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DUB

DUB

DUB inhibitors target deubiquitinases, enzymes that remove ubiquitin molecules from proteins, thereby regulating the stability, localization, and activity of proteins within the cell. Deubiquitinases play essential roles in various cellular processes, including cell cycle regulation, DNA repair, and immune responses. Dysregulation of DUB activity is linked to cancer, neurodegenerative disorders, and viral infections. Inhibitors of DUBs can modulate these processes, offering potential therapeutic approaches for these conditions. At CymitQuimica, we provide DUB inhibitors to support your research in protein homeostasis, cancer, and neurobiology.

Found 84 products of "DUB"

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  • HBX28258
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    HBX28258

    CAS:
    <p>HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.</p>
    Formula:C26H30ClN3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:435.99

    Ref: TM-T24129

  • MF-095
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    MF-095

    CAS:
    <p>MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.</p>
    Formula:C27H31N3O4S
    Color and Shape:Solid
    Molecular weight:493.62

    Ref: TM-T69744

  • XL-188
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    XL-188

    CAS:
    <p>XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.</p>
    Formula:C32H42N6O4
    Color and Shape:Solid
    Molecular weight:574.71

    Ref: TM-T69690

  • Capzimin
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    Capzimin

    CAS:
    <p>Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.</p>
    Formula:C30H24N6O2S4
    Purity:98.31% - 99.32%
    Color and Shape:Solid
    Molecular weight:628.81

    Ref: TM-T10672

  • I-138
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    I-138

    CAS:
    <p>I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.</p>
    Formula:C26H23F3N6O
    Purity:99.41%
    Color and Shape:Solid
    Molecular weight:492.5

    Ref: TM-T73560

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    USP28-IN-2

    CAS:
    <p>USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.</p>
    Formula:C23H20Cl2N2O3S
    Color and Shape:Solid
    Molecular weight:475.39

    Ref: TM-T74792

  • GSK2643943A
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    GSK2643943A

    CAS:
    <p>GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.</p>
    Formula:C17H12FN3
    Purity:97.09%
    Color and Shape:Solid
    Molecular weight:277.3

    Ref: TM-T11485

  • SJB3-019A
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    SJB3-019A

    CAS:
    <p>SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times</p>
    Formula:C16H8N2O3
    Purity:99.72%
    Color and Shape:Solid
    Molecular weight:276.25

    Ref: TM-T12926

  • USP30 inhibitor 11
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    USP30 inhibitor 11

    CAS:
    <p>USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.</p>
    Formula:C17H16N6O2S
    Purity:98.84% - 99.59%
    Color and Shape:Solid
    Molecular weight:368.41

    Ref: TM-T13267

  • 6RK73
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    6RK73

    CAS:
    <p>6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).</p>
    Formula:C13H17N5O2S
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:307.37

    Ref: TM-T10188

  • P22074
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    P22074

    CAS:
    <p>P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.</p>
    Formula:C12H9NO3S2
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:279.33

    Ref: TM-T28284

  • USP22-IN-1
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    USP22-IN-1

    CAS:
    <p>USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.</p>
    Formula:C22H18N4
    Purity:98.2%
    Color and Shape:Solid
    Molecular weight:338.41

    Ref: TM-T73151

  • OTUB1/USP8-IN-1
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    OTUB1/USP8-IN-1

    CAS:
    <p>OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.</p>
    Formula:C22H16ClFN2O4
    Purity:98.59%
    Color and Shape:Soild
    Molecular weight:426.83

    Ref: TM-T72784

  • USP1-IN-3
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    USP1-IN-3

    CAS:
    <p>USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50&lt;30 nM). USP1-IN-3 can be used to study cancer.</p>
    Formula:C27H24F3N7O
    Color and Shape:Solid
    Molecular weight:519.52

    Ref: TM-T63625

  • USP1-IN-5
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    USP1-IN-5

    CAS:
    <p>USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less than</p>
    Formula:C27H23F3N8O
    Color and Shape:Solid
    Molecular weight:532.52

    Ref: TM-T79795

  • USP7-IN-12
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    USP7-IN-12

    CAS:
    <p>USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].</p>
    Formula:C29H28ClFN4O2S
    Color and Shape:Solid
    Molecular weight:551.07

    Ref: TM-T79164

  • FT206
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    FT206

    CAS:
    <p>FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].</p>
    Formula:C25H29N5OS
    Color and Shape:Solid
    Molecular weight:447.6

    Ref: TM-T36306

  • USP7-IN-1
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    USP7-IN-1

    CAS:
    <p>USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).</p>
    Formula:C23H24ClN3O3
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:425.91

    Ref: TM-T13268

  • DUB-IN-7
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    DUB-IN-7

    CAS:
    <p>DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].</p>
    Formula:C17H19N5O
    Color and Shape:Solid
    Molecular weight:309.37

    Ref: TM-T79672

  • FT671
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    FT671

    CAS:
    <p>FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).</p>
    Formula:C24H23F4N7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:533.48

    Ref: TM-T12621L

  • USP7-IN-3
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    USP7-IN-3

    CAS:
    <p>USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).</p>
    Formula:C29H31F3N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:568.59

    Ref: TM-T13269

  • LDN-91946
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    LDN-91946

    CAS:
    <p>LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).</p>
    Formula:C15H10N2O4S
    Purity:97.12%
    Color and Shape:Solid
    Molecular weight:314.32

    Ref: TM-T15729

  • USP30 inhibitor 18
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    USP30 inhibitor 18

    CAS:
    <p>USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.</p>
    Formula:C26H28FN3O4S
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:497.58

    Ref: TM-T36682

  • USP1-IN-6
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    USP1-IN-6

    CAS:
    <p>USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.</p>
    Formula:C29H27F3N8O
    Color and Shape:Solid
    Molecular weight:560.57

    Ref: TM-T79796

  • CT1113
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    CT1113

    CAS:
    <p>CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDX</p>
    Formula:C25H29N5O2S
    Color and Shape:Solid
    Molecular weight:463.6

    Ref: TM-T79187

  • USP7-IN-13
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    USP7-IN-13

    CAS:
    <p>USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].</p>
    Formula:C24H28N4O3
    Color and Shape:Solid
    Molecular weight:420.5

    Ref: TM-T84710

  • IMP-1710
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    IMP-1710

    CAS:
    <p>IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.</p>
    Formula:C23H19N5O
    Purity:99.3%
    Color and Shape:Solid
    Molecular weight:381.43

    Ref: TM-T37591

  • USP7-IN-10
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    USP7-IN-10

    CAS:
    <p>USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.</p>
    Formula:C26H29ClN4O3S
    Color and Shape:Solid
    Molecular weight:513.05

    Ref: TM-T73136

  • FT709
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    FT709

    CAS:
    <p>FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.</p>
    Formula:C23H22N4O7S
    Color and Shape:Solid
    Molecular weight:498.51

    Ref: TM-T63375

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    FT3967385

    <p>FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.</p>
    Formula:C21H19N5O2
    Color and Shape:Solid
    Molecular weight:373.41

    Ref: TM-T61512

  • USP7-IN-6
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    USP7-IN-6

    CAS:
    <p>USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).</p>
    Formula:C41H43N7O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:729.89

    Ref: TM-T13271

  • USP7-797
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    USP7-797

    CAS:
    <p>USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.</p>
    Formula:C27H28ClN3O3S
    Purity:95.90%
    Color and Shape:Solid
    Molecular weight:510.05

    Ref: TM-T73234

  • USP5-IN-1
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    USP5-IN-1

    <p>USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.</p>
    Formula:C19H20ClN3O5S
    Purity:99.76%
    Color and Shape:Soild
    Molecular weight:437.9

    Ref: TM-T60130

  • USP15-IN-1
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    USP15-IN-1

    CAS:
    <p>USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).</p>
    Formula:C22H23N3O3
    Purity:99.509% - 99.81%
    Color and Shape:Solid
    Molecular weight:377.44

    Ref: TM-T61575