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Cytoskeletal Signaling

Cytoskeletal Signaling

Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.

Found 1472 products of "Cytoskeletal Signaling"

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  • FO-4-15
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    FO-4-15

    CAS:
    <p>FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.</p>
    Formula:C18H20N4O4S
    Color and Shape:Solid
    Molecular weight:388.44

    Ref: TM-T200203

  • 6-B345TTQ
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    6-B345TTQ

    CAS:
    <p>6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.</p>
    Formula:C22H20BrNO4
    Color and Shape:Solid
    Molecular weight:442.303

    Ref: TM-T204244

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    PROTAC α-synuclein degrader 6

    CAS:
    <p>PROTACα-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with an EC50 of 1.57 μM and 4.09 μM, respectively. This compound plays a significant role in neurodegenerative disease (ND) research.</p>
    Formula:C37H39N5O9S
    Molecular weight:729.80

    Ref: TM-T209298

  • HPK1-IN-61
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    HPK1-IN-61

    CAS:
    HPK1-IN-61 (Compound 1) serves as an inhibitor of hematopoietic progenitor kinase 1 (HPK1) with a Ki of 0.4 nM, and also inhibits Abl with an IC50 of less than 0.51 nM. Additionally, HPK1-IN-61 displays inhibitory activity against LCK, with an IC50 of 24 nM.
    Formula:C23H22N4O2
    Color and Shape:Solid
    Molecular weight:386.45

    Ref: TM-T212057

  • Hsp110-STAT3 interaction-IN-1
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    Hsp110-STAT3 interaction-IN-1

    CAS:
    Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.
    Formula:C23H31N3O4S
    Color and Shape:Solid
    Molecular weight:445.58

    Ref: TM-T201209

  • AChE/BChE-IN-23
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    AChE/BChE-IN-23

    AChE/BChE-IN-23 (Compound 6e) is a dual inhibitor of acetylcholinesterase and butyrylcholinesterase, exhibiting IC50 values of 0.91 μM for AChE, 1.19 μM for eqBChE, and 1.01 μM for hBChE. This compound also demonstrates antioxidant properties and inhibits the aggregation of Aβ1-42 and Tau proteins. Moreover, AChE/BChE-IN-23 prevents the activation of microglial cells by inhibiting the release of reactive oxygen species and mitochondrial damage. Additionally, it reduces the levels of the NLRP3 inflammasome in human microglial cells and reverses memory impairment in mice induced by scopolamine.
    Formula:C19H21N5O3
    Color and Shape:Solid
    Molecular weight:367.4

    Ref: TM-T201792

  • ML175
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    ML175

    CAS:
    ML175 is a specific inhibitor of glutathione transferase Omega 1-1 (GSTO1-1). Additionally, it significantly activates Akt and MEK1/2 kinases. ML175 can be utilized in research related to diseases such as Parkinson's.
    Formula:C13H13ClF3N3O4
    Color and Shape:Solid
    Molecular weight:367.71

    Ref: TM-T212536

  • Antitubulin agent 1
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    Antitubulin agent 1

    Antitubulin agents-1 disrupts microtubules, ups α-tubulin acetylation, and has anticancer properties.
    Formula:C21H19N3O3
    Color and Shape:Solid
    Molecular weight:361.39

    Ref: TM-T72503

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    HSP90-IN-11

    HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.
    Formula:C27H30FN3O6
    Color and Shape:Solid
    Molecular weight:511.54

    Ref: TM-T63528

  • Fradafiban
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    Fradafiban

    CAS:
    Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.
    Formula:C20H21N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:367.40

    Ref: TM-T11322

  • Hsp90-IN-34
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    Hsp90-IN-34

    CAS:
    Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.
    Formula:C22H14F2N6O
    Color and Shape:Solid
    Molecular weight:416.38

    Ref: TM-T201432

  • Myoseverin B
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    Myoseverin B

    CAS:
    Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.
    Formula:C27H32N6O2
    Color and Shape:Solid
    Molecular weight:472.582

    Ref: TM-T204800

  • SR121566A
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    SR121566A

    CAS:
    SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).
    Formula:C20H25N5O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:431.51

    Ref: TM-T12999

  • Kolavenic acid analog
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    Kolavenic acid analog

    CAS:
    KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.
    Formula:C25H38O4
    Color and Shape:Solid
    Molecular weight:402.57

    Ref: TM-T61970

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    APN/AKT-IN-1

    APN/AKT-IN-1, a dual APN (IC50=0.21μM) & AKT (IC50=0.27μM) inhibitor, hinders GSK3β phosphorylation.
    Formula:C18H27N7O3
    Color and Shape:Solid
    Molecular weight:389.45

    Ref: TM-T61756

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    Tubulin inhibitor 22

    Compound 4c: Strong tubulin inhibitor with anti-cancer & anti-angiogenic effects; halts MGC-803 cells in G2/M, triggers Caspase-mediated apoptosis.
    Formula:C20H17BrFNO4
    Color and Shape:Solid
    Molecular weight:434.26

    Ref: TM-T62445

  • JC168
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    JC168

    CAS:
    JC168 is a phenyl analog of peloruside and functions as a microtubule inhibitor with antiproliferative and anticancer properties. It enhances tubulin polymerization, thereby disrupting microtubule dynamics, making it a useful agent in the study of microtubule-associated diseases.
    Formula:C26H40O7
    Color and Shape:Solid
    Molecular weight:464.592

    Ref: TM-T204381

  • Quinagolide hydrochloride
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    Quinagolide hydrochloride

    CAS:
    Quinagolide hydrochloride is a selective agonist of dopamine D2 receptor.
    Formula:C20H34ClN3O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:432.02

    Ref: TM-T12605

  • HG-7-86-01
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    HG-7-86-01

    CAS:
    HG-7-86-01 is a selective type II tyrosine kinase inhibitor with antiproliferative activity against mutant T315I- Bcr-Abl for chronic myeloid leukemia (CML).
    Formula:C28H21F3N6O2S
    Purity:99.07%
    Color and Shape:Solid
    Molecular weight:562.57

    Ref: TM-T86575

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    Monomethyl auristatin E intermediate-17

    CAS:
    MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).
    Formula:C27H35NO7S
    Molecular weight:517.63

    Ref: TM-T208363