Opioid Receptor

MT-7716 hydrochloride is a selective agonist of non-peptide nociceptin receptor (NOP)

(S,S)-J-113397 is an isomer of J-113397 . J-113397 is an Opioid Receptor antagonist [1] .

DPI-287, a selective delta-opioid receptor (DOP) agonist, has a K\(_i\) value of 0.39 nM and is applicable for pain research [1].

Dynorphin A (1-13) amide, an endogenous opioid peptide, counteracts the analgesic effects of morphine [1].

Clocinnamox mesylate: irreversible μ-opioid blocker; Ki: 0.7 nM (mouse μ), 1.9 nM (δ), 5.7 nM (κ).

α-Neoendorphin (1-8) is a 8-amino acid peptide derived from the N-terminal of α-Neoendorphin.

Opioid receptor agonist1 (Compound 2638-28) is an orally active opioid receptor agonist that shows strong affinity for MOR, DOR, and KOR, with Ki values of 5, 24, and 212 nM, respectively. It exhibits analgesic activity in both the mouse warm water tail-flick model and the acetic acid writhing model.

[Met5]-Enkephalin, amide activates δ and ζ opioid receptors; has multiple forms and varying plasma levels.

N-Acetyl-α-Endorphin is a chemical compound consisting of α-Endorphin that has been acetylated at the N-terminal.

N-terminally acetylated Endomorphin-1 is a modified Endomorphin-1.

non-peptide δ1 opioid receptor agonist

PIPE-3297 (compound 25) is a selective kappa opioid receptor (KOR) agonist that activates the G protein signaling pathway with an EC50 of 1.1 nM and exhibits low β-arrestin-2 recruitment activity (10%). Additionally, PIPE-3297 promotes myelination and has anti-inflammatory properties.

BPR1M97 is a mu opioid receptor (MOP) and neuropeptide-orphin FQ (NOP) receptor agonist with blood-brain barrier permeability and potency, with Kis values of 1.

Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain

Ac-RYYRWK-NH2: potent, specific NOP receptor partial agonist with 0.071 nM affinity; no affinity for μ/κ/δ-opioid receptors.

Dynorphin B (1-13) TFA acts as an agonist on opioid κ-receptor .

E-2078, known chemically as (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8), is a stable analog of Dynorphin A (1–8) and functions as a kappa opioid

[Nphe1]Nociceptin(1-13)NH2 is a selective nociceptin receptor antagonist with potential analgesic properties, pKi=8.4, pA2=6.0.

Nocistatin, a neuropeptide, blocks Nociceptin effects and inhibits 5-HT release, acting on an opioid-related receptor.

β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities.

Helianorphin-19: Potent KOR agonist (Ki=25 nM; EC50=45 nM), 200x selective over μ/δ receptors, effective in mouse pain model, non-sedative.

β-Lipotropin (60-65) (β-LPH (60-65)), an opioid agonist, is a significant [1] opioid peptide.

'[DAla2, DArg6] Dynorphin A (1-13) porcine is a potent opioid peptide resistant to enzymatic degradation.'

4-Hydroxy-1-(2-phenylethyl)piperidine is a synthetic ligand for muscarinic acetylcholine receptors (mAChR) or non-opioid intracellular sigma-1 receptors (σ1 receptors). It serves as a metabolite of the opioid compounds furanylfentanyl and 4-fluoroisobutyryl fentanyl (FIBF).

U-48520 is an agonist of the μ-opioid receptor (μ-opioid receptor) with an EC50 of 1561 nM.

DPDPE is selective δ-opioid receptor agonist peptide.

Dermorphin is agonist of μ-opioid receptor (MOR) agonist.

DBPR116 is a prodrug of BPRMU191 that can penetrate the blood-brain barrier. It significantly enhances the delivery efficiency of drugs targeting the central nervous system. When combined with the antagonist Naltrexone, DBPR116 demonstrates superior safety and analgesic effects compared to morphine in various in vivo pharmacological studies, including thermal pain models, cancer pain models, constipation, sedation, psychological dependence, heart rate, and respiratory frequency. As a strategy for peripheral administration, DBPR116 effectively alleviates pain while reducing adverse effects, showing promise as a safer opioid analgesic.

AH 7959 is an orally active N-substituted cyclohexylmethylbenzamide compound that exhibits analgesic properties. In mice, the ED50 for oral and subcutaneous administration of AH 7959 exceeds 100 mg/kg.

Orphine is an opioid compound that can amplify the antinociceptive effects reduced by naloxone in mice.

AH 7563 is structurally classified as an opioid compound with analgesic properties. In mice, its ED50 for pain relief was 15.3 mg/kg when administered orally in the Phenylquinone test, and 15.5 mg/kg when injected subcutaneously in the Hot plate test.

SNC 80, a non-peptide δ-opioid agonist (Ki=1.78 nM, IC50=2.73 nM), also targets μ-δ heteromers (EC50=52.8 nM), with analgesic and antidepressant potential.

Alvimopan dihydrate is a potent, oral μ-opioid receptor blocker (IC50 1.7 nM, Ki 0.47 nM) used in postoperative ileus research.

BMS-986121 is a selective positive allosteric modulator (PAM) of the μ opioid receptor with analgesic effects.

Porcine dynorphin A (1-13) is a potent κ opioid receptor agonist; it's antinociceptive and raises [Ca2+]i in neurons like NMDA.

Loperamide phenyl, an impurity detected in Loperamide, is an opioid receptor agonist.

Endomorphin 2 TFA, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM.

Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany.

[Leu5]-Enkephalin (Leu-enkephalin) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM

BAN ORL 24 dihydrochloride is a highly potent nociceptin/orphan FQ (N/OFQ) receptor (NOP) antagonist that can be used to study neurological diseases.

EST73502 HCl is an oral dual MOR agonist/σ1R antagonist, BBB-penetrant, Ki: 64 nM (MOR), 118 nM (σ1R), with antinociceptive properties.

GR 89696 free base is a potent κ2 opioid receptor agonist with a high selectivity, offering potential benefits in pruritus prevention.

[Met5]-Enkephalin, amide TFA (5-Methionine-enkephalin amide (TFA)) is a δ opioid receptors agonist as well as putative ζ (zeta) opioid receptors.

Ac-RYYRIK-NH2 acetate is an agonist at nociceptin/orphanin FQ(noc/OFQ) receptors, affecting spontaneous locomotor activity.

Naloxegol oxalate (NKTR-118) is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.

Nalmefene antagonizes the effects of opioids by competing for the opioid receptors in the CNS.

MCOPPB: potent, selective nociceptin receptor agonist, pKi 10.07, minor opioid activity, anxiolytic in animals, non-sedative.

Nociceptin (1-13), amide: ORL1 receptor agonist, pEC50 7.9 (mouse vas deferens), Ki 0.75 nM (rat forebrain binding).

Deltorphin 2 ([D-Ala2]-Deltorphin II) is an agonist of δ opioid receptor with an IC50 of 1 nM.

LY2795050 is a novel specific κ-Opioid Receptor antagonist (IC50: 0.72 nM).

Gluten exorphin C is an opioid peptide derived from wheat gluten.

MCOPPB triHydrochloride (MCOPPB 3HCl) is a nociceptin receptor agonist.

CTAP(TFA) (103429-32-9 free base) is a potent, highly selective, and brain-penetrant antagonist of the μ-opioid receptor with IC50 of 3.5 nM.

DPDPE TFA is selective δ-opioid receptor agonist peptide. DPDPE TFA has an analgesic effect and is antinociceptive in vivo.

Bisacodyl (Fenilaxan) is a diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation.

Dynorphin B (1-13) acetate acts as an agonist on opioid κ-receptor.

BMS986188 is a novel Potent and Selective Positive Allosteric Modulator of the delta-Opioid Receptor.

DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents.

PZM21 is an effective and selective μ opioid receptor agonist (EC50: 1.8 nM).

Adrenorphin 3TFA(88377-68-8(free base)) (Metorphamide) is an agonist of μ-opioid receptor(Ki :12 nM).

[D-Ala2]-Leucine enkephalin is a delta opioid agonist used to study the signaling pathway of delta opioid receptors.

Alvimopan monohydrate is a mu-opioid receptor antagonist that intended for the treatment of constipation in patients who take opiates for pain.

Naloxegol (NKTR-118; AZ-13337019) is an opioid-receptor antagonist[1].

Porcine dynorphin A(1-13) acetate is a potent κ-opioid agonist with antinociceptive properties, increasing [Ca2+]i like NMDA.

Difelikefalin acetate (CR 845 acetate) is a peripherally restricted kappa opioid receptor agonist.

(D-Ser2)-Leu-Enkephalin-Thr is a delta selective agent of opioid receptor and shows analgesic effects.

BAM 22P acetate is a potent opioid agonist.

EM-2 reduces sEPSC frequency/amplitude in lamina IX motoneurons; CTOP reverses this. EM-2-IR affects limb muscles via presynaptic/postsynaptic mechanisms.

LY-2940094, a nociceptin receptor antagonist, is used potentially for the treatment of major depressive disorder and alcoholism.

Dynorphin A acetate is an Endogenous kappa receptor agonist.

Salvinorin A is a non-nitrogenous κ-opioid selective agonist.

ARM-390 HCl is a δ-opioid receptor agonist, brain-penetrant, nonpeptidic, prevents hyperalgesia without desensitization. Derived from SNC 80.

Dermorphin TFA is a new class of opioids-like peptides

BW-180C (DADLE) is a prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.

Sec-O-Glucosylhamaudol has anti-inflammatory and strong antinociceptive properties, acting on p38 MAPK and opioid receptors.

N-Desmethylclozapine: 5-HT2C antagonist (IC50: 7.1 nM), dopamine D4 antagonist, δ-opioid agonist.

Nociceptin (Orphanin FQ) is a 17-amino-acid polypeptide that is structurally related to the opioid peptide dynorphin A.

Nociceptin (1-7) acetate is a potent agonist of opioid receptor-like 1 (ORL1) receptor.

[Leu5]-Enkephalin, amide acetate is a δ opioid receptor agonist.

DAMGO TFA (78123-71-4(Free base)) is a potent and selective agonist of the Mu-opioid receptor.Cost-effective and quality-assured.