Aurora Kinase
Aurora kinase inhibitors target the Aurora kinases, a family of serine/threonine kinases that play a critical role in the regulation of mitosis. These kinases are essential for proper chromosome alignment, segregation, and cytokinesis during cell division. Abnormal Aurora kinase activity can lead to uncontrolled cell proliferation and cancer. By inhibiting Aurora kinases, these compounds can induce cell cycle arrest and apoptosis in cancer cells, making them valuable tools in cancer research and therapy. At CymitQuimica, we offer a wide range of high-quality Aurora kinase inhibitors to support your research in cell cycle regulation, mitosis, and oncology.
Found 94 products of "Aurora Kinase"
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TAK-901
CAS:<p>TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others</p>Formula:C28H32N4O3SPurity:99.02% - 99.59%Color and Shape:SolidMolecular weight:504.64NU6140
CAS:<p>NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).</p>Formula:C23H30N6O2Purity:98.33%Color and Shape:SolidMolecular weight:422.52dAURK-4 hydrochloride
<p>dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].</p>Formula:C52H53Cl2FN8O12Purity:99.44%Color and Shape:SolidMolecular weight:1071.93TAS-119
CAS:<p>TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95</p>Formula:C23H22Cl2FN5O3Purity:99.65%Color and Shape:SolidMolecular weight:506.36Barasertib
CAS:<p>AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.</p>Formula:C26H31FN7O6PPurity:99.63% - 99.92%Color and Shape:SolidMolecular weight:587.54AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Formula:C28H32FN9O2Color and Shape:SolidMolecular weight:545.61GSK-1070916
CAS:<p>GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.</p>Formula:C30H33N7OPurity:99.73%Color and Shape:SolidMolecular weight:507.63JB300
CAS:<p>JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.</p>Formula:C43H45ClFN7O10SColor and Shape:SolidMolecular weight:906.375CD532 hydrochloride
<p>CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.</p>Color and Shape:SolidSP-96
CAS:<p>SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.</p>Formula:C25H20FN7OPurity:99.54%Color and Shape:SolidMolecular weight:453.47Retreversine
CAS:<p>Retreversine serves as an inactive control counterpart to Reversine, a pioneering class of ATP-competitive Aurora kinase inhibitor.</p>Formula:C21H27N7OColor and Shape:SolidMolecular weight:393.49dAURK-4
CAS:<p>dAURK-4, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].</p>Formula:C52H52ClFN8O12Color and Shape:SolidMolecular weight:1035.47CAM2602
<p>CAM2602 is an inhibitor of Aurora A-TPX2 interaction, demonstrating a binding affinity of 19 nM with Aurora A. This compound has been shown to inhibit the growth of pancreatic cancer cells. In solid tumor xenograft models, CAM2602 increases the proportion of PH3-positive cells while decreasing the ratio of P-Thr288Aurora A-positive cells, ultimately inhibiting tumor growth.</p>Color and Shape:Odour SolidPROTAC MPS1 degrader 2
<p>PROTAC MPS1 Degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB with DC50 values of 42.0, 2.1, and 154.0 nM respectively. It is utilized in the research of acute myeloid leukemia.</p>Formula:C41H41N11O8SColor and Shape:SolidMolecular weight:847.90PROTAC MPS1 degrader 1
<p>PROTAC MPS1 degrader 1 (Compound 19) acts as a potent degrader of Monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB, with DC50 values of 17.7, 108.7, and 570.3 nM respectively. It is utilized in the study of acute myeloid leukemia. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase)</p>Formula:C41H46N12O7Color and Shape:SolidMolecular weight:818.88Aurora-A ligand 1
CAS:<p>Aurora-A ligand 1 is a potent and selective inhibitor of Aurora-A, exhibiting a dissociation constant (Kd) of 0.85 nM. It serves as a target protein ligand [PROTAC target protein ligand] in the development of PROTAC Aurora-A degraders with antitumor activity. Additionally, Aurora-A ligand 1 is utilized in the synthesis of HLB-0532259, which exhibits antitumor effects against neuroblastoma.</p>Formula:C21H23N5O3Color and Shape:SolidMolecular weight:393.439HLB-0532259
CAS:<p>HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)</p>Formula:C40H44N8O7Color and Shape:SolidMolecular weight:748.827JB170
CAS:<p>JB170 is a specific Aurora A degradator. Alisertib and Thalidomide, induces S-phase arrest in cell growth and inhibits the non-catalytic function.</p>Formula:C48H44ClFN8O11Purity:99.82%Color and Shape:SolidMolecular weight:963.36AKI603
CAS:<p>AKI603: Aurora A kinase blocker; IC50 12.3 nM; targets BCR-ABL-T315I resistance; halts leukemia cell growth.</p>Formula:C19H23N9O2Purity:99.81%Color and Shape:SolidMolecular weight:409.45Aurora A inhibitor 3
<p>Aurora A Inhibitor 3 (Compound 5h) effectively inhibits Aurora-A kinase, exhibiting an IC50 of 0.78 μM, and demonstrates cytotoxicity against MCF-7 and MDA-MB-</p>Purity:98%Color and Shape:Odour Solid11α-O-Tigloyl-12β-O-acetyltenacigenin B
CAS:<p>11α-O-Tigloyl-12β-O-acetyltenacigenin B, an ester derivative isolated from Garcinia cambogia (MTC), modulates the antitumor effects of Aurora-A in lymphoma</p>Formula:C28H40O7Purity:98%Color and Shape:SolidMolecular weight:488.61Palmatine
CAS:<p>Palmatine, also known as Burasaine, inhibits dopamine production and may treat flavivirus, jaundice, dysentery, hypertension, and liver issues.</p>Formula:C21H22NO4Purity:96.28% - 99.49%Color and Shape:SolidMolecular weight:352.4SNS-314 Mesylate
CAS:<p>SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.</p>Formula:C18H15ClN6OS2·CH4O3SPurity:99.44% - 99.92%Color and Shape:SolidMolecular weight:527.04PHA-680632
CAS:<p>PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.</p>Formula:C28H35N7O2Purity:98.2%Color and Shape:SolidMolecular weight:501.627BIO
CAS:<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Formula:C16H10BrN3O2Purity:99.67%Color and Shape:SolidMolecular weight:356.17GW779439X
CAS:<p>GW779439X is an inhibitor of CDK.</p>Formula:C22H21F3N8Purity:97.87%Color and Shape:SolidMolecular weight:454.45AT9283
CAS:<p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>Formula:C19H23N7O2Purity:99.83% - 99.98%Color and Shape:SolidMolecular weight:381.43SNS-314
CAS:<p>SNS-314 inhibits Aurora kinases A and B, blocking cell division in AK-overexpressing tumors.</p>Formula:C18H15ClN6OS2Purity:98%Color and Shape:SolidMolecular weight:430.93AMG 900
CAS:<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Formula:C28H21N7OSPurity:98.4% - 99.51%Color and Shape:SolidMolecular weight:503.58CCT241736
CAS:<p>CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3</p>Formula:C22H23Cl2N7Purity:96.2% - 99.81%Color and Shape:SolidMolecular weight:456.37Reversine
CAS:<p>Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).</p>Formula:C21H27N7OPurity:98% - 98.42%Color and Shape:SolidMolecular weight:393.49BI-847325
CAS:<p>BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.</p>Formula:C29H28N4O2Purity:97.13% - 97.54%Color and Shape:SolidMolecular weight:464.56Aurora kinase inhibitor-2
CAS:<p>Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).</p>Formula:C23H20N4O3Purity:98.66%Color and Shape:SolidMolecular weight:400.43Protein kinase inhibitor 6
CAS:<p>Protein kinase inhibitor 6 is a protein kinase inhibitor.</p>Formula:C13H9FN2SPurity:98.01%Color and Shape:SolidMolecular weight:244.29Alisertib
CAS:<p>Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.</p>Formula:C27H20ClFN4O4Purity:98.31% - >99.99%Color and Shape:SolidMolecular weight:518.92MLN8054
CAS:<p>MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.</p>Formula:C25H15ClF2N4O2Purity:98.07% - 98.26%Color and Shape:SolidMolecular weight:476.86ZM-447439
CAS:<p>ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.</p>Formula:C29H31N5O4Purity:99.11% - 99.59%Color and Shape:Pale Yellow SolidMolecular weight:513.59PF 477736
CAS:<p>PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (</p>Formula:C22H25N7O2Purity:97.58% - 99.94%Color and Shape:SolidMolecular weight:419.48AT-9283 HCl
CAS:<p>AT-9283, a multi-targeted kinase inhibitor, is used potentially for the treatment of multiple myeloma.</p>Formula:C19H24ClN7O2Color and Shape:SolidMolecular weight:417.89ENMD-2076
CAS:<p>ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.</p>Formula:C21H25N7Purity:97.63% - ≥95%Color and Shape:SolidMolecular weight:375.47TAK-632
CAS:<p>TAK-632 is a potent pan-Raf inhibitor.</p>Formula:C27H18F4N4O3SPurity:98% - 99.5%Color and Shape:SolidMolecular weight:554.52Aurora kinase inhibitor-3
CAS:<p>Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,</p>Formula:C21H18F3N5OPurity:98.91%Color and Shape:SolidMolecular weight:413.4Danusertib
CAS:<p>Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.</p>Formula:C26H30N6O3Purity:97.88% - 98.79%Color and Shape:White PowderMolecular weight:474.55KW-2449
CAS:<p>KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.</p>Formula:C20H20N4OPurity:98.43% - 99.69%Color and Shape:SolidMolecular weight:332.4JNJ-7706621
CAS:<p>JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.</p>Formula:C15H12F2N6O3SPurity:99.1% - 99.85%Color and Shape:SolidMolecular weight:394.36TCS7010
CAS:<p>TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay.</p>Formula:C31H31ClFN7O2Purity:98.49% - 99.62%Color and Shape:SolidMolecular weight:588.07Phthalazinone pyrazole
CAS:<p>Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.</p>Formula:C18H15N5OPurity:97.03%Color and Shape:SolidMolecular weight:317.34Barasertib-HQPA
CAS:<p>Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.</p>Formula:C26H30FN7O3Purity:98.43% - 99.29%Color and Shape:SolidMolecular weight:507.56Palmatine chloride
CAS:<p>Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.</p>Formula:C21H22ClNO4Purity:97.9% - 99.47%Color and Shape:SolidMolecular weight:387.857Tozasertib
CAS:<p>Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).</p>Formula:C23H28N8OSPurity:99.99%Color and Shape:SolidMolecular weight:464.59
