PKA
Protein kinase A (PKA) is a key enzyme in the GPCR signaling cascade, activated by cyclic AMP (cAMP) in response to various extracellular signals. PKA regulates a wide range of cellular processes, including metabolism, gene expression, and cell growth. Dysregulation of PKA activity is associated with various diseases, including cancer, metabolic disorders, and cardiovascular conditions. PKA modulators are valuable tools in research aimed at understanding GPCR signaling pathways and developing new therapeutic strategies. At CymitQuimica, we provide a selection of high-quality PKA modulators to support your research in signal transduction, cellular regulation, and disease mechanisms.
Found 57 products for "PKA".
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
STAD 2
CAS:STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akapFormula:C102H182N24O22Color and Shape:SolidMolecular weight:2096.724(2S,4R)-DS89002333
(2S,4R)-DS89002333 is an enantiomer of DS89002333 and functions as an orally active PRKACA inhibitor, exhibiting an IC50 of 0.3 nM.Formula:C22H20ClF2N3O3Molecular weight:447.11613PKA Inhibitor Fragment (6-22) amide TFA
PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is an inhibitor of cAMP-dependent protein kinase A (PKA).Formula:C82H131F3N28O26Purity:99.61% - 99.87%Color and Shape:White SolidMolecular weight:1982.08Kemptide
CAS:Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).Formula:C32H61N13O9Purity:98%Color and Shape:SolidMolecular weight:771.91RI-STAD-2
RI-STAD-2 is a high-affinity peptide that interferes with the regulatory subunit RI of protein kinase A (PKA). It disrupts the binding between A-kinase anchoring proteins (AKAPs) and PKA-RI by mimicking the α-helical domain of AKAPs, interacting with the dimerization/docking (D/D) domain of PKA-RI. This disruption affects the activity and intracellular localization of PKA. RI-STAD-2 is utilized in studying the role of AKAPs and PKA-RI interactions in pathological processes such as cardiovascular diseases and cancer.Formula:C109H181N25O35Color and Shape:SolidMolecular weight:2400.31519PKItide
CAS:PKItide demonstrates an inhibitory concentration 50 (IC50) of 0.2 μM against cAMP-dependent protein kinase (cAMP-PK) [1].Formula:C85H149N31O24Purity:98%Color and Shape:SolidMolecular weight:1989.29PKA-IN-1
CAS:PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to studyFormula:C13H11N3OPurity:99.12%Color and Shape:SolidMolecular weight:225.25AP-C2
CAS:AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.Formula:C18H16N4SPurity:99.99%Color and Shape:SolidMolecular weight:320.41PKA/AKAP-IN-2
CAS:PKA/AKAP-IN-2 (WAY-298350) is a PKA and AKAP interaction inhibitor, used in metabolic disease research.Formula:C17H17NO3Purity:99.82%Color and Shape:SolidMolecular weight:283.32DT-3 acetate
DT-3 acetate is a cell-permeable peptide that acts as an inhibitor of protein kinase G (PKGIα), effectively blocking the cGMP-PKG signaling pathway.Formula:C152H258N52O28S·xC2H4O2Color and Shape:SolidMolecular weight:3294.07 (free acid)Bilobetin
CAS:Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.Formula:C31H20O10Purity:97% - 99.69%Color and Shape:Yellow SolidMolecular weight:552.48Ref: TM-T4S2128
1mg44.00€2mg66.00€5mg137.00€1mL*10mM (DMSO)166.00€10mg236.00€25mg403.00€50mg582.00€100mg800.00€PKA inhibitor fragment (6-22) amide Acetate
PKA inhibitor fragment (6-22) amide Acetate is a synthetic peptide which selectively inhibits PKA activity by binding to its substrate site (IC50 < 2 nM).Formula:C82H134N28O26Purity:99.72%Color and Shape:SolidMolecular weight:1928.11Ref: TM-T21674L
1mg90.00€2mg116.00€5mg166.00€10mg264.00€1mL*10mM (DMSO)432.00€25mg442.00€50mg645.00€100mg888.00€Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Formula:C9H6O4Purity:97.47% - 99.95%Color and Shape:SolidMolecular weight:178.14Fasudil dihydrochloride
CAS:Fasudil dihydrochloride inhibits ROCK1/2, PKA, PKC, PKG, and acts as a Ca²⁺ channel blocker and vasodilator, supporting vascular, cardiovascular, and signaling research.Formula:C14H19Cl2N3O2SPurity:99.86%Color and Shape:White SolidMolecular weight:364.29Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formula:C14H18ClN3O2SPurity:99.54% - ≥95%Color and Shape:White SolidMolecular weight:327.83H-89 dihydrochloride
CAS:H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).Formula:C20H20BrN3O2S·2HClPurity:98.22% - >99.99%Color and Shape:SolidMolecular weight:519.28Ref: TM-T6250
5mg37.00€1mL*10mM (DMSO)44.00€10mg55.00€25mg101.00€50mg192.00€100mg326.00€200mg485.00€500mg772.00€Staurosporine
CAS:Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFormula:C28H26N4O3Purity:99.24% - 99.82%Color and Shape:SolidMolecular weight:466.53Ref: TM-T6680
1mg58.00€2mg82.00€5mg92.00€1mL*10mM (DMSO)103.00€10mg138.00€25mg234.00€50mg380.00€100mg565.00€500mg1,215.00€Metadoxine
CAS:Metadoxine (Metadoxil) is a neurotransmitter stimulant.Formula:C8H11NO3·C5H7NO3Purity:99.19%Color and Shape:White SolidMolecular weight:298.298-Bromo-cAMP sodium salt
CAS:8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.Formula:C10H10BrN5NaO6PPurity:98% - 99.94%Color and Shape:White SolidMolecular weight:430.08HA-100
CAS:HA-100 is an inhibitor of protein kinaseFormula:C13H15N3O2SPurity:99.44%Color and Shape:White SolidMolecular weight:277.34
