Endothelin Receptor
Endothelin receptors are GPCRs that mediate the effects of endothelins, potent vasoconstrictor peptides that play a significant role in vascular tone regulation, blood pressure control, and cell proliferation. Endothelin receptor antagonists are used in the treatment of conditions such as pulmonary arterial hypertension and heart failure. These receptors are also important targets in research on cardiovascular diseases and cancer. At CymitQuimica, we offer a selection of high-quality endothelin receptor modulators to support your research in cardiovascular biology, oncology, and vascular physiology.
Found 86 products of "Endothelin Receptor"
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Sulfisoxazole
CAS:Sulfisoxazole: a short-acting antibacterial targeting gram-positive/negative bacteria and inhibits breast cancer exosome by affecting endothelin receptor A.Formula:C11H13N3O3SPurity:99.87% - 99.98%Color and Shape:White To Cream PowderMolecular weight:267.30Enrasentan
CAS:Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure and protects myocardial function.Formula:C29H30O8Purity:97.9% - 98.39%Color and Shape:SolidMolecular weight:506.54Atrial Natriuretic Peptide (ANP) (1-28), rat
CAS:Atrial Natriuretic Peptide (1-28), rat is the major circulating form of ANP in rats.Formula:C128H205N45O39S2Purity:98%Color and Shape:SolidMolecular weight:3062.41Atrial natriuretic factor (1-28) (rat) TFA
ANP (1-28), rat (TFA) inhibits Ang II-induced endothelin-1 secretion; main circulating ANP form in rats.Formula:C130H206N45F3O41S2Purity:98%Color and Shape:SolidMolecular weight:3176.43ACT-373898
CAS:ACT-373898 is a metabolite of the endothelin (ET) receptor type A (ETA) and ETBdual antagonist macitentan .1
Formula:C15H17BrN4O5SColor and Shape:SolidMolecular weight:445.29IRL-1038
CAS:ETB endothelin receptor antagonistFormula:C68H92N14O15S2Purity:98%Color and Shape:SolidMolecular weight:1409.67[Ala1,3,11,15]-Endothelin
CAS:Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively).Formula:C109H163N25O32SPurity:98%Color and Shape:SolidMolecular weight:2368Nebentan
CAS:Nebentan (YM598) is an oral, selective ETA antagonist; Ki: 0.697 nM (ETA), 569 nM (ETB); may slow cor pulmonale, myocardial infarction.
Formula:C24H21N5O5SColor and Shape:SolidMolecular weight:491.52SB234551
CAS:SB234551 is a selective antagonist of endothelin ETA receptor.Formula:C34H34N2O9Color and Shape:SolidMolecular weight:614.64IRL-3630
CAS:IRL 3460 is an enantiomer.Formula:C31H40N4O6SPurity:98%Color and Shape:SolidMolecular weight:596.74Sarafotoxin S6b
CAS:non-selective endothelin receptor agonistFormula:C110H163N27O34S5Purity:98%Color and Shape:SolidMolecular weight:2567.96Sarafotoxin S6c
CAS:Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).Formula:C103H147N27O37S5Purity:98%Color and Shape:SolidMolecular weight:2516PD 142893
CAS:PD 142893 is a functional endothelin-stimulated vasoconstriction antagonist.Formula:C50H65N7O10Purity:98%Color and Shape:SolidMolecular weight:924.09IRL-1620
CAS:IRL-1620 is an effective and selective agonist of endothelin receptor type B (ETB) (Ki: 16 pM).Formula:C86H117N17O27Purity:98%Color and Shape:SolidMolecular weight:1820.974Sarafotoxin S6a
CAS:Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.Formula:C105H156N28O34S5Purity:98%Color and Shape:SolidMolecular weight:2514.85BQ-123 TFA
BQ-123 TFA: Potent ETA antagonist, IC50 = 7.3 nM, Ki = 25 nM, inhibits ET-1 cell proliferation, lowers rat BP.Formula:C33H43F3N6O9Color and Shape:SolidMolecular weight:724.72[Ala2] Endothelin-3, human
CAS:[Ala2] Endothelin-3, a linear ET-3 analog with Ala replacing Cys, stimulates endothelial cell migration.Formula:C120H166N26O32S4Color and Shape:SolidMolecular weight:2613.02Endothelin 1 (swine, human), Alexa Fluor 488-labeled
Synthetic human/swine Endothelin 1 peptide, tagged with Alexa Fluor 488, acts as a strong vasoconstrictor via ET A/B receptors.Color and Shape:SolidMolecular weight:2848.4[Lys4] Sarafotoxin S6c
CAS:[Lys4] Sarafotoxin S6c: potent partial endothelin receptor agonist; causes pig coronary contraction, EC50=1.5 nM.Formula:C105H153N27O36S5Color and Shape:SolidMolecular weight:2529.82Endothelin-2 (49-69), human TFA
Endothelin-2 (49-69), human (TFA) is a 21-amino acid vasoactive peptide that binds to ET-RA and ET-RB.Formula:C117H161N26F3O34S4Purity:98%Color and Shape:SolidMolecular weight:2660.94Methylsolfonyl 25(S)-Δ7-dafachronic acid
Methylsulfonyl 25(S)-Δ7-dafachronic acid (compound 3) is a selective ssDAF-12 agonist with an IC50 value of 0.41 μM. It exhibits low cytotoxicity in HepG2 cells, with an IC50 value greater than 200 μM. Methylsulfonyl 25(S)-Δ7-dafachronic acid is applicable in the study of parasitic diseases.Formula:C28H45NO4SMolecular weight:491.30693Endothelin 1 (swine, human) (TFA)
CAS:Synthetic human/swine Endothelin 1 (TFA) peptide; a potent vasoconstrictor acting on ET A and ET B receptors.Formula:C111H160F3N25O34S5Molecular weight:2605.93Bosentan-d4
CAS:Bosentan-d4: deuterium version of Bosentan, competitive ET A/B antagonist, Ki: 4.7nM (ET A), 95nM (ET B) in human SMC.Formula:C27H25D4N5O6SColor and Shape:SolidMolecular weight:555.64ANP (1-30), frog
CAS:ANP (1-30), frog, a peptide fragment sourced from atrial natriuretic peptide of frog origin, exhibits natriuretic, diuretic, and vasorelaxant properties.Formula:C131H217N49O41S4Color and Shape:SolidMolecular weight:3262.69Big endothelin-1 (rat 1-39)
CAS:Big endothelin-1 (rat 1-39), a 39-residue peptide, induces a diuretic and natriuretic response in conscious Sprague-Dawley rats and elevates blood pressure inColor and Shape:Solid[Asn18] Endothelin-1, human
CAS:[Asn18] Endothelin-1, human, a peptide, represents a predominant isoform of Endothelin, significantly contributing to the regulation of vascular function [1].Formula:C109H164N26O31S5Molecular weight:2494.96Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate
CAS:Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate is an NPR-A agonist and ANP hormone. Carperitide increases cGMP levels and reduces the heart's workload.Formula:C129H207N45O41S3Purity:99.78%Color and Shape:SoildMolecular weight:3140.5IRL-1038 acetate
IRL-1038 acetate is a potent ETB endothelin receptor antagonist.Formula:C70H96N14O17S2Purity:97.51%Color and Shape:SoildMolecular weight:1469.73IRL-1038 TFA
IRL-1038 TFA is an ETB receptor antagonist used in the study of cardiovascular disease.Formula:C70H93F3N14O17S2Purity:98.79%Color and Shape:SolidMolecular weight:1523.7IRL-1620 acetate
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.Formula:C88H121N17O29Purity:96.64%Color and Shape:SolidMolecular weight:1881Atrial natriuretic peptide (3-28) (human)
CAS:Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)), a peptide hormone produced by the atrial myocardium, plays a critical role in the regulation ofFormula:C118H187N43O36S3Purity:98%Color and Shape:SolidMolecular weight:2880.21Sulfatroxazole
CAS:Sulfatroxazole (Isosulfafurazole) (compound 12) is a selective antagonist of the ETA receptor with an IC50 of 0.26 μM.Formula:C11H13N3O3SColor and Shape:SolidMolecular weight:267.3BQ-3020 ammonium
BQ-3020 ammonium, a selective endothelin receptor (ET B receptor) agonist, demonstrates inhibition of [125 I] ET-1 binding to ET B receptors with an IC50 of 0.2Formula:C96H140N20O25S·xNH3Purity:98%Color and Shape:SolidMolecular weight:2006.32 (free base)Endothelin-3 (Rat,Human) (TFA)
Endothelin-3 (Rat, Human) (TFA) is a 21-amino acid vasoactive peptide of endothelial origi, an agonist for the endothelin receptor type B (EDNRB).Formula:C123H169F3N26O35S4·xC2HF3O2Purity:98%Color and Shape:SolidMolecular weight:2757.07 (free base)Sitaxsentan sodium
CAS:Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.Formula:C18H14ClN2O6S2·NaPurity:98.39% - 99.01%Color and Shape:SolidMolecular weight:476.89Bosentan
CAS:Bosentan is a competitive endothelin receptor antagonist, used for treating pulmonary arterial hypertension.Formula:C27H29N5O6SPurity:99.74% - 99.84%Color and Shape:Pale Yellow To Off-White SolidMolecular weight:551.614Ref: TM-T6264
10mg35.00€25mg52.00€50mg77.00€100mg120.00€200mg195.00€500mg294.00€1mL*10mM (DMSO)84.00€Darusentan
CAS:Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteriesFormula:C22H22N2O6Purity:98.72%Color and Shape:SolidMolecular weight:410.43Ref: TM-T5458
2mg43.00€5mg65.00€10mg100.00€25mg173.00€50mg288.00€100mg414.00€200mg583.00€1mL*10mM (DMSO)67.00€BQ-123
CAS:BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.Formula:C31H42N6O7Purity:99.22% - ≥95%Color and Shape:SolidMolecular weight:610.7Ambrisentan sodium
CAS:Ambrosentan (BSF 208075) sodium is a selective and oral effective antagonist of ET type A receptor ( ETAR ).Formula:C22H21N2NaO4Color and Shape:SolidMolecular weight:400.41BQ-788 sodium salt
CAS:BQ-788 sodium salt is a potent and selective antagonist of ETB receptor(ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells).Formula:C34H51N5NaO7Color and Shape:SolidMolecular weight:664.8Atrasentan sodium
CAS:Atrasentan (ABT-627) is an oral ETA receptor blocker with potential cancer-fighting properties, inhibiting angiogenesis and tumor growth.Formula:C29H37N2NaO6Color and Shape:SolidMolecular weight:532.61Ro 46-2005
CAS:Ro 46-2005: Synthetic non-peptide, blocks 125I-ET-1 at ETA receptors on human vascular cells (IC50: 220 nM).Formula:C23H27N3O6SPurity:98.02% - 98.8%Color and Shape:SolidMolecular weight:473.54RO 46-8443
CAS:RO 46-8443: First non-peptide ETB receptor antagonist, >2000-fold ETB selectivity in binding and function.Formula:C31H35N3O8SPurity:98.77% - 99.77%Color and Shape:SolidMolecular weight:609.69Bosentan (hydrate)
CAS:Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.Formula:C27H29N5O6S·H2OPurity:99.31% - 99.86%Color and Shape:White PowderMolecular weight:569.63Ambrisentan
CAS:Ambrisentan, an endothelin antagonist for PAH, has a low risk of liver enzyme elevation, not linked to acute liver injury.Formula:C22H22N2O4Purity:99.65% - 99.86%Color and Shape:SolidMolecular weight:378.42Atrasentan
CAS:Atrasentan (ABT-627) is an endothelin receptor antagonist that can inhibit the activity of ETA.Cost-effective and quality-assured.Formula:C29H38N2O6Purity:97.65% - 99.08%Color and Shape:SolidMolecular weight:510.62Ref: TM-TQ0259
1mg46.00€5mg90.00€10mg130.00€25mg250.00€50mg356.00€100mg580.00€200mg798.00€1mL*10mM (DMSO)109.00€Aprocitentan
CAS:Aprocitentan (ACT-132577) is ETA and ETB antagonist .Formula:C16H14Br2N6O4SPurity:99.17%Color and Shape:SolidMolecular weight:546.19Ref: TM-T7817
1mg58.00€5mg116.00€10mg170.00€25mg311.00€50mg439.00€100mg655.00€200mg887.00€1mL*10mM (DMSO)142.00€Sparsentan
CAS:Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM,Formula:C32H40N4O5SPurity:97.94% - 98.69%Color and Shape:SolidMolecular weight:592.75Ref: TM-T5355
2mg37.00€5mg55.00€10mg89.00€25mg161.00€50mg245.00€100mg360.00€200mg512.00€1mL*10mM (DMSO)73.00€BMS 182874 hydrochloride
CAS:BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.Formula:C17H20ClN3O3SPurity:97.01%Color and Shape:SolidMolecular weight:381.88Ref: TM-T21790
1mg77.00€2mg92.00€5mg140.00€10mg205.00€25mg343.00€50mg477.00€100mg665.00€200mg897.00€1mL*10mM (DMSO)146.00€ANP(1-28) Acetate (human, porcine)
CAS:Carperitide acetate: 28-amino acid hormone from human heart, counters cardiac injury/stretch, reduces endothelin-1.Formula:C129H207N45O41S3Purity:98.24%Color and Shape:SolidMolecular weight:3140.5Ref: TM-TP1220L
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,388.00€100mg1,872.00€200mg2,527.00€
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