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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1038 products of "PI3K/Akt/mTOR Signaling"

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  • Sevabertinib
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    Sevabertinib

    CAS:
    <p>Sevabertinib (BAY 2927088) is an EGFR tyrosine kinase inhibitor, with anticancer activity, used in research on non-small cell lung cancer.</p>
    Formula:C24H25ClN4O5
    Purity:99.81%
    Color and Shape:Solid
    Molecular weight:484.93

    Ref: TM-T200964

  • Rheb inhibitor NR1
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    Rheb inhibitor NR1

    CAS:
    <p>Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.</p>
    Formula:C25H19BrCl2N2O3S
    Purity:99.72%
    Color and Shape:Solid
    Molecular weight:578.3

    Ref: TM-T16741

  • PI3K-IN-54
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    PI3K-IN-54

    CAS:
    <p>Compound 10w, a substituted pyrazolo[1,5-a]pyrimidinamide compound, is a ZSTK474 analog that shows anticancer activity against HeLa cells.</p>
    Formula:C20H24F2N8O3
    Purity:98.15%
    Color and Shape:Solid
    Molecular weight:462.45

    Ref: TM-T77771

  • GSK-F1
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    GSK-F1

    CAS:
    <p>GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.</p>
    Formula:C27H18F5N5O4S
    Purity:97.03%
    Color and Shape:Solid
    Molecular weight:603.52

    Ref: TM-T19840

  • PF-04979064
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    PF-04979064

    CAS:
    <p>PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).</p>
    Formula:C24H26N6O3
    Purity:98.20% - ≥98%
    Color and Shape:Solid
    Molecular weight:446.5

    Ref: TM-T7343

  • PKI-402
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    PKI-402

    CAS:
    <p>PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.</p>
    Formula:C29H34N10O3
    Purity:99.94%
    Color and Shape:Solid
    Molecular weight:570.65

    Ref: TM-T3656

  • GSK-3 inhibitor 1
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    GSK-3 inhibitor 1

    CAS:
    <p>GSK-3 inhibitor 1 is a GSK-3 inhibitor.</p>
    Formula:C22H17ClFN5O2
    Purity:98.42%
    Color and Shape:Solid
    Molecular weight:437.85

    Ref: TM-T11468

  • EGFR-IN-8
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    EGFR-IN-8

    CAS:
    <p>EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLC</p>
    Formula:C32H23ClF3N7O4
    Purity:99.51%
    Color and Shape:Solid
    Molecular weight:662.02

    Ref: TM-T11162

  • GDC-0349
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    GDC-0349

    CAS:
    <p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>
    Formula:C24H32N6O3
    Purity:96.00% - 98.17%
    Color and Shape:Solid
    Molecular weight:452.55

    Ref: TM-T6510

  • GLPG3312
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    GLPG3312

    CAS:
    <p>GLPG3312 is a selective and potent pan-SIK inhibitor with the advantage of oral activity, for SIK1, SIK2 and SIK3, anti-inflammatory and immunomodulatory .</p>
    Formula:C23H21F2N5O3
    Purity:98.53%
    Color and Shape:Solid
    Molecular weight:453.44

    Ref: TM-T86509

  • CymitQuimica logo
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    EGFR/HER2/DHFR-IN-1

    <p>Potent EGFR/HER2/DHFR inhibitor for MCF-7 breast cancer; IC50: 0.153/0.108/0.291 μM; arrests G1/S phase, triggers apoptosis.</p>
    Formula:C14H11BrN4O2S
    Color and Shape:Solid
    Molecular weight:379.23

    Ref: TM-T61596

  • DNA-PK-IN-15
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    DNA-PK-IN-15

    CAS:
    <p>DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.</p>
    Formula:C23H23N9O
    Color and Shape:Solid
    Molecular weight:441.49

    Ref: TM-T201160

  • HER2-IN-7
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    HER2-IN-7

    CAS:
    <p>HER2-IN-7 is a potent HER2 inhibitor with potential for researching ErbB-related diseases, especially cancer.</p>
    Formula:C28H26F3N7O3
    Color and Shape:Solid
    Molecular weight:565.55

    Ref: TM-T64003

  • EGFR-IN-160
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    EGFR-IN-160

    CAS:
    <p>EGFR-IN-160 is an EGFR inhibitor with IC50 values of 1.62, 0.49, and 0.98 μM for EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S, respectively. It can induce cell cycle arrest at the G2/M and S phases and apoptosis (Apoptosis) in NCI-H522 cells, demonstrating anticancer properties. Additionally, EGFR-IN-160 exhibits antioxidant activity against DPPH (IC50: 12.11 µM) and H2O2 (IC50: 8.89 µM).</p>
    Formula:C15H12N2O4
    Color and Shape:Solid
    Molecular weight:284.27

    Ref: TM-T207600

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    EGFR/HER2-IN-4

    <p>EGFR/HER2-IN-4: oral, irreversible dual EGFR inhibitor (IC50: 0.6 nM), targets L858R/T790M mutations, potent anti-lung cancer effects in vivo.</p>
    Color and Shape:Solid

    Ref: TM-T64253

  • EGFR-IN-147
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    EGFR-IN-147

    CAS:
    <p>EGFR-IN-147 (compound ID-5841161) is a potent EGFR inhibitor, demonstrating a 14% inhibition rate at a concentration of 1μM. It holds promise for cancer research applications.</p>
    Formula:C13H13N5O
    Color and Shape:Solid
    Molecular weight:255.275

    Ref: TM-T204935

  • EGFR/VEGFR2-IN-2
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    EGFR/VEGFR2-IN-2

    <p>EGFR/VEGFR2-IN-2 (compound 4b) serves as a dual inhibitor of VEGFR-2 and EGFR.</p>
    Formula:C24H15FO3
    Color and Shape:Solid
    Molecular weight:370.37

    Ref: TM-T201505

  • EGFR-IN-130
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    EGFR-IN-130

    <p>EGFR-IN-130 (compound 14b) is an EGFR inhibitor and an inducer of apoptosis (apoptoosis). It effectively kills HeLa cancer cells by inducing apoptosis.</p>
    Formula:C27H25N3O6S
    Color and Shape:Solid
    Molecular weight:519.57

    Ref: TM-T201686

  • LAS195319
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    LAS195319

    CAS:
    <p>LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases.</p>
    Formula:C29H26N10O3S
    Color and Shape:Solid
    Molecular weight:594.65

    Ref: TM-T70402

  • EGFR-IN-23
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    EGFR-IN-23

    CAS:
    <p>EGFR-IN-23, identified as compound 8 in WO2021244502A1, is a potent EGFR tyrosine kinase inhibitor (TKI) demonstrating an inhibitory concentration (IC50) of 8.</p>
    Formula:C36H44BrN10O3P
    Color and Shape:Solid
    Molecular weight:775.68

    Ref: TM-T73104