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AMPK

AMPK

AMPK inhibitors are compounds that target and inhibit AMP-Activated Protein Kinase (AMPK), an enzyme that plays a critical role in cellular energy homeostasis. AMPK is activated in response to low energy levels in cells and helps regulate processes such as glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. Inhibiting AMPK is important for studying its role in metabolic diseases, cancer, and aging. At CymitQuimica, we offer a range of AMPK inhibitors to support your research in metabolism, oncology, and age-related diseases.

Found 158 products of "AMPK"

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  • Demethyleneberberine chloride
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    Demethyleneberberine chloride

    CAS:
    <p>Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-</p>
    Formula:C19H18ClNO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:359.8

    Ref: TM-T78095

  • HDAC11-IN-2
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    HDAC11-IN-2

    CAS:
    <p>HDAC11-IN-2 (compound B6) is a highly selective inhibitor of Histone Deacetylase 11 (HDAC11). It demonstrates IC50 values of 51.1 ×10^-3 μM for HDAC11 and 5 μM for HDAC8. HDAC11-IN-2 reduces de novo lipogenesis (DNL) and enhances fatty acid oxidation, which alleviates hepatic lipid accumulation and pathological symptoms in MASLD mice. By inhibiting HDAC11, HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at the Thr172 site, thereby modulating de novo lipogenesis and fatty acid oxidation in the liver.</p>
    Formula:C25H35N3O3
    Color and Shape:Solid
    Molecular weight:425.564

    Ref: TM-T205581

  • Equisetin
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    Equisetin

    CAS:
    <p>Equisetin: a QSI from Fusarium equiseti, curbs P. aeruginosa virulence, fights Gram-positive bacteria &amp; HIV-1 integrase; not antibacterial to Gram-negative.</p>
    Formula:C22H31NO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:373.49

    Ref: TM-T11219

  • EGFR-IN-146
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    EGFR-IN-146

    CAS:
    <p>EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.</p>
    Formula:C20H16N4
    Color and Shape:Solid
    Molecular weight:312.368

    Ref: TM-T206146

  • NPC26
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    NPC26

    CAS:
    <p>NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.</p>
    Formula:C19H23N3O5S2
    Color and Shape:Solid
    Molecular weight:437.533

    Ref: TM-T204250

  • Aldometanib
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    Aldometanib

    CAS:
    <p>Aldometanib (LXY-05-029) is an oral aldolase inhibitor that maintains metabolic balance by blocking FBP and activating lysosomal AMPK.</p>
    Formula:C27H43Cl2IN2
    Purity:99.32% - 99.55%
    Color and Shape:Solid
    Molecular weight:593.46

    Ref: TM-T60122

  • XMD-17-51 Trifluoroacetate
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    XMD-17-51 Trifluoroacetate

    CAS:
    <p>XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases.</p>
    Formula:C23H25F3N8O3
    Purity:99.65%
    Color and Shape:Solid
    Molecular weight:518.49

    Ref: TM-T9191

  • AMPK activator C2
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    AMPK activator C2

    CAS:
    <p>AMPK activator C2 is an AMPK allosteric activator.</p>
    Formula:C7H6NO6P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:231.1

    Ref: TM-T23734

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