SGLT
Sodium-glucose co-transporters (SGLTs) are membrane proteins that facilitate the reabsorption of glucose in the kidneys by coupling glucose transport with sodium ions. SGLT inhibitors are an important class of drugs used in the treatment of type 2 diabetes, as they help reduce blood glucose levels by preventing glucose reabsorption in the renal tubules. These inhibitors are also being investigated for their potential benefits in cardiovascular and renal protection. At CymitQuimica, we provide a range of high-quality SGLT modulators to support your research in diabetes, renal physiology, and metabolic disorders.
Found 35 products for "SGLT".
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KGA-2727
CAS:KGA-2727: potent, selective SGLT1 inhibitor (human Ki 97.4 nM, rat 43.5 nM), with high selectivity over SGLT2 for diabetes treatment.Formula:C26H40N4O8Purity:98.46%Color and Shape:SolidMolecular weight:536.6178Sergliflozin A
CAS:Sergliflozin A is a selective SGLT2 inhibitor that induces diabetes in a dose-dependent manner. It reduces hyperglycemia.Formula:C20H24O7Purity:99.71%Color and Shape:SolidMolecular weight:376.4004Empagliflozin-d8
CAS:Empagliflozin-d8 is the deuterium-labeled form of Empagliflozin. Empagliflozin (BI 10773) acts as a selective inhibitor of the sodium-glucose co-transporter-2 (SGLT-2), exhibiting an IC50 value of 3.1 nM for human SGLT-2.Formula:C23H27ClO7Molecular weight:458.96SGLT2-IN-4
SGLT2-IN-4 (Compound 1) is a selective and orally active inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2). It increases the proportion of α-helices in proteins and enhances the stability of the SGLT2-D201A mutant. SGLT2-IN-4 is applicable in research for type 2 diabetes.Remogliflozin etabonate-d7
CAS:Remogliflozin etabonate-d7 (GSK189075-d7) is a deuterium-labeled form of Remogliflozin etabonate. Remogliflozin etabonate (GSK189075), an orally active, selective, and low-affinity sodium-glucose co-transporter (SGLT2) inhibitor, exhibits Ki values of 1.95 μM for hSGLT2, 43.1 μM for rSGLT2, 2.14 μM for hSGLT1, and 8.57 μM for rSGLT1. As a benzylpyrazole glucoside-based prodrug, it is metabolized in vivo to its active form, Remogliflozin, and demonstrates antidiabetic efficacy in rodent models.Formula:C26H38N2O9Molecular weight:529.64O-Desethyl Dapagliflozin
CAS:O-Desethyl Dapagliflozin (Empagliflozin-4) is a SGLT2 inhibitor, IC50=33nM.Formula:C19H21ClO6Purity:98.33%Color and Shape:Yellow OilMolecular weight:380.82Canagliflozin (Standard)
CAS:Canagliflozin (Standard) is the standard substance of Canagliflozin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor that inhibits CHO cells expressing mSGLT2, rSGLT2, and hSGLT2 (IC50=2/3.7/4.4 nM). Canagliflozin can be used for the treatment of type II diabetes mellitus (T2DM).Formula:C24H25FO5SColor and Shape:SolidMolecular weight:444.52Dapagliflozin (Standard)
CAS:Dapagliflozin (Standard) is the standard for Dapagliflozin (T2389). Dapagliflozin is a competitive sodium-glucose cotransporter 2 (SGLT2) inhibitor that can reduce renal glucose reabsorption and promote urinary glucose excretion. Dapagliflozin can also inhibit renal mesangial cell fibrosis by regulating the HO-1/TGF-β1/Smad2/3 axis, and is related to research on glucose transport, renal cell responses, and fibrosis signaling. Dapagliflozin can also be used in research on SGLT2 pharmacology and mechanisms of renal fibrosis-related pathways.Formula:C21H25ClO6Molecular weight:408.87Mizagliflozin
CAS:Mizagliflozin is an orally active, selective SGLT1 inhibitor with a Ki value of 27 nM for human SGLT1.Cost-effective and quality-assured.Formula:C28H44N4O8Purity:98.66% - 99.67%Color and Shape:SolidMolecular weight:564.671Phlorizin
CAS:Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .Formula:C21H24O10Purity:99.73% - 99.77%Color and Shape:Solid CrystallineMolecular weight:436.41Sotagliflozin
CAS:Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potentialFormula:C21H25ClO5SPurity:99% - 99.86%Color and Shape:SolidMolecular weight:424.94Ipragliflozin
CAS:Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.Formula:C21H21FO5SPurity:99.38% - 99.70%Color and Shape:White SolidMolecular weight:404.45T-1095
CAS:T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).Formula:C26H28O11Purity:99.78%Color and Shape:SolidMolecular weight:516.4939Trilobatin
CAS:Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentiallyFormula:C21H24O10Purity:97.16%Color and Shape:SolidMolecular weight:436.41Phloretin
CAS:Phloretin (NSC-407292) inhibits eukaryotic urea transporters, has antioxidative properties, and can induce cancer cell apoptosis. Found in apples and apricots.Formula:C15H14O5Purity:98.53% - >99.99%Color and Shape:White SolidMolecular weight:274.2687Ertugliflozin
CAS:PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).Formula:C22H25ClO7Purity:99.89% - 99.96%Color and Shape:SolidMolecular weight:436.88Tofogliflozin (hydrate)
CAS:Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(Ki of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2).Formula:C22H28O7Purity:97.03% - 98.78%Color and Shape:White SolidMolecular weight:404.45Bexagliflozin
CAS:Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 2 nM for human SGLT2.Formula:C24H29ClO7Purity:98.99% - 99.89%Color and Shape:SolidMolecular weight:464.936Dapagliflozin
CAS:Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.Formula:C21H25ClO6Purity:99.5% - 99.97%Color and Shape:SolidMolecular weight:408.87Empagliflozin
CAS:Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6.Formula:C23H27ClO7Purity:98% - 99.98%Color and Shape:SolidMolecular weight:450.91
