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Autophagy

Autophagy

Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.

Found 1424 products of "Autophagy"

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  • (R)-SCH 546738
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    (R)-SCH 546738

    CAS:
    <p>(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.</p>
    Formula:C23H31Cl2N7O
    Color and Shape:Solid
    Molecular weight:492.45

    Ref: TM-T200169

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    CXCR2 antagonist 4

    <p>CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.</p>
    Formula:C15H14F2N4OS2
    Color and Shape:Solid
    Molecular weight:368.42

    Ref: TM-T61447

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    CXCR7 antagonist-1 hydrochloride

    CAS:
    <p>CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.</p>
    Formula:C21H20ClFN6O
    Color and Shape:Solid
    Molecular weight:426.87

    Ref: TM-T62325

  • HDAC10-IN-2
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    HDAC10-IN-2

    <p>HDAC10-IN-2, a selective HDAC10 inhibitor (IC50=20nM), modulates autophagy in FLT3-ITD+ acute myeloid leukemia.</p>
    Formula:C19H22N2O2
    Color and Shape:Solid
    Molecular weight:310.39

    Ref: TM-T60760

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    LRRK2-IN-6

    <p>LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).</p>
    Formula:C23H24F2N4O2S
    Color and Shape:Solid
    Molecular weight:458.52

    Ref: TM-T62871

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    CXCR2 antagonist 6

    <p>CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).</p>
    Formula:C17H16F2N4OS
    Color and Shape:Solid
    Molecular weight:362.4

    Ref: TM-T61359

  • Autophagy activator-1
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    Autophagy activator-1

    CAS:
    <p>Autophagyactivator-1 (Compound B2) is an autophagy activator that induces autophagy by downregulating key members of the HSP70 family and activating the unfolded protein response.</p>
    Formula:C25H32O8
    Color and Shape:Solid
    Molecular weight:460.517

    Ref: TM-T204947

  • DC-LC3in-D5
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    DC-LC3in-D5

    CAS:
    <p>DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B.</p>
    Formula:C19H22Cl2N2O3
    Purity:99.79%
    Color and Shape:Solid
    Molecular weight:397.3

    Ref: TM-T61871

  • LC3B recruiter 1
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    LC3B recruiter 1

    CAS:
    <p>LC3B recruiter 1 (compound 33R) is an LC3B recruiting fragment. It directly interacts with LC3B, exhibiting a Kd value of 2.87 µM.</p>
    Formula:C14H10ClN3O2
    Color and Shape:Solid
    Molecular weight:287.701

    Ref: TM-T204521

  • ACT-672125
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    ACT-672125

    CAS:
    <p>ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.</p>
    Formula:C25H25F3N10O2S
    Color and Shape:Solid
    Molecular weight:586.59

    Ref: TM-T70616

  • CXCR4 antagonist 10
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    CXCR4 antagonist 10

    CAS:
    <p>CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.</p>
    Formula:C18H18N4O4
    Color and Shape:Solid
    Molecular weight:354.36

    Ref: TM-T200568

  • PARL-IN-1
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    PARL-IN-1

    <p>PARL-IN-1: Strong PARL blocker, IC50 28 nM, boosts PINK1/Parkin mitophagy.</p>
    Formula:C40H58N6O7
    Color and Shape:Solid
    Molecular weight:734.92

    Ref: TM-T73324

  • ACT-777991
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    ACT-777991

    CAS:
    <p>ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.</p>
    Formula:C20H20F6N8O2S
    Color and Shape:Solid
    Molecular weight:550.48

    Ref: TM-T73148

  • LRRK2-IN-2
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    LRRK2-IN-2

    CAS:
    <p>LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.</p>
    Formula:C23H23Cl2F3N6O2
    Color and Shape:Solid
    Molecular weight:543.37

    Ref: TM-T63824

  • HMG499
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    HMG499

    CAS:
    <p>HMG499 inhibits HMG-CoA reductase (IC50: 0.41μM), reduces statin-induced HMGCR, lowers cholesterol, and lessens atherosclerosis.</p>
    Formula:C33H54O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:498.78

    Ref: TM-T11572

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    HDAC10-IN-1

    <p>HDAC10-IN-1 is a potent, selective HDAC10 inhibitor (IC50=58 nM) affecting autophagy in FLT3-ITD+ acute myeloid leukemia cells.</p>
    Formula:C18H23N3O2
    Color and Shape:Solid
    Molecular weight:313.39

    Ref: TM-T60794

  • Stauprimide
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    Stauprimide

    CAS:
    <p>Stauprimide inhibits MYC by blocking NME2, reducing MYC transcription in ESCs.</p>
    Formula:C35H28N4O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:584.62

    Ref: TM-T16941

  • DQ661
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    DQ661

    CAS:
    <p>DQ661 is a potent inhibitor of PPT1 and a dimeric quinacrine autophagy (autophagy) inhibitor. It effectively suppresses the activity of mTORC1 and reduces protein expression levels of pS6K T389 and pS6 S240-244. Additionally, DQ661 exhibits anticancer properties.</p>
    Formula:C41H47Cl2N5O2
    Color and Shape:Solid
    Molecular weight:712.75

    Ref: TM-T204315

  • BRD1991
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    BRD1991

    CAS:
    <p>BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.</p>
    Formula:C33H35Cl2N3O4
    Color and Shape:Solid
    Molecular weight:608.55

    Ref: TM-T69752

  • Z-FY-CHO
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    Z-FY-CHO

    CAS:
    <p>Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.</p>
    Formula:C26H26N2O5
    Purity:95.88%
    Color and Shape:Solid
    Molecular weight:446.5

    Ref: TM-T41236