DUB
DUB inhibitors target deubiquitinases, enzymes that remove ubiquitin molecules from proteins, thereby regulating the stability, localization, and activity of proteins within the cell. Deubiquitinases play essential roles in various cellular processes, including cell cycle regulation, DNA repair, and immune responses. Dysregulation of DUB activity is linked to cancer, neurodegenerative disorders, and viral infections. Inhibitors of DUBs can modulate these processes, offering potential therapeutic approaches for these conditions. At CymitQuimica, we provide DUB inhibitors to support your research in protein homeostasis, cancer, and neurobiology.
Found 110 products for "DUB".
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USP7-IN-8
CAS:Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.Formula:C21H21N3O2Purity:99.31%Color and Shape:SolidMolecular weight:347.4103SJB2-043
CAS:SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).Formula:C17H9NO3Purity:98.44%Color and Shape:SolidMolecular weight:275.2583DUB-IN-2
CAS:Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.Formula:C15H9N5OPurity:98.96%Color and Shape:SolidMolecular weight:275.27NSC632839
CAS:NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2Formula:C21H22ClNOPurity:99.74% - 99.88%Color and Shape:SolidMolecular weight:339.86DUB-IN-1
CAS:DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Formula:C20H11N5OPurity:98.33% - 98.96%Color and Shape:SolidMolecular weight:337.3342USP7/USP47 inhibitor
CAS:USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,Formula:C18H11Cl2N3O3S3Purity:98.5% - 98.71%Color and Shape:SolidMolecular weight:484.399XL177A
CAS:XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.Formula:C48H57ClN8O5Purity:98.75% - 99.49%Color and Shape:Yellow SolidMolecular weight:861.47USP25/28 inhibitor AZ1
CAS:USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.Formula:C17H16BrF4NO2Purity:99.81% - 99.86%Color and Shape:White SolidMolecular weight:422.212P 22077
CAS:P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Formula:C12H7F2NO3S2Purity:97.9% - 99.64%Color and Shape:Yellow SolidMolecular weight:315.32STAMBP-IN-1
CAS:STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release afterFormula:C27H28N4O4SPurity:99.64%Color and Shape:SolidMolecular weight:504.601P005091
CAS:P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.Formula:C12H7Cl2NO3S2Purity:99.53% - 99.87%Color and Shape:SolidMolecular weight:348.23VLX1570
CAS:VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Formula:C23H17F2N3O6Purity:98.53% - 99.91%Color and Shape:SolidMolecular weight:469.3944ML-323
CAS:ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.Formula:C23H24N6Purity:99.87% - 99.96%Color and Shape:SolidMolecular weight:384.4769GNE-6640
CAS:GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).Formula:C20H18N4OPurity:98.64%Color and Shape:SolidMolecular weight:330.3831DUB-IN-3
CAS:DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Formula:C16H9N5OPurity:99.26%Color and Shape:SolidMolecular weight:287.2756ML364
CAS:ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.Formula:C24H18F3N3O3S2Purity:99.35% - >99.99%Color and Shape:SolidMolecular weight:517.54IU1-248
CAS:IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Formula:C20H23N3O2Purity:99.3%Color and Shape:SolidMolecular weight:337.4155GNE-6776
CAS:GNE-6776 is a selective USP7 inhibitor.Formula:C20H20N4O2Purity:96.59% - 99.24%Color and Shape:SolidMolecular weight:348.3984TCID
CAS:TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Formula:C9H2Cl4O2Purity:98.87% - 99.34%Color and Shape:SolidMolecular weight:283.923USP1-IN-2
CAS:USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.Formula:C26H22F4N6OPurity:98.78% - 99.99%Color and Shape:SolidMolecular weight:510.4861
