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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1038 products of "PI3K/Akt/mTOR Signaling"

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  • PI3Kγ inhibitor 5
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    PI3Kγ inhibitor 5

    CAS:
    <p>PI3Kγ inhibitor 5 is a potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ), exhibiting an exceptional IC50 value of 34 nM.</p>
    Formula:C28H32F2N6O4
    Color and Shape:Solid
    Molecular weight:554.599

    Ref: TM-T40196

  • Amdizalisib
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    Amdizalisib

    CAS:
    <p>Amdizalisib is a PI3K inhibitor and used for the research of inflammatory disease, autoimmune disease or cancer.</p>
    Formula:C19H15ClN8
    Color and Shape:Solid
    Molecular weight:390.84

    Ref: TM-T39327

  • FDA-Approved Kinase Inhibitor Library
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    FDA-Approved Kinase Inhibitor Library

    <p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>
    Color and Shape:Liquid

    Ref: TM-L1610

  • Kinase Inhibitor Library
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    Kinase Inhibitor Library

    <p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>
    Color and Shape:Odour Solid

    Ref: TM-L1600

  • PX-13-17OH
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    PX-13-17OH

    CAS:
    <p>PX-13-17OH has a wide range of applications in life science related research.</p>
    Formula:C29H42N2O8
    Color and Shape:Solid
    Molecular weight:546.65

    Ref: TM-T36311

  • DNA Damage & Repair Compound Library
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    DNA Damage & Repair Compound Library

    <p>A unique collection of xnum DNA Damage &amp;amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>
    Color and Shape:Odour Solid

    Ref: TM-L3900

  • bpV(pic) (potassium hydrate)
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    bpV(pic) (potassium hydrate)

    CAS:
    <p>bpV(pic) (potassium hydrate) can be used in related research in the field of life sciences. Its product number is T35630 and CAS number is 148556-27-8.</p>
    Formula:C6H8K2NO9V
    Color and Shape:Solid
    Molecular weight:367.266

    Ref: TM-T35630

  • EGFR-IN-22
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    EGFR-IN-22

    CAS:
    <p>EGFR-IN-22: potent for EGFR (IC50: 4.91 nM) &amp; L858R/T790M/C797S mutation (IC50: 0.54 nM).</p>
    Formula:C38H47BrFN10O2P
    Color and Shape:Solid
    Molecular weight:805.72

    Ref: TM-T74215

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    Anti-ERBB3/HER3 (29Z6)

    <p>Anti-ERBB3/HER3 (29Z6) is an antibody inhibitor targeting human ERBB3/HER3.</p>
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-975

  • QL-IX-55
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    QL-IX-55

    CAS:
    <p>QL-IX-55 has a wide range of applications in life science related research.</p>
    Formula:C24H14F4N4O
    Color and Shape:Solid
    Molecular weight:450.39

    Ref: TM-T36313

  • BI-4732
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    BI-4732

    CAS:
    <p>DL-Homocystine is a mutagen secreted by F. nucleatum.</p>
    Formula:C32H36N10O2
    Purity:98.88%
    Color and Shape:Solid
    Molecular weight:592.69

    Ref: TM-T85354

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    EGFR/VEGFR2-IN-5

    <p>EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.</p>
    Formula:C17H15N7O5S
    Color and Shape:Solid
    Molecular weight:429.41

    Ref: TM-T205483

  • MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Conjugate
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    MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Conjugate

    CAS:
    <p>MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Conjugate is a conjugate formed by linking MC-Val-Cit-PAB-Amide and TLR7 agonist 4, useful for cancer research.</p>
    Formula:C52H72N12O11
    Purity:97.70%
    Color and Shape:Solid
    Molecular weight:1041.2

    Ref: TM-T74468

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    DS06652923

    <p>DS06652923 is an orally active inhibitor targeting EGFR triple mutations. It exhibits growth-inhibitory effects on Ba/F3EGFRdel19/T90M/C795S cells, with a GI50 value of 9.4 nM. Additionally, DS06652923 induces tumor regression in the Ba/F3 syngeneic transplantation model.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200714

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    Cetuximab (PBS)

    <p>Cetuximab (PBS) is a human IgG1 monoclonal antibody that inhibits the epidermal growth factor receptor (EGFR), with a dissociation constant (Kd) of 0.201 nM for EGFR as measured by the SPR method. It exhibits potent antitumor activity.</p>
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-920

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    ALKBH1-IN-3

    <p>ALKBH1-IN-3 is an effective inhibitor of the DNA N6-methyladenosine (6mA) demethylase ALKBH1. This compound enhances the abundance of 6mA in gastric cancer cell lines HGC27 and AGS, simultaneously inhibiting cell viability and upregulating the AMP-activated protein kinase (AMPK) signaling pathway. ALKBH1-IN-3 holds potential for use in cancer research, including studies on gastric cancer.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200756

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    Duligotuzumab

    CAS:
    <p>Duligotuzumab is a dual-targeting anti-EGFR/HER3 mAb that blocks signaling and induces ADCC for tumors with poor prognosis.</p>
    Purity:95% - 95%
    Color and Shape:Liquid

    Ref: TM-T9901A-828

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    DA-143

    <p>DA-143 is a selective inhibitor of DNA-PKcs (IC50: 2.5 nM), demonstrating disparate inhibitory effects on mTOR, PI3KΔ, and ATM, with IC50 values of 280 nM, 106 nM, and 6,594 nM, respectively. This compound effectively blocks the phosphorylation of DNA-PKcs substrates and enhances the sensitivity of cancer cells to doxorubicin.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200773

  • GSK-3β inhibitor 24
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    GSK-3β inhibitor 24

    <p>GSK-3β inhibitor24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. It increases GSK-3β phosphorylation at the Ser9 site in a dose-dependent manner and inhibits tau protein hyperphosphorylation by reducing the abundance of p-tau-Ser396. The compound upregulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2), demonstrating significant anti-Alzheimer's disease (AD) activity.</p>
    Formula:C26H18N4O3
    Color and Shape:Solid
    Molecular weight:434.446

    Ref: TM-T204492

  • EGFR-IN-15
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    EGFR-IN-15

    CAS:
    <p>EGFR-IN-15 (compound I-005) is a potent EGFR inhibitor, exhibiting an IC50 value of 4 nM. This compound holds potential for oncological research applications.</p>
    Formula:C24H25BrN6O2
    Color and Shape:Solid
    Molecular weight:509.408

    Ref: TM-T40209