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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1014 products of "PI3K/Akt/mTOR Signaling"

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  • BPIQ-II (hydrochloride)
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    BPIQ-II (hydrochloride)

    CAS:
    BPIQ-II, a selective EGFR inhibitor with an IC50 of 8 pM, targets ATP sites and halts EGF signals inside cells.
    Formula:C15H11BrClN5
    Color and Shape:Solid
    Molecular weight:376.64

    Ref: TM-T36783

  • PF-06672131
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    PF-06672131

    CAS:
    PF-06672131 is a selective EGFR kinase inhibitor.
    Formula:C23H21ClFN5O2
    Color and Shape:Solid
    Molecular weight:453.9

    Ref: TM-T70369

  • TWS-119
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    TWS-119

    CAS:
    TWS-119 blocks GSK-3β, prompting neuronal formation in mouse stem cells.
    Formula:C22H16F6N4O6
    Color and Shape:Solid
    Molecular weight:546.38

    Ref: TM-T70520

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    EGFR/HER2-IN-12

    CAS:
    EGFR/HER2-IN-12 (compound 14b) serves as a dual inhibitor targeting EGFR and HER2, demonstrating 81% and 51% inhibition respectively at a concentration of 10 μM. This compound exhibits minimal toxicity towards A431 and MDA-MB-361 cancer cells [1].
    Formula:C25H17ClN4O3S
    Molecular weight:488.95

    Ref: TM-T86353

  • SPH5030
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    SPH5030

    CAS:
    SPH5030 is an irreversible, selective inhibitor of HER2.
    Formula:C31H31FN8O3
    Color and Shape:Solid
    Molecular weight:582.63

    Ref: TM-T64114

  • EAI001
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    EAI001

    CAS:
    EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.
    Formula:C19H15N3O2S
    Purity:99.94%
    Color and Shape:Solid
    Molecular weight:349.41

    Ref: TM-T61191

  • AP1867
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    AP1867

    CAS:
    AP1867 (FK506-binding protein) is a synthetic FKBP12 F36V-directed ligand coupled to THOX derivatives, facilitating targeted protein interactions and intracellular modulation studies.
    Formula:C38H47NO11
    Purity:99.86%
    Color and Shape:Solid
    Molecular weight:693.78

    Ref: TM-T14297

  • RG 14467
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    RG 14467

    CAS:
    RG 14467 is an antagonist of epidermal growth factor-urogastrone.
    Formula:C14H14N2O3
    Color and Shape:Solid
    Molecular weight:258.27

    Ref: TM-T28526

  • RG 14921
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    RG 14921

    CAS:
    RG 14921 is a pyridone analog of erbstatin, epidermal growth factor (EGF) receptor tyrosine kinase, and cAMP-dependent kinase.
    Formula:C11H9NO3
    Color and Shape:Solid
    Molecular weight:203.19

    Ref: TM-T34310

  • AFN941
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    AFN941

    CAS:
    AFN941 is a staurosporine analog, acting as a Jak3-specific inhibitor.
    Formula:C28H30N4O3
    Color and Shape:Solid
    Molecular weight:470.56

    Ref: TM-T69812

  • mTOR inhibitor-2
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    mTOR inhibitor-2

    CAS:
    mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).
    Formula:C23H21N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:411.46

    Ref: TM-T12124

  • AZD6482 (S-isomer)
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    AZD6482 (S-isomer)

    CAS:
    AZD6482 is a potent PI3Kβ inhibitor with IC(50) of 0.01 μm, blocking insulin-stimulated glucose uptake. IC(50) for adipocytes is 4.4 μm.
    Formula:C22H24N4O4
    Color and Shape:Solid
    Molecular weight:408.45

    Ref: TM-T30261

  • NC03
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    NC03

    CAS:
    NC03 is a PI4K2A inhibitor that reduces intracellular PI4P pools in the Golgi apparatus and endosomes, cancer research.
    Formula:C21H21N3O7S
    Purity:99.73%
    Color and Shape:Solid
    Molecular weight:459.47

    Ref: TM-T71797

  • HKI-357 dimaleate
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    HKI-357 dimaleate

    CAS:
    HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.
    Formula:C39H37ClFN5O11
    Color and Shape:Solid
    Molecular weight:806.2

    Ref: TM-T68360

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    EGFR T790M/L858R-IN-5

    CAS:
    EGFR T790M/L858R-IN-5 (example 52) functions as a potent EGFR T790M/L858R inhibitor, demonstrating a 92.9% inhibition rate at a concentration of 0.05 μM [1].
    Formula:C28H31N9O
    Molecular weight:509.61

    Ref: TM-T86346

  • (E/Z)-CP-724714
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    (E/Z)-CP-724714

    CAS:
    (E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].
    Formula:C27H27N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:469.54

    Ref: TM-T6046

  • Nemiralisib
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    Nemiralisib

    CAS:
    Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.
    Formula:C26H28N6O
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:440.54

    Ref: TM-T15431

  • CAL-130
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    CAL-130

    CAS:
    CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
    Formula:C23H22N8O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:426.47

    Ref: TM-T10660

  • Tarlox-TKI
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    Tarlox-TKI

    CAS:
    Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.
    Formula:C19H18BrClN6O
    Purity:97.03%
    Color and Shape:Solid
    Molecular weight:461.74

    Ref: TM-T11761

  • RTC-5
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    RTC-5

    CAS:
    RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.
    Formula:C24H22ClF3N2O3S
    Purity:98.14%
    Color and Shape:Solid
    Molecular weight:510.96

    Ref: TM-T12777