Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Found 1537 products for "Cytoskeletal Signaling".
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SNIPER(ABL)-050
SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker.Formula:C68H84N12O9Purity:98%Color and Shape:SolidMolecular weight:1213.47PYRIB-SO 2
PYRIB-SO 2 is an effective antimitotic (mitotic) agent that exhibits antiproliferative activity and induces cell cycle arrest at the G2/M phase. It disrupts and reduces microtubule structures by binding to the colchicine-binding site (C-BS) on α, β-tubulin.Formula:C14H12ClN3O4SColor and Shape:SolidMolecular weight:353.0237MEK Inhibitor II
CAS:MEK Inhibitor II, Selective MEK1 inhibitor (IC50=0.38 μM), inhibits tubulin polymerization in T. cruzi, exhibits anti-trypanosome activity.Formula:C14H8ClNO4Purity:99.40%Molecular weight:289.67(2S,3R)-Dap-NE hydrochloride
(2S,3R)-Dap-NE hydrochloride is an amino acid residue of the pentapeptide Dolastatin 10. Dolastatin 10 inhibits tubulin polymerization and mitosis, exhibiting anticancer properties.Formula:C18H29ClN2O3Color and Shape:SolidMolecular weight:356.18667AFM15
AFM15 is a humanized monoclonal antibody inhibitor that targets CD3E. It is useful for researching metabolic and immune system disorders, including type 1 diabetes and inflammatory bowel disease (IBD).Color and Shape:Odour LiquidKatanin-IN-1
Katanin-IN-1 (122589735) is an effective inhibitor of katanin, and it holds potential for cancer research.Formula:C24H33N9O3Color and Shape:SolidMolecular weight:495.58NMS-E973
CAS:NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Formula:C22H22N4O7Purity:99.84%Color and Shape:Yellow SolidMolecular weight:454.43Ref: TM-T6609
2mg39.00€5mg60.00€1mL*10mM (DMSO)66.00€10mg92.00€25mg187.00€50mg294.00€100mg419.00€200mg590.00€Sangivamycin
CAS:Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.Formula:C12H15N5O5Purity:99.85%Color and Shape:SolidMolecular weight:309.28Ref: TM-T9605
1mg119.00€5mg260.00€1mL*10mM (DMSO)341.00€10mg394.00€25mg640.00€50mg893.00€100mg1,198.00€SNIPER(ABL)-015
SNIPER(ABL)-015, a compound that conjugates GNF5 (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 of 5Formula:C58H70F3N9O9Purity:98%Color and Shape:SolidMolecular weight:1094.23EMD-132338
CAS:EMD 132338 is a GPIIb/IIIa antagonist.Formula:C17H23N5O4Color and Shape:SolidMolecular weight:361.4Tubulin polymerization-IN-62
Tubulin polymerization-IN-62 (Compound 14b) is a microtubule polymerization inhibitor (IC50 of 7.5 μM) that also functions as a degradation agent for α-/β-tubulin. This compound suppresses the proliferation of cancer cells MCF-7, A549, and HCT-116 with IC50 values of 32, 60, and 29 nM, respectively. It induces G2/M phase cell cycle arrest and inhibits the migration of MCF-7 cells. In a 4T1 syngeneic mouse model, Tubulin polymerization-IN-62 demonstrates antitumor efficacy with a tumor growth inhibition rate (TGI) of 74.27%.Formula:C37H44N4O4Color and Shape:SolidMolecular weight:608.33626β-catenin-IN-7
β-Catenin-IN-7 (Compound 9) is an inhibitor of β-catenin that disrupts its interaction with Tcf-4, consequently impeding Wnt-dependent gene expression, andFormula:C17H13BrN2O2SColor and Shape:SolidMolecular weight:389.27Monomethyl auristatin E intermediate-8
MonomethylauristatinE intermediate-8 is an intermediate compound in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) acts as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).Formula:C20H31NO5Color and Shape:SolidMolecular weight:365.220222-Methylbutyrylcarnitine chloride
2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.Formula:C12H24ClNO4Color and Shape:SolidMolecular weight:281.78Vinflunine Tartrate
CAS:Vinflunine Tartrate, a uniquely fluorinated vinca alkaloid, exhibits mitotic-arresting and tubulin-interacting properties.Formula:C45H54F2N4O8·xC4H6O6Purity:98%Color and Shape:SolidMolecular weight:967.02Ref: TM-T6722
2mgTo inquire5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire1mL*10mM (DMSO)To inquireαVβ8-IN-1
CAS:αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).Formula:C25H32ClN5O4Color and Shape:White SolidMolecular weight:502.01αvβ6-BP
αvβ6-BP is a selective αvβ6-binding peptide, useful for research in molecular imaging.Formula:C93H164N34O27Molecular weight:2189.25052LY 379196
LY 379196, a potent PKC-β inhibitor (IC 50: 50 nM for PKC βI and 30 nM for PKC βII), effectively suppresses the proliferation of bovine retinal microvascular endothelial cells (BREC) induced by VEGF, IGF-1, and bFGF. This compound serves as an antiproliferative agent for proliferative retinopathy.Formula:C30H34N4O5SColor and Shape:SolidMolecular weight:562.68gp96-II
Gp96-II is a gp96-blocking peptide that antagonizes cytokine production induced by gp96-mediated LPS. This compound is useful for research into inflammatory diseases.Formula:C200H353N59O53SColor and Shape:SolidMolecular weight:4464.37Larazotide
CAS:Larazotide: octapeptide from V. cholerae, treats Coeliac disease by inhibiting paracellular permeability.Formula:C32H55N9O10Purity:98%Color and Shape:SolidMolecular weight:725.83
