Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Found 1537 products for "Cytoskeletal Signaling".
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Tubulin inhibitor 37
Tubulin Inhibitor 37 (Compound 12) effectively impedes tubulin aggregation (IC50 = 1.3 µM) and demonstrates antiproliferative activity against human tumor cellFormula:C16H10Cl2N6OColor and Shape:SolidMolecular weight:373.2Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS:Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.Formula:C56H110N22O14Purity:98%Color and Shape:SolidMolecular weight:1315.61BCR-ABL-IN-10
BCR-ABL-IN-10 (compound B4) is a covalent BCR-ABL inhibitor featuring an arylvinylsulfonate (AVS) moiety, demonstrating an IC50 of 43.1 nM against ABL kinase. It forms a covalent and stable adduct with ABL kinase, enabling the sustained inhibition of intrinsic BCR-ABL activity. This compound is utilized in the study of chronic myeloid leukemia (CML).Formula:C24H22N4O5SColor and Shape:SolidMolecular weight:478.527-Epi-docetaxel
CAS:7-Epi-10-oxo-docetaxel (7-Epitaxotere) is a impurity of docetaxel.Formula:C43H53NO14Purity:98%Color and Shape:SolidMolecular weight:807.88P259
P259 is a Drp1-Mff inhibitor that selectively impedes the interaction between Drp1 and Mff, thereby differentiating physiological fission from pathological fission. It leads to mitochondrial elongation and impairs mitochondrial function and motility. P259 reduces ATP levels in the brain, alters mitochondrial structure, induces behavioral defects in wild-type mice, and shortens the lifespan of Huntington's disease (HD) model mice.Color and Shape:Odour SolidMyrtucommulone
CAS:Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.Formula:C38H52O10Purity:98%Color and Shape:SolidMolecular weight:668.81Tubulin inhibitor 38
Tubulin Inhibitor 38 (Compound 14), a tetrazole-based agent, demonstrates significant antiproliferative effects by inducing mitotic arrest and blocking the cellFormula:C17H13ClN6OSColor and Shape:SolidMolecular weight:384.84BGC0222
BGC0222 is a novel Irinotecan prodrug. As a PEG-cRGD conjugated derivative of Irinotecan, BGC0222 enables the slow and steady release of Irinotecan. It binds to the αVβ3 target with an IC50 of 4.25 μM and has an IC50 of 58.7 μM for αVβ5. BGC0222 can induce angiogenesis and demonstrates significant antitumor activity in various tumors.Formula:C1241H2276N64O552Color and Shape:SolidMolecular weight:26927.36hCA/Wnt/β-catenin-IN-1
hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8Color and Shape:Odour SolidAkt/SKG Substrate Peptide
CAS:substrate for Akt/PKBFormula:C36H59N13O9Purity:98%Color and Shape:SolidMolecular weight:817.94TAT-P110
CAS:TAT-P110 is a peptide inhibitor that disrupts the interaction between Drp1 and Fis1, effectively reducing pathological changes in various models of neurodegenerative diseases, ischemia, and sepsis without impairing the physiological function of Drp1.Formula:C100H178N44O26Color and Shape:SolidMolecular weight:2412.76Tubulin polymerization-IN-48
Tubulin polymerization-IN-48 (Compound 4k) is an inhibitor of tubulin polymerization, moderately disrupting the microtubule network.Formula:C20H15Cl2N3OColor and Shape:SolidMolecular weight:384.26tau/Aβ40 aggregation-IN-1
Tau/Aβ40 aggregation-IN-1 (Compound 20) functions as an inhibitor for tau and Aβ 40 aggregation, exhibiting IC50 values of 1.8 μM and 1.3 μM, respectively [1].Formula:C23H28N2O2SColor and Shape:SolidMolecular weight:396.55Lys-Gln-Ala-Gly-Asp-Val
CAS:KQAGDV is a fibrinogen γ-chain cell adhesion peptide, targeting α2bβ3 integrin, and binds SMCs.Formula:C25H44N8O10Color and Shape:SolidMolecular weight:616.66para-amino-Blebbistatin
CAS:para-amino-Blebbistatin is a water-soluble, stable, non-phototoxic inhibitor of non-muscle myosin II, with enhanced properties over blebbistatin.Formula:C18H17N3O2Color and Shape:SolidMolecular weight:307.353DynaMin inhibitory peptide, myristoylated
CAS:Cell-permeable dynamin inhibitor; blocks its binding to amphiphysin, hindering endocytosis; curbs NMDA receptor internalization.Formula:C61H107N19O14Purity:98%Color and Shape:SolidMolecular weight:1330.64(8R)-8-Hydroxyepoxyboetirane A
(8R)-8-Hydroxyepoxyboetirane A is a neuroactivating compound that interacts with PKCδ-C1B. This compound binds into the PKC enzyme pocket through hydrogen bonds with glycine-253, leucine-251, and threonine-242. It induces the release of NRG1 and promotes the differentiation of neural stem cells into neurons. (8R)-8-Hydroxyepoxyboetirane A holds potential for research into nervous system disorders.Color and Shape:Odour SolidMS21
CAS:MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations in the PI3K/PTEN pathway, alongside wild-type KRAS and BRAF.Formula:C58H79ClN12O6SColor and Shape:SolidMolecular weight:1107.86LT25
CAS:LT25 (compound 17) acts as an agonist for the α5β1 integrin, exhibiting an EC50 value of 9.9 nM.Formula:C15H17N3O5Color and Shape:SolidMolecular weight:319.31SNIPER(ABL)-024
CAS:SNIPER(ABL)-024, a compound that conjugates GNF5 (ABL inhibitor) to an LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels,Formula:C52H61F3N8O9SPurity:98%Color and Shape:SolidMolecular weight:1031.15Tubulin inhibitor 21
Compound 6f, a chalcone-melatonin hybrid, is a potent tubulin inhibitor with IC50=0.26μM in SW480 cells, less toxic to non-cancer cells.Formula:C28H25N3O4SColor and Shape:SolidMolecular weight:499.58Plecstatin-1 hydrochloride
Plecstatin-1 hydrochloride, an organoeuropium-containing anticancer agent, selectively targets the scaffolding protein plectin within tumor spheroids [1].Color and Shape:Odour SolidMyelin Basic Protein
CAS:Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.Formula:C60H103N21O17Purity:98%Color and Shape:SolidMolecular weight:1390.59MEK Inhibitor II
CAS:MEK Inhibitor II, Selective MEK1 inhibitor (IC50=0.38 μM), inhibits tubulin polymerization in T. cruzi, exhibits anti-trypanosome activity.Formula:C14H8ClNO4Purity:99.40%Molecular weight:289.67PROTAC BCR-ABL1 ligand 1
CAS:GMB-475 is a PROTAC ligand targeting BCR-ABL1 for degradation via E3 ligase recruitment.Formula:C17H12F3N3O2Color and Shape:SolidMolecular weight:347.2911H-Benzo[a]carbazole
CAS:11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.Formula:C16H11NPurity:99.14%Color and Shape:SolidMolecular weight:217.27ARM165
ARM165 is a heterobifunctional molecule that degrades the protein PIK3CG and inhibits the PI3Kγ-Akt signaling pathway, thereby exerting anti-leukemic effects. It is capable of suppressing the proliferation of AML cells, with an IC50 of less than 1 μM.Formula:C44H51N7O8SColor and Shape:SolidMolecular weight:837.35198α2β1 Integrin Ligand Peptide
CAS:The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFormula:C14H22N4O9Purity:98%Color and Shape:SolidMolecular weight:390.35PYRIB-SO 2
PYRIB-SO 2 is an effective antimitotic (mitotic) agent that exhibits antiproliferative activity and induces cell cycle arrest at the G2/M phase. It disrupts and reduces microtubule structures by binding to the colchicine-binding site (C-BS) on α, β-tubulin.Formula:C14H12ClN3O4SColor and Shape:SolidMolecular weight:353.0237PROTAC tubulin-Degrader-1
PROTAC tubulin-Degrader-1 (Compound W13) functions as an inhibitor of PROTAC tubulin and exhibits anti-tumor activity against human lung cancer.Color and Shape:Odour SolidLarazotide
CAS:Larazotide: octapeptide from V. cholerae, treats Coeliac disease by inhibiting paracellular permeability.Formula:C32H55N9O10Purity:98%Color and Shape:SolidMolecular weight:725.83Dentonin TFA
Dentonin TFA (AC-100 TFA) is a short peptide fragment derived from MEPE. It enhances osteogenesis by promoting the adhesion of osteoprogenitor cells and supports the survival of immature adherent cells. Dentonin TFA does not have a significant effect on mature osteoblasts and can be utilized in studies of phosphate homeostasis and bone metabolism.Formula:C109H161F3N30O44Molecular weight:2651.1235NSC 357754 dihydrochloride
NSC 357754 dihydrochloride is an inhibitor of Claudin. It can enhance trans-epithelial electrical resistance and reduce the permeability of specific cations. This compound is useful for research into intestinal diseases mediated by Claudin-2 and/or Claudin-15.Color and Shape:Odour SolidMS170
CAS:MS170, specific PROTAC AKT degrader, potent with DC 50 of 32 nM, binds AKT1/2/3 with Kd 1.3, 77, 6.5 nM respectively.Formula:C45H56ClN9O7Color and Shape:SolidMolecular weight:870.45Hsp110/sGC-modulator-1
Hsp110/sGC-modulator-1 (compound 17i) is a dual-target modulator of Hsp110 and sGC with oral activity, exhibiting optimal molecular activity against both Hsp110 and sGC targets. Additionally, it demonstrates significant inhibitory effects on malignant cellular phenotypes and vasodilation. Hsp110/sGC-modulator-1 (compound 17i) alleviates pulmonary vascular remodeling and right ventricular hypertrophy by inhibiting Hsp110.Color and Shape:Odour SolidPROTAC HSP90 degrader BP3
CAS:PROTAC BP3 selectively degrades HSP90, inhibits breast cancer growth (DC50=0.99µM), CRBN-dependent.Formula:C32H29ClN8O5Color and Shape:SolidMolecular weight:641.08KGP591
KGP591, a tubulin polymerization inhibitor with an IC50 of 0.57 µM, effectively induces G2/M arrest, inhibits cell migration, and disrupts microtubule structureFormula:C24H21NO5Color and Shape:SolidMolecular weight:403.43Fibronectin Active Fragment Control
CAS:Fibronectin: a ~440kDa glycoprotein, binds integrins, collagen, fibrin, and heparan sulfate in the extracellular matrix.Formula:C18H32N8O9Purity:98%Color and Shape:SolidMolecular weight:504.49LDV-FITC TFA
LDV-FITC TFA is a fluorescent peptide, specifically an FITC-conjugated LDV peptide. This compound binds to the α4β1 integrin with high affinity, displaying a Kd of 0.3 nM in the presence of Mn2+ and 12 nM in its absence, when binding to U937 cells. LDV-FITC TFA is useful for assessing α4β1 integrin affinity.Formula:C69H81N11O17S·xC2HF3O2Gly-Arg-Gly-Asp-Ser
CAS:Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.Formula:C17H30N8O9Purity:98%Color and Shape:SolidMolecular weight:490.47GRGDSP
CAS:GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) is a linear RGD peptide and a fibronectin-derived peptide, and is also an effective integrin inhibitor.Formula:C22H37N9O10Purity:99.75%Color and Shape:White SolidMolecular weight:587.58Anti-GPRC5D Antibody
Anti-GPRC5D Antibody is a humanized IgG1 monoclonal antibody targeting GPRC5D. It serves as the antibody component of the ADC molecule LM-305.Color and Shape:Odour LiquidHypoglycemic agent 3
Compound H26, a derivative of corosolic acid, functions as Hypoglycemic agent 3. It exhibits lipid-lowering and significant blood glucose-reducing properties, making it a potential hypoglycemic drug. Hypoglycemic agent 3 targets MCCC1 to mitigate insulin resistance, and may be useful in researching type 2 diabetes.Formula:C32H51NO5Color and Shape:SolidMolecular weight:529.751Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a mAb targeting CD147 used to study the inhibition mechanisms of viral infection by blocking receptor binding to viralColor and Shape:Odour LiquidAKTide-2T
CAS:Peptide substrate for Akt/PKBFormula:C74H114N28O20Purity:98%Color and Shape:SolidMolecular weight:1715.87MAL3-101
CAS:MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).Formula:C54H66N4O10Color and Shape:SolidMolecular weight:931.12Dynamin IN-2
CAS:Dynamin IN-2 (compound 43) is a Wiskostatin analogue.Formula:C22H21ClN2OPurity:99.40% - 99.52%Color and Shape:SolidMolecular weight:364.87Ref: TM-T64369
1mg133.00€5mg314.00€1mL*10mM (DMSO)324.00€10mg416.00€25mg632.00€50mg847.00€100mg1,134.00€200mg1,513.00€JNJ-70218902
JNJ-70218902 is a bispecific antibody capable of binding to tumor cells expressing TMEFF2 and CD3 on T cells. It induces an exposure-dependent pro-inflammatory response and targeted tumor cell lysis, and enhances T cell-mediated tumor cell killing (EC50: 1.4 nM). JNJ-70218902 holds significant potential for prostate cancer research.Color and Shape:Odour LiquidMS15 TFA
MS15 TFA is a potent, selective AKT PROTAC degrader, effectively inhibiting AKT1, AKT2, and AKT3 with IC50 values of 798 nM, 90 nM, and 544 nM, respectively [1Formula:C66H80F3N11O7SPurity:98%Color and Shape:SolidMolecular weight:1228.47Tubulin inhibitor 48
CAS:Tubulin inhibitor 48 (compound 16) is an anticancer agent targeting microtubules. It exhibits IC50 values of 0.1 μM and 0.07 μM against LN-229 and Capan-1 cells, respectively.Formula:C21H22N4OColor and Shape:SolidMolecular weight:346.43
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