Antibacterial

<p>Mtb-IN-10 (Compound P15) is an Rv1625c/Cya activator that influences the growth of Mycobacterium tuberculosis (Mtb) by modulating cAMP metabolism. It demonstrates an anti-tuberculosis activity with an EC50 of 1.96 µM in Mtb-infected macrophage models and achieves an oral bioavailability of 58.0% when administered orally to mice at 20 mg/kg. Mtb-IN-10 potentially regulates intracellular signaling and disrupts cholesterol metabolism within Mtb, thereby inhibiting bacterial proliferation. It holds promise for tuberculosis (TB) research, particularly targeting multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains of Mtb.</p>

<p>QST4 possessed antitubercular and antifungal activities with a MIC value of 6.25 μM in Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv.</p>

<p>KT5823 is a cGMP-dependent protein kinase (PKG) inhibitor that increases iodide ion uptake by regulating the expression of sodium iodide symporter protein.</p>

<p>Ascr#18: nematode hormone boosts infection resistance in plants like Arabidopsis, tomato, potato, barley.</p>

<p>FLGFVGQALNALLGKL-NH2, an antimicrobial peptide derived from frogs, exhibits activity against Staphylococcus aureus ATCC 29213 with a minimum inhibitory</p>

<p>FASN-IN-6 (compound 44), a potent fatty acid biosynthesis (FAB) inhibitor, serves as an antibacterial agent, exhibiting minimum inhibitory concentrations (MICs</p>

<p>RvD4, derived from docosahexaenoic acid, reduces neutrophil infiltration and promotes phagocytosis/clearance by human cells.</p>

<p>Cefotiam (SCE-963), a parenteral cephalosporin antibiotic, exhibits broad-spectrum activity against both Gram-positive and Gram-negative bacteria [1] [2].</p>

<p>JH-LPH-28, a sulfonyl piperazine, inhibits LpxH with strong antibiotic activity, MIC of 0.83 μg/mL.</p>

<p>Nyssoside, an ellagic acid derivative, exhibits notable antioxidant and antibacterial properties against a variety of pathogenic bacteria.</p>

<p>Myricetin 3-O-α-L-arabinopyranoside, a quercetin derivative and plant flavonoid, exhibits antioxidant, antibacterial, and antiurease properties.</p>

<p>Anti-MRSA agent 25 (Compound 10c) is an antibacterial compound with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Its antimicrobial activity is achieved by inhibiting biofilm formation, disrupting the cell wall (interacting with peptidoglycan and lipoteichoic acid), acting on the cell membrane (causing depolarization, increasing permeability, and compromising integrity), reducing metabolic activity, interfering with cellular redox homeostasis, and binding to DNA. Anti-MRSA agent 25 holds potential for research in the field of anti-infective therapeutics.</p>

<p>S-6123: Oxazolidinone antimicrobial that blocks ribosomal protein synthesis, sparing DNA/RNA.</p>

<p>Pexiganan, a synthetic magainin 2 analog, is a broad-spectrum antimicrobial peptide for researching infections like diabetic foot ulcers.</p>

<p>Ansatrienin B: antibiotic, antifungal, inhibits PTH-induced calcium release and protein synthesis, enhances certain chemotherapies.</p>

<p>Antibacterial agent 153 is a broad-spectrum agent that eradicates bacteria by targeting their cell membranes and is employed in research on bacterial infections</p>

<p>Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species.</p>

<p>Actinorhodin is a blue pigment and a redox-active microbial secondary metabolite. It is a potent, antibacterial, pH-responsive antibiotic (antibiotic) exhibiting antimicrobial activity against Gram-positive bacteria.</p>

<p>Eremomycin, an antibiotic, can be used intramuscularly due to low toxicity.</p>

<p>Spiramycin III is an antibiotic within the erythromycin/carbomycin group of compounds.</p>

<p>Lysozyme chloride: enzyme that kills gram-positive bacteria; used in HIV, emphysema research.</p>

<p>Clindamycin phosphate HCl: prodrug, becomes active clindamycin in vivo; used for acne, bacterial vaginosis research.</p>

<p>Tropodithietic acid, a sulfur-based antibiotic from Phaeobacter inhibens, targets many bacteria types.</p>

<p>Antibacterial agent 127 (Compound 23) is a potent antibacterial agent [1] .</p>

<p>Cefquinome is a cephem antibiotic that inhibits Enterobacteriaceae (family [1]).</p>

<p>NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.</p>

<p>Clovibactin, a novel antibiotic, effectively eradicates drug-resistant bacterial pathogens and demonstrates no discernible resistance.</p>

<p>Kalimantacin A: a potent antibiotic effective against MRSA and other staphylococci.</p>

<p>Setomimycin is an antibiotic against Gram positive bacteria, including mycobacteria.</p>

<p>Gemifloxacin is a fluoronaphthyridone with strong antibacterial effect.</p>

<p>Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.</p>

<p>Isocryptomerin, from Selaginella tamariscina, is an antifungal that depolarizes membranes and has anticancer, antibacterial effects.</p>

<p>Furaltadone L-tartrate, a nitrofuran, may help study Salmonella enteritidis in chickens; it's an antibacterial agent against staphylococci.</p>

<p>BAL30072: Antibiotic effective against MDR Acinetobacter (4 μg/mL) and P. aeruginosa (8 μg/mL); a monocyclic beta-lactam.</p>

<p>Tomopenem is a penem antibiotic.</p>

<p>Nybomycin, a fungal metabolite from Streptomyces sp. A717, has antibacterial properties; effective against various bacteria including M. tuberculosis.</p>

<p>Dienone B is a cytotoxic secondary metabolite from tyrosine as isolated from the sponges Verongia aerophoba &amp;amp; Aplysina aerophoba.</p>

<p>Siomycin A: thiopeptide antibiotic, selectively inhibits FOXM1, anti-tumor, induces apoptosis.</p>

<p>Nafcillin sodium: an antibiotic, β-lactamase inhibitor, treats staph infections.</p>

<p>Loloatin B 10 is a bioactive chemical.</p>

<p>Arylomycin B1 is a lipid hexapeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Aurein 2.6, an antibiotic antimicrobial peptide, exhibits activity against various Gram-positive bacteria with minimum inhibitory concentrations (MIC) of 25, 25</p>

<p>2-Benzylaniline is a potential Cytochrome P450 2B6 inhibitor with an IC50 value of 4.36 μM.</p>

<p>Antitubercular agent-9 exhibits potent activity against tuberculosis, demonstrating a minimum inhibitory concentration (MIC) range of 1.03-2.32 μM.</p>

<p>Iedaborbactam, as a beta-lactamase inhibitor (WO2015191907, Example 62), can be used for the research of bacterial infections.</p>

<p>DprE1-IN-6 (Compound 56) is a DprE1 inhibitor with demonstrated anti-TB activity, exhibiting a minimum inhibitory concentration (MIC) of 1 μM against the Mtb</p>

<p>Parvodicin C2, a glycopeptide antibiotic derived from A. parvosata and part of the parvodicin complex, serves as a component of the A40926 antibiotic complex utilized as a precursor for synthesizing dalbavancin. It exhibits activity against methicillin-sensitive and methicillin-resistant strains of S. aureus, S. epidermidis, S. saprophyticus, S. hemolyticus, and E. faecalis.</p>

<p>Kapurimycin A3 is an antitumor antibiotics.</p>

<p>Galbinic acid, a lichen-derived depsidone from U. undulata, inhibits B. cereus, B. subtilis, S. aureus, and E. coli, with varying MICs.</p>

<p>Cecropin A TFA: a 37-residue peptide from Hyalaphora cecropia, with antibacterial, anti-inflammatory, and anticancer properties.</p>