Organometallic Ligands

<p>Bisoprolol is a β1- adrenergic antagonist agent that is used to treat hypertension and prevent myocardial infarction. As adrenergic neurotransmitters activate β1-receptors it causes an increase in blood pressure and heart rate. By reducing contractility and the need for oxygen through competitive inhibition of β1-adrenergic receptors, bisoprolol reduces the cardiac workload.</p>

<p>Semaglutide is a peptide that is used as a pharmacological agent for the treatment of type 2 diabetes, and other diseases and is also used for long-term weight management in obesity. It is an analogue of glucagon-like peptide-1 (GLP-1) and acts as a GLP-1 receptor agonist and inhibitor of the enzyme DPP-4, which is responsible for the degradation of GLP-1. As a result, semaglutide increases levels of GLP-1, which stimulates insulin release from pancreatic beta cells. Semaglutide has been shown to reduce body weight, blood pressure and HbA1c levels in patients with type 2 diabetes, through its action to increase insulin production and inhibit the production of glucagon. Semaglutide acetate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Cymit Quimica provides this product solely for uses within the scope of any statute or law providing for an immunity, exemption, or exception to patent infringement (“Exempted Uses”), including but not limited to 35 U.S.C. § 271(e)(1) in the United States, the Bolar type exemption in Europe, and any corresponding exception to patent infringement in any other country. It is the sole responsibility of the purchaser or user of this product, and the purchaser or user of this product agrees to engage only in such Exempted Uses, and to comply with all applicable intellectual property laws and/or regulations. The purchaser of this product agrees to indemnify Cymit Quimica against all claims in connection with the performance of the respective commercial agreement (e.g. supply agreement) and possible infringements of intellectual property rights.</p>

<p>Biperiden hydrochloride is an anticholinergic medication, which is a synthetic derivative. It exerts its effects primarily through the central nervous system by blocking acetylcholine receptors. This blockade reduces the activity of acetylcholine, a neurotransmitter, which plays a role in muscle contractions and various neural functions. By antagonizing the muscarinic receptors, Biperiden hydrochloride helps in modulating the balance between neurotransmitters in the brain.</p>

<p>Ketanserin is a 5-HT2A serotonin receptor antagonist that is used for the treatment of hypertension. This drug is also used in research to study the serotonergic system. Ketanserin has been found to also block the vesicular monoamine transporter 2.</p>

<p>Agonist of β3-adrenoreceptors with thermogenic properties and potential to control diet-induced obesity. The compound reversed obesity in adult rats and was effective even in animals that continued to feed on high-fat food. It caused the enlarged white adipocytes to shrink and triggered remodelling of the white adipose tissue.</p>

<p>3-Hydroxy-5-{[(naphthalen-2-yl)carbamoyl]amino}benzoic acid is a synthetic compound characterized by its complex molecular structure incorporating naphthalene and benzoic acid moieties. As a derivative of benzoic acid, it is typically synthesized through a series of chemical reactions designed to introduce the 3-hydroxy and carbamoyl functional groups, creating a compound with potentially unique bioactive properties.</p>

<p>PF 00835231 is an investigational viral polymerase inhibitor, which is derived from the structural optimization of existing antiviral compounds. This small molecule manifests its mechanism of action by directly inhibiting the activity of the viral RNA-dependent RNA polymerase, a crucial enzyme in the replication machinery of coronaviruses. By binding to the active site of the polymerase, PF 00835231 effectively obstructs the replication process of viral RNA, thereby limiting viral proliferation within the host.</p>

<p>mTOR serine/threonine kinase inhibitor</p>

<p>Potent and selective GSK3-β inhibitor, with IC50 value of 48 nM. Increases Nanog expression and regulates self-renewal in murine embryonic stem cells (ESCs). Induces reprograming of induced pluripotent stem cells (iPSCs) to derive cells from specific lineages.</p>

<p>Potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 2.4 nM. Its anti-inflammatory activity was examined in a mouse model for acute colitis. The compound protected from intestinal inflammation by prevention of infiltration of CD19+ B-cells into the lamina propria of colonic epithelium and attenuated neutrophil activation. Its broad anti-inflammatory response involved decrease in 24 inflammatory chemokines and cytokines. Also, it is a potent inhibitor of cell proliferation in pancreatic cancer cell lines.</p>

<p>Inverse agonist of 5-HT2A serotonin receptor; anti-psychotic</p>

<p>Inhibitor of HMG-CoA reductase</p>

<p>Il-1β is a pro-inflammatory cytokine, which is a type of signaling molecule involved in immune system regulation and inflammation. It is primarily produced by activated macrophages, which are a type of white blood cell that engulfs and digests cellular debris and pathogens. The mode of action of Il-1β involves binding to the interleukin-1 receptor (IL-1R) on target cells, which triggers a cascade of intracellular signaling pathways that lead to the expression of various inflammatory genes.</p>

<p>Carboplatin is an antineoplastic alkylating agent that is used in the treatment of ovarian cancer. This drug attaches alkyl groups to nucleotides leading to the formation of monoadducts. Carboplatin’s main mechanism of action is preventing DNA strands from separating for synthesis and transcription.</p>

<p>Inhibits multiple protein kinases, such as PKC and FLT3</p>

<p>Seratrodast is a thromboxane receptor antagonist that is used to treat asthma. However, this drug does not affect thrombus formation as other thromboxane synthase inhibitors do such as ozagrel.</p>

<p>Inhibitor of VEGF receptors</p>

<p>Piracetam is a nootropic drug that is used for the treatment of sickle cell disease, alcohol dependence and as a cognitive enhancer. This drug is a cyclic derivative of GABA and has neuroprotective and anticonvulsant properties. Piracetam has been said to improve neuronal plasticity.</p>

<p>Potent and selective positive allosteric modulator (PAM) of metabotropic glutamate receptor mGlu4. Valiglurax is orally bioavailable and CNS-penetrant mGlu4 PAM in preclinical development for the Parkinson’s disease therapy and alleviation of the motor symptoms.</p>

<p>Olaparib is a small molecule inhibitor of DNA polymerase and topoisomerase, which are enzymes that maintain the integrity of DNA. Olaparib inhibits the proliferation of cancer cells by preventing the synthesis of DNA, RNA, and proteins. Olaparib has been shown to be effective against breast cancer tissues in mouse models. It also has minimal toxicity in humans and has been shown to inhibit the growth of diseased cells with significant cytotoxicity.</p>