Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1504 products of "Autophagy"
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NSC 33994
CAS:NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.Formula:C28H42N2O2Purity:98%Color and Shape:SolidMolecular weight:438.65SR 3677 dihydrochloride
CAS:Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).Formula:C22H26Cl2N4O4Color and Shape:SolidMolecular weight:481.37Lamotrigine isethionate
CAS:Water-soluble salt of lamotrigine . Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.Formula:C11H13Cl2N5O4SColor and Shape:SolidMolecular weight:382.22Evogliptin tartrate
CAS:Evogliptin tartrate: Oral DPP-4 inhibitor, may treat atherosclerosis and diabetes.Formula:C23H32F3N3O9Color and Shape:SolidMolecular weight:551.51PF-06371900
CAS:PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).Formula:C17H16N6O2SColor and Shape:SolidMolecular weight:368.41Ralimetinib
CAS:Ralimetinib blocks MK2 phosphorylation at Thr334 without affecting p38α MAPK or JNK. It is an ATP-competitive inhibitor of p38 MAPK α/β (IC50 5.3/3.2 nM).Formula:C24H29FN6Purity:99.16% - 99.21%Color and Shape:SolidMolecular weight:420.53CXCR4 antagonist 5
CAS:CXCR4 antagonist with IC50 of 8.8 nM, inhibits CXCL12-induced calcium increase and chemotaxis, with good safety and minimal CYP, hERG impact.Formula:C21H30N6Color and Shape:SolidMolecular weight:366.5Ivacaftor benzenesulfonate
CAS:Ivacaftor benzenesulfonate used for cystic fibrosis treatment. is an orally bioavailable CFTR potentiator.Formula:C30H34N2O6SPurity:98%Color and Shape:SolidMolecular weight:550.67PF-06455943
CAS:PF-06455943: LRRK2 inhibitor, IC50=3nM, PET radioligand, used for ADME/neuro PK & Parkinson's research.Formula:C17H14FN5OColor and Shape:SolidMolecular weight:323.32Dinoprost
CAS:Dinoprost (Prostaglandin F2a) is a naturally occurring prostaglandin. It is used in medicine to induce labor and as an abortifacient.Formula:C20H34O5Purity:97.94% - 98.04%Color and Shape:White To Off-White Crystalline SolidMolecular weight:354.48Ref: TM-T15133
5mg49.00€10mg74.00€25mg137.00€50mg205.00€100mg326.00€200mg485.00€1mL*10mM (DMSO)54.00€Ivacaftor hydrate
CAS:Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment.Formula:C24H30N2O4Purity:98%Color and Shape:SolidMolecular weight:410.514Poloppin
CAS:Poloppin modulates polo-like kinases, targets mutant KRAS, and enhances Crizotinib's effects against KRAS-mutant cancers.Formula:C20H15BrF3NO2Purity:98%Color and Shape:SolidMolecular weight:438.24Amsacrine
CAS:Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.Formula:C21H19N3O3SPurity:99.2% - 99.34%Color and Shape:Yellow Crystalline Powder SolidMolecular weight:393.46CUR5g
CAS:CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells.Formula:C22H20N2O2Purity:98.92%Color and Shape:SolidMolecular weight:344.41Ref: TM-T73550
1mg58.00€5mg128.00€10mg197.00€25mg394.00€50mg627.00€100mg928.00€1mL*10mM (DMSO)141.00€p38 MAPK-IN-2
CAS:p38 MAPK-IN-2 is an inhibitor of p38 kinase.Formula:C20H19ClFN5O2Purity:98%Color and Shape:SolidMolecular weight:415.85(3S,5R)-Rosuvastatin
CAS:(3S,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).Formula:C22H28FN3O6SPurity:98%Color and Shape:SolidMolecular weight:481.54ACT-660602
CAS:ACT-660602: Oral CXCR3 blocker, T-cell migration inhibitor, effective in acute lung injury models, potential for autoimmune research. IC50: 204 nM.Formula:C20H20F6N8OSColor and Shape:SolidMolecular weight:534.48BC-1485
CAS:BC-1485 is a small molecule inhibitor of FIEL1 that inhibits the degradation of PIAS4 and ameliorates fibrosis in a mouse model.Formula:C19H21N5O5SPurity:97.03% - 97.15%Color and Shape:SolidMolecular weight:431.473HOI-BA-01
CAS:3HOI-BA-01 is a mammalian targeting effective rapamycin activation inhibitor.Formula:C19H15NO5Purity:98%Color and Shape:SolidMolecular weight:337.33DK-1-49
CAS:DK-1-49 is an autophagonizer. It causes accumulation of autophagy-associated LC3-II and enhanced levels of autophagosomes and acidic vacuoles.Formula:C28H31N5O3S2Purity:98%Color and Shape:SolidMolecular weight:549.71LRRK2-IN-10
CAS:LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2Formula:C20H15N5OPurity:98%Color and Shape:SolidMolecular weight:341.37MF-095
CAS:MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.Formula:C27H31N3O4SColor and Shape:SolidMolecular weight:493.62FAAH-IN-1
CAS:FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.Formula:C20H19ClN4OSPurity:98%Color and Shape:SolidMolecular weight:398.91Momelotinib Mesylate
CAS:Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.Formula:C24H26N6O5SPurity:98%Color and Shape:SolidMolecular weight:510.57SB02024
CAS:SB02024 inhibits VPS34, boosts cGAS-STING, hinders autophagy, and shrinks breast cancer xenografts; enhances Sunitinib/Erlotinib efficacy.Formula:C16H22F3N3O2Color and Shape:SolidMolecular weight:345.36Metofenazate
CAS:Metofenazate is an selective inhibitor of calmodulin .Formula:C31H36ClN3O5SPurity:98%Color and Shape:SolidMolecular weight:598.15GSK3-IN-3
CAS:GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy.
Formula:C24H35N3O4Purity:99.37%Color and Shape:SolidMolecular weight:429.55HF50731
CAS:HF50731 is a CXCR4 antagonist with high binding affinity (IC50: 19.8 nM) and inhibits calcium mobilization, cell migration, and HIV-1 (IC50: 1.5 nM).Formula:C26H46N4Color and Shape:SolidMolecular weight:414.67LV-320
CAS:LV-320, potent ATG4B inhibitor; IC50: 24.5 μM, Kd: 16 μM. Blocks autophagy, stable, non-toxic, active in vivo. Useful for ATG4B research in cancer.Formula:C29H26ClNO2S2Purity:98%Color and Shape:SolidMolecular weight:520.11SA 47
CAS:SA 47 is a selective and effective inhibitor of fatty acid amide hydrolase and carbamate.Formula:C17H26N4O3Purity:98%Color and Shape:SolidMolecular weight:334.41Rimacalib
CAS:Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).Formula:C22H23FN4O2Purity:98%Color and Shape:SolidMolecular weight:394.44SR-17398
CAS:SR-17398 is an inhibitor of Unc-51-Like Kinase 1 (ULK1) (IC50 = 22.4 uM).Formula:C14H18N4OPurity:98%Color and Shape:SolidMolecular weight:258.32ABTL-0812
CAS:ABTL-0812 induces endoplasmic reticulum (ER) stress-mediated autophagy, and with anti-cancer activity.Formula:C18H32O3Color and Shape:SolidMolecular weight:296.44FR 167653 free base
CAS:FR 167653 is an oral p38 MAPK inhibitor for inflammation, trauma, ischemia relief; it suppresses TNF-α, IL-1β.Formula:C24H18FN5O2Purity:98%Color and Shape:SolidMolecular weight:427.43ROC-325
CAS:ROC-325: orally active autophagy inhibitor with anticancer effects, induces kidney cancer cell death; selective action.Formula:C28H27ClN4OSPurity:99.26%Color and Shape:SolidMolecular weight:503.06AMDE-1
CAS:AMDE-1, an autophagy modulator, triggers Atg5-dependent autophagy, recruits Atg16, and induces LC3 lipidation.Formula:C18H8ClF6N3Purity:90%Color and Shape:SolidMolecular weight:415.72AGN 205728
CAS:AGN 205728 is a potent and selective RARγ antagonist (Ki: 3 nM; IC95: 0.6 nM) and has no inhibition on RARα and RARβ.Formula:C29H27NO3Purity:98%Color and Shape:SolidMolecular weight:437.53CCT128930
CAS:'CCT128930, potent Akt2 inhibitor (IC50=6 nM), 28x more selective over PKA.'Formula:C18H20ClN5Purity:99.07% - 99.18%Color and Shape:SolidMolecular weight:341.84Ref: TM-T6303
2mg39.00€5mg62.00€10mg88.00€25mg166.00€50mg259.00€100mg388.00€200mg617.00€1mL*10mM (DMSO)67.00€Autophagy inducer 3
CAS:Autophagy Inducer 3 triggers selective cancer cell death via autophagy, sparing healthy cells.Formula:C24H43NO2Color and Shape:SolidMolecular weight:377.6SRT3190
CAS:SRT3190 is an antagonist of CXCR2.Formula:C18H23F2N5O4S2Purity:98%Color and Shape:SolidMolecular weight:475.53SCH 546738
CAS:SCH 546738 is an orally available, selective and potent CXCR3 antagonist that attenuates the development of autoimmune diseases and delays graft rejection.Formula:C23H31Cl2N7OPurity:98.67%Color and Shape:SolidMolecular weight:492.45K67
CAS:K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.Formula:C29H30N2O7S2Purity:98.43%Color and Shape:SolidMolecular weight:582.69(-)-Talarozole
CAS:(-)-Talarozole is a potent retinoic acid metabolism inhibitor.Formula:C21H23N5SColor and Shape:SolidMolecular weight:377.51AZ10397767
CAS:AZ10397767: Potent CXCR2 blocker (IC50=1nM); lowers neutrophil infiltration in tumors in vitro/in vivo.Formula:C15H14ClFN4O2S2Color and Shape:SolidMolecular weight:400.88PS372424
CAS:PS372424 is a specific agonist of human CXCR3, with anti-inflammatory activity.Formula:C33H44N6O4Purity:98%Color and Shape:SolidMolecular weight:588.74MDK-6983
CAS:MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.Formula:C22H18Cl2N2O3Purity:99.68%Color and Shape:SolidMolecular weight:429.3Ref: TM-T28001
1mg115.00€5mg249.00€10mg368.00€25mg562.00€50mg787.00€100mg1,054.00€500mgTo inquire1mL*10mM (DMSO)284.00€(Rac)-AZD 6482
CAS:(Rac)-AZD 6482 is the racemate of AZD 6482. AZD 6482 is a potent and selective inhibitor of p110β (IC50 of 0.69 nM).Formula:C22H24N4O4Color and Shape:SolidMolecular weight:408.45LRRK2-IN-7
CAS:LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.Formula:C24H26N6OPurity:99.26%Color and Shape:SolidMolecular weight:414.5CCT020312
CAS:CCT020312 (0-9 µM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB.Cost-effective and quality-assured.Formula:C31H30Br2N4O2Purity:98.63%Color and Shape:SolidMolecular weight:650.4Ref: TM-T14902
1mg58.00€5mg133.00€10mg227.00€25mg386.00€50mg572.00€100mg795.00€500mg1,648.00€1mL*10mM (DMSO)178.00€
