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Hedgehog/Smoothened
ALLO-2
CAS:1357350-60-7
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in …
Formula:
C18H12F3N5O
Purity:
98.00%
Color and Shape:
Solid
Molecular weight:
371.32
Estimated delivery in United States, on Monday 7 Feb 2022
SANT1
CAS:304909-07-7
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects …
Formula:
C23H27N5
Purity:
99.84%
Color and Shape:
solid
Molecular weight:
373.49
Estimated delivery in United States, on Monday 7 Feb 2022
Tolnaftate
CAS:2398-96-1
Tolnaftate is a synthetic antifungal agent.
Formula:
C19H17NOS
Purity:
99.92%
Color and Shape:
White Powder
Molecular weight:
307.42
Estimated delivery in United States, on Monday 7 Feb 2022
GANT61
CAS:500579-04-4
GANT 61 is an inhibitor for Gli1 and Gli2.
Formula:
C27H35N5
Purity:
100.00%
Color and Shape:
solid
Molecular weight:
429.6
Estimated delivery in United States, on Monday 7 Feb 2022
SAG hydrochloride (912545-86-9(free base))
SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.
Formula:
C28H29Cl2N3OS
Purity:
99.19%
Color and Shape:
solid
Molecular weight:
526.52
Estimated delivery in United States, on Monday 7 Feb 2022
Vismodegib
CAS:879085-55-9
Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 …
Formula:
C19H14Cl2N2O3S
Purity:
99.99%
Color and Shape:
solid
Molecular weight:
421.3
Estimated delivery in United States, on Monday 7 Feb 2022
NVP-LDE225
CAS:956697-53-3
LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 …
Formula:
C26H26F3N3O3
Purity:
98.19%
Color and Shape:
solid
Molecular weight:
485.5
Estimated delivery in United States, on Monday 7 Feb 2022
Ciliobrevin A
CAS:302803-72-1
Ciliobrevin A is a hedgehog (Hh) signaling pathway inhibitor with IC50 less than 10 μM.
Formula:
C17H9Cl2N3O2
Purity:
99.22%
Color and Shape:
solid
Molecular weight:
358.18
Estimated delivery in United States, on Monday 7 Feb 2022
Glasdegib
CAS:1095173-27-5
Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 …
Formula:
C21H22N6O
Purity:
98.00%
Color and Shape:
solid
Molecular weight:
374.44
Estimated delivery in United States, on Monday 7 Feb 2022
Cyclopamine
CAS:4449-51-8
Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group …
Formula:
C27H41NO2
Purity:
98.31%
Color and Shape:
White Crystalline Solid
Molecular weight:
411.63
Estimated delivery in United States, on Monday 7 Feb 2022
GANT 58
CAS:64048-12-0
GANT 58 is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).
Formula:
C24H16N4S
Purity:
99.88%
Color and Shape:
solid
Molecular weight:
392.48
Estimated delivery in United States, on Monday 7 Feb 2022
Jervine
CAS:469-59-0
The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane …
Formula:
C27H39NO3
Purity:
99.86%
Color and Shape:
Needles From Methanol + Water
Molecular weight:
425.61
Estimated delivery in United States, on Monday 7 Feb 2022
BMS833923
CAS:1059734-66-5
BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent …
Formula:
C30H27N5O
Purity:
99.74%
Color and Shape:
solid
Molecular weight:
473.57
Estimated delivery in United States, on Monday 7 Feb 2022
Taladegib
CAS:1258861-20-9
Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor …
Formula:
C26H24F4N6O
Purity:
100.00%
Color and Shape:
solid
Molecular weight:
512.5
Estimated delivery in United States, on Monday 7 Feb 2022
Naftifine hydrochloride
CAS:65473-14-5
Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum …
Formula:
C21H22ClN
Purity:
99.84%
Color and Shape:
solid
Molecular weight:
323.86
Estimated delivery in United States, on Monday 7 Feb 2022
Purmorphamine
CAS:483367-10-8
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is …
Formula:
C31H32N6O2
Purity:
98.00%
Color and Shape:
Light Tan Solid
Molecular weight:
520.62
Estimated delivery in United States, on Monday 7 Feb 2022
JK184
CAS:315703-52-7
JK184 is a potent Hedgehog (Hh) pathway inhibitor.
Formula:
C19H18N4OS
Purity:
99.37%
Color and Shape:
solid
Molecular weight:
350.44
Estimated delivery in United States, on Monday 7 Feb 2022
Smoothened Agonist
CAS:912545-86-9
SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.
Formula:
C28H28ClN3OS
Molecular weight:
490.06
Estimated delivery in United States, on Monday 7 Feb 2022
MK4101
CAS:935273-79-3
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of …
Formula:
C24H24F5N5O
Purity:
98.91%
Color and Shape:
Solid
Molecular weight:
493.47
Estimated delivery in United States, on Monday 7 Feb 2022
HhAntag
CAS:496794-70-8
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the …
Formula:
C24H23ClN4O3
Purity:
95.73%
Color and Shape:
solid
Molecular weight:
450.92
Estimated delivery in United States, on Monday 7 Feb 2022
Ellagic acid
CAS:476-66-4
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata …
Formula:
C14H6O8
Purity:
99.75%
Color and Shape:
Cream Colored Needles From Pyridine Physical Description Cream-Colored Needles (From Pyridine) Or Yellow Powder
Molecular weight:
302.19
Estimated delivery in United States, on Monday 7 Feb 2022
