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PKA

PKA

Protein kinase A (PKA) is a key enzyme in the GPCR signaling cascade, activated by cyclic AMP (cAMP) in response to various extracellular signals. PKA regulates a wide range of cellular processes, including metabolism, gene expression, and cell growth. Dysregulation of PKA activity is associated with various diseases, including cancer, metabolic disorders, and cardiovascular conditions. PKA modulators are valuable tools in research aimed at understanding GPCR signaling pathways and developing new therapeutic strategies. At CymitQuimica, we provide a selection of high-quality PKA modulators to support your research in signal transduction, cellular regulation, and disease mechanisms.

Found 48 products of "PKA"

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  • 6-Bn-cAMP
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    6-Bn-cAMP

    CAS:
    <p>6-Bn-cAMP is a selective activator of cAMP-dependent protein kinase (PKA) that does not activate Epac. Compared to cAMP, 6-Bn-cAMP enhances hydrolytic stability against PDE, esterases, and amidases, and significantly increases membrane permeability.</p>
    Formula:C17H18N5O6P
    Color and Shape:Solid
    Molecular weight:419.33

    Ref: TM-T88687

  • 8-Chloro-cAMP sodium
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    8-Chloro-cAMP sodium

    CAS:
    <p>8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.</p>
    Formula:C10H10ClN5NaO6P
    Color and Shape:Solid
    Molecular weight:385.63

    Ref: TM-T88665

  • 8-MA-cAMP
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    8-MA-cAMP

    CAS:
    <p>8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.</p>
    Formula:C11H15N6O6P
    Color and Shape:Solid
    Molecular weight:358.25

    Ref: TM-T88462

  • BGC201531
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    BGC201531

    CAS:
    <p>BGC201531 (AP-1531) is a EP4 antagonist for the treatment of acute migraine.</p>
    Formula:C26H28N2O6S
    Purity:98.51% - 99.33%
    Color and Shape:Solid
    Molecular weight:496.58

    Ref: TM-T8993

  • Rp-cAMPS triethylammonium salt
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    Rp-cAMPS triethylammonium salt

    CAS:
    <p>Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.</p>
    Formula:C16H27N6O5PS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:446.46

    Ref: TM-T12764

  • FMP-API-1
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    FMP-API-1

    CAS:
    <p>FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).</p>
    Formula:C13H14N2O2
    Color and Shape:Solid
    Molecular weight:230.262

    Ref: TM-T204439

  • 8-Br-cGMP-AM
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    8-Br-cGMP-AM

    CAS:
    <p>8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.</p>
    Formula:C13H15BrN5O9P
    Color and Shape:Solid
    Molecular weight:496.16

    Ref: TM-T88538

  • PET-cGMP
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    PET-cGMP

    CAS:
    <p>PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.</p>
    Formula:C18H16N5O7P
    Color and Shape:Solid
    Molecular weight:445.323

    Ref: TM-T204785