CymitQuimica logo
PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

Show 2 more subcategories

Found 1030 products of "PI3K/Akt/mTOR Signaling"

Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
products per page.
  • SIKs-IN-1
    Targetmol
    + Info

    SIKs-IN-1

    CAS:
    <p>SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in the M1/M2</p>
    Formula:C27H31F2N7O
    Color and Shape:Solid
    Molecular weight:507.58

    Ref: TM-T78762

  • (E/Z)-AG490
    Targetmol
    + Info

    (E/Z)-AG490

    CAS:
    <p>(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.</p>
    Formula:C17H14N2O3
    Color and Shape:Solid
    Molecular weight:294.3

    Ref: TM-T60624

  • PI3K-IN-36
    Targetmol
    + Info

    PI3K-IN-36

    CAS:
    <p>PI3K-IN-36 is a potent inhibitor of PI3K, suitable for research applications in follicular lymphoma (FL).</p>
    Formula:C30H36F2N8O
    Color and Shape:Solid
    Molecular weight:562.66

    Ref: TM-T73150

  • PI3Kγ inhibitor 6
    Targetmol
    + Info

    PI3Kγ inhibitor 6

    CAS:
    <p>PI3Kγ Inhibitor 6, a specific inhibitor of PI3Kγ, is utilized in the study of inflammatory and autoimmune diseases.</p>
    Formula:C16H11NO5S
    Color and Shape:Solid
    Molecular weight:329.33

    Ref: TM-T72613

  • PKI-179 hydrochloride
    Targetmol
    + Info

    PKI-179 hydrochloride

    CAS:
    <p>PKI-179: oral PI3K/mTOR inhibitor; IC50: PI3Kα/β/δ/γ (8-74 nM), PI3Kα mutants (11-14 nM), mTOR (0.42 nM); selective; inhibits cancer cell growth.</p>
    Formula:C25H29ClN8O3
    Color and Shape:Solid
    Molecular weight:525

    Ref: TM-T36085

  • PI3Kα-IN-4
    Targetmol
    + Info

    PI3Kα-IN-4

    CAS:
    <p>PI3Kα-IN-4 is a potent, selective, and orally active PI3Kα inhibitor, demonstrating an IC50 of 1.8 nM and exhibiting antitumor activity[1].</p>
    Formula:C25H23ClFN5O5S
    Color and Shape:Solid
    Molecular weight:560

    Ref: TM-T35527

  • PI3K-IN-28
    Targetmol
    + Info

    PI3K-IN-28

    CAS:
    <p>PI3K-IN-28, a potent PI3K inhibitor with low toxicity in MCF-10a, has IC50 values of 5.8, 2.3, 7.9 μM and high selectivity index of 39.</p>
    Formula:C26H16F9N3O3S2
    Color and Shape:Solid
    Molecular weight:653.54

    Ref: TM-T73118

  • EGFR-IN-75
    Targetmol
    + Info

    EGFR-IN-75

    <p>EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.</p>
    Formula:C10H6N6S2
    Color and Shape:Solid
    Molecular weight:274.32

    Ref: TM-T73178

  • Leniolisib phosphate
    Targetmol
    + Info

    Leniolisib phosphate

    CAS:
    <p>Leniolisib phosphate is an effective PI3K inhibitor.</p>
    Formula:C21H28F3N6O6P
    Color and Shape:Solid
    Molecular weight:548.45

    Ref: TM-T5166L

  • DNA-PK-IN-5
    Targetmol
    + Info

    DNA-PK-IN-5

    CAS:
    DNA-PK-IN-5: potent DNA-PK inhibitor, reduces tumor repair, induces apoptosis, enhances radiotherapy, overcomes resistance.
    Formula:C21H22N8O2
    Color and Shape:Solid
    Molecular weight:418.45

    Ref: TM-T62191

  • CAY10717
    Targetmol
    + Info

    CAY10717

    CAS:
    <p>CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.</p>
    Formula:C29H25F3N6O3
    Color and Shape:Solid
    Molecular weight:562.54

    Ref: TM-T36193

  • UNC-CA359
    Targetmol
    + Info

    UNC-CA359

    CAS:
    <p>UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.</p>
    Formula:C18H14ClN3O2
    Color and Shape:Solid
    Molecular weight:339.78

    Ref: TM-T61077

  • EGFR-IN-55
    Targetmol
    + Info

    EGFR-IN-55

    CAS:
    <p>"EGFR-IN-55 targets EGFRWT (70 nM IC50) &amp; EGFRL858R/T790M (3.9 nM IC50), halts NCI-H1975 cell cycle in G0/G1, showing anticancer properties."</p>
    Formula:C25H25Cl2N7O2
    Color and Shape:Solid
    Molecular weight:526.42

    Ref: TM-T63693

  • NVP-CLR457
    Targetmol
    + Info

    NVP-CLR457

    CAS:
    <p>NVP-CLR457 is an oral pan-class I PI3K inhibitor with dose-dependent antitumor activity.</p>
    Formula:C18H20F3N7O4
    Color and Shape:Solid
    Molecular weight:455.39

    Ref: TM-T62816

  • EAI001
    Targetmol
    + Info

    EAI001

    CAS:
    <p>EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.</p>
    Formula:C19H15N3O2S
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:349.41

    Ref: TM-T61191

  • DNA-PK-IN-3
    Targetmol
    + Info

    DNA-PK-IN-3

    CAS:
    <p>DNA-PK-IN-3 is a potent DNA-PK inhibitor, enhancing radio/chemotherapy and reducing tumors with limited side effects.</p>
    Formula:C19H19N9O
    Color and Shape:Solid
    Molecular weight:389.41

    Ref: TM-T61751

  • PI3Kδ/γ-IN-2
    Targetmol
    + Info

    PI3Kδ/γ-IN-2

    CAS:
    <p>PI3Kδ/γ-IN-2 is a potent, orally bioavailable dual inhibitor of PI3Kδ (IC50: 1 nM) and PI3Kγ (IC50: 4.3 nM) with potential for use in anti-B-cell malignancy</p>
    Formula:C25H21ClN8O
    Color and Shape:Solid
    Molecular weight:484.94

    Ref: TM-T63221

  • PI3Kγ inhibitor 4
    Targetmol
    + Info

    PI3Kγ inhibitor 4

    CAS:
    <p>PI3Kγ inhibitor 4 is a selective, potent, orally active PI3Kγ inhibitor (IC50: 40 nM).</p>
    Formula:C20H24N4O4S
    Color and Shape:Solid
    Molecular weight:416.49

    Ref: TM-T62165

  • Nimotuzumab
    Targetmol
    + Info

    Nimotuzumab

    CAS:
    <p>Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).</p>
    Purity:95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)
    Color and Shape:Liquid

    Ref: TM-T9923

  • PI3K-IN-38
    Targetmol
    + Info

    PI3K-IN-38

    CAS:
    <p>PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.</p>
    Formula:C20H24N6O2
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:380.44

    Ref: TM-T61618