodium salt
CAS:Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.Formula:C8H15NaO2Purity:98% - 99.78%Color and Shape:White PowderMolecular weight:166.2Corydalmine hydrochloride
CAS:Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.Formula:C20H24ClNO4Color and Shape:SolidMolecular weight:377.86Clionamine B
CAS:Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.Formula:C27H45NO3Color and Shape:SolidMolecular weight:431.65Zn-DPA-maytansinoid conjugate 1
Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.Formula:C115H145ClN18O31S2Zn2Color and Shape:SolidMolecular weight:2505.83PHTPP-1304
CAS:PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.Formula:C51H50F6N4O7Color and Shape:SolidMolecular weight:944.96E70K
E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuateFormula:C108H178N34O28Purity:98%Color and Shape:SolidMolecular weight:2400.78Peptide 78
CAS:Peptide 78 is identical to peptide 74 except that serine replaces cysteine. It does not inhibit 72-kDa type IV collagenase.Formula:C62H107N23O21SPurity:98%Color and Shape:SolidMolecular weight:1542.74SDF-1α (human)
CAS:SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processesFormula:C356H578N106O93S4Purity:98%Color and Shape:SolidMolecular weight:7959.34Desethylamiodarone hydrochloride
CAS:Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.Formula:C23H26ClI2NO3Purity:98%Color and Shape:SolidMolecular weight:653.72ITIC
CAS:"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."Formula:C94H82N4O2S4Purity:98%Color and Shape:SolidMolecular weight:1427.96Dusquetide TFA
Dusquetide TFA (SGX942) is an IDR that modulates immunity by targeting p62, reducing inflammation, and enhancing bacterial clearance.Formula:C27H48F3N9O7Color and Shape:SolidMolecular weight:667.72G-quadruplex DNA fluorescence probe 1
<p>Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.</p>Formula:C27H31IN2O3Color and Shape:SolidMolecular weight:558.45TSPO Ligand-Linker Conjugates 1
TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.Formula:C32H55N3O10SColor and Shape:SolidMolecular weight:673.86Tetramethylrhodamine-dUTP
Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .Formula:C43H52N6O19P3Color and Shape:SolidMolecular weight:1049.82VUF-11222
CAS:VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).Formula:C25H31BrINPurity:99.82%Color and Shape:SolidMolecular weight:552.334-Amino-D-phenylalanine
CAS:4-Amino-D-phenylalanine ([D-Phe(4-NH2)]) is a cyclic pentapeptide that inhibits the binding of CXCL12 to CXCR4 in FC131, with an IC50 value of 0.1 μM.Formula:C9H12N2O2Color and Shape:SolidMolecular weight:180.2Vimnerixin
CAS:Vimnerixin (AZD4721) is an orally administered CXCR2 antagonist for inflammation studies.Formula:C19H25FN4O5S2Color and Shape:SolidMolecular weight:472.55
