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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1038 products of "PI3K/Akt/mTOR Signaling"

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  • MTI-31
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    MTI-31

    CAS:
    <p>MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, &gt;5,000-fold selectivity, and an IC50 of 39 nM.</p>
    Formula:C26H30N6O3
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:474.55

    Ref: TM-T35343

  • LAS191954
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    LAS191954

    CAS:
    <p>LAS191954 is a selective, potent and orally active PI3Kδ inhibitor for inflammatory diseases treatment(IC50 : 2.6 nM).</p>
    Formula:C20H15N9O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:397.39

    Ref: TM-T11818

  • MIPS-21335
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    MIPS-21335

    CAS:
    <p>MIPS-21335 is a potent PI3KC2α inhibitor with an IC50 value of 7 nM and additionally exhibits inhibitory activity against PI3KC2β, p110α, p110β, and p110δ with</p>
    Formula:C24H21N7O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:487.47

    Ref: TM-T81791

  • MP7
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    MP7

    CAS:
    <p>MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).</p>
    Formula:C28H22F2N4O4
    Purity:99.84% - 99.89%
    Color and Shape:Solid
    Molecular weight:516.5

    Ref: TM-T12398

  • ZL-2201
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    ZL-2201

    CAS:
    <p>ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.</p>
    Formula:C20H25N9O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:503.54

    Ref: TM-T78645

  • EGFR-IN-1
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    EGFR-IN-1

    CAS:
    <p>EGFR-IN-1: an oral, irreversible EGFR inhibitor targeting L858R/T790M mutations with high selectivity, showing potent antitumor effects.</p>
    Formula:C28H30N6O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:514.58

    Ref: TM-T11157

  • MSC2360844
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    MSC2360844

    CAS:
    <p>MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).</p>
    Formula:C26H27FN4O5S
    Purity:99.54% - 99.9%
    Color and Shape:Solid
    Molecular weight:526.58

    Ref: TM-T12115

  • Tenalisib R Enantiomer
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    Tenalisib R Enantiomer

    CAS:
    <p>Tenalisib R Enantiomer is an R enantiomer of Tenalisib .</p>
    Formula:C23H18FN5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:415.42

    Ref: TM-T13120

  • (Z)-RG-13022
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    (Z)-RG-13022

    CAS:
    <p>(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor that preferentially inhibits the TK activity of the EGF receptor, restricting the EGF-stimulated growth of cultured cells. It demonstrates an IC50 of 11 μM for DNA synthesis in HN5 cells, showcasing thrice the potency of its isomer, (E)-RG-13022 (IC50 = 38 μM). This compound is applied in breast cancer cell research [1] [2].</p>
    Formula:C16H14N2O2
    Color and Shape:Solid
    Molecular weight:266.29

    Ref: TM-T84525

  • EGFR-IN-33
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    EGFR-IN-33

    CAS:
    <p>EGFR-IN-33, a low-toxicity acrylamide, inhibits EGFR, aiding against cancer, especially NSCLC (from WO2021185348A1, comp. 13).</p>
    Formula:C26H25ClN6O2
    Color and Shape:Solid
    Molecular weight:488.97

    Ref: TM-T63264

  • PIK-inhibitors
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    PIK-inhibitors

    CAS:
    <p>PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.</p>
    Formula:C19H17N5O2
    Purity:96.98%
    Color and Shape:Solid
    Molecular weight:347.37

    Ref: TM-T3190

  • EGFR-IN-71
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    EGFR-IN-71

    CAS:
    <p>EGFR-IN-71 is a potent inhibitor of epidermal growth factor receptor (EGFR) (IC50= 3.7 μM). EGFR-IN-71 has research value in chordoma.</p>
    Formula:C16H9ClIN3
    Color and Shape:Solid
    Molecular weight:405.62

    Ref: TM-T62009

  • GNE-490
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    GNE-490

    CAS:
    <p>GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.</p>
    Formula:C18H22N6O2S
    Purity:99.77%
    Color and Shape:Solid
    Molecular weight:386.47

    Ref: TM-T22339

  • SAR-260301
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    SAR-260301

    CAS:
    <p>SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).</p>
    Formula:C19H22N4O3
    Purity:99.74%
    Color and Shape:Solid
    Molecular weight:354.4

    Ref: TM-T16841

  • BGB-102
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    BGB-102

    CAS:
    <p>BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3.</p>
    Formula:C22H25BrN4O2
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:457.36

    Ref: TM-T10531

  • DNA-PK-IN-10
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    DNA-PK-IN-10

    CAS:
    <p>DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].</p>
    Formula:C25H28N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:444.53

    Ref: TM-T79165

  • PI5P4K-β-IN-1
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    PI5P4K-β-IN-1

    CAS:
    <p>PI5P4K-β-IN-1 (compound vs1) is a potent PI5P4K-β inhibitor with an IC50 of 0.80 μM [1].</p>
    Formula:C23H17Cl2N3O2
    Color and Shape:Solid
    Molecular weight:438.31

    Ref: TM-T81465

  • JND3229
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    JND3229

    CAS:
    <p>JND3229 inhibits EGFRC797S; IC50: 5.8-30.5 nM; halts cell growth; effective in non-small cell lung cancer study.</p>
    Formula:C33H41ClN8O2
    Purity:98.75%
    Color and Shape:Solid
    Molecular weight:617.18

    Ref: TM-T15615

  • mTOR inhibitor-11
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    mTOR inhibitor-11

    CAS:
    <p>mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.</p>
    Formula:C21H26N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:394.47

    Ref: TM-T79211

  • BRD5648
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    BRD5648

    CAS:
    <p>BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.</p>
    Formula:C20H23N3O
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:321.42

    Ref: TM-T10608