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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1030 products of "PI3K/Akt/mTOR Signaling"

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  • JBJ-04-125-02
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    JBJ-04-125-02

    CAS:
    <p>JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.</p>
    Formula:C29H26FN5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:543.61

    Ref: TM-T11714

  • JBJ-09-063 hydrochloride
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    JBJ-09-063 hydrochloride

    <p>JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.</p>
    Formula:C31H30ClFN4O3S
    Color and Shape:Solid
    Molecular weight:593.11

    Ref: TM-T72237

  • NSC114126
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    NSC114126

    CAS:
    <p>NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>
    Formula:C22H20O4
    Color and Shape:Solid
    Molecular weight:348.39

    Ref: TM-T61177

  • TCS 2002
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    TCS 2002

    CAS:
    <p>GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.</p>
    Formula:C18H14N2O3S
    Color and Shape:Solid
    Molecular weight:338.38

    Ref: TM-T22157

  • BRD3731
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    BRD3731

    CAS:
    <p>BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.</p>
    Formula:C24H31N3O
    Color and Shape:Solid
    Molecular weight:377.52

    Ref: TM-T61578

  • EGFR-IN-25
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    EGFR-IN-25

    CAS:
    <p>EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.</p>
    Formula:C34H43N9O2
    Color and Shape:Solid
    Molecular weight:609.76

    Ref: TM-T73101

  • PIKfyve-IN-2
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    PIKfyve-IN-2

    CAS:
    <p>PIKfyve-IN-2 is a potent inhibitor of the PIKfyve kinase, with potential applications in cancer and autoimmune disorder research [1].</p>
    Formula:C22H22N8O
    Color and Shape:Solid
    Molecular weight:414.46

    Ref: TM-T79210

  • Epertinib
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    Epertinib

    CAS:
    <p>Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).</p>
    Formula:C30H27ClFN5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:560.02

    Ref: TM-T11213L

  • EGFR-IN-67
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    EGFR-IN-67

    CAS:
    <p>EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].</p>
    Formula:C18H17N3S
    Color and Shape:Solid
    Molecular weight:307.41

    Ref: TM-T60729

  • PI3K-IN-10
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    PI3K-IN-10

    CAS:
    <p>PI3K-IN-10 is a potent inhibitor of pan-PI3K .</p>
    Formula:C23H19ClN6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:430.89

    Ref: TM-T12456

  • DNA-PK-IN-1
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    DNA-PK-IN-1

    CAS:
    <p>DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.</p>
    Formula:C23H26N8O2
    Color and Shape:Solid
    Molecular weight:446.5

    Ref: TM-T62648

  • EGFR-IN-64
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    EGFR-IN-64

    CAS:
    <p>EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.</p>
    Formula:C20H21N3O3
    Color and Shape:Solid
    Molecular weight:351.4

    Ref: TM-T61225

  • GW 583340 dihydrochloride
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    GW 583340 dihydrochloride

    CAS:
    <p>GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.</p>
    Formula:C28H27Cl3FN5O3S2
    Purity:98.80%
    Color and Shape:Solid
    Molecular weight:671.03

    Ref: TM-T22827

  • (R)-PS210
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    (R)-PS210

    CAS:
    (R)-PS210, the R enantiomer of PS210 is a substrate-selective allosteric PDK1 activator with an (AC50 of 1.8 μM).
    Formula:C19H15F3O5
    Color and Shape:Solid
    Molecular weight:380.31

    Ref: TM-T12639

  • FD2056
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    FD2056

    CAS:
    <p>FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.</p>
    Formula:C23H17ClN6O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:476.94

    Ref: TM-T79370

  • EGFR-IN-89
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    EGFR-IN-89

    CAS:
    <p>EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM against</p>
    Formula:C26H31FN8O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:538.64

    Ref: TM-T79775

  • EGFR-IN-5
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    EGFR-IN-5

    CAS:
    <p>EGFR-IN-5 inhibits EGFR &amp; mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.</p>
    Formula:C31H38FN9O
    Purity:98.17%
    Color and Shape:Solid
    Molecular weight:571.69

    Ref: TM-T11160

  • PI3-Kinase α Inhibitor 2
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    PI3-Kinase α Inhibitor 2

    CAS:
    <p>Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and</p>
    Formula:C16H15N3O2S
    Color and Shape:Solid
    Molecular weight:313.37

    Ref: TM-T35525

  • PI3K/mTOR Inhibitor-3
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    PI3K/mTOR Inhibitor-3

    CAS:
    <p>PI3K/mTOR Inhibitor-3, a potent dual-action anti-cancer imidazoline, targets PI3K and mTOR.</p>
    Formula:C22H23N5O
    Color and Shape:Solid
    Molecular weight:373.45

    Ref: TM-T61516

  • EGFR-IN-54
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    EGFR-IN-54

    CAS:
    <p>EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.</p>
    Formula:C17H14N4O4S3
    Color and Shape:Solid
    Molecular weight:434.51

    Ref: TM-T62457