Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1424 products of "Autophagy"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
CXCR4 modulator-1
CAS:<p>CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.</p>Formula:C23H27N5O2Color and Shape:SolidMolecular weight:405.49CXCR4 antagonist 3
<p>CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.</p>Formula:C22H31N5Color and Shape:SolidMolecular weight:365.52CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Formula:C15H14F2N4O2SColor and Shape:SolidMolecular weight:352.36Autophagy-lysosome activator-1
<p>Autophagy-lysosome Activator-1 (Compound F1) is an autophagy-lysosome stimulator that effectively induces the degradation of PD-L1 or VISTA in tumor cells.</p>Formula:C17H18N4O2Color and Shape:SolidMolecular weight:310.35Rosiglitazone sodium
CAS:<p>Rosiglitazone sodium is an effective and selective PPARγ activator, with EC50 values of 30 nM for PPARγ1, 100 nM for PPARγ2, and 60 nM for PPARγ. It also has an approximate Kd of 40 nM for PPARγ. Additionally, Rosiglitazone sodium acts as a regulator of TRP channels, inhibiting the activities of TRPM2 and TRPM3, while activating TRPC5.</p>Formula:C18H18N3NaO3SColor and Shape:SolidMolecular weight:379.41BRD5631
CAS:<p>BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway.</p>Formula:C30H35N3O4Purity:98%Color and Shape:SolidMolecular weight:501.62LRRK2-IN-3
CAS:<p>LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.</p>Formula:C25H29ClF2N6O2Color and Shape:SolidMolecular weight:518.99SLW131
CAS:<p>SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.</p>Formula:C21H27N5O5SColor and Shape:SolidMolecular weight:461.535Acetylpepstatin
CAS:<p>Acetylpepstatin is an inhibitor of HIV-1 protease, HIV-2 protease, aspartyl protease.</p>Formula:C33H61N5O11Purity:98%Color and Shape:SolidMolecular weight:703.875SCH-900875
CAS:<p>SCH-900875 is an orally active, brain-penetrant, and selective inhibitor of the CXCR3 receptor, demonstrating significant selectivity towards CXCR1 and CXCR2 receptors as well. By binding to CXCR3, SCH-900875 blocks the ligands CXCL9, CXCL10, and CXCL11, thereby inhibiting downstream G protein and β-arrestin signaling pathways and reducing inflammation cell migration. This compound holds potential for research into autoimmune diseases (such as rheumatoid arthritis and multiple sclerosis) and inflammatory conditions (such as psoriasis and inflammatory bowel disease).</p>Formula:C28H37ClN8O2Color and Shape:SolidMolecular weight:553.10CCX662
CAS:<p>CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.</p>Formula:C28H37N5O4SColor and Shape:SolidMolecular weight:539.69LRRK2-IN-5
<p>LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.</p>Formula:C24H26F2N4O2SColor and Shape:SolidMolecular weight:472.55QW24
CAS:<p>QW24 down-regulates BMI-1, exhibits potent antitumour effects and is used as an effective therapeutic agent in the treatment of clinical colorectal cancer.</p>Formula:C27H28N2O4Color and Shape:SolidMolecular weight:444.52EMU-116
CAS:<p>EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.</p>Formula:C25H35N5Color and Shape:SolidMolecular weight:405.58Gepotidacin mesylate dihydrate
CAS:<p>Gepotidacin mesylate dihydrate (GSK2140944 mesylate dihydrate) is an antibiotic and an inhibitor of bacterial type II topoisomerase.</p>Formula:C25H36N6O8SPurity:99.85%Color and Shape:SolidMolecular weight:580.65DCC-3116
CAS:<p>DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.</p>Formula:C26H36F3N7O2Purity:98.55%Color and Shape:SoildMolecular weight:535.61Dihydrocelastrol
CAS:<p>Dihydrocelastrol is synthesized by hydrogenation of celastrol, a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE co</p>Formula:C29H40O4Color and Shape:SolidMolecular weight:452.63Dusquetide
CAS:<p>Dusquetide is a first-in-class innate defense regulator. Dusquetide displays activity in both reducing inflammation and increasing the clearance of bacterial infection.</p>Formula:C25H47N9O5Purity:98%Color and Shape:SolidMolecular weight:553.709VUF11207 trifluoroacetate salt
CAS:<p>VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.</p>Formula:C29H36F4N2O6Color and Shape:SolidMolecular weight:584.609Pepstatin Ammonium
<p>Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM</p>Formula:C34H66N6O9Purity:98%Color and Shape:SolidMolecular weight:702.92
