Antibacterial

<p>Erythromycin dihydrate, a macrolide antibiotic from Streptomyces erythreus, targets 50S ribosomal subunits, blocking protein synthesis.</p>

<p>Agent 46 from patent WO2013030735A1, example 9, is a potent antibacterial with research potential.</p>

<p>Cyclacillin (Wy-4508), an oral aminopenicillin, fights many gram-positive/negative bacteria.</p>

<p>Faropenem: an oral beta-lactam antibiotic resistant to beta-lactamases, effective against various bacteria, used for respiratory infections.</p>

<p>AM-8191, a bacterial topoisomerase inhibitors, has broad-spectrum antibacterial activity.</p>

<p>Tigecycline hydrate: broad-spectrum, glycylcycline antibiotic, bacteriostatic, inhibits protein synthesis, effective against resistant bacteria.</p>

<p>Sedecamycin is a 17-membered macrolide antibiotic. It is used for treating swine dysentery.</p>

<p>Aurachin SS, a natural product isolated from Streptomyces sp. NA04227, is an antibiotic compound with demonstrated antibacterial activity [1].</p>

<p>2,2-Dithiobis(Benzothiazole) inhibits MAPK8 and Pseudomonas aeruginosa and is commonly used as an accelerator in rubber and plastic synthesis.</p>

<p>Aibellin is a peptide antibiotic and serves as an effective and beneficial modulator of rumen fermentation.</p>

<p>TXY541 is an orally active antibacterial agent that is converted into PC190723 under physiological conditions. It demonstrates strong antibacterial activity against Staphylococcus aureus and exhibits low cytotoxicity towards mammalian cells.</p>

<p>Bactenecin is a cyclic antimicrobial peptide isolated from bovine neutrophils with potent activity against Bacterial and Fungal species.</p>

<p>Aurein 2.3, an antibiotic antimicrobial peptide, partially inhibits E. coli ATPase activity and suppresses cell growth [1] [2].</p>

<p>Aurodox is a biochemical.</p>

<p>Sitafloxacin: potent broad-spectrum oral fluoroquinolone effective against resistant strains.</p>

<p>Dalbavancin HCl (MDL-63397 HCl), a semi-synthetic antibiotic, targets Gram-positive bacteria with low MICs for S. aureus and B. anthracis.</p>

<p>Antileishmanial agent-22 (compound 15b) serves as an antiparasitic and antibacterial, exhibiting activities against Leishmania (IC50 = 0.408 μM), malaria, and</p>

<p>Aldgamycin E is a neutral macrolide antibiotic agent from culture filtrates of Streptomyces lavendulae. Methanolysis produces methyl algarosides A &amp; B.</p>

<p>4-(2-Octylamino)diphenylamine is an aromatic amine antioxidant known to be toxic to V. fischeri, with an IC50 value of 0.68 mg/mL. It induces skin sensitization and contact dermatitis in the murine local lymph node assay and can be used as a rubber additive.</p>

<p>Cephamycin C (CepC) is a nontoxic β-lactam antibiotic. CepC stands out from other cephalosporins for its greater resistance to β-lactamases.</p>

<p>ONX-0914 (PR-957) TFA is a selective LMP7 inhibitor, blocking cytokines and arthritis progression, and reactivates HIV-1.</p>

<p>Arylomycin B4 is a lipidic hexapeptide antibiotic (antibiotic) targeting Gram-positive bacteria.</p>

<p>Natural stilbene Longistyline A from Cajanus cajan leaves; antimicrobial against MRSA, MIC 1.56 μg/mL; neuroprotective.</p>

<p>Oxiran-2-ylmethanol exhibits antibacterial activity against Escherichia coli and can be used in related research in the field of life sciences.</p>

<p>IDR-1018 acetate is an innate defense regulator conjugate with a minimum inhibitory concentration (MIC) of 16 μg/mL against MRSA USA300 LAC, MRSA SAP 0017, and S. epidermidis ATCC14990. It serves a role in the synthesis of V-IDR1018 (vancomycin-innate defense regulator conjugate).</p>

<p>Amphipathic peptide LAH4 forms a-helix, binds phospholipid membranes, and shows in vitro transfection on par with commercial reagents.</p>

<p>Reveromycin D, from Streptomyces, blocks EGF in Balb/MK, halts KB/K562 growth, and shows pH-sensitive antifungal traits.</p>

<p>Antibacterialagent 275 (Ⅲ1) is an antibacterial compound with a λmax value of 730 nm. It is applicable for research in antimicrobial photodynamic therapy (aPDT).</p>

<p>Ceftaroline fosamil (TAK-599) is a cephalosporin-derived MRSA antibiotic prodrug.</p>

<p>LL-37, Human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.</p>

<p>Ecubectedin (PM14), a derivative of ecteinascidins family, has antitumor and antimicrobial properties.</p>

<p>Calpinactam, from M. alpina, fights M. smegmatis (MIC 0.78 μg/ml), boosts silkworm survival, but ineffective against 13 other species.</p>

<p>Pristinamycin, from Streptomyces pristinaespiralis, is a streptogramin antibiotic targeting Gram-positive and resistant bacteria like MRSA.</p>

<p>Somantadine has antiviral activities and can be used for research on preventing and treating coronavirus-related diseases.</p>

<p>Antibacterial peptide. Stimulates angiogenesis and inhibits inflammatory responses by selectively blocking proteasome degradation of IκBα.</p>

<p>Compound C-2, a non-mutagenic antibacterial against gram-positive/negative bacteria, inhibits protein synthesis.</p>

<p>Arylomycin B1 is a lipid hexapeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Anthracen-1-amine exhibits inhibitory activity against Escherichia coli.</p>

<p>(±)-Emodin bianthrone (compound 10), a naturally occurring substance, demonstrates antimalarial, antitubercular, and antifungal properties [1].</p>

<p>DNA Gyrase-IN-9 (compound 4j), an antibacterial agent, selectively targets DNA gyrase.</p>

<p>Urdamycin B, an antibiotic derived from the metabolic products of Streptomyces fradiae, effectively inhibits fungi and bacteria, and exhibits anti-proliferative activity against mouse leukemia cells L1210. Its potential uses include research on cancer, bacterial, and fungal infections [1] [2].</p>

<p>Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.</p>

<p>Cefazolin sodium pentahydrate: first-gen cephalosporin, treats bacterial infections, has anti-inflammatory properties, may reduce POCD.</p>

<p>Amphotericin B trihydrate, a polyene antibiotic, is derived from Streptomyces nodosus fermenter cultures. It exhibits antileishmanial properties.</p>

<p>Antibacterial agent 39 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>Erythromycin aspartate is a enzyme.</p>

<p>Wychimicin C, a spirotetronate polyketide, combats MRSA and Enterococcus (IC50: 0.125-0.5 µg/mL), from Actinocrispum MI503-AF4.</p>

<p>Antibacterial agent 132 showed antimicrobial activity against C.</p>

<p>Isepamicin (Sch 21420) is a strong aminoglycoside antibiotic, effective on Enterobacteriaceae and staphylococci, less so on other bacteria.</p>

<p>Arginomycin is a nucleoside antibiotic (antibiotic) that inhibits the growth of Gram-positive bacteria and fungi in vitro.</p>

<p>FPI-1523 inhibits β-lactamase (Kd: CTX-M-15 = 4 nM, OXA-48 = 34 nM), blocks PBP2 (IC50 = 3.2 μM), and has strong antimicrobial effects.</p>

<p>broad spectrum antibiotic</p>

<p>Lauryl-LF 11 displays antimicrobial activity.</p>

<p>Antofloxacin: Broad-spectrum antibiotic, potent against gyrA mutant H. pylori; mild reversible CYP1A2 inhibitor; used for bacterial infections.</p>

<p>UX4O is an allosteric inhibitor of UDP-glucose dehydrogenase (UGDH). The human UGDH (hUGDH) is a hexamer that catalyzes the oxidation of UDP-glucose to UDP-glucuronic acid. It exists in an active (E) state and an inactive (EΩ) state, which requires binding with the allosteric inhibitor UDP-xylose (UDP-Xyl) to stabilize the inactive form. UX4O may also serve as a physiologically relevant inhibitor of bacterial allosteric UGDH that does not produce UDP-Xyl.</p>

<p>Dodec-1-ene is toxic to MIAPaCa2 cells, Pseudokirchneriella subcapitata, and Daphnia magna,antibacterial. It can also be used in the synthesis of surfactants.</p>

<p>Impurity B in Cefpodoxime Proxetil, a broad-spectrum oral antibiotic, is a third-generation cephalosporin.</p>

<p>Glutathione S-Transferase (GST) π class inhibitor is a chemical compound designed to inhibit the action of the π class of GST enzymes.</p>

<p>Sulfamerazine sodium salt is a sulfonamide antibacterial.</p>

<p>Sanfetrinem (GV104326) sodium is a β-lactamase antibiotic with antimicrobial activity for the study of bacterial infections.</p>

<p>10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures.</p>

<p>Antibacterial Agent 33 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>Desferriferribactin is a biogenetic precursor of pyoverdin.</p>

<p>Iboxamycin: potent, orally active antibiotic effective against Gram-positive and Gram-negative bacteria in mice.</p>

<p>Antibacterial agent 116 is a benzophenone salicylanilide with potent activity, inhibiting peptidoglycan synthesis and labeling PBP1b to halt bacterial growth.</p>

<p>HS-291 is a HtpG inhibitor targeting Borrelia burgdorferi (Bb), composed of BX-2819 (high affinity for Bb HtpG), a PEG linker, and Verteporfin (a photoactive</p>

<p>Maximin 63, an antimicrobial peptide sourced from toad brain, exhibits potent efficacy against Staphylococcus aureus with a minimum inhibitory concentration (</p>

<p>Lydicamycin is a new antibiotic isolated from the fermentation broth of an actinomycete strain identified as Streptomyces solani. Lydicamycin is active against Gram-positive bacteria and certain yeasts, but inactive against Gram-negative bacteria. Cost-effective and quality-assured.</p>

<p>Chlortetracycline, a broad-spectrum antibiotic, halts protein synthesis in Gram-positive/negative bacteria.</p>

<p>Cloflucarban can be used as a disinfectant agent.</p>

<p>NDM-1 inhibitor-8 (Compound 18b) is a covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), with an IC50 of 7.03 μM. It effectively inhibits resistant bacterial strains and demonstrates synergistic antibacterial effects when used in combination with Meropenem. In mouse models, NDM-1 inhibitor-8 exhibits anti-infective activity.</p>

<p>DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth.</p>

<p>AVX 13616: potent antibacterial vs. drug-resistant Staph, similar to mupirocin with single-use efficiency. MIC: 2-4 ug/ml. Targets various staph, MRSA.</p>

<p>Antifungalagent 123 (Compound 4b) demonstrates strong affinity for the oxidoreductase of Staphylococcus aureus or membrane proteins of Candida albicans, exhibiting both antibacterial and antifungal properties. Additionally, it is capable of scavenging free radicals, showcasing antioxidant effects. Antifungalagent 123 also inhibits the TLR signaling pathway and possesses anti-inflammatory activity.</p>

<p>Carbazomycin A: antimicrobial, antifungal, and cytotoxic; MIC 12.5-25 μg/ml; IC50 18.4-32.6 μg/ml.</p>

<p>A 26771B is an antibiotic in the class of macrolide lactone.</p>

<p>Verruculogen, a toxin from Penicillium/Aspergillus, blocks Ca2+-K+ channels and halts mammalian M phase.</p>

<p>Repromicin is a chemical compound whose derivatives have strong antibacterial characteristics.</p>

<p>Pomolic Acid 3-Acetate, an antitubercular compound, exhibits a minimum inhibitory concentration (MIC) of 32 μM against Mycobacterium tuberculosis H37Rv [1].</p>

<p>Cyclothialidine is an inhibitor of DNA gyrase.</p>

<p>KU13 is an inhibitor of non-tuberculous mycobacteria (NTM), demonstrating minimum inhibitory concentrations (MIC) of 0.032-8 μg/mL against Mycobacterium and 2 μg/mL against E. coli. It is applicable in research focused on anti-infective treatments.</p>

<p>Ceftaroline: a cephalosporin antibiotic effective against MRSA, drug-resistant S. pneumoniae, and Gram-negatives; used for cSSSIs and CABP research.</p>

<p>Daunosamnyl-daunorubicin is used as an antibody conjugate.</p>

<p>Massarigenin C from M. flavorosea inhibits neuraminidase (IC50=4.15μM) and α-glucosidase (IC50=1.25mM), reduces blood glucose in mice.</p>

<p>Sericin is a globular protein isolated from silkworm cocoons. It has cognitive enhancement and pain-relieving properties. Additionally, Sericin serves as a cryoprotectant, potentially replacing fetal bovine serum or dimethyl sulfoxide (DMSO). It helps reduce oxidative stress and reactive oxygen species (ROS). Sericin aids in wound repair by promoting collagen production and exhibits activities such as antioxidant, antidiabetic, antihyperlipidemic, anti-inflammatory, moisturizing, wound healing promotion, antibacterial, and antitumor effects.</p>

<p>Thiomarinol A: potent antibiotic, dithiolopyrrolone-marinolic acid hybrid with MRSA-targeting antimicrobial activity; inhibits IleRS, Ki app 19 nM.</p>

<p>Antibacterial agent 43 from patent WO2013030735A1 shows strong activity against infections and has research potential.</p>

<p>(8'α,9'β-Dihydroxy)-3-farnesylindole exhibits significant inhibitory effectiveness (EC 50 9.8 μM) against B. subtilis.</p>

<p>Gepotidacin S enantiomer is an S enantionmer of gepotidacin.</p>

<p>7-Oxoganoderic acid Z is a useful organic compound for research related to life sciences. The catalog number is T123920 and the CAS number is 929248-72-6.</p>

<p>Naphthomycin B is an antibiotic that was originally isolated from Streptomyces sp. It exhibits antibacterial activity against gram-positive bacteria and various fungi.</p>

<p>LL-BM123γ2 is an antimicrobial agent that exhibits activity against various microorganisms. It is utilized in research related to antimicrobial properties.</p>

<p>β-Lactamase-IN-5, a β-lactamase inhibitor isolated from compound 720, holds significant potential for studying bacterial infections.</p>

<p>Ecteinascidin-Analog-1, a tetrahydroisoquinoline, is key for synthesizing ecteinascidin analogs with antitumor and antimicrobial properties.</p>

<p>Brilacidin is a nonpeptidic anti-infective in a new class of defensin mimetics used for the research of eye infections.</p>

<p>2,5-Dimethylcyclohexa-2,5-diene-1,4-dione inhibits the viability of HL60 and K562 cells and exhibits antibacterial and anticancer properties.</p>

<p>CysHHC10 is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria.</p>

<p>Antibacterialagent 181 (Compound 3f) is an effective cationic antibacterialagent (antibacterialagent) with low cytotoxicity. It exhibits a minimum inhibitory concentration (MIC) of 2 μg/mL against both Staphylococcus aureus and Escherichia coli.</p>

<p>Nucleocidin, an antitrypanosomal antibiotic, inhibits the transfer of labeled amino acids from S-RNA to protein.</p>

<p>Arbekacin is an aminoglycoside antibiotic.</p>