Hedgehog/Smoothened

25 products on this category.

Product data	Purity	Price range	Estimated delivery
ALLO-2 REF: TM-T14188CAS: 1357350-60-7	98.00%	163.00 €~3,573.00 €	Thu 09 Feb 23
Tolnaftate REF: TM-T1094CAS: 2398-96-1	99.92%	58.00 €~63.00 €	Thu 09 Feb 23
GANT 58 REF: TM-T15370CAS: 64048-12-0	99.88%	58.00 €~426.00 €	Thu 09 Feb 23
Naftifine hydrochloride REF: TM-T1543CAS: 65473-14-5	99.84%	43.00 €~185.00 €	Thu 09 Feb 23
Ellagic acid REF: TM-T0465CAS: 476-66-4	99.75%	59.00 €~85.00 €	Thu 09 Feb 23
Dynarrestin REF: TM-T15183CAS: 2222768-84-3	- - -	79.00 €~423.00 €	Thu 09 Feb 23
Cyclopamine REF: TM-T2825CAS: 4449-51-8	98.31%	64.00 €~290.00 €	Thu 16 Feb 23
SAG REF: TM-T1779CAS: 912545-86-9	- - -	63.00 €~883.00 €	Thu 16 Feb 23
Jervine REF: TM-T3363CAS: 469-59-0	99.86%	63.00 €~986.00 €	Thu 16 Feb 23
Taladegib REF: TM-T2666CAS: 1258861-20-9	100.00%	83.00 €~706.00 €	Thu 16 Feb 23
SANT-1 REF: TM-T2450CAS: 304909-07-7	99.84%	49.00 €~377.00 €	Thu 16 Feb 23
Purmorphamine REF: TM-T1810CAS: 483367-10-8	98.00%	69.00 €~663.00 €	Thu 16 Feb 23
JK184 REF: TM-T3588CAS: 315703-52-7	99.37%	58.00 €~546.00 €	Thu 16 Feb 23
HhAntag REF: TM-T3460CAS: 496794-70-8	95.73%	75.00 €~2,149.00 €	Thu 16 Feb 23
MRT-10 REF: TM-T23027CAS: 330829-30-6	99.47%	133.00 €~3,100.00 €	Thu 16 Feb 23
GSA-10 REF: TM-T22814CAS: 300833-95-8	98.00%	231.00 €~1,958.00 €	Thu 16 Feb 23
HPI 1 REF: TM-T22089CAS: 599150-20-6	- - -	59.00 €~1,795.00 €	Thu 16 Feb 23
GANT 61 REF: TM-T3070CAS: 500579-04-4	100.00%	45.00 €~454.00 €	Thu 16 Feb 23
Sonidegib REF: TM-T1926CAS: 956697-53-3	98.19%	38.00 €~278.00 €	Thu 16 Feb 23
BMS-833923 REF: TM-T2299CAS: 1059734-66-5	99.74%	62.00 €~615.00 €	Thu 16 Feb 23
MK-4101 REF: TM-T6891CAS: 935273-79-3	98.91%	59.00 €~577.00 €	Thu 16 Feb 23
SAG hydrochloride (912545-86-9(free base)) REF: TM-T4211	99.19%	To inquire	Thu 16 Feb 23
Vismodegib REF: TM-T2590CAS: 879085-55-9	99.99%	48.00 €~114.00 €	Thu 16 Feb 23
Ciliobrevin A REF: TM-T3156CAS: 302803-72-1	99.22%	64.00 €~1,313.00 €	Thu 16 Feb 23
Glasdegib REF: TM-T6514CAS: 1095173-27-5	98.00%	86.00 €~1,472.00 €	Thu 16 Feb 23

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ALLO-2

CAS:1357350-60-7

ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in …

Formula:

C₁₈H₁₂F₃N₅O

Purity:

98.00%

Color and Shape:

Solid

Molecular weight:

371.32

Ref: TM-T14188

1mg	163.00 €
5mg	309.00 €
10mg	488.00 €
25mg	986.00 €
50mg	1,514.00 €
100mg	2,372.00 €
200mg	3,573.00 €
1ml*10 (DMSO)	316.00 €

Estimated delivery in United States, on Thursday 9 Feb 2023

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Tolnaftate

CAS:2398-96-1

Tolnaftate is a synthetic antifungal agent.

Formula:

C₁₉H₁₇NOS

Purity:

99.92%

Color and Shape:

White Powder

Molecular weight:

307.41

Ref: TM-T1094

1g	63.00 €
500mg	59.00 €
1ml*10 (DMSO)	58.00 €

Estimated delivery in United States, on Thursday 9 Feb 2023

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GANT 58

CAS:64048-12-0

GANT 58 is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).

Formula:

C₂₄H₁₆N₄S

Purity:

99.88%

Color and Shape:

Solid

Molecular weight:

392.48

Ref: TM-T15370

5mg	58.00 €
10mg	90.00 €
25mg	172.00 €
50mg	264.00 €
100mg	426.00 €
1ml*10 (DMSO)	68.00 €

Estimated delivery in United States, on Thursday 9 Feb 2023

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Naftifine hydrochloride

CAS:65473-14-5

Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum …

Formula:

C₂₁H₂₂ClN

Purity:

99.84%

Color and Shape:

Solid

Molecular weight:

323.86

Ref: TM-T1543

1g	185.00 €
50mg	43.00 €
500mg	120.00 €

Estimated delivery in United States, on Thursday 9 Feb 2023

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Ellagic acid

CAS:476-66-4

Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata …

Formula:

C₁₄H₆O₈

Purity:

99.75%

Color and Shape:

Cream Colored Needles From Pyridine 1992)

Molecular weight:

302.194

Ref: TM-T0465

1g	85.00 €
500mg	59.00 €

Estimated delivery in United States, on Thursday 9 Feb 2023

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Dynarrestin

CAS:2222768-84-3

Dynarrestin is a cytoplasmic dynein 1 and 2 aminothiazole inhibitor that reversibly inhibits dynein 1-driven …

Formula:

C₂₂H₂₃F₂N₃O₂S

Color and Shape:

Solid

Molecular weight:

431.5

Ref: TM-T15183

2mg	79.00 €
5mg	101.00 €
10mg	169.00 €
25mg	294.00 €
50mg	423.00 €
1ml*10 (DMSO)	114.00 €

Estimated delivery in United States, on Thursday 9 Feb 2023

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Cyclopamine

CAS:4449-51-8

Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group …

Formula:

C₂₇H₄₁NO₂

Purity:

98.31%

Color and Shape:

White Crystalline Solid

Molecular weight:

411.63

Ref: TM-T2825

5mg	64.00 €
10mg	76.00 €
25mg	91.00 €
50mg	134.00 €
100mg	207.00 €
200mg	290.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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SAG

CAS:912545-86-9

SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.

Formula:

C₂₈H₂₈ClN₃OS

Color and Shape:

Solid

Molecular weight:

490.06

Ref: TM-T1779

1mg	63.00 €
5mg	108.00 €
10mg	168.00 €
25mg	296.00 €
50mg	410.00 €
100mg	606.00 €
200mg	883.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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Jervine

CAS:469-59-0

The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane …

Formula:

C₂₇H₃₉NO₃

Purity:

99.86%

Color and Shape:

Needles From Methanol + Water Solid

Molecular weight:

425.613

Ref: TM-T3363

2mg	63.00 €
5mg	84.00 €
10mg	139.00 €
25mg	318.00 €
50mg	569.00 €
100mg	986.00 €
1ml*10 (DMSO)	79.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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Taladegib

CAS:1258861-20-9

Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor …

Formula:

C₂₆H₂₄F₄N₆O

Purity:

100.00%

Color and Shape:

Solid

Molecular weight:

512.513

Ref: TM-T2666

2mg	83.00 €
5mg	105.00 €
10mg	159.00 €
50mg	407.00 €
100mg	706.00 €
1ml*10 (DMSO)	107.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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SANT-1

CAS:304909-07-7

SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects …

Formula:

C₂₃H₂₇N₅

Purity:

99.84%

Color and Shape:

Solid

Molecular weight:

373.504

Ref: TM-T2450

2mg	49.00 €
5mg	57.00 €
10mg	91.00 €
25mg	136.00 €
50mg	208.00 €
100mg	377.00 €
1ml*10 (DMSO)	61.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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Purmorphamine

CAS:483367-10-8

Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is …

Formula:

C₃₁H₃₂N₆O₂

Purity:

98.00%

Color and Shape:

Light Tan Solid

Molecular weight:

520.637

Ref: TM-T1810

2mg	69.00 €
5mg	86.00 €
10mg	148.00 €
50mg	663.00 €
1ml*10 (DMSO)	93.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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JK184

CAS:315703-52-7

JK184 is a potent Hedgehog (Hh) pathway inhibitor.

Formula:

C₁₉H₁₈N₄OS

Purity:

99.37%

Color and Shape:

Solid

Molecular weight:

350.44

Ref: TM-T3588

5mg	58.00 €
10mg	92.00 €
25mg	191.00 €
50mg	318.00 €
100mg	546.00 €
1ml*10 (DMSO)	61.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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HhAntag

CAS:496794-70-8

HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the …

Formula:

C₂₄H₂₃ClN₄O₃

Purity:

95.73%

Color and Shape:

Solid

Molecular weight:

450.92

Ref: TM-T3460

1mg	75.00 €
2mg	121.00 €
5mg	207.00 €
10mg	366.00 €
25mg	834.00 €
50mg	1,511.00 €
100mg	2,149.00 €
1ml*10 (DMSO)	224.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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MRT-10

CAS:330829-30-6

MRT 10 is a smoothened (Smo) receptor antagonist (an IC50 = 0.5 μM in HEK293 …

Formula:

C₂₄H₂₃N₃O₅S

Purity:

99.47%

Color and Shape:

Solid

Molecular weight:

465.52

Ref: TM-T23027

2mg	133.00 €
5mg	172.00 €
10mg	264.00 €
25mg	542.00 €
50mg	866.00 €
100mg	1,123.00 €
200mg	1,633.00 €
500mg	3,100.00 €
1ml*10 (DMSO)	197.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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GSA-10

CAS:300833-95-8

GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM. It …

Formula:

C₂₆H₃₀N₂O₅

Purity:

98.00%

Color and Shape:

Solid

Molecular weight:

450.53

Ref: TM-T22814

2mg	231.00 €
5mg	345.00 €
10mg	523.00 €
25mg	899.00 €
50mg	1,346.00 €
100mg	1,958.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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HPI 1

CAS:599150-20-6

HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced …

Formula:

C₂₇H₂₉NO₆

Color and Shape:

Solid

Molecular weight:

463.53

Ref: TM-T22089

1mg	59.00 €
2mg	86.00 €
5mg	105.00 €
10mg	173.00 €
25mg	288.00 €
50mg	443.00 €
100mg	638.00 €
200mg	953.00 €
500mg	1,795.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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GANT 61

CAS:500579-04-4

GANT 61 is an inhibitor for Gli1 and Gli2.

Formula:

C₂₇H₃₅N₅

Purity:

100.00%

Color and Shape:

Solid

Molecular weight:

429.612

Ref: TM-T3070

2mg	45.00 €
5mg	63.00 €
10mg	86.00 €
25mg	183.00 €
50mg	333.00 €
100mg	454.00 €
1ml*10 (DMSO)	62.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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Sonidegib

CAS:956697-53-3

LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 …

Formula:

C₂₆H₂₆F₃N₃O₃

Purity:

98.19%

Color and Shape:

Solid

Molecular weight:

485.5

Ref: TM-T1926

1mg	38.00 €
5mg	64.00 €
10mg	83.00 €
25mg	132.00 €
50mg	167.00 €
100mg	278.00 €
1ml*10 (DMSO)	62.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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BMS-833923

CAS:1059734-66-5

BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent …

Formula:

C₃₀H₂₇N₅O

Purity:

99.74%

Color and Shape:

Solid

Molecular weight:

473.58

Ref: TM-T2299

5mg	69.00 €
10mg	93.00 €
25mg	154.00 €
50mg	229.00 €
100mg	419.00 €
200mg	615.00 €
1ml*10 (DMSO)	62.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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MK-4101

CAS:935273-79-3

MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of …

Formula:

C₂₄H₂₄F₅N₅O

Purity:

98.91%

Color and Shape:

Solid

Molecular weight:

493.482

Ref: TM-T6891

2mg	59.00 €
5mg	85.00 €
10mg	125.00 €
25mg	221.00 €
50mg	352.00 €
100mg	577.00 €
1ml*10 (DMSO)	90.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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SAG hydrochloride (912545-86-9(free base))

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SAG hydrochloride (912545-86-9(free base))

SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.

Formula:

C₂₈H₂₉Cl₂N₃OS

Purity:

99.19%

Color and Shape:

Solid

Molecular weight:

526.52

Ref: TM-T4211

1mg	70.00 €
2mg	114.00 €
5mg	176.00 €
10mg	307.00 €
25mg	To inquire
1ml*10 (DMSO)	306.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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Vismodegib

CAS:879085-55-9

Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 …

Formula:

C₁₉H₁₄Cl₂N₂O₃S

Purity:

99.99%

Color and Shape:

Solid

Molecular weight:

421.29

Ref: TM-T2590

5mg	48.00 €
10mg	63.00 €
50mg	79.00 €
100mg	91.00 €
200mg	114.00 €
1ml*10 (DMSO)	66.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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Ciliobrevin A

CAS:302803-72-1

Ciliobrevin A is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.

Formula:

C₁₇H₉Cl₂N₃O₂

Purity:

99.22%

Color and Shape:

Solid

Molecular weight:

358.18

Ref: TM-T3156

2mg	64.00 €
5mg	85.00 €
10mg	102.00 €
25mg	210.00 €
50mg	357.00 €
100mg	596.00 €
200mg	712.00 €
500mg	1,313.00 €
1ml*10 (DMSO)	92.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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Glasdegib

CAS:1095173-27-5

Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 …

Formula:

C₂₁H₂₂N₆O

Purity:

98.00%

Color and Shape:

Solid

Molecular weight:

374.448

Ref: TM-T6514

1mg	86.00 €
2mg	119.00 €
5mg	179.00 €
10mg	236.00 €
25mg	455.00 €
50mg	686.00 €
100mg	1,006.00 €
200mg	1,472.00 €
1ml*10 (DMSO)	252.00 €

Estimated delivery in United States, on Thursday 16 Feb 2023

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