Deuterated Compounds

<p>Applications Propio-d5-phenone (CAS# 342610-99-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexanedioic-d8 Acid (CAS# 52089-65-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,5-Dimethylbenzoyl Chloride-d9 is an intermediate in the synthesis of Methoxyfenozide-d9 (M262768), deuterium labelled Methoxyfenozide (M262765). It is used primarily as an insecticide, and pesticide.<br>References Zhao, Q., et al.: J. Agricul, Food Chem., 56, 10799 (2008)<br></p>

<p>Applications 4-Oxo-2,2,6,6-tetramethylpiperidine-d16;1-15N-1-oxyl (CAS# 80404-14-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications α-Tetralone-13C6 (cas# 189811-58-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Isotope labelled 1,2-Hexanediol is used in the synthesis of sulfamidates which lead a simple route into β-amino acids. Also used in the controlled growth of GE nanowires.<br>References Nicolaou, K. et al.: Angew. Chem. Int. Ed., 41, 834 (2002); Lotty, O. et al.: J. Mat. Chem. C., Mat. Optic. Electro. Devices., 1, 4450 (2013);<br></p>

<p>Applications Benzyl-alpha,alpha-d2 Bromide (CAS# 51271-29-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Tridecyl-d27 Alcohol (CAS# 203633-18-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Chloropyridine-d4 (CAS# 1001003-95-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-​Chloro-​2-​phenyl-diazene-13C6 is an intermediate in synthesizing N-Acetyl-S-(phenyl-13C6)-L-cysteine (A187357), a labelled N-Acetyl-S-phenyl-L-cysteine (P335600). It is an important metabolite of Benzene.<br>References Muller, G., et al.: Anal. Hazard. Subst. Biol. Mater., 5, 143 (1997)<br></p>

<p>Applications Cyclopropyl-2,2,3,3-d4 Methyl Ketone (CAS# 350818-63-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(4-Aminophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.<br>References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>

<p>Applications N-Acetylglycine N-Methylamide-d8 is an isotopic analog of N-Acetylglycine N-Methylamide (7606-79-3).<br></p>

<p>Applications 4-tert-Butylaniline-d15 (CAS# 1219794-71-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Nitroaniline acts as an azo dye used in analytical toxicity studies. 3-Nitroaniline-2,4,5,6-d4 is the labeled version.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Garner, R.C. et al.: Mut. Res., et al 44, 9 (1977);<br></p>

<p>Applications 3-Aminobenzotrifluoride-D4 is a labelled analogue of 3-Aminobenzotrifluoride (A591720).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1-Iodopropane-1,1,2,2-d4 (CAS# 1219804-45-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Heptylbenzene-d20 (CAS# 634897-84-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled 1-Pentene, used in the synthesis of iminosugars such as d-xylitol and l-arabinitol. Also usd in the synthesis of hydrazones of substituted salicylaldehydes.<br> E3<br>References Biela, A. et al.: Tetrahedron, 69, 3348 (2013); Ding, S. et al.: J. Coord. Chem., 66, 2023 (2013);<br></p>

<p>Applications Tolan-d10 (CAS# 19339-46-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Didesmethyl Loperamide-d4 is the isotope labelled analog of N-Didesmethyl Loperamide (D441135); a metabolite of the antidiarrheal Loperamide (L469450, HCl). Also a new and improved PET radiotracer for imaging P-gp function.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stokbroekx, et al.: J. Med. Chem., 1, 782 (1973); Carter, J.E., et al.: Anal. Profiles Drug Subs., 19, 341 (1990); Rahman, A., et al.: Cancer Res., 54, 5543 (1994); Sai, Y., et al.: Xenobiotica, 30, 327 (2000); Eneroth, A., et al.: Eur. J. Pharm. Sci., 12, 205 (2001); Kim, K., et al.: Drug Metab. Dispos., 31, 1090 (2003)<br></p>

<p>Applications N-Desmethyl Nefopam-D5 is deuterium labelled analogue of N-Desmethyl Nefopam (D422355), which is the main metabolite of Nefopam (N389418), which is a non-opioid non-steroidal centrally acting analgesic.<br>References Chawla, J., et al.: Ther. Drug Monit., 25, 203 (2003); Aymard, G., et al.: Pharmacol. Toxicol., 92, 279 (2003); Yoon, J., et al.: Korean J. Anesthesiol., 69, 161 (2016); Petrault, M., et al.: Fundam. Clin. Pharmacol., 31, 194 (2017);<br></p>

<p>Applications Isotope labelled Isopropyl DL-Mandelate is used in nonporous silica/alumina amorphous material. Pregabalin (P704800) impurity.<br>References Wang, Z. et al.:; ACS Catal., 3, 1573 (2013);<br></p>

<p>Applications p-Toluic-2,3,5,6-d4 Acid (CAS# 1219798-71-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled analogue 4-(2-Hydroxyethyl)morpholine, a morphiline derivative used in the preparation of ester prodrugs of naproxen. 4-(2-Hydroxyethyl)morpholine was also shown to induce repair in rat hepatocyte primary culture/DNA.<br></p>

<p>Applications A volatile lactone found in fruits giving ripe produce their aroma.<br>References Tavori, H., et al.: Bioorg. Med. Chem., 16, 7504 (2008), Pandit, S., et al.: J. Sci. Food Agric., 89, 2071 (2009), Xiang, D., et al.: Biochem., 48, 2237 (2009), Pandit, S., et al.: Food Chem., 114, 363 (2009),<br></p>

<p>Applications Acetophenone-d3 is an isotopic analog of acetophenone (A164015), a reagent used in the production of fragrances and resin polymers. This compound is a contaminant of emerging concern (CECs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Perez, D., et al.; Bioorg. Med. Chem., 17, 6914 (2009), Giet, J., et al.: J. Agric. Food Chem., 57, 6787 (2009), Dimoula, K., et al.: Biotechnol. J., 4, 712 (2009),<br></p>

<p>Applications Heptanoic-5,5,6,6-d4 Acid (CAS# 352431-36-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetradecanoic-2,2-d2 Acid (CAS# 30719-21-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromohexane-1,1,2,2-d4 (CAS# 1219802-83-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phenyltrimethyl-d9-ammonium Methane-d3-sulfonate is an intermediate in the synthesis of Oxycodone-d3 (O870603), a labelled Oxycodone (O870600), a controlled substance (opiate). Analgesic (narcotic).<br>References Mendelson, J., et al.: Clin. Pharmacol. Ther., 60, 105 (1996); Fudala, P., et al.: N. Engl. J. Med., 349, 949 (2003); Alho, H., et al.: Drug Alcohol Depend., 88, 75 (2007)<br></p>

<p>Applications δ-Tocotrienol-d6 is labelled δ-Tocotrienol (T526195) which is a natural substance with vitamin E activity. It can work as an antioxidant. It inhibits the growth of human breast cancer cells.<br>References Sen, C., et al.: Life Sci., 78, 2088 (2006); Yoshida, Y., et al.: Chem. Phys. Lipids, 123, 63 (2005)<br></p>

<p>Applications Tryptamine-beta,beta-d2 HCl (CAS# 362049-48-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications O-(2,3,4,5,6-Pentafluorobenzyl-alpha,alpha-d2)hydroxylamine HCl (CAS# 358730-85-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Fluoro-N-isopropylaniline-13C6 is an intermediate for the synthesis of Flufenacet-13C6 (F599422), labelled Flufenacet (F599420) which is an anilide based herbicide that is applied to the soil surface or incorporated before the crop is emerged. Flufenacet is often used in field corn, corn grown for silage or soybeans to control annual grasses and broadleaf weeds.<br>References Hulting, A.G., et al.: Weed. Technol., 26, 230 (2012); Bailly, G.C., et al.: Crop Protect., 34, 96 (2012)<br></p>

<p>Applications 1,2-Cyclohexane-d10-diamine (cis/trans mixture) (CAS# 2120097-66-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Nonanoic-2,2-d2 Acid (CAS# 62689-94-5) is used as a tracer for detecting metabolic pathways in anaerobic alkane degradation in methane production. It can be used for NMR analysis.<br>References Chen, D., et.al., Can. J. Chem, 55, 2404-2410, (1977); Mou, B., et.al., Faming Zhuanli Shenqing, 5,(2012);<br></p>

<p>Applications Pentanedioic-d6 Acid (CAS# 154184-99-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1H-Indole-d5-3-acetamide is the isotope labelled analogue of Indole-3-acetamide, a compound that is converted to indole-3-acetic acid by indole-3-acetamide hydrolase in auxin biosynthesis in plants.<br>References Mano, Y., et al.: J. Exp. Bot., 61, 25 (2010);<br></p>

<p>Applications 2-Nitrobenzonitrile-d4 (CAS# 1219795-50-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications An intermediate of Rosuvastatin (R700502). Rosuvastatin is a selective, competitive HMG-CoA reductase inhibitor.<br>References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006),<br></p>

<p>Applications n-Propyl-2,2,3,3,3-d5-amine Hydrochloride is the hydrochloride salt of 1-Propyl-d5-amine (P833702); the isotope labelled analog of 1-Propylamine (P833700) which is used in the synthesis of pyrimidine derivatives as novel and highly potent PDE4 inhibitors. It is also used in the preparation of fluorenone analogs with DNA topisomerase I inhibitors.<br>References Goto, T. et al.: Bioorg. Med. Chem., 21, 7025 (2013); Lee, C. et al.: Bioorg. Med. Chem. 21, 7125, (2013)<br></p>

<p>Applications n-Propyl-1,1,2,2-d4 Alcohol (CAS# 70907-80-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-threo-α-Phenyl-2-piperidineacetamide-d10 is an labelled intermediate in the synthesis of labelled L-threo-Ritalinic Acid (R533132).<br>References Chavan, A.B. et al.: Otg. Proc. Res. Dev., 14, 1473 (2010);<br></p>

<p>Applications 1-Bromodecane-9,9,10,10,10-d5 (CAS# 1219802-02-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromooctane-1,1-d2 (CAS# 86423-34-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Pentamidine-d4 2HCl (pentane-1,1,5,5-d4) (CAS# 1276197-32-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Hexyl-5,5,6,6,6-d5-triphenylphosphonium Bromide (CAS# 1169764-53-7) is a useful isotopically labeled research compound. It can be used for mass spectrometric characterization of protein modifications.<br>References Zhu, X., et.al., Chem. Res. Toxicol., 22, 1386-1397, (2009);<br></p>

<p>Applications Trimethyl Orthopropionate-2,2,3,3,3-d5 (CAS# 1219803-49-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Chloro-2,4,6-trideuteroaniline, is the labeled analogue of 3-Chlorobenzenamine (C364610), which is used in the synthesis of pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity.It can also be used in the synthesis of novel COX-2 inhibitors.<br>References Yang, H. et al.: Eur. J. Med. Chem., 63, 558 (2013); Penning, T. et al.: J. Med. Chem., 40, 1347 (1997);<br></p>

<p>Applications n-Pentyl Alcohol-d12 (CAS# 158778-85-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl 5-Chloro-2-methoxy-d3-benzoate (CAS# 1219803-33-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Hydroxymethyl-(1-oxy-2,2,5,5-tetramethylpyrroline)-15N is an isotope labelled spin-labelling compound.<br></p>

<p>Applications 3,4-Dichlorotoluene-2,5,6-d3 (CAS# 1219795-29-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Acetic Acid-2-13C-2,2,2-d3 is used in a biosynthetic study such as the biosynthesis of Asperlactone.<br>References Garson, M.J., et al.: J. Chem. Soc., Chem. Communic., 14, 708 (1981),<br></p>

<p>Applications DL-2-aminobutyric Acid-D5 is an intermediate used in the synthesis of Methyl Ergonovine-d5 Maleate Salt (M304602), which is a labeled metabolite of Methysergide. Semisynthetic ergot alkaloid. Oxytocic.<br>References Mueller, L., et al.: Headache, 37, 437 (1997), de Groot, A.N., et al.: Drugs, 56, 523 (1998)<br></p>

<p>Applications 2-Aminofluorene-9-13C (CAS# 335081-08-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Isonipecotic Acid Methyl Ester is a an ester derivative of 4-piperidinecarboxylic acid used as a reagent in the organic synthesis of neurochemicals, antibacterials and other biologically active compounds.<br>References Kim, E.-K. et al.: Yak. Hoechi, 48, 182 (2004); Tanitame, A. et al.: Bioorg. Med. Chem. Lett., 14, 2857 (2004);<br></p>

<p>Applications Pyrrolidine-2,2,5,5-d4 Hydrochloride is the salt, labeled analogue of Pyrrolidine (P997950), a heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs).<br>References Li, X. et al.: Mini-Rev. Med. Chem., 10, 794 (2010); Gragutan, I. et al.: Beil. J. Org. Chem., 7, 699 (2011)<br></p>

<p>Applications Ethyl-2,2,2-d3 Acetate (CAS# 109545-01-9) is a useful isotopically labeled reagent for radiolysis and reactions with radical-cations of esters in freon matrixes.<br>References Belevskii, V. N., et al.: Khimiya Vysokikh Energii, 21, 209 (1987)<br></p>

<p>Applications 2-Chloro-6-ethyl-N,N-dimethylthieno[2,3-d]pyrimidin-4-amine-d6 is the isotope labelled analog of 2-Chloro-6-ethyl-N,N-dimethylthieno[2,3-d]pyrimidin-4-amine (C367635); a useful synthetic intermediate.<br></p>

<p>Applications 4-​Pyridin-​2,​3,​5,​6-​d4-​ol-​d is one of the azepanone derivatives studies as CGRP receptor antagonists.<br>References Liu, J.: PCT Int. Appl. (2010), WO 2010108103 A1 20100923.<br></p>

<p>Applications DL-4-Hydroxyphenyl-2,6-d2-alanine-2-d1 (CAS# 73036-42-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled ethyl alcohol, used in alcoholic beverages in suitable dilutions. Other uses are as solvent in laboratory and industry , in the manufacture of denatured alcohol, pharmaceuticals, in perfumery, in organic synthesis. Used as antiseptic.<br>References Wiberg, G.S., et al.: Toxicol. Appl. Pharmacol., 16, 718 (1970), Brown, N.A., et al.: Science, 206, 573 (1979),<br></p>

<p>Applications Indoramin-d5 (phenyl-d5) (CAS# 57165-41-0) is a useful isotopically labeled research compound. This compound can be used for detecting drugs and their metabolites in biological specimens using gas chromatography-mass spectrometry.<br>References Draffan, G., et.al., Adv. Mass Spec., 6,245-250,(1974);<br></p>