Antibacterial

<p>Clostomycin B2 is a bioactive chemical.</p>

<p>TP0586352 is a potent inhibitor of LpxC, exhibiting efficacy against carbapenem-resistant strains of Klebsiella pneumoniae without inducing cardiovascular risks</p>

<p>Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.</p>

<p>Azidocillin, a semi-synthetic oral β-lactam antibiotic, treats various bacterial infections including osteitis and septicemia.</p>

<p>Antibacterial agent 150 (compound 5g) exhibits potent activity against a wide range of bacteria, including both Gram-positive and Gram-negative species, with</p>

<p>Amoxycillin arginine salt is a bioactive chemical.</p>

<p>Spirolaxine from Sporotrichum laxum shows anti-Helicobacter pylori activity.</p>

<p>LL-37 peptide: acetylated at N-terminus, amidated at C-terminus; crucial in initial infection defense.</p>

<p>Amycolatopsin A, a macrolide from Amycolatopsis, fights M. bovis/tuberculosis and some cancers, not effective on common bacteria.</p>

<p>Framycetin is an aminoglycoside antibiotic and it also inhibits hammerhead ribozyme (Ki: 13.5 μM).</p>

<p>Omadacycline: an aminomethylcycline antibiotic, cidal against four Streptococcus pneumoniae strains.</p>

<p>Tunicamycin 15:1 is a mixture of tunicamycin structural isomers that contains a 15-carbon N-acyl chain with variable branching patterns.</p>

<p>Maximin 15, an antimicrobial peptide originating from toad brain, exhibits activity against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis, with</p>

<p>Globomycin: a lipopeptide antibiotic that irreversibly inhibits signal peptidase II, blocking prolipoprotein processing.</p>

<p>Monensin, from Streptomyces cinnamonensis, inhibits Wnt/β-catenin. Potential anticancer agent.</p>

<p>SC 28538, a 5-nitroimidazole, matches metronidazole in potency against multiple pathogens in vitro.</p>

<p>Antibacterial agent 49 (example 12) is a antibacterial agent.</p>

<p>AA45 boosts Ceftazidime's efficacy by lowering its MIC value, showcasing strong antibacterial properties.</p>

<p>Oritavancin, a semisynthetic antibiotic for skin infections, approved by FDA on August 6, 2014, targets resistant Gram-positive bacteria.</p>

<p>C12-rrw-NH2 (Compound Lip7) is an antimicrobial agent effective against Gram-positive bacteria, particularly demonstrating significant activity against Methicillin-resistant Staphylococcus aureus (MRSA). It induces bacterial cell death by depolarizing the bacterial cell membrane, disrupting membrane integrity, causing nucleic acid and protein leakage, and promoting the generation of Reactive Oxygen Species (ROS). C12-rrw-NH2 is applicable in research focused on developing highly stable antimicrobial peptides.</p>

<p>N-3-oxo-hexadecanoyl-L-homoserine lactone, a C16 AHL, aids bacterial quorum sensing and primes plant systemic resistance.</p>

<p>Cuprichydroxide exhibits inhibitory activity against Ralstonia solanacearum and A549 cells and has acute pulmonary toxicity.</p>

<p>Helvolic acid, an antibiotic derived from Xylaria sp., exhibits effectiveness against Gram-positive bacteria.</p>

<p>Aerocyanidin is an antibiotic (antibiotic) that contains an isonitrile group and is primarily effective against Gram-positive bacteria.</p>

<p>Capoamycin is an insotatracine antibiotic investigated for anti tumor properties.</p>

<p>Aurein 2.2, a principal constituent of L.aurea skin secretions, exhibits broad-spectrum antibacterial properties, particularly effective against Gram-positive</p>

<p>DprE1-IN-7 (Compound 64) is a DprE1 inhibitor with potent anti-tuberculosis (TB) activity, demonstrating a minimum inhibitory concentration (MIC) of 1 μM</p>

<p>Antibacterialagent 275 (Ⅲ1) is an antibacterial compound with a λmax value of 730 nm. It is applicable for research in antimicrobial photodynamic therapy (aPDT).</p>

<p>Luminamicin is active against anaerobic bacteria, especially Clostridium sp.; isolated from actinomycete strain OMR-59.</p>

<p>β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.</p>

<p>Lankacidinol A is a metabolite of macrolide antibiotic.</p>

<p>Cefsulodin, a β-lactam antibiotic, targets E. coli's penicillin-binding proteins, aiding with cell wall synthesis disruption.</p>

<p>Compound 12: a potent anti-MRSA, inhibits S. aureus/E. coli DNA gyrases/topo IV; IC50: 0.185-0.365/0.341-0.059 μM.</p>

<p>Xenopsin precursor fragment, an antimicrobial peptide, exhibits both antibacterial/antifungal activity at concentrations ranging from 10 to 500 μg/mL and anti-</p>

<p>Dusquetide TFA (SGX942) is an IDR that modulates immunity by targeting p62, reducing inflammation, and enhancing bacterial clearance.</p>

<p>Nafcillin sodium, a penicillin antibiotic, treats Gram-positive, penicillin-resistant staph infections.</p>

<p>PA3552-IN-1: Antibiotic adjuvant, lowers PA3552 expression, resensitizes MDR P. aeruginosa to Polymyxin B.</p>

<p>KT5823 is a cGMP-dependent protein kinase (PKG) inhibitor that increases iodide ion uptake by regulating the expression of sodium iodide symporter protein.</p>

<p>Vitamin K5, a photosensitizer &amp; antimicrobial, inhibits PKM2, PKM1 &amp; PKL, induces apoptosis in colon cells, and preserves food &amp; medicine.</p>

<p>Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.</p>

<p>Gramicidin S (Gramicidin Soviet), a cationic cyclic peptide antibiotic, disrupts the membrane integrity of both Gram-positive and Gram-negative bacteria and</p>

<p>Mafenide, a sulfonamide, inhibits the enzyme carbonic anhydrase and is used as a topical anti-infective drug, especially in burn therapy.</p>

<p>Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.</p>

<p>Albofungin is a xanthone isolated from A. tumemacerans.</p>

<p>Sphinganine is a synthetic sphingolipid fungicide against C. glabrata and C. albicans; MFC 0.5 μg/ml. Used as an analysis standard.</p>

<p>Antibacterial Agent 42 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>Urechistachykinin I (Uru-TK I) is an invertebrate kalinin-related peptide (TRPs) isolated from thylakoid nematodes.</p>

<p>Reltecimod, a CD28 antigen inhibitor, is used potentially for the treatment of necrotizing soft tissue infection.</p>

<p>Midecamycin acetate is a broad-spectrum antibiotic active against Gram-positive and some Gram-negative strains.</p>

<p>Allolactose is a disaccharide used as an inducer of the lac operon in Escherichia coli and many other enteric bacteria.</p>

<p>Amythiamicin C is an antimicrobial antibiotic effective against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and also exhibits activity against Plasmodium falciparum (the causative agent of malaria).</p>

<p>AA35 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>Myristoyl glutamic acid sodium, a surfactant in amino acid cleansers, has mild antibacterial properties and cleanses the skin surface of excess oil and dirt.</p>

<p>Rugulosin (RUG) is a bis-anthraquinoid pigment produced by fungi.</p>

<p>Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.</p>

<p>Aurein 2.5, an antimicrobial peptide with antibiotic properties, exhibits both antibacterial and antifungal activities [1] [2].</p>

<p>Platencin, a broad-spectrum antibiotic from S. platensis, inhibits FabF and FabH, with IC50s of 1.95 and 3.91 μg/ml; fights resistant bacteria.</p>

<p>DS86760016 inhibits LeuRS; potent against MDR Gram-negative bacteria; IC50: E. coli 0.38μM, P. aeruginosa 0.62μM, A. baumannii 0.16μM.</p>

<p>Terephthalonitrile exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa and can be used in related research in the field of life sciences.</p>

<p>Ro 41-1879 is a catechol cephalosporin with antimicrobial activity.</p>

<p>Nyssoside, an ellagic acid derivative, exhibits notable antioxidant and antibacterial properties against a variety of pathogenic bacteria.</p>

<p>Ro 25-0534 is an antipseudomonal dual-action drug with antimicrobial activity.</p>

<p>ANT3310 inhibits several Serine β-Lactamases (IC50: 1-175 nM); useful for bacterial infection research.</p>

<p>RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase [1] .</p>

<p>Thiomandelic acid is a simple, broad-spectrum and quite potent metallo-β-lactamase inhibitor, an antimicrobial compound.</p>

<p>Pentalysine is a peptide.</p>

<p>MBL-IN-1 (compound 41), a β-Lactamase inhibitor, exhibits an IC50 range of 0.10 to 25.85 µM and is utilized in the study of bacterial infections [1].</p>

<p>Neoaureothin, a Streptomyces metabolite, is an AR antagonist with anti-androgen and cytotoxic effects, also active against B. xylophilus.</p>

<p>Mycothiol detoxifies, links foreign compounds, and acts as microbes' glutathione.</p>

<p>Arylomycin B1 is a lipid hexapeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Samandarone is a major alkaloid from the European fire salamander (Salamandra salamandra terrestris).</p>

<p>FR-295389 is a cephalosporin. FR-295389 shows effective antibacterial activity against metallo-beta-lactamase (MBL)-producers in vitro.</p>

<p>Clorobiocin is an aminocoumarin antibacterial that suppresses the enzyme DNA gyrase.</p>

<p>Carbazomycin A: antimicrobial, antifungal, and cytotoxic; MIC 12.5-25 μg/ml; IC50 18.4-32.6 μg/ml.</p>

<p>Natural stilbene Longistyline A from Cajanus cajan leaves; antimicrobial against MRSA, MIC 1.56 μg/mL; neuroprotective.</p>

<p>Thiotropocin is an antibiotic.</p>

<p>15-acetoxyscirpenol: ASM that induces apoptosis, inhibits Jurkat T cell growth dose-dependently, and activates caspases other than caspase-3.</p>

<p>Desotamide: an antibiotic cyclic hexapeptide targeting S. aureus, S. pneumoniae, and MRSE with MICs 16, 12.5, 32 μg/ml.</p>

<p>SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.</p>

<p>Defensin HNP-3 human, a cytotoxic antibiotic peptide referred to as "defensin," exhibits inhibitory effects on Staphylococcus aureus, Pseudomonas aeruginosa,</p>

<p>Reveromycin B: a spiroketal from Streptomyces, blocks EGF in Balb/MK (IC50=6 μg/ml), antifungal vs. C. albicans, pH-sensitive, not active on KB, K562 cells.</p>

<p>Maximin 1, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal</p>

<p>Racemomycin B is a beta-lysine-rich streptothricin antibiotic.</p>

<p>Sulfamerazine sodium salt is a sulfonamide antibacterial.</p>

<p>Ceftaroline fosamil (TAK-599) is a cephalosporin-derived MRSA antibiotic prodrug.</p>

<p>Piscidin-1 (22-42) (TFA) is a highly potent, multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides).</p>

<p>Rifasutenizol (TNP-2198) is a powerful, oral dual-target antibacterial effective against microaerophilic and anaerobic bacteria.</p>

<p>Urechistachykinin II (Uru-TK II) is an invertebrate rapid kinin-related peptide (TRPs) isolated from carotenoid worms.</p>

<p>Antibacterial agent 53 (example 19) is a antibacterial agent.</p>

<p>Arisostatin A is a secondary metabolite produced by microorganisms, recognized as an antibiotic (antibiotic) with activity against Gram-positive bacteria. This compound also exhibits potent antitumor properties. It induces apoptosis (apoptosis) by activating caspase-3 and generating reactive oxygen species (ROS) in AMC-HN-4 cells.</p>

<p>FtsZ-IN-6: strong FtsZ polymerization promoter, GTPase inhibitor, kills bacteria, low resistance and toxicity.</p>

<p>Cefazolin sodium pentahydrate: first-gen cephalosporin, treats bacterial infections, has anti-inflammatory properties, may reduce POCD.</p>

<p>Amythiamicin A is an antibiotic effective against gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), and exhibits activity against Plasmodium falciparum.</p>

<p>Malacidin B, a macrocyclic lipopeptide antibiotic, demonstrates calcium-dependent antibacterial activity [1] [2].</p>

<p>Viomycin sulfate hydrate is an effective antimycobacterial antibiotic (antibiotic). It rapidly inhibits the elongation of polypeptide chains when added to purified endogenous polypeptide-synthesizing Escherichia coli polypeptide systems.</p>

<p>Lenapenem is a broad-spectrum, carbapenem antibiotic with bactericidal activity by weakens the bacterial cell wall and leads to lytic cell death.</p>

<p>Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin.</p>

<p>MtbHU-IN-1 is a Mycobacterium tuberculosis nucleoid-associated protein HU (MtbHU)inhibitor(binding to WT MtbHU with a Kd of 98 nM).</p>

<p>Aldgamycin E is a neutral macrolide antibiotic agent from culture filtrates of Streptomyces lavendulae. Methanolysis produces methyl algarosides A &amp; B.</p>

<p>NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.</p>