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DUB

DUB

DUB inhibitors target deubiquitinases, enzymes that remove ubiquitin molecules from proteins, thereby regulating the stability, localization, and activity of proteins within the cell. Deubiquitinases play essential roles in various cellular processes, including cell cycle regulation, DNA repair, and immune responses. Dysregulation of DUB activity is linked to cancer, neurodegenerative disorders, and viral infections. Inhibitors of DUBs can modulate these processes, offering potential therapeutic approaches for these conditions. At CymitQuimica, we provide DUB inhibitors to support your research in protein homeostasis, cancer, and neurobiology.

Found 84 products of "DUB"

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  • STD1T
    Targetmol
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    STD1T

    CAS:
    <p>STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.</p>
    Formula:C19H19N3O4S2
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:417.5

    Ref: TM-T36970

  • GNE-6776
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    GNE-6776

    CAS:
    <p>GNE-6776 is a selective USP7 inhibitor.</p>
    Formula:C20H20N4O2
    Purity:96.59% - 98.2%
    Color and Shape:Solid
    Molecular weight:348.4

    Ref: TM-T4634

  • DUB-IN-1
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    DUB-IN-1

    CAS:
    <p>DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).</p>
    Formula:C20H11N5O
    Purity:98.33% - 98.96%
    Color and Shape:Solid
    Molecular weight:337.33

    Ref: TM-T11110

  • STAMBP-IN-1
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    STAMBP-IN-1

    CAS:
    <p>STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after</p>
    Formula:C27H28N4O4S
    Purity:99.64%
    Color and Shape:Solid
    Molecular weight:504.6

    Ref: TM-T8706

  • P 22077
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    P 22077

    CAS:
    <p>P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.</p>
    Formula:C12H7F2NO3S2
    Purity:97.9% - 99.58%
    Color and Shape:Solid
    Molecular weight:315.32

    Ref: TM-T2424

  • USP25/28 inhibitor AZ1
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    USP25/28 inhibitor AZ1

    CAS:
    <p>USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.</p>
    Formula:C17H16BrF4NO2
    Purity:99.79% - 99.79%
    Color and Shape:Solid
    Molecular weight:422.21

    Ref: TM-T7685

  • XL177A
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    XL177A

    CAS:
    <p>XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.</p>
    Formula:C48H57ClN8O5
    Purity:98.75%
    Color and Shape:Solid
    Molecular weight:861.47

    Ref: TM-T9122

  • NSC632839
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    NSC632839

    CAS:
    <p>NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2</p>
    Formula:C21H22ClNO
    Purity:99.74% - 99.88%
    Color and Shape:Solid
    Molecular weight:339.86

    Ref: TM-T3951

  • SJB2-043
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    SJB2-043

    CAS:
    <p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>
    Formula:C17H9NO3
    Purity:98.44%
    Color and Shape:Solid
    Molecular weight:275.26

    Ref: TM-T7678

  • IU1-248
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    IU1-248

    CAS:
    <p>IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].</p>
    Formula:C20H23N3O2
    Purity:99.3%
    Color and Shape:Solid
    Molecular weight:337.42

    Ref: TM-T9375

  • USP7-IN-8
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    USP7-IN-8

    CAS:
    <p>Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.</p>
    Formula:C21H21N3O2
    Purity:99.31%
    Color and Shape:Solid
    Molecular weight:347.41

    Ref: TM-T9217

  • VLX1570
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    VLX1570

    CAS:
    <p>VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.</p>
    Formula:C23H17F2N3O6
    Purity:98.53% - 99.91%
    Color and Shape:Solid
    Molecular weight:469.39

    Ref: TM-T4067

  • EOAI3402143
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    EOAI3402143

    CAS:
    <p>EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.</p>
    Formula:C25H28Cl2N4O3
    Purity:99.6%
    Color and Shape:Solid
    Molecular weight:503.42

    Ref: TM-T11209

  • P005091
    Targetmol
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    P005091

    CAS:
    <p>P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.</p>
    Formula:C12H7Cl2NO3S2
    Purity:99.53% - 99.87%
    Color and Shape:Solid
    Molecular weight:348.22

    Ref: TM-T6925

  • DUB-IN-3
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    DUB-IN-3

    CAS:
    <p>DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.</p>
    Formula:C16H9N5O
    Purity:99.34%
    Color and Shape:Solid
    Molecular weight:287.28

    Ref: TM-T11112

  • ML-323
    Targetmol
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    ML-323

    CAS:
    <p>ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.</p>
    Formula:C23H24N6
    Purity:99.87% - 99.96%
    Color and Shape:Solid
    Molecular weight:384.48

    Ref: TM-T1757

  • DUB-IN-2
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    DUB-IN-2

    CAS:
    <p>Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.</p>
    Formula:C15H9N5O
    Purity:98.96%
    Color and Shape:Solid
    Molecular weight:275.26

    Ref: TM-T11111

  • USP7/USP47 inhibitor
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    USP7/USP47 inhibitor

    CAS:
    <p>USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,</p>
    Formula:C18H11Cl2N3O3S3
    Purity:98.5% - 98.71%
    Color and Shape:Solid
    Molecular weight:484.4

    Ref: TM-T4338

  • GNE-6640
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    GNE-6640

    CAS:
    <p>GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).</p>
    Formula:C20H18N4O
    Purity:98.64%
    Color and Shape:Solid
    Molecular weight:330.38

    Ref: TM-T5461

  • ML364
    Targetmol
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    ML364

    CAS:
    <p>ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.</p>
    Formula:C24H18F3N3O3S2
    Purity:99.35% - >99.99%
    Color and Shape:Solid
    Molecular weight:517.54

    Ref: TM-T3555