Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1483 products of "Autophagy"
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Balixafortide
CAS:Balixafortide (POL6326), a potent CXCR4 blocker with IC50 < 10 nM, mobilizes HSPCs and is anti-cancer, 1000x more selective than CXCR7.Formula:C84H118N24O21S2Purity:98%Color and Shape:SolidMolecular weight:1864.14(S)-Sitagliptin phosphate
CAS:(S)-Sitagliptin phosphate, less active enantiomer, is a potent DPP4 inhibitor with an IC50 of 19 nM.Formula:C16H18F6N5O5PColor and Shape:SolidMolecular weight:505.314PF-543
CAS:PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Formula:C27H31NO4SPurity:99.02%Color and Shape:SolidMolecular weight:465.6Acridine homodimer
CAS:Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.Formula:C38H42Cl2N6O2Color and Shape:SolidMolecular weight:685.69HDAC6-IN-58
<p>HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM for HDAC6 and 7374.5 nM for HDAC1. It enhances tubulin acetylation, exhibits antiproliferative effects, and induces autophagy (autophagy).</p>Color and Shape:Odour SolidFDW028
CAS:FDW028 is a FUT8 inhibitor with antitumor activity that works by promoting B7-H3 lysosomal degradation through defucosylation and CMA pathways.Formula:C22H24N6OPurity:98.73% - 99.55%Color and Shape:SoildMolecular weight:388.47Desethylamiodarone hydrochloride
CAS:Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.Formula:C23H26ClI2NO3Purity:98%Color and Shape:SolidMolecular weight:653.72Cytochalasin E
CAS:Cytochalasin E, from Aspergillus, disrupts actin, inhibits angiogenesis, and halts tumor growth.Formula:C28H33NO7Purity:98%Color and Shape:Crystals From Acetone-Hexane White PowderMolecular weight:495.56NAMPT degrader-1
Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.Formula:C56H68ClN9O5S2Color and Shape:SolidMolecular weight:1046.78Flavopiridol
CAS:Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.Formula:C21H20ClNO5Purity:97.74% - 99.99%Color and Shape:SolidMolecular weight:401.84STO-609 acetate
CAS:STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for theFormula:C19H10N2O3·C2H4O2Purity:99.75%Color and Shape:SolidMolecular weight:374.35TSPO Ligand-Linker Conjugates 1
TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.Formula:C32H55N3O10SColor and Shape:SolidMolecular weight:673.86RK-682 (calcium salt)
CAS:RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.Formula:C42H74CaO10Color and Shape:SolidMolecular weight:779.122CCR7 antagonist 1
CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.Formula:C13H22N6OSMolecular weight:310.15758Tetramethylrhodamine-dUTP
Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .Formula:C43H52N6O19P3Color and Shape:SolidMolecular weight:1049.82Tat-beclin 1 acetate
Tat-beclin 1 acetate is a potent inducer of autophagy and interacts with the negative regulator of autophagy, GAPR-1.Purity:99.44%Color and Shape:Soild(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc
<p>(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. It acts as a Cereblon ligand, recruiting CRBN proteins, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formula:C30H39N5O6Molecular weight:565.29003CXCL8 (54-72)
CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.Formula:C107H173N33O30Molecular weight:2400.30261Insecticidal agent 364
CAS:<p>Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein.</p>Formula:C23H18N4O3SPurity:99.81%Color and Shape:SolidMolecular weight:430.48Biotin-11-dCTP
Biotin-11-dCTP is a fluorescent dye for DNA labeling [1] .Formula:C28H43Li3N7O16P3SColor and Shape:SolidMolecular weight:879.49
