Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1424 products of "Autophagy"
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Pentixafor
CAS:<p>Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emission</p>Formula:C60H80N14O14Purity:98%Color and Shape:SolidMolecular weight:1221.36Cisd2 agonist 1
CAS:<p>Cisd2 agonist 1 is a CISD2) agonist (EC50: 34 nM) with potential anticancer activity and can be used to study non-alcoholic fatty liver disease (NAFLD).</p>Formula:C14H13FN2O3SPurity:99.06%Color and Shape:SolidMolecular weight:308.33AGN 194310
CAS:<p>AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].</p>Formula:C28H24O2SColor and Shape:SolidMolecular weight:424.55ATG12-ATG3 inhibitor 1
CAS:<p>ATG12-ATG3 Inhibitor 1 (compound 189) serves as a potent inhibitor of autophagy [1].</p>Formula:C18H17NO3SColor and Shape:SolidMolecular weight:327.4EACC
CAS:<p>EACC inhibits Stx17, blocking autophagosome-lysosome fusion, and is a reversible autophagy inhibitor.</p>Formula:C13H11N3O6S2Purity:99.8%Color and Shape:SolidMolecular weight:369.37NUCC-390 dihydrochloride (1060524-97-1 free base)
<p>NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.</p>Formula:C23H35Cl2N5OPurity:98%Color and Shape:SolidMolecular weight:468.46SLLN-15
CAS:<p>SLLN-15: oral, potent autophagy enhancer; targets macroautophagy in TNBC.</p>Formula:C19H23N7Se2Purity:98%Color and Shape:SolidMolecular weight:507.35CXCR2 antagonist 2
CAS:<p>CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.</p>Formula:C17H17FN2O4SColor and Shape:SolidMolecular weight:364.39SAFit2
CAS:<p>SAFit2 is a highly potent and selective inhibitor of fk506 binding protein 51 (FKBP51).Cost-effective and quality-assured</p>Formula:C46H62N2O10Purity:98.16% - >99.99%Color and Shape:SolidMolecular weight:802.99PHY34
CAS:<p>PHY34 inhibits autophagy at nanomolar potency, with anti-tumor effects on HGSOC in vivo.</p>Formula:C30H30O12Purity:98.71%Color and Shape:SolidMolecular weight:582.55AZ PFKFB3 26
CAS:<p>AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.</p>Formula:C24H26N4O2Purity:99.85%Color and Shape:SolidMolecular weight:402.49CXCR2-IN-1
CAS:<p>CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.</p>Formula:C19H20Cl2FN3O4SPurity:99.89%Color and Shape:SolidMolecular weight:476.35GDC-0349
CAS:<p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>Formula:C24H32N6O3Purity:96.00% - 98.17%Color and Shape:SolidMolecular weight:452.55SW063058
CAS:<p>SW063058 is an autophagy inducer that specifically disrupts the interaction between Beclin 1 and Bcl-2 without affecting the interactions of Bcl-2 with pro-apoptotic members (such as Bax and BIM). By inhibiting the negative regulation of Beclin 1 (key to autophagy initiation) by Bcl-2, SW063058 enhances autophagic activity without inducing cytotoxicity, apoptosis, or other forms of cell death in vitro.</p>Formula:C22H15BrFIN2O2Color and Shape:SolidMolecular weight:565.17CXCR7 modulator 2
CAS:<p>CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.</p>Formula:C29H42N6O3Color and Shape:SolidMolecular weight:522.68SCH 563705
CAS:<p>SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.</p>Formula:C23H27N3O5Purity:98.03%Color and Shape:SolidMolecular weight:425.48SORT1-IN-2
CAS:<p>SORT1-IN-2 (compound 6) is an inhibitor of SORT1.</p>Formula:C21H29N3O4Color and Shape:SolidMolecular weight:387.47CXCR2 antagonist 7
<p>CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.</p>Formula:C14H14F2N6OSColor and Shape:SolidMolecular weight:352.36Autophagy-IN-7
CAS:<p>Autophagy-IN-7 is an autophagy inhibitor for use in studying solid tumours.</p>Formula:C15H11N7Purity:98.47%Color and Shape:SolidMolecular weight:289.29ATG12-IN-1
CAS:<p>ATG12-IN-1 (compound 4) acts as an autophagy inhibitor targeting the ATG12-ATG3 protein-protein interaction (IC50= 9 μM), suitable for research in cancer studies.</p>Formula:C23H15ClN4O2Color and Shape:SolidMolecular weight:414.84CXCR2/CCR7 antagonist-1
CAS:<p>CXCR2/CCR7 antagonist-1 (compound 6) is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 μM and 0.0014 μM, respectively. It is valuable for research in tumor metastasis and autoimmune diseases.</p>Formula:C23H27N3O5Color and Shape:SolidMolecular weight:425.48SHS206
<p>SHS206 (compound 6n) is an orally active mitochondrial uncoupler that decreases triglyceride levels in the liver. Demonstrating in vivo efficacy in a GAN mouse model, SHS206 also exhibits inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH).</p>Formula:C14H7F6N3OColor and Shape:SolidMolecular weight:347.22YOK-1304
CAS:<p>YOK-1304, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62.</p>Formula:C28H35NO4Color and Shape:SolidMolecular weight:449.58LRRK2-IN-4
CAS:<p>LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.</p>Formula:C25H29ClF2N6O2Color and Shape:SolidMolecular weight:518.99ST-539
CAS:<p>ST-539 is an inhibitor of the deubiquitinating enzyme USP30, with an IC50 of 0.37 μM. It enhances the ubiquitination of mitochondrial proteins and induces mitophagy (autophagy), thereby regulating mitochondrial homeostasis. ST-539 is applicable for research in neurodegenerative diseases.</p>Formula:C30H31N3O4SColor and Shape:SolidMolecular weight:529.65SH498
CAS:<p>SH498 is a novel Bmi-1-mediated anti-tumor agent with significant anti-proliferative effects.</p>Formula:C27H25F3N2O4Color and Shape:SolidMolecular weight:498.49Anle138b-F105
CAS:<p>Anle138b-F105 is an autophagy-targeting chimera (AUTOTAC) with a DC50 value of 3 nM. It targets tauP301L for lysosomal degradation.</p>Formula:C36H37FN4O5Color and Shape:SolidMolecular weight:624.7SYUIQ-5
CAS:<p>SYUIQ-5 is a ligand for G-quadruplex structures. It plays a role in stabilizing G-quadruplexes and inducing senescence. Additionally, SYUIQ-5 inhibits the activity of the c-myc gene promoter. By displacing TRF2 from telomeres, SYUIQ-5 induces telomeric damage, which triggers autophagy (autophagy) in cancer cells.</p>Formula:C20H22N4Color and Shape:SolidMolecular weight:318.415LRRK2-IN-16
CAS:<p>LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.</p>Formula:C18H19N5OSColor and Shape:SolidMolecular weight:353.441Hesperadin hydrochloride
<p>Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.</p>Formula:C29H33ClN4O3SColor and Shape:SolidMolecular weight:553.12(R)-SCH 546738
CAS:<p>(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.</p>Formula:C23H31Cl2N7OColor and Shape:SolidMolecular weight:492.45CXCR2 antagonist 4
<p>CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.</p>Formula:C15H14F2N4OS2Color and Shape:SolidMolecular weight:368.42CXCR7 antagonist-1 hydrochloride
CAS:<p>CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.</p>Formula:C21H20ClFN6OColor and Shape:SolidMolecular weight:426.87HDAC10-IN-2
<p>HDAC10-IN-2, a selective HDAC10 inhibitor (IC50=20nM), modulates autophagy in FLT3-ITD+ acute myeloid leukemia.</p>Formula:C19H22N2O2Color and Shape:SolidMolecular weight:310.39LRRK2-IN-6
<p>LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).</p>Formula:C23H24F2N4O2SColor and Shape:SolidMolecular weight:458.52CXCR2 antagonist 6
<p>CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).</p>Formula:C17H16F2N4OSColor and Shape:SolidMolecular weight:362.4Autophagy activator-1
CAS:<p>Autophagyactivator-1 (Compound B2) is an autophagy activator that induces autophagy by downregulating key members of the HSP70 family and activating the unfolded protein response.</p>Formula:C25H32O8Color and Shape:SolidMolecular weight:460.517DC-LC3in-D5
CAS:<p>DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B.</p>Formula:C19H22Cl2N2O3Purity:99.79%Color and Shape:SolidMolecular weight:397.3LC3B recruiter 1
CAS:<p>LC3B recruiter 1 (compound 33R) is an LC3B recruiting fragment. It directly interacts with LC3B, exhibiting a Kd value of 2.87 µM.</p>Formula:C14H10ClN3O2Color and Shape:SolidMolecular weight:287.701ACT-672125
CAS:<p>ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.</p>Formula:C25H25F3N10O2SColor and Shape:SolidMolecular weight:586.59CXCR4 antagonist 10
CAS:<p>CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.</p>Formula:C18H18N4O4Color and Shape:SolidMolecular weight:354.36PARL-IN-1
<p>PARL-IN-1: Strong PARL blocker, IC50 28 nM, boosts PINK1/Parkin mitophagy.</p>Formula:C40H58N6O7Color and Shape:SolidMolecular weight:734.92ACT-777991
CAS:<p>ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.</p>Formula:C20H20F6N8O2SColor and Shape:SolidMolecular weight:550.48LRRK2-IN-2
CAS:<p>LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.</p>Formula:C23H23Cl2F3N6O2Color and Shape:SolidMolecular weight:543.37HMG499
CAS:<p>HMG499 inhibits HMG-CoA reductase (IC50: 0.41μM), reduces statin-induced HMGCR, lowers cholesterol, and lessens atherosclerosis.</p>Formula:C33H54O3Purity:98%Color and Shape:SolidMolecular weight:498.78HDAC10-IN-1
<p>HDAC10-IN-1 is a potent, selective HDAC10 inhibitor (IC50=58 nM) affecting autophagy in FLT3-ITD+ acute myeloid leukemia cells.</p>Formula:C18H23N3O2Color and Shape:SolidMolecular weight:313.39Stauprimide
CAS:<p>Stauprimide inhibits MYC by blocking NME2, reducing MYC transcription in ESCs.</p>Formula:C35H28N4O5Purity:98%Color and Shape:SolidMolecular weight:584.62DQ661
CAS:<p>DQ661 is a potent inhibitor of PPT1 and a dimeric quinacrine autophagy (autophagy) inhibitor. It effectively suppresses the activity of mTORC1 and reduces protein expression levels of pS6K T389 and pS6 S240-244. Additionally, DQ661 exhibits anticancer properties.</p>Formula:C41H47Cl2N5O2Color and Shape:SolidMolecular weight:712.75BRD1991
CAS:<p>BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.</p>Formula:C33H35Cl2N3O4Color and Shape:SolidMolecular weight:608.55Z-FY-CHO
CAS:<p>Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.</p>Formula:C26H26N2O5Purity:95.88%Color and Shape:SolidMolecular weight:446.5
