Hedgehog/Smoothened
The Hedgehog/Smoothened signaling pathway is a crucial GPCR-related pathway involved in embryonic development, tissue regeneration, and stem cell maintenance. Smoothened (SMO) is a key transmembrane protein that transduces signals from the Hedgehog (Hh) ligands to activate downstream signaling cascades. Dysregulation of the Hedgehog/Smoothened pathway is implicated in various cancers and developmental disorders, making it a significant target for therapeutic intervention. At CymitQuimica, we offer a range of high-quality modulators for the Hedgehog/Smoothened pathway to support your research in developmental biology, oncology, and regenerative medicine.
Found 44 products of "Hedgehog/Smoothened"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
GANT 58
CAS:<p>GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).</p>Formula:C24H16N4SPurity:99.53%Color and Shape:SolidMolecular weight:392.48Dynarrestin
CAS:<p>Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.</p>Formula:C22H23F2N3O2SPurity:99.64%Color and Shape:SolidMolecular weight:431.5ALLO-2
CAS:<p>ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.</p>Formula:C18H12F3N5OPurity:99.19%Color and Shape:SolidMolecular weight:371.32HL2-m5
CAS:<p>HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM.</p>Formula:C70H101N15O24S3Color and Shape:SolidMolecular weight:1632.83CUR61414 hydrochloride
<p>CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces cancer cell apoptosis.</p>Formula:C31H43ClN4O5Purity:94.05%Color and Shape:SolidMolecular weight:587.15SAG dihydrochloride
CAS:<p>SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.</p>Formula:C28H30Cl3N3OSPurity:>99.99%Color and Shape:SoildMolecular weight:562.98HSP70-IN-3
<p>HSP70-IN-3: Strong HSP70 blocker; IC50=1.1μM/1.9μM (ASZ001/C3H10T1/2); hinders Hedgehog signaling and cancer cell growth, lowers GLI1 levels.</p>Formula:C48H78N6O7SColor and Shape:SolidMolecular weight:883.23GI-560192
CAS:<p>GI-560192 (RL-0070933), a potent smo modulator, EC50: 0.02µM; affects smoothened in cilia via hedgehog signaling.</p>Formula:C20H16N2O2Purity:99.53%Color and Shape:SoildMolecular weight:316.35GLI1-IN-3
<p>GLI1-IN-3 (Compound 11a) is a triterpenoid-like compound that inhibits Hedgehog signaling in cancer cells with GLI1 overexpression. It suppresses the proliferation of non-small cell lung cancer and prostate cancer cell lines with excessive Hh signaling activation. Additionally, GLI1-IN-3 reduces the expression of GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells.</p>Color and Shape:Odour SolidHPP-9
<p>HPP-9, a Proteolysis-Targeting Chimera (PROTAC) derived from Hedgehog Pathway Inhibitor-1 (HPI-1) with a pIC50 value of 6.71, is designed to degrade BET</p>Formula:C49H52N6O11Color and Shape:SolidMolecular weight:900.97SANT 2
CAS:<p>SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.</p>Formula:C26H26ClN3O4Purity:99.23%Color and Shape:SolidMolecular weight:479.96Ciliobrevin A
CAS:<p>Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.</p>Formula:C17H9Cl2N3O2Purity:98.54% - 99.57%Color and Shape:SolidMolecular weight:358.18MRT-81
CAS:<p>MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.</p>Formula:C31H29N3O5SPurity:99.72%Color and Shape:SolidMolecular weight:555.64HPI 1
CAS:<p>HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.</p>Formula:C27H29NO6Purity:97.6%Color and Shape:SolidMolecular weight:463.52HhAntag
CAS:<p>HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity</p>Formula:C24H23ClN4O3Purity:95.73%Color and Shape:SolidMolecular weight:450.92SAG hydrochloride (912545-86-9(free base))
CAS:<p>SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.</p>Formula:C28H29Cl2N3OSPurity:99.19% - 99.77%Color and Shape:SolidMolecular weight:526.52Glasdegib
CAS:<p>Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.</p>Formula:C21H22N6OPurity:98.72%Color and Shape:SolidMolecular weight:374.44Taladegib
CAS:<p>Taladegib (LY2940680), an oral Smo receptor antagonist, targets Hedgehog signaling for cancer treatment.</p>Formula:C26H24F4N6OPurity:98.75% - >99.99%Color and Shape:SolidMolecular weight:512.5JK184
CAS:<p>JK184 is a potent Hedgehog (Hh) pathway inhibitor.</p>Formula:C19H18N4OSPurity:98.93% - 99.89%Color and Shape:SolidMolecular weight:350.44SAG
CAS:<p>SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.</p>Formula:C28H28ClN3OSPurity:97.37% - 98.88%Color and Shape:SolidMolecular weight:490.06Sonidegib
CAS:<p>Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.</p>Formula:C26H26F3N3O3Purity:98% - 99.97%Color and Shape:SolidMolecular weight:485.5MRT-10
CAS:<p>MRT-10 is a Smoothened (Smo) receptor antagonist.</p>Formula:C24H23N3O5SPurity:99.73%Color and Shape:SolidMolecular weight:465.52SANT-1
CAS:<p>SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).</p>Formula:C23H27N5Purity:99.98% - >99.99%Color and Shape:SolidMolecular weight:373.49Neurodazine
CAS:<p>Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.</p>Formula:C27H21ClN2O3Purity:98.01%Color and Shape:SolidMolecular weight:456.92RUSKI-201
CAS:<p>RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.</p>Formula:C20H27N3OSColor and Shape:SolidMolecular weight:357.51SANT-2
CAS:<p>SANT-2 is a potent inhibitor of Shh signaling pathway.</p>Formula:C23H20ClN3O4Color and Shape:SolidMolecular weight:437.88Hedgehog Antagonist VIII
CAS:<p>Hh antagonist VIII is a quinazolinyl-urea that inhibits Gli transcription in the Hh pathway, linked to cancer, with an IC50 of 70 nM.</p>Formula:C23H15ClF4N4O2Color and Shape:SolidMolecular weight:490.84RUSKI-201 dihydrochloride
CAS:<p>RUSKI-201 dihydrochloride: potent Hhat inhibitor (IC50: 0.20 μM), blocks Hh signaling, and inhibits Hh palmitoylation.</p>Formula:C20H29Cl2N3OSColor and Shape:SolidMolecular weight:430.43SMANT hydrochloride
CAS:<p>SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.</p>Formula:C16H24BrClN2OPurity:99.81%Color and Shape:SolidMolecular weight:375.733-epi-Vitamin D3
CAS:<p>3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM in</p>Formula:C27H44OColor and Shape:SolidMolecular weight:384.64SMO-IN-3
CAS:<p>SMO-IN-3: Strong SMO blocker, disrupts Hh pathway (IC50=34.09 nM), hinders Daoy cell growth, has anticancer properties.</p>Formula:C27H25F4N3O2Color and Shape:SolidMolecular weight:499.5MS-0022
CAS:<p>MS-0022: SMO antagonist, inhibits Hh signaling in nM-µM ranges, curbs tumor cell growth, and delays tumor progression in vivo.</p>Formula:C21H16BrN3OColor and Shape:SolidMolecular weight:406.28Hedgehog IN-3
CAS:<p>Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].</p>Formula:C18H13ClF3N5OColor and Shape:SolidMolecular weight:407.78AZD8542
CAS:<p>AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.</p>Formula:C25H24N4O2Purity:99.96%Color and Shape:SolidMolecular weight:412.48SMO-IN-2
CAS:<p>SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.</p>Formula:C25H25F4N5O2Purity:98.64%Color and Shape:SolidMolecular weight:503.49GSA-10
CAS:<p>GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.</p>Formula:C26H30N2O5Purity:99.71%Color and Shape:SolidMolecular weight:450.53Robotnikinin
CAS:<p>Robotnikinin is an Shh signaling inhibitor in a concentration-dependent manner. It acts by exhibiting significant repression of Shh-induced Gli1/Gli2.</p>Formula:C25H27ClN2O4Purity:98%Color and Shape:SolidMolecular weight:454.95Hh-Ag1.5
CAS:<p>Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.</p>Formula:C28H26ClF2N3OSPurity:99.8%Color and Shape:SolidMolecular weight:526.04Hedgehog IN-2
CAS:<p>Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].</p>Formula:C24H22N4O2Color and Shape:SolidMolecular weight:398.46TAK-441
CAS:<p>TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.</p>Formula:C28H31F3N4O6Purity:99.82%Color and Shape:SolidMolecular weight:576.56SAG 21k
CAS:<p>SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.</p>Formula:C29H28ClF2N3O2SPurity:99.51%Color and Shape:SolidMolecular weight:556.07MRT-92
CAS:<p>MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC50=0.4 nM). MRT-92 is utilized for research into cerebellar gliomas.</p>Formula:C33H34N4O5Color and Shape:SolidMolecular weight:566.65IMP-1575
CAS:<p>IMP-1575 is a highly effective inhibitor of hedgehog acyltransferase (HHAT), with an IC50 of 0.75 μM when inhibiting purified HHAT. IMP-1575 has potential applications in cancer research.</p>Formula:C19H25N3OSMolecular weight:343.49BRD50837
CAS:<p>BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).</p>Formula:C26H32ClN3O6SPurity:98%Color and Shape:SolidMolecular weight:550.07
