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Autophagy

Autophagy

Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.

Found 1483 products of "Autophagy"

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  • CXCR4 antagonist 8
    Targetmol
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    CXCR4 antagonist 8

    CAS:
    CXCR4 antagonist 8 (Compound 3) blocks CXCR4, IC50 of 57 nM; stops CXCL12-induced Ca2+ increase, IC50 of 0.24 nM; hinders cell migration.
    Formula:C21H26N6
    Color and Shape:Solid
    Molecular weight:362.47

    Ref: TM-T61363

  • KSI-3716
    Targetmol
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    KSI-3716

    CAS:
    KSI-3716 is a c-Myc inhibitor, a bladder chemotherapy agent that blocks the formation of complexes between c-MYC/MAX and target gene promoters.
    Formula:C17H11BrCl2N2O2
    Purity:98.94%
    Color and Shape:Solid
    Molecular weight:426.09

    Ref: TM-T11783

  • Antiproliferative agent-5
    Targetmol
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    Antiproliferative agent-5

    CAS:
    Compound 4o inhibits gastric cancer growth, blocks G2/M cell cycle, induces ROS, and triggers autophagy. Used in anti-cancer studies.
    Formula:C28H21BrN8OS
    Color and Shape:Solid
    Molecular weight:597.49

    Ref: TM-T64212

  • MOPIPP
    Targetmol
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    MOPIPP

    CAS:
    MOPIPP: crosses blood-brain barrier, fights glioblastoma, induces vacuolization, boosts autophagy, triggers methuosis, hinders glucose metabolism.
    Formula:C20H20N2O2
    Color and Shape:Solid
    Molecular weight:320.39

    Ref: TM-T60858

  • AUTEN-67
    Targetmol
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    AUTEN-67

    CAS:
    AUTEN-67 inhibits MTMR14, boosts autophagy, has antiaging/neuroprotective properties, and combats Huntington's disease onset/severity.
    Formula:C23H14N4O6S
    Color and Shape:Solid
    Molecular weight:474.45

    Ref: TM-T26683

  • VUF11211
    Targetmol
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    VUF11211

    CAS:
    VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.
    Formula:C26H35Cl2N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:504.49

    Ref: TM-T23656

  • Levomepromazine Maleate
    Targetmol
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    Levomepromazine Maleate

    CAS:
    Levomepromazine Maleate: TCA and SNRI with antihistamine, antiadrenergic, and anticholinergic properties.
    Formula:C23H28N2O5S
    Color and Shape:Solid
    Molecular weight:444.546

    Ref: TM-T71773

  • 8-Nitro-cGMP
    Targetmol
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    8-Nitro-cGMP

    CAS:
    8-Nitro-cGMP is a unique cytoprotective mediator which inhibits oxidative stress. 8-Nitro-cGMP is also a probe of the protein S-guanylation.
    Formula:C10H11N6O9P
    Color and Shape:Solid
    Molecular weight:390.20

    Ref: TM-T68374

  • CXCR4 antagonist 9
    Targetmol
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    CXCR4 antagonist 9

    CAS:
    CXCR4 antagonist 9, with IC50s of 15 nM & 1.3 nM against CXCR4 & Ca²⁺ rise by CXCL12 respectively.
    Formula:C21H27FN6
    Color and Shape:Solid
    Molecular weight:382.48

    Ref: TM-T61650

  • Autophagy-IN-C1
    Targetmol
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    Autophagy-IN-C1

    CAS:
    Autophagy-IN-C1 is a cinchona alkaloid derivative containing urea.
    Formula:C29H28F6N4O2
    Color and Shape:Solid
    Molecular weight:578.55

    Ref: TM-T38977

  • SB-332235
    Targetmol
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    SB-332235

    CAS:
    SB-332235 is an effective specific CXCR2 antagonist. And it is effectively inhibited CS-induced neutrophilia in a dose-dependent manner.
    Formula:C13H10Cl3N3O4S
    Color and Shape:Solid
    Molecular weight:410.66

    Ref: TM-T34544

  • ICT5040
    Targetmol
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    ICT5040

    CAS:
    ICT5040 is a CXCR4 antagonist.
    Formula:C10H8F3N3OS
    Color and Shape:Solid
    Molecular weight:275.25

    Ref: TM-T25523

  • Norswertianin
    Targetmol
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    Norswertianin

    CAS:
    Norswertianin, a xanthone, induces GBM cell differentiation and autophagy via oxidative stress and Akt/mTOR.
    Formula:C13H8O6
    Color and Shape:Solid
    Molecular weight:260.2

    Ref: TM-T72904

  • Omeprazole Sodium
    Targetmol
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    Omeprazole Sodium

    CAS:
    Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion.
    Formula:C17H18N3NaO3S
    Purity:99.84%
    Color and Shape:Clear In Water
    Molecular weight:367.4

    Ref: TM-T22391

  • PF 750
    Targetmol
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    PF 750

    CAS:
    PF 750 (ZINC27647189) is a selective and covalent inhibitor of FAAH. PF 750 shows IC50s varying from 16.2 to 595 nM in different incubation times.
    Formula:C22H23N3O
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:345.44

    Ref: TM-T16515

  • Quinacrine analog 34
    Targetmol
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    Quinacrine analog 34

    CAS:
    Quinacrine: anti-protozoal, autophagy inhibitor (toxic at 2.5 μM). Analog 34 less toxic (LD50 = 27 μM), raises LC3-II protein, deacidifies lysosomes.
    Formula:C20H27ClN4
    Color and Shape:Solid
    Molecular weight:358.91

    Ref: TM-T35747

  • SMYD3-IN-2
    Targetmol
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    SMYD3-IN-2

    SMYD3-IN-2, a cancer research chemical, inhibits SMYD3 (IC50 0.81 μM) and BGC823 (IC50 0.75 μM), inducing fatal autophagy in gastric cancer.
    Formula:C26H21BrN2O4
    Color and Shape:Solid
    Molecular weight:505.36

    Ref: TM-T73183

  • Dilmapimod tosylate
    Targetmol
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    Dilmapimod tosylate

    CAS:
    Dilmapimod tosylate, a p38 MAPK inhibitor, targets IL-1β, was in phase III trials by GlaxoSmithKline for rheumatoid arthritis and more.
    Formula:C30H27F3N4O6S
    Color and Shape:Solid
    Molecular weight:628.62

    Ref: TM-T68297

  • CXCR4 modulator-2
    Targetmol
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    CXCR4 modulator-2

    CAS:
    CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.
    Formula:C21H32N8O2
    Color and Shape:Solid
    Molecular weight:428.53

    Ref: TM-T62352

  • NSC 33994
    Targetmol
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    NSC 33994

    CAS:
    NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.
    Formula:C28H42N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:438.65

    Ref: TM-T23091

  • SR 3677 dihydrochloride
    Targetmol
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    SR 3677 dihydrochloride

    CAS:
    Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).
    Formula:C22H26Cl2N4O4
    Color and Shape:Solid
    Molecular weight:481.37

    Ref: TM-T35828

  • Lamotrigine isethionate
    Targetmol
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    Lamotrigine isethionate

    CAS:
    Water-soluble salt of lamotrigine . Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.
    Formula:C11H13Cl2N5O4S
    Color and Shape:Solid
    Molecular weight:382.22

    Ref: TM-T36482

  • PF-06371900
    Targetmol
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    PF-06371900

    CAS:
    PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).
    Formula:C17H16N6O2S
    Color and Shape:Solid
    Molecular weight:368.41

    Ref: TM-T70363

  • Ralimetinib
    Targetmol
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    Ralimetinib

    CAS:
    Ralimetinib blocks MK2 phosphorylation at Thr334 without affecting p38α MAPK or JNK. It is an ATP-competitive inhibitor of p38 MAPK α/β (IC50 5.3/3.2 nM).
    Formula:C24H29FN6
    Purity:99.16% - 99.21%
    Color and Shape:Solid
    Molecular weight:420.53

    Ref: TM-T16721

  • Glaucocalyxin B
    Targetmol
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    Glaucocalyxin B

    CAS:
    Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).
    Formula:C22H30O5
    Purity:99.13% - 99.35%
    Color and Shape:Solid
    Molecular weight:374.47

    Ref: TM-TQ0309

  • Ivacaftor benzenesulfonate
    Targetmol
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    Ivacaftor benzenesulfonate

    CAS:
    Ivacaftor benzenesulfonate used for cystic fibrosis treatment. is an orally bioavailable CFTR potentiator.
    Formula:C30H34N2O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:550.67

    Ref: TM-T13742

  • PF-06455943
    Targetmol
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    PF-06455943

    CAS:
    PF-06455943: LRRK2 inhibitor, IC50=3nM, PET radioligand, used for ADME/neuro PK & Parkinson's research.
    Formula:C17H14FN5O
    Color and Shape:Solid
    Molecular weight:323.32

    Ref: TM-T72999

  • Poloppin
    Targetmol
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    Poloppin

    CAS:
    Poloppin modulates polo-like kinases, targets mutant KRAS, and enhances Crizotinib's effects against KRAS-mutant cancers.
    Formula:C20H15BrF3NO2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:438.24

    Ref: TM-T24652

  • AMD 3465
    Targetmol
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    AMD 3465

    CAS:
    AMD 3465 (GENZ-644494) blocks CXCR4, hinders X4 HIV replication (IC50: 1-10 nM), ineffective against R5 viruses, IC50: 0.75 nM (12G5 mAb), 18 nM (CXCL12AF647).
    Formula:C24H38N6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:410.60

    Ref: TM-T14208

  • p38 MAPK-IN-2
    Targetmol
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    p38 MAPK-IN-2

    CAS:
    p38 MAPK-IN-2 is an inhibitor of p38 kinase.
    Formula:C20H19ClFN5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:415.85

    Ref: TM-T11241

  • Fluoxetine oxalate
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    Fluoxetine oxalate

    CAS:
    Fluoxetine oxalate, an SSRI, treats depression, OCD, bulimia, panic, and PMS.
    Formula:C19H20F3NO5
    Color and Shape:Solid
    Molecular weight:399.36

    Ref: TM-T71389

  • Nicodicosapent
    Targetmol
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    Nicodicosapent

    CAS:
    Nicodicosapent is a fatty acid niacin conjugate that inhibits SREBP, a regulator of cholesterol metabolism.
    Formula:C28H39N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:449.63

    Ref: TM-T16322

  • GSK3-IN-3
    Targetmol
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    GSK3-IN-3

    CAS:
    <p>GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy.</p>
    Formula:C24H35N3O4
    Purity:99.37%
    Color and Shape:Solid
    Molecular weight:429.55

    Ref: TM-T73331

  • Xantocillin
    Targetmol
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    Xantocillin

    CAS:
    Xanthocillin is a marine agent. Xanthocillin also induces autophagy through inhibition of the MEK/ERK pathway.
    Formula:C18H12N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:288.3

    Ref: TM-T17261

  • Methophenazine diethanesulfonate
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    Methophenazine diethanesulfonate

    CAS:
    Methophenazine diethanesulfonate is a Calmodulin antagonist.
    Formula:C35H48ClN3O11S3
    Color and Shape:Solid
    Molecular weight:818.41

    Ref: TM-T70288

  • Olacaftor
    Targetmol
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    Olacaftor

    CAS:
    Olacaftor, also known as VX-440, is a protein modulator of cystic fibrosis transmembrane regulator (CFTR).
    Formula:C29H34FN3O4S
    Color and Shape:Solid
    Molecular weight:539.66

    Ref: TM-T25898

  • (3S,5R)-Rosuvastatin
    Targetmol
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    (3S,5R)-Rosuvastatin

    CAS:
    (3S,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).
    Formula:C22H28FN3O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:481.54

    Ref: TM-T10131

  • CXCR4 antagonist 5
    Targetmol
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    CXCR4 antagonist 5

    CAS:
    CXCR4 antagonist with IC50 of 8.8 nM, inhibits CXCL12-induced calcium increase and chemotaxis, with good safety and minimal CYP, hERG impact.
    Formula:C21H30N6
    Color and Shape:Solid
    Molecular weight:366.5

    Ref: TM-T61419

  • CUR5g
    Targetmol
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    CUR5g

    CAS:
    CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells.
    Formula:C22H20N2O2
    Purity:98.92%
    Color and Shape:Solid
    Molecular weight:344.41

    Ref: TM-T73550

  • Ivacaftor hydrate
    Targetmol
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    Ivacaftor hydrate

    CAS:
    Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment.
    Formula:C24H30N2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:410.514

    Ref: TM-T13742L

  • CymitQuimica logo
    Targetmol
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    Ambroxol-d5

    CAS:
    Ambroxol-d5 is a standard for quantifying ambroxol in GC/LC-MS, an expectorant metabolite of bromhexine improving mucociliary functions.
    Formula:C13H13Br2D5N2O
    Molecular weight:383.13

    Ref: TM-T71143

  • Dinoprost
    Targetmol
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    Dinoprost

    CAS:
    Dinoprost (Prostaglandin F2a) is a naturally occurring prostaglandin. It is used in medicine to induce labor and as an abortifacient.
    Formula:C20H34O5
    Purity:97.94% - 98.04%
    Color and Shape:White To Off-White Crystalline Solid
    Molecular weight:354.48

    Ref: TM-T15133

  • CP-53631
    Targetmol
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    CP-53631

    CAS:
    CP-53631 is a selective serotonin reuptake inhibitor (SSRI)
    Formula:C17H19BrClN
    Color and Shape:Solid
    Molecular weight:352.7

    Ref: TM-T68680

  • GSK812397
    Targetmol
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    GSK812397

    CAS:
    GSK812397 inhibits X4-tropic HIV-1 with high potency, targeting CXCR4 receptor noncompetitively and showing broad efficacy and good pharmacokinetics.
    Formula:C24H32N6O
    Color and Shape:Solid
    Molecular weight:420.55

    Ref: TM-T68457

  • MF-095
    Targetmol
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    MF-095

    CAS:
    MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.
    Formula:C27H31N3O4S
    Color and Shape:Solid
    Molecular weight:493.62

    Ref: TM-T69744

  • Momelotinib Mesylate
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    Momelotinib Mesylate

    CAS:
    Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.
    Formula:C24H26N6O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:510.57

    Ref: TM-T15037

  • SMER18
    Targetmol
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    SMER18

    CAS:
    SMER18, a small molecule enhancer of rapamycin, acts as an mTOR-independent inducer of autophagy and can be used to study neurodegenerative diseases.
    Formula:C16H14ClNO2
    Purity:97.27%
    Color and Shape:Solid
    Molecular weight:287.74

    Ref: TM-T16900

  • Metofenazate
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    Metofenazate

    CAS:
    Metofenazate is an selective inhibitor of calmodulin .
    Formula:C31H36ClN3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:598.15

    Ref: TM-T12021

  • Amsacrine
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    Amsacrine

    CAS:
    Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.
    Formula:C21H19N3O3S
    Purity:99.2% - 99.34%
    Color and Shape:Yellow Crystalline Powder Solid
    Molecular weight:393.46

    Ref: TM-T1206

  • DK-1-49
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    DK-1-49

    CAS:
    DK-1-49 is an autophagonizer. It causes accumulation of autophagy-associated LC3-II and enhanced levels of autophagosomes and acidic vacuoles.
    Formula:C28H31N5O3S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:549.71

    Ref: TM-T27187