Polycyclic Compounds

<p>Applications A useful intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.<br>References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),<br></p>

<p>Applications 2-Aminoquinoline-6-carboxylic Acid tert-Butyl ester is a substituted quinoline used in pharmaceuticals for treatment of obesity and related conditions.<br>References Bertinato, P., et al.:PCT Int. Appl. (2005), WO 2005080373 A1 20050901<br></p>

<p>Applications 6-Bromo-3-cyanoindole<br></p>

<p>Applications 5,7-Dichloro-1,2,3,4-tetrahydro-2-(triphenylmethyl)-6-isoquinolinecarboxylic Acid, can be sued in the preparation of novel series of compounds which has been found to be a potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for treating dry eye.<br>References Zhong, M. et al,: ACS Med. Chem. Let. Vol. 3, page 203-206 (2012);<br></p>

<p>Applications N-(2,6-Dichlorophenyl)isatin can be obtained from 2,6-Dichloroiodobenzene (D434690) which is a reactant in the synthesis of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors. Also an impurity of Diclofenac (D436465).<br>References Van Orden, L.J., et. al.: Bioorg. Med. Chem. Lett., 23, 1456 (2013)<br></p>

<p>Applications tert-​Butyl 5-​(4,​4,​5,​5-​tetramethyl-​1,​3,​2-​dioxaborolan-​2-​yl)​isoindoline-​2-​carboxylate is a reactant in the synthesis of tyrosine kinase inhibitors in the treatment of proliferative diseases.<br>References WO Patent 2014089324 (2014); CN 104016979 (2014);<br></p>

<p>Applications 3-Aminoquinoline-2-carboxylic acid (cas# 887245-74-1) is a useful research chemical.<br></p>

<p>Applications tert-butyl 7-hydroxy-3,4-dihydroisoquinoline-2(1h)-carboxylate (cas# 188576-49-0) is a useful research chemical.<br></p>

<p>Applications Tricyclohexylchlorotin is used as in the synthesis of organotin derivatives of 2-thiophene carboxylic acid as enzyme inhibitors and antibacterial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abbas, S. et al.: J. Organometal. Chem., 724, 255 (2003); Zia-ur-Rehman et al.: J. Coord. Chem., 65, 3238 (2012);<br></p>

<p>Applications 1-Benzylindole-5-boronic Acid Pinacol Ester acts as a reagent in the synthesis of 3,3-difluoro-2-oxindoles via electrophilic fluorination of indoles using N-fluorobenzenesulfonimide. Preparation of triazolopyridine compounds as JAK kinase inhibitors useful in the treatment of neurodegenerative and inflammatory diseases.<br>References : Lim, Y., et al.: Org. Lett., 14, 5676; Menet, C., et al.: PCT Int. Appl. (2010), WO 2010010190 A1 20100128.<br></p>

<p>Stability Moisture Sensitive<br>Applications Isoquinoline-5-sulfonyl Chloride, Hydrochloride (cas# 105627-79-0) is a compound useful in organic synthesis.<br></p>

<p>Stability Air Sensitive<br>Applications Alpha-Pyridoin (cas# 1141-06-6) is a useful research chemical.<br></p>

<p>Applications 4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 5488-36-8) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 2-(1,3-Dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetic Acid (cas# 52208-61-4) is a useful research chemical.<br></p>

<p>Applications 2-[(Dimethylamino)methyl]indole (cas# 3978-16-3) is a compound useful in organic synthesis.<br>References Inion, H., et al.: Eur. J. Med. Chem., 10, 276 (1975),<br></p>

<p>Stability Light Sensitive<br>Applications Reacts with aldehydes to produce highly fluorescent imidazole derivatives. A fluorometric labeling reagent.<br></p>

<p>Applications 2-chloro-1-{1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2-yl}ethan-1-one (cas# 1087784-16-4) is a useful research chemical.<br></p>

<p>Applications 2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'-dione (cas# 31267-07-9) is a useful research chemical.<br></p>

<p>Applications 3-(prop-2-en-1-yl)-1h-indole (cas# 16886-09-2) is a useful research chemical.<br></p>

<p>Applications 4,7-Dichloro-2-phenyl-1H-isoindole-1,3(2H)-dione is an intermediate in the synthesis of phthalic compounds, phthalazines, and quinones with antimicrobial activity.<br>References Marriott, G. J., et al.: J. Chem. Soc., 134 (1939); Katayama, H., et al.: Tetrahedron., 63, 6642 (2007);<br></p>

<p>Applications 4,4'-Dicyano-2,2'-bipyridine is a photosensitizers for solar fuel generation<br>References Mills, I. N., et al.: Polyhedron, 82, 104 (2014)<br></p>

<p>Applications 4,4-Dimethyl-1,2,3,4-tetrahydroquinoline<br></p>

<p>Applications 5-Chloroisoindoline hydrochloride (cas# 912999-79-2) is a useful research chemical.<br></p>

<p>Applications 4-Chloro-1-hydroxy-7-isoquinolinesulfonyl Chloride (cas# 223671-81-6) is a compound useful in organic synthesis.<br></p>