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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1038 products of "PI3K/Akt/mTOR Signaling"

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  • BX-320
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    BX-320

    CAS:
    <p>BX-320, a PDK1 inhibitor (IC50=30nM), selectively blocks Akt/p70S6K1 phosphorylation, induces apoptosis, and inhibits cancer cell growth.</p>
    Formula:C23H31BrN8O3
    Color and Shape:Solid
    Molecular weight:547.45

    Ref: TM-T37561

  • BEBT-109
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    BEBT-109

    CAS:
    <p>BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.</p>
    Formula:C27H32N8O3
    Purity:97.26%
    Color and Shape:Solid
    Molecular weight:516.6

    Ref: TM-T80643

  • EGFR-IN-30
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    EGFR-IN-30

    CAS:
    <p>EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, &lt;1 nM WT/mutants) with potential in cancer research.</p>
    Formula:C28H33BrN7O2P
    Color and Shape:Solid
    Molecular weight:610.49

    Ref: TM-T73108

  • EGFR-IN-61
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    EGFR-IN-61

    CAS:
    <p>EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 &amp; H1975 cell growth (IC50: 2.14 &amp; 1.82 μM).</p>
    Formula:C33H37ClN8O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:629.15

    Ref: TM-T73128

  • EGFR-IN-85
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    EGFR-IN-85

    CAS:
    <p>EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFR</p>
    Formula:C26H30N8O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:486.57

    Ref: TM-T78574

  • JGK-068S
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    JGK-068S

    CAS:
    <p>Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].</p>
    Formula:C22H23BrFN5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:488.35

    Ref: TM-T79124

  • PI3K/mTOR Inhibitor-12
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    PI3K/mTOR Inhibitor-12

    CAS:
    <p>PI3K/mTOR Inhibitor-12: oral, potent, selective; IC50: PI3Kα 0.06 nM, mTOR 3.12 nM; strong antitumor; less liver toxicity.</p>
    Formula:C27H27F2N9O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:611.62

    Ref: TM-T72374

  • Simotinib
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    Simotinib

    CAS:
    <p>Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.</p>
    Formula:C25H26ClFN4O4
    Purity:99.7%
    Color and Shape:Solid
    Molecular weight:500.95

    Ref: TM-T35916

  • CymitQuimica logo
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    EGFR/CSC-IN-1

    CAS:
    <p>EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potential</p>
    Formula:C54H54Cl2FN7O7S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1067.08

    Ref: TM-T73995

  • 2′-Thioadenosine
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    2′-Thioadenosine

    CAS:
    <p>2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM against</p>
    Formula:C10H13N5O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:283.31

    Ref: TM-T78634

  • DZD1516
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    DZD1516

    CAS:
    <p>DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in both</p>
    Formula:C28H27F2N7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:547.56

    Ref: TM-T79297

  • EGFR mutant-IN-1
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    EGFR mutant-IN-1

    <p>EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.</p>
    Formula:C34H39ClFN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:632.17

    Ref: TM-T11164

  • GSK-3β inhibitor 8
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    GSK-3β inhibitor 8

    CAS:
    <p>GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine</p>
    Formula:C20H20ClN5OS
    Purity:98.46%
    Color and Shape:Solid
    Molecular weight:413.92

    Ref: TM-T35556

  • EGFR-IN-36
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    EGFR-IN-36

    CAS:
    <p>EGFR-IN-36 inhibits EGFR, HER2, &amp; mutants with IC50s: 19.09 nM (EGFR WT), 120.01 nM (HER2 WT), 2.35 nM (HER2 mutant).</p>
    Formula:C26H25ClN6O2
    Color and Shape:Solid
    Molecular weight:488.97

    Ref: TM-T63265

  • EGFR-IN-32
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    EGFR-IN-32

    CAS:
    <p>EGFR-IN-32, a potent EGFR blocker, shows promise for EGFR-mutated illnesses. (Patent WO2021185297A1, compound 2)</p>
    Formula:C31H34N6O3
    Color and Shape:Solid
    Molecular weight:538.64

    Ref: TM-T63798

  • AMPK-α1β1γ1 activator 1
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    AMPK-α1β1γ1 activator 1

    CAS:
    <p>AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1</p>
    Formula:C25H24ClNO9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:517.91

    Ref: TM-T83125

  • EGFR-IN-87
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    EGFR-IN-87

    CAS:
    <p>EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750,</p>
    Formula:C28H33N7O2
    Purity:98.64%
    Color and Shape:Solid
    Molecular weight:499.61

    Ref: TM-T79888

  • EGFR-IN-1 hydrochloride
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    EGFR-IN-1 hydrochloride

    CAS:
    <p>EGFR-IN-1 HCl targets L858R/T790M EGFR mutants over wild-type; IC50: 4 nM in H1975, 28 nM in mutant HCC827 cells.</p>
    Formula:C28H31ClN6O4
    Purity:99.16%
    Color and Shape:Solid
    Molecular weight:551.04

    Ref: TM-T11157L

  • BGB-8035
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    BGB-8035

    CAS:
    <p>BGB-8035 is a BTK inhibitor with antitumor activity that inhibits BTK, TEC, and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.</p>
    Formula:C24H31N5O4
    Purity:96.74%
    Color and Shape:Solid
    Molecular weight:453.53

    Ref: TM-T73381

  • EGFR/ErbB-2 inhibitor-1
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    EGFR/ErbB-2 inhibitor-1

    CAS:
    <p>EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling.</p>
    Formula:C23H15ClFN3OS2
    Purity:98.93%
    Color and Shape:Solid
    Molecular weight:467.97

    Ref: TM-T79861