PI3K
PI3K inhibitors are compounds that block the activity of Phosphoinositide 3-Kinases (PI3Ks), a family of enzymes involved in a wide range of cellular processes, including growth, proliferation, survival, and metabolism. The PI3K/Akt/mTOR pathway is often dysregulated in cancer, making PI3K a key target for cancer therapy. PI3K inhibitors are critical tools for studying signal transduction, cancer biology, and the development of targeted therapies. At CymitQuimica, we provide a variety of PI3K inhibitors to support your research in cell signaling, oncology, and therapeutic development.
Found 231 products of "PI3K"
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PI3Kδ-IN-17
CAS:PI3Kδ-IN-17 (Compound S5) is a potent PI3K δ inhibitor, exhibiting an IC50 value of 2.82 nM and demonstrates significant efficacy in suppressing theFormula:C23H24F3N7O2Purity:98%Color and Shape:SolidMolecular weight:487.48PI3Kγ inhibitor 2
CAS:PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).Formula:C20H18F3N5O3Purity:98%Color and Shape:SolidMolecular weight:433.38PF-04979064
CAS:PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).
Formula:C24H26N6O3Purity:98.20% - ≥98%Color and Shape:SolidMolecular weight:446.5GSK-F1
CAS:GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.Formula:C27H18F5N5O4SPurity:97.03%Color and Shape:SolidMolecular weight:603.52Ref: TM-T19840
1mg104.00€5mg215.00€1mL*10mM (DMSO)304.00€10mg318.00€25mg510.00€50mg692.00€100mg888.00€200mg1,251.00€PI3Kδ-IN-23
CAS:PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with an IC50 of 0.27 nM. It binds to PI3Kδ through covalent interaction with Lys779 and plays a significant role in cancer research.Formula:C30H30N6O5Color and Shape:SolidMolecular weight:554.596PI3kδ inhibitor 1
CAS:PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).Formula:C28H33FN6O2Purity:98%Color and Shape:SolidMolecular weight:504.60VVD-699
CAS:VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110α, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.Formula:C25H30ClFN2O6S2Color and Shape:SolidMolecular weight:573.097UNI418
CAS:UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).Formula:C22H16N6Color and Shape:SolidMolecular weight:364.40Sonolisib
CAS:Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).Formula:C29H35NO8Purity:98%Color and Shape:SolidMolecular weight:525.59Duvelisib (R enantiomer)
CAS:Duvelisib R enantiomer (IPI-145 R enantiomer) is an enantiomer of Duvelisib with lower activity. Duvelisib is a PI3K inhibitor.Formula:C22H17ClN6OPurity:98%Color and Shape:SolidMolecular weight:416.86PI3Kδ-IN-13
CAS:PI3Kδ-IN-13 (compound 89), with an IC50 value of 2.6 nM, is an inhibitor of PI3Kδ, applicable for researching diseases involving cell proliferation, including
Formula:C27H39N7O4S2Color and Shape:SolidMolecular weight:589.77
