
DUB
DUB inhibitors target deubiquitinases, enzymes that remove ubiquitin molecules from proteins, thereby regulating the stability, localization, and activity of proteins within the cell. Deubiquitinases play essential roles in various cellular processes, including cell cycle regulation, DNA repair, and immune responses. Dysregulation of DUB activity is linked to cancer, neurodegenerative disorders, and viral infections. Inhibitors of DUBs can modulate these processes, offering potential therapeutic approaches for these conditions. At CymitQuimica, we provide DUB inhibitors to support your research in protein homeostasis, cancer, and neurobiology.
Found 84 products of "DUB"
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SJB2-043
CAS:<p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>Formula:C17H9NO3Purity:98.44%Color and Shape:SolidMolecular weight:275.26USP1-IN-2
CAS:<p>USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.</p>Formula:C26H22F4N6OPurity:99.69% - 99.88%Color and Shape:SolidMolecular weight:510.486BC-1471
CAS:<p>BC-1471 is a STAMBP deubiquitinase inhibitor that blocks NALP7 inflammasome activity.</p>Formula:C27H32N4O4SPurity:99.98%Color and Shape:SolidMolecular weight:508.63POSH-IN-1
CAS:<p>POSH-IN-1 (Compound 108) is an inhibitor of the POSH polypeptide (e3 ligase) and has antiviral, anticancer, and neurodegenerative disease potential.</p>Formula:C14H8FNO3SPurity:99.29%Color and Shape:SolidMolecular weight:289.28LCAHA
CAS:<p>LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.</p>Formula:C24H41NO3Color and Shape:SolidMolecular weight:391.59USP28-IN-3
CAS:<p>USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Formula:C23H20Cl2N2O3SPurity:99.92%Color and Shape:SolidMolecular weight:475.39USP28-IN-4
CAS:<p>USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Formula:C22H18Cl2N2O3SPurity:98.48%Color and Shape:SolidMolecular weight:461.368RK64
CAS:<p>8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .</p>Formula:C14H16N8O2SColor and Shape:SolidMolecular weight:360.4USP7-IN-4
CAS:<p>USP7-IN-4 is a non-competitive, potent and selective inhibitor of USP7, up-regulates p53 and p21, down-regulates MDM2,anti-proliferativity RS4;11 (leukemia) .</p>Formula:C29H34N6O3Purity:98.27% - 99.09%Color and Shape:SolidMolecular weight:514.62FT827
CAS:<p>FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.</p>Formula:C27H28N6O5SPurity:98.76%Color and Shape:SolidMolecular weight:548.61HBX28258
CAS:<p>HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.</p>Formula:C26H30ClN3OPurity:98%Color and Shape:SolidMolecular weight:435.99MF-095
CAS:<p>MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.</p>Formula:C27H31N3O4SColor and Shape:SolidMolecular weight:493.62XL-188
CAS:<p>XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.</p>Formula:C32H42N6O4Color and Shape:SolidMolecular weight:574.71Capzimin
CAS:<p>Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.</p>Formula:C30H24N6O2S4Purity:98.31% - 99.32%Color and Shape:SolidMolecular weight:628.81I-138
CAS:<p>I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.</p>Formula:C26H23F3N6OPurity:99.41%Color and Shape:SolidMolecular weight:492.5USP28-IN-2
CAS:<p>USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.</p>Formula:C23H20Cl2N2O3SColor and Shape:SolidMolecular weight:475.39GSK2643943A
CAS:<p>GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.</p>Formula:C17H12FN3Purity:97.09%Color and Shape:SolidMolecular weight:277.3SJB3-019A
CAS:<p>SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times</p>Formula:C16H8N2O3Purity:99.72%Color and Shape:SolidMolecular weight:276.25USP30 inhibitor 11
CAS:<p>USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.</p>Formula:C17H16N6O2SPurity:98.84% - 99.59%Color and Shape:SolidMolecular weight:368.416RK73
CAS:<p>6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).</p>Formula:C13H17N5O2SPurity:99.91%Color and Shape:SolidMolecular weight:307.37

