DUB
DUB inhibitors target deubiquitinases, enzymes that remove ubiquitin molecules from proteins, thereby regulating the stability, localization, and activity of proteins within the cell. Deubiquitinases play essential roles in various cellular processes, including cell cycle regulation, DNA repair, and immune responses. Dysregulation of DUB activity is linked to cancer, neurodegenerative disorders, and viral infections. Inhibitors of DUBs can modulate these processes, offering potential therapeutic approaches for these conditions. At CymitQuimica, we provide DUB inhibitors to support your research in protein homeostasis, cancer, and neurobiology.
Found 104 products for "DUB".
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
MS7131
MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.Color and Shape:Odour SolidUCHL1-IN-1
UCHL1-IN-1 (Compound 46) is an inhibitor of ubiquitin C-terminal hydrolase L1 (UCHL1), with an IC50 of 5.1 μM. This compound is applicable in cancer research.Formula:C11H13Cl2N3O2Color and Shape:SolidMolecular weight:289.03848USP8-IN-2
CAS:USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.Formula:C19H20ClF3N4OSPurity:99.92%Color and Shape:SolidMolecular weight:444.9Ref: TM-T67876
1mg94.00€5mg200.00€1mL*10mM (DMSO)220.00€10mg313.00€25mg520.00€50mg740.00€100mg982.00€USP8-IN-3
CAS:USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.Formula:C18H18F3N5O2SPurity:99.79%Color and Shape:SolidMolecular weight:425.43Ref: TM-T67873
1mg34.00€5mg60.00€1mL*10mM (DMSO)79.00€10mg92.00€25mg195.00€50mg311.00€100mg449.00€500mg888.00€USP1-IN-9
USP1-IN-9 (Compound 1m) is a reversible and non-competitive inhibitor of ubiquitin-specific protease (USP1) with an IC50 value of 8.8 nM. It is synthesized based on the structures of ML323 and KSQ-4279 as a pyrido[2,3-d]pyrimidin-7(8H)-one derivative. USP1-IN-9 exhibits excellent inhibition of USP1/UAF and demonstrates strong antiproliferative effects on breast cancer cells. When combined with the PARP inhibitor olaparib, USP1-IN-9 enhances the cytotoxic effect on MDA-MB-436/OP cells. USP1-IN-9 holds potential for research in the field of cancer.Color and Shape:Odour SolidUbiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Color and Shape:Odour SolidRef: TM-L8600
1mgTo inquire10μL*10mM (DMSO)To inquire20μL*10mM (DMSO)To inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireEN523
CAS:EN523 targets non-catalytic allosteric cysteine C23 in K48 ubiquitin-specific deuquitinase OTUB1.Formula:C12H14N2O3Purity:99.5%Color and Shape:White SolidMolecular weight:234.25Ref: TM-T9884
1mg34.00€5mg66.00€1mL*10mM (DMSO)67.00€10mg99.00€25mg222.00€50mg356.00€100mg570.00€200mg800.00€BAY-728
BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].Formula:C24H28F3N5O2SColor and Shape:SolidMolecular weight:507.57USP7 ligand-2
USP7ligand-2 is a target protein ligand that can be utilized in the synthesis of PROTACs, such as [PROTACUSP7 Degrader-2].FT206
CAS:FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].Formula:C25H29N5OSColor and Shape:SolidMolecular weight:447.6Q14
Q14 is a polypeptide derived from the transmembrane (TM) domain of USP30 (ubiquitin specific peptidase30) and is capable of inhibiting the deubiquitination activity of USP30 (IC50=57.2 nM). By hindering the interaction between USP30’s transmembrane and catalytic domains, it lowers USP30 activity. The Q14 polypeptide contains an LC3 interaction region (LIR) motif, enabling it to bind with LC3, thereby accelerating autophagosome formation and promoting mitophagy. Q14 is applicable in the study of neurodegenerative diseases, mitochondrial quality control, and cellular metabolism.Formula:C101H168N32O23Color and Shape:SolidMolecular weight:2197.29601USP7 Ligand-Linker Conjugates 1
USP7Ligand-Linker Conjugates 1 is a Target Protein Ligand-Linker Conjugate comprising a USP7 ligand and a PROTAC linker, capable of recruiting E3 ligase. It is utilized in the synthesis of PROTACUSP7 Degrader-1.Color and Shape:Odour SolidUSP8-IN-1
CAS:USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].Formula:C18H21N5O3SPurity:99.07%Color and Shape:SoildMolecular weight:387.46Ref: TM-T60146
1mg50.00€5mg110.00€1mL*10mM (DMSO)122.00€10mg156.00€25mg264.00€50mg371.00€100mg537.00€STD1T
CAS:STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.Formula:C19H19N3O4S2Purity:98.77%Color and Shape:SolidMolecular weight:417.5P 22077
CAS:P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Formula:C12H7F2NO3S2Purity:97.9% - 99.64%Color and Shape:Yellow SolidMolecular weight:315.32EOAI3402143
CAS:EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Formula:C25H28Cl2N4O3Purity:99.6%Color and Shape:SolidMolecular weight:503.42Ref: TM-T11209
1mg63.00€5mg137.00€1mL*10mM (DMSO)152.00€10mg215.00€25mg423.00€50mg680.00€100mg1,009.00€P005091
CAS:P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.Formula:C12H7Cl2NO3S2Purity:99.53% - 99.87%Color and Shape:SolidMolecular weight:348.22NSC632839
CAS:NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2Formula:C21H22ClNOPurity:99.74% - 99.88%Color and Shape:SolidMolecular weight:339.86VLX1570
CAS:VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Formula:C23H17F2N3O6Purity:98.53% - 99.91%Color and Shape:SolidMolecular weight:469.39Ref: TM-T4067
1mg90.00€2mg146.00€5mg245.00€1mL*10mM (DMSO)251.00€10mg385.00€25mg645.00€50mg888.00€100mg1,234.00€SJB2-043
CAS:SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).Formula:C17H9NO3Purity:98.44%Color and Shape:SolidMolecular weight:275.26
