Antibiotic

Lincophenicol is an Escherichia coli ribosomal peptidyltransferase-catalyzed puromycin reaction inhibitor.

Pentachloropseudilin inhibits Myosin-1 and speeds up TGF-β receptor turnover, suppressing TGF-β activity.

Rosaramicin, a lipid-soluble basic macrolide, is an antibacterial substance similar to erythromycin but with a better activity against Gram-negative bacteria.

Linogliride: a guanidine derivative, inhibits insulin release, and enhances glucose tolerance by blocking ATP-sensitive K+ channels in pancreatic beta cells.

SQ109 (NSC-722041) is an effective inhibitor of the trypomastigote form of the parasite (IC50 = 50 nM). SQ109 is an antitubercular agent and targets MmpL3.

Epirubicin, a doxorubicin derivative, is an antineoplastic, inhibits topoisomerase, DNA/RNA synthesis, and Foxp3, reducing T cell activity.

Lipoxamycin hemisulfate (Lipoxamycin) is an inhibitor of serine palmitoyltransferase (IC50 = 21 nM) with antifungal activity.

CRK12-IN-1: strong inhibitor of CRK12, kills T.b. brucei & T. congolense (EC50s: 1.3 & 18 nM).

S 863390 is a renin inhibitor.

Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase & orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).

Tunicamine is a reversible polyprenol-phosphate inhibitor.

Ferric citrate as a source of iron used in cell culture applications can provide iron with a less toxic form compared to free iron salts.

Xenalamine is a synthetic compound of antiviral.

Abimtrelvir exhibited antiviral activity.

Pafuramidine is an orally bioavailable prodrug of formamidine which was developed for the treatment of human African trypanosomiasis.

IID432, TopoII inhibitor against Trypanosoma cruzi (EC50=8 nM), achieves parasite clearance in Chagas disease models.

Phenosulfazole is a potent antiviral agent which has the potential for the research of poliomyelitis virus [1].

Vidarabine phosphate is an adenosine monophosphate analog.

Saquayamycin B, a glycoside, targets Gram-positive bacteria and both adriamycin-sensitive and -resistant P388 leukemia cells.

RMI 10874 is a tilorone analogue. Tilorone is an orally bioavailable antiviral agent.

Azidamfenicol inhibits ribosomal peptidyltransferase with a Ki of 22 µM. Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic.

Carnidazole (ME-108) shows antiprotozoal activity and can be used in studies about the treatment of Trichomonas infection.

Clofoctol is a bacteriostatic antibiotic with activity against Gram-positive bacteria, used in the treatment of upper and lower respiratory tract infections.

Trombodipine (PCA-4230) is a platelet aggregation inhibitor with antithrombotic activity and protection against Listeria monocytogenes.

Antiviral agent 17, EC50 0.015 μM in human assay, effective against murine norovirus, may aid infectious/malignant disease research.

Quinupristin, a macrolide-lincosamide-streptogramin antibiotic, inhibits protein synthesis in bacteria.

Nortopixantrone HCl (BBR 3438) is a novel 9-azacyclonopyrazole that shows antitumor activity in a human prostate cancer model.

β-Lactamase-IN-2 is an inhibitor of β-Lactamase with anti-microbial and anti-bacterial effects.

Alatrofloxacin is a prodrug of trovafloxacin.

Aranciamycin (Compound 1), an anthracycline antibiotic, exhibits collagenase inhibitory activity (IC50 3.7*10^-7 M) and can inhibit DNA synthesis in tumor cells

Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.

S-Adenosylhomocysteine (SAH) hydrolase is responsible for the reversible hydrolysis of SAH into adenosine and homocysteine. Inhibition of this enzyme leads to the accumulation of SAH within cells, thereby increasing the SAH to S-adenosylmethionine (SAM) ratio and subsequently inhibiting SAM-dependent methyltransferases. (−)-Neplanocin A, a potent and irreversible inhibitor of SAH hydrolase (Ki= 8.39 nM), exhibits significant antitumor activity against mouse leukemia L1210 cells and holds broad-spectrum antiviral properties. Its efficacy notably surpasses that of the reversible inhibitor 3-deazaneplanocin, especially in combating vesicular stomatitis, evidencing a higher potency with ID50 values of 0.07 μg/ml for Neplanocin A versus 0.3 μg/ml for 3-deazaneplanocin.

SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor, demonstrating potent antifungal activity with an inhibition concentration (IC50) of 7.2 μg/mL and an

N-Acetylpurinomycin is a selective agonist of CB2 receptor.

Gusperimus trihydrochloride is a derivative of the antitumor antibiotic spergualin with immunosuppressant activity.

Annamycin, a semi-synthetic doxorubicin derivative, binds DNA, blocks topoisomerase II, and evades MDR, inhibiting DNA/RNA/protein synthesis.

4'-Acetyl-chrysomycin B, a 4'-acetylated analog of chrysomycin B, exhibits anti-Gram-positive bacterial and antimicrobial activities [1].

Caerulomycin A (Caerulomycin) (Cerulomycin; Caerulomycin) is an antifungal compound.

Rosoxacin (Acrosoxacin) shows antibacterial activities against a broad spectrum of Gram-negative bacteria including Neisseria gonorrhoeae (MIC90 = 0.03mg/ml).

Myxopyronin A is an inhibitor of bacterial RNA polymerase.

CcpA-IN-1 is a Staphylococcus aureus antibiotic exhibiting significant bactericidal activity (MICs=460 nM) [1].

AS-2077715, an antifungal agent, exhibits inhibitory activity against Trichophyton species and is derived from the fermentation broth of Capnodium sp. 339855. It is utilized in the study of fungal infections [1].

Cladosporin, from Cladosporium cladosporioid fungus, halts dermatophyte growth on agar at 75 μg/mL.

Compound 6d (Antibacterial agent 159) is an antibiotic effective against impetigo and Clostridium difficile infection (CDI), with no observed recurrence for CDI

DuP-721: broad-spectrum, oral antibiotic targeting various bacteria, including M. tuberculosis.

OM173-αA is a quinone bacterial metabolite that inhibits the growth of the bacteria M.

N-(3-Oxobutanoyl)-L-homoserine lactone (3-oxo-C4-HSL) serves as an autoregulator for carbapenem antibiotic biosynthesis in Erwinia carotovora ATCC 39048 and induces the expression of rhiI in R. leguminosarum [1].

Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).