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DUB

DUB

DUB inhibitors target deubiquitinases, enzymes that remove ubiquitin molecules from proteins, thereby regulating the stability, localization, and activity of proteins within the cell. Deubiquitinases play essential roles in various cellular processes, including cell cycle regulation, DNA repair, and immune responses. Dysregulation of DUB activity is linked to cancer, neurodegenerative disorders, and viral infections. Inhibitors of DUBs can modulate these processes, offering potential therapeutic approaches for these conditions. At CymitQuimica, we provide DUB inhibitors to support your research in protein homeostasis, cancer, and neurobiology.

Found 84 products of "DUB"

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  • SJB2-043

    CAS:
    <p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>
    Formula:C17H9NO3
    Purity:98.44%
    Color and Shape:Solid
    Molecular weight:275.26
  • USP1-IN-2

    CAS:
    <p>USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.</p>
    Formula:C26H22F4N6O
    Purity:99.69% - 99.88%
    Color and Shape:Solid
    Molecular weight:510.486
  • BC-1471

    CAS:
    <p>BC-1471 is a STAMBP deubiquitinase inhibitor that blocks NALP7 inflammasome activity.</p>
    Formula:C27H32N4O4S
    Purity:99.98%
    Color and Shape:Solid
    Molecular weight:508.63
  • POSH-IN-1

    CAS:
    <p>POSH-IN-1 (Compound 108) is an inhibitor of the POSH polypeptide (e3 ligase) and has antiviral, anticancer, and neurodegenerative disease potential.</p>
    Formula:C14H8FNO3S
    Purity:99.29%
    Color and Shape:Solid
    Molecular weight:289.28
  • LCAHA

    CAS:
    <p>LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.</p>
    Formula:C24H41NO3
    Color and Shape:Solid
    Molecular weight:391.59
  • USP28-IN-3

    CAS:
    <p>USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>
    Formula:C23H20Cl2N2O3S
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:475.39
  • USP28-IN-4

    CAS:
    <p>USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>
    Formula:C22H18Cl2N2O3S
    Purity:98.48%
    Color and Shape:Solid
    Molecular weight:461.36
  • 8RK64

    CAS:
    <p>8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .</p>
    Formula:C14H16N8O2S
    Color and Shape:Solid
    Molecular weight:360.4
  • USP7-IN-4

    CAS:
    <p>USP7-IN-4 is a non-competitive, potent and selective inhibitor of USP7, up-regulates p53 and p21, down-regulates MDM2,anti-proliferativity RS4;11 (leukemia) .</p>
    Formula:C29H34N6O3
    Purity:98.27% - 99.09%
    Color and Shape:Solid
    Molecular weight:514.62
  • FT827

    CAS:
    <p>FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.</p>
    Formula:C27H28N6O5S
    Purity:98.76%
    Color and Shape:Solid
    Molecular weight:548.61
  • HBX28258

    CAS:
    <p>HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.</p>
    Formula:C26H30ClN3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:435.99
  • MF-095

    CAS:
    <p>MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.</p>
    Formula:C27H31N3O4S
    Color and Shape:Solid
    Molecular weight:493.62
  • XL-188

    CAS:
    <p>XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.</p>
    Formula:C32H42N6O4
    Color and Shape:Solid
    Molecular weight:574.71
  • Capzimin

    CAS:
    <p>Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.</p>
    Formula:C30H24N6O2S4
    Purity:98.31% - 99.32%
    Color and Shape:Solid
    Molecular weight:628.81
  • I-138

    CAS:
    <p>I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.</p>
    Formula:C26H23F3N6O
    Purity:99.41%
    Color and Shape:Solid
    Molecular weight:492.5
  • USP28-IN-2

    CAS:
    <p>USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.</p>
    Formula:C23H20Cl2N2O3S
    Color and Shape:Solid
    Molecular weight:475.39
  • GSK2643943A

    CAS:
    <p>GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.</p>
    Formula:C17H12FN3
    Purity:97.09%
    Color and Shape:Solid
    Molecular weight:277.3
  • SJB3-019A

    CAS:
    <p>SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times</p>
    Formula:C16H8N2O3
    Purity:99.72%
    Color and Shape:Solid
    Molecular weight:276.25
  • USP30 inhibitor 11

    CAS:
    <p>USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.</p>
    Formula:C17H16N6O2S
    Purity:98.84% - 99.59%
    Color and Shape:Solid
    Molecular weight:368.41
  • 6RK73

    CAS:
    <p>6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).</p>
    Formula:C13H17N5O2S
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:307.37