Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Found 1472 products of "Cytoskeletal Signaling"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
HSN748
CAS:<p>HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.</p>Formula:C27H24F3N7OColor and Shape:SolidMolecular weight:519.521Terpendole E
CAS:Terpendole E is an atypical L5 site inhibitor.Formula:C28H39NO3Color and Shape:SolidMolecular weight:437.61MKLP2-IN-1
CAS:<p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>Formula:C23H19BrFN3O2Color and Shape:SolidMolecular weight:468.318Tyrosine kinase-IN-9
CAS:<p>Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.</p>Formula:C20H14ClN3O3Color and Shape:SolidMolecular weight:379.796Tubulin inhibitor 19
Tubulin inhibitor 19 (9b), a potent indole chalcone, strongly blocks tubulin, valuable in cancer studies.Formula:C21H23NO5Color and Shape:SolidMolecular weight:369.41Cemdomespib
CAS:Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.Formula:C24H30FNO6Color and Shape:SolidMolecular weight:447.5Lisavanbulin
CAS:<p>Lisavanbulin (BAL-101553) is a prodrug of Avanbulin (BAL 27862), a microtubule-targeting agent. It exhibits antitumor activity, particularly effective against tumors with high expression of end-binding protein 1.</p>Formula:C26H29N9O3Color and Shape:SolidMolecular weight:515.57TACC3 inhibitor 2
CAS:<p>TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. It induces mitotic arrest, apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 is applicable for research in the field of cancer.</p>Formula:C20H22FN5O2Color and Shape:SolidMolecular weight:383.419α5β1 integrin agonist-1
CAS:α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.Formula:C24H26FN5O9Color and Shape:SolidMolecular weight:547.49Zalunfiban dihydrochloride
<p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>Formula:C16H20Cl2N8O2SColor and Shape:SolidMolecular weight:459.35GR 83895
CAS:GR 83895 is an antagonist of prototype fibrinogen receptor.Formula:C29H39N9O8SPurity:98%Color and Shape:SolidMolecular weight:673.74EX05
CAS:EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.Formula:C26H30F2N4O5SColor and Shape:SolidMolecular weight:548.60Tubulin polymerization-IN-33
<p>Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.</p>Formula:C27H28N2O6Color and Shape:SolidMolecular weight:476.52NVP-BQS481
CAS:NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs).Formula:C27H33F3N4O2Color and Shape:SolidMolecular weight:502.57L 734217
CAS:L 734217 is an antagonist of the fibrinogen receptor.Formula:C18H31N3O4Purity:98%Color and Shape:SolidMolecular weight:353.46PM-060184
CAS:<p>PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.</p>Formula:C31H45N3O7Purity:98%Color and Shape:SolidMolecular weight:571.7MT-134
MT-134 is a SkMII -specific inhibitor and has excellent exposure in muscles.Formula:C19H16N4O3Color and Shape:SolidMolecular weight:348.36Alfalone
CAS:<p>Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.</p>Formula:C17H14O5Color and Shape:SolidMolecular weight:298.29TTBK1/2-IN-1
CAS:<p>TTBK1/2-IN-1 (compound 3) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 816 nM and 384 nM, respectively.</p>Formula:C17H16N4OColor and Shape:SolidMolecular weight:292.335KY-02327 acetate
KY-02327 acetate inhibits Dvl-CXXC5, stabilizes Wnt/β-catenin signaling, and enhances osteoblast differentiation.Formula:C22H31N3O6Color and Shape:SolidMolecular weight:433.5FO-4-15
CAS:<p>FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.</p>Formula:C18H20N4O4SColor and Shape:SolidMolecular weight:388.446-B345TTQ
CAS:<p>6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.</p>Formula:C22H20BrNO4Color and Shape:SolidMolecular weight:442.303PROTAC α-synuclein degrader 6
CAS:<p>PROTACα-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with an EC50 of 1.57 μM and 4.09 μM, respectively. This compound plays a significant role in neurodegenerative disease (ND) research.</p>Formula:C37H39N5O9SMolecular weight:729.80HPK1-IN-61
CAS:HPK1-IN-61 (Compound 1) serves as an inhibitor of hematopoietic progenitor kinase 1 (HPK1) with a Ki of 0.4 nM, and also inhibits Abl with an IC50 of less than 0.51 nM. Additionally, HPK1-IN-61 displays inhibitory activity against LCK, with an IC50 of 24 nM.Formula:C23H22N4O2Color and Shape:SolidMolecular weight:386.45Hsp110-STAT3 interaction-IN-1
CAS:Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.Formula:C23H31N3O4SColor and Shape:SolidMolecular weight:445.58AChE/BChE-IN-23
AChE/BChE-IN-23 (Compound 6e) is a dual inhibitor of acetylcholinesterase and butyrylcholinesterase, exhibiting IC50 values of 0.91 μM for AChE, 1.19 μM for eqBChE, and 1.01 μM for hBChE. This compound also demonstrates antioxidant properties and inhibits the aggregation of Aβ1-42 and Tau proteins. Moreover, AChE/BChE-IN-23 prevents the activation of microglial cells by inhibiting the release of reactive oxygen species and mitochondrial damage. Additionally, it reduces the levels of the NLRP3 inflammasome in human microglial cells and reverses memory impairment in mice induced by scopolamine.Formula:C19H21N5O3Color and Shape:SolidMolecular weight:367.4ML175
CAS:ML175 is a specific inhibitor of glutathione transferase Omega 1-1 (GSTO1-1). Additionally, it significantly activates Akt and MEK1/2 kinases. ML175 can be utilized in research related to diseases such as Parkinson's.Formula:C13H13ClF3N3O4Color and Shape:SolidMolecular weight:367.71Antitubulin agent 1
Antitubulin agents-1 disrupts microtubules, ups α-tubulin acetylation, and has anticancer properties.Formula:C21H19N3O3Color and Shape:SolidMolecular weight:361.39HSP90-IN-11
HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.Formula:C27H30FN3O6Color and Shape:SolidMolecular weight:511.54Fradafiban
CAS:Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.Formula:C20H21N3O4Purity:98%Color and Shape:SolidMolecular weight:367.40Hsp90-IN-34
CAS:Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.Formula:C22H14F2N6OColor and Shape:SolidMolecular weight:416.38Myoseverin B
CAS:Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.Formula:C27H32N6O2Color and Shape:SolidMolecular weight:472.582SR121566A
CAS:SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).Formula:C20H25N5O4SPurity:98%Color and Shape:SolidMolecular weight:431.51Kolavenic acid analog
CAS:KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.Formula:C25H38O4Color and Shape:SolidMolecular weight:402.57APN/AKT-IN-1
APN/AKT-IN-1, a dual APN (IC50=0.21μM) & AKT (IC50=0.27μM) inhibitor, hinders GSK3β phosphorylation.Formula:C18H27N7O3Color and Shape:SolidMolecular weight:389.45Tubulin inhibitor 22
Compound 4c: Strong tubulin inhibitor with anti-cancer & anti-angiogenic effects; halts MGC-803 cells in G2/M, triggers Caspase-mediated apoptosis.Formula:C20H17BrFNO4Color and Shape:SolidMolecular weight:434.26JC168
CAS:JC168 is a phenyl analog of peloruside and functions as a microtubule inhibitor with antiproliferative and anticancer properties. It enhances tubulin polymerization, thereby disrupting microtubule dynamics, making it a useful agent in the study of microtubule-associated diseases.Formula:C26H40O7Color and Shape:SolidMolecular weight:464.592Quinagolide hydrochloride
CAS:Quinagolide hydrochloride is a selective agonist of dopamine D2 receptor.Formula:C20H34ClN3O3SPurity:98%Color and Shape:SolidMolecular weight:432.02HG-7-86-01
CAS:HG-7-86-01 is a selective type II tyrosine kinase inhibitor with antiproliferative activity against mutant T315I- Bcr-Abl for chronic myeloid leukemia (CML).Formula:C28H21F3N6O2SPurity:99.07%Color and Shape:SolidMolecular weight:562.57Monomethyl auristatin E intermediate-17
CAS:MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).Formula:C27H35NO7SMolecular weight:517.63FPDT
FPDT combats glioblastoma by inhibiting the AKT pathway; IC50: >100 μM (astrocytes), 45-68 μM (GBM cells).Formula:C16H12FNO2SColor and Shape:SolidMolecular weight:301.34Icafolin-methyl
CAS:<p>Icafolin-methyl is a plant-specific herbicide that acts as an inhibitor of tubulin polymerization. In plants, it metabolizes into the carboxylic acid icafolin, potentially inhibiting plant tubulin polymerization by binding to β-tubulin.</p>Formula:C18H18F2N2O5Color and Shape:SolidMolecular weight:380.343PI3K-IN-29
CAS:<p>PI3K-IN-29: Strong PI3K block, inhibits Akt phosphorylation. IC50: U87MG 0.264µM, HeLa 2.04µM, HL60 1.14µM.</p>Formula:C27H22ClN7O3SColor and Shape:SolidMolecular weight:560.03C086
CAS:<p>C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.</p>Formula:C29H28O8Color and Shape:SolidMolecular weight:504.53XD23
CAS:XD23 is a potent osteosarcoma inhibitor that functions by downregulating DKK1 and activating the WNT/β-catenin signaling pathway.Formula:C22H26ClN7O3Color and Shape:SolidMolecular weight:471.94AMXI-5001 hydrochloride
<p>AMXI-5001 hydrochloride, an oral inhibitor of PARP1/2 and microtubules, shows greater potency and selective anti-cancer effects.</p>Formula:C25H21ClFN5O3Color and Shape:SolidMolecular weight:493.92Tubulin inhibitor 16
<p>Tubulin inhibitor 16 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 16 exhibits cytotoxicity in HepG2 cells [1].</p>Formula:C16H12FNO2Color and Shape:SolidMolecular weight:269.27HSP90-IN-32
CAS:HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.Formula:C33H40N2O4Color and Shape:SolidMolecular weight:528.68ETB
CAS:ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.Formula:C24H33NO6Molecular weight:431.52KUNG65
CAS:KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Formula:C23H20ClFO4Color and Shape:SolidMolecular weight:414.85ZLY06
CAS:<p>ZLY06 is a dual agonist of peroxisome proliferator-activated receptors (PPAR) δ and γ with oral activity (PPAR δ: EC50=341 nM; PPARγ: EC50=237 nM). It mediates the upregulation of CD36 and induces hepatic lipid accumulation by inhibiting the phosphorylation of AKT1. Moreover, ZLY06 significantly improves glucose and lipid metabolism without increasing body weight, primarily by enhancing the β-oxidation of fatty acids and reducing hepatic lipid synthesis, thereby alleviating fatty liver disease.</p>Formula:C25H26O6Color and Shape:SolidMolecular weight:422.47DCEM1
CAS:<p>DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.</p>Formula:C22H23N3O2SColor and Shape:SolidMolecular weight:393.50Tubulin polymerization-IN-34
"Tubulin-IN-34 inhibits oxazolylisoindole microtubule assembly, selective for VL51 lymphoma."Formula:C31H35N3O6Color and Shape:SolidMolecular weight:545.63AM-9022
CAS:AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].Formula:C27H36F2N6O4SColor and Shape:SolidMolecular weight:578.67Tasidotin hydrochloride
CAS:Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.Formula:C32H59ClN6O5Purity:98%Color and Shape:SolidMolecular weight:643.30INS018 055
CAS:INS018 055 (TNIK&MAP4K4-IN-2) is a TNIK and MAP4K4 inhibitor with anti-fibrotic activity.Formula:C27H30FN7OPurity:98.53%Color and Shape:SolidMolecular weight:487.57NRX-252114
CAS:NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).Formula:C22H12Cl2F3N3O2SPurity:99.70%Color and Shape:SolidMolecular weight:510.32NRX-1532
NRX-1532 is a small molecule β-catenin:β-TrCP interaction enhancer.Formula:C16H11F3N4O2Purity:98.95% - 99.94%Color and Shape:SolidMolecular weight:348.28NRX-103094
CAS:NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.Formula:C20H11Cl2F3N2O4SPurity:99.13%Color and Shape:SolidMolecular weight:503.28AKT Kinase Inhibitor
CAS:AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.Cost-effective and quality-assured.Formula:C16H19N7O3Purity:97.83% - 99.13%Color and Shape:SolidMolecular weight:357.37Ombrabulin
CAS:Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.Formula:C21H26N2O6Purity:98%Color and Shape:SolidMolecular weight:402.44Tau tracer 2
CAS:Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].Formula:C15H9FN4Color and Shape:SolidMolecular weight:264.263Cercosporin
CAS:<p>Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).</p>Formula:C29H26O10Purity:98%Color and Shape:SolidMolecular weight:534.51Sevasemten
CAS:<p>Sevasemten is an allosteric inhibitor that targets skeletal muscle myosin. It displays selectivity in its inhibition, demonstrated by IC50 values of ≤10 μM for skeletal muscle myosin and >100 μM for cardiac myosin, respectively.</p>Formula:C16H11F4N5O2Color and Shape:SolidMolecular weight:381.2820-HETE
CAS:<p>20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.</p>Formula:C20H32O3Purity:99.79%Color and Shape:SolidMolecular weight:320.4724-Methylenecycloartanyl ferulate
CAS:24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells. Furthermore, it exhibits potential as an ATP-competitive Akt1 inhibitor, with an EC 50 value of 33.3 μM.Formula:C41H60O4Color and Shape:SolidMolecular weight:616.927Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate
CAS:Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T65302 and the CAS number is 20367-38-8.Formula:C9H8ClN3O2Color and Shape:SolidMolecular weight:225.63ZW4864
CAS:ZW4864 is a selective inhibitor of the β-catenin/B-Cell Lymphoma 9 protein (β-catenin/BCL9 PPI) interaction, demonstrating oral activity. It inhibits β-catenin/BCL9 PPI with a K_i value of 0.76 μM and an IC_50 value of 0.87 μM.Formula:C33H43ClN6O3Color and Shape:SolidMolecular weight:607.2CMX-2043
CAS:<p>CMX-2043 is a drug potentially to block oxidative damage and activate cell survival pathways.</p>Formula:C16H26N2O6S2Purity:98%Color and Shape:SolidMolecular weight:406.52Cevipabulin fumarate
CAS:Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).Formula:C22H22ClF5N6O5Purity:98%Color and Shape:SolidMolecular weight:580.89BCR-ABL-IN-8
CAS:<p>BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].</p>Formula:C30H33N7O5Purity:98%Color and Shape:SolidMolecular weight:571.63
![Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT65302.webp&w=3840&q=75)
