Deuterated Compounds

Applications Dodecanoic-2-13C Acid (CAS# 287100-78-1) is a useful isotopically labeled research compound.

Applications 4-Nitrotoluene-2,3,5,6-d4 (CAS# 1276197-16-0) is a useful isotopically labeled research compound.

Applications 4-n-Butylphenol-2,3,5,6-d4,OD (CAS# 1219795-04-6) is a useful isotopically labeled research compound.

Applications 1-Propanol-d8 is an intermediate used in the preparation of perdeuterated carboxylates, alcohols and alkyl bromides.
References Lipinski, K., et al.: Pol. J. Chem., 67, 667 (1993)

Applications Thiophanate Ethyl-d10 is the isotope labelled analog of Thiophanate Ethyl; a systemic fungicide used in plant protection. Thiophanate Ethyl was shown to be effective against Botryotinia [ Sclerotinia] fuckeliana and Uncinula necator on grapevines, Mycosphaerella fragariae on strawberries, and powdery mildew of cucumber.
References Baicu, T., et al.: Analele Institutului de Cercetari pentru Protectia Plantelor, 8, 227 (1970)

Applications Acetylcholine-d13 Bromide (N,N,N-trimethyl-d9; 1,1,2,2-d4) is the deuterium labelled form of Acetylcholine Bromide (A172073), which is an endogenous neurotransmitter at cholinergic synapses.
References Kobayashi, M., et al.: Adv. Physiol. Sci., 22, 319 (1981); Hulme, C., et al.: Biophys. J., 91, 2371 (2006);

Applications N-2-Hydroxy-3-[[2-(methoxyphenoxy)ethyl]amine Carvedilol-d5 is the isotope labelled analog of N-2-Hydroxy-3-[[2-(methoxyphenoxy)ethyl]amine Carvedilol (H946145); the impurity A of Carvedilol (C184625) which is a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is also an antihypertensive used in the treatment of congestive heart failure.
References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990); Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996)

Applications Amisometradine-d3, is a labeled analogue of Amisometradine (A633600), which is an oral diuretic.
References Papesch, V., et al.: J. Org. Chem., 16, 1879 (1951); Moskalyk, R., et al.: J. Pharma. Sci., 64, 1406 (1975)

Applications Sodium Octanoate-d15 (CAS# 56408-90-3) is a useful isotopically labeled research compound.

Applications 2,3-Dimethylpentane-d16 (CAS# 1219795-08-0) is a useful isotopically labeled research compound.

Applications 3,4-Dichlorobenzoic-d3 Acid (CAS# 350818-53-0) is a useful isotopically labeled research compound.

Applications 1,5-Dinitronaphthalene-d6 (CAS# 1219804-48-4) is a useful isotopically labeled research compound.

Applications Prednisolamate-D10 is a labelled analogue of Prednisolamate (P703715).

Applications 2-Bromo-4'-fluoroacetophenone-2',3',5',6'-d4 (CAS# 1219803-30-1) is a useful isotopically labeled research compound.

Applications 2,4-Dimethyl-d6-nitrobenzene (CAS# 1398065-58-1) is a useful isotopically labeled research compound.

Applications Desacetyl Diltiazem-d4 Hydrochloride is the labeled analogue of Desacetyl Diltiazem Hydrochloride (D289335), a metabolite of Diltiazem Hydrochloride (D460620), a calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).
References Shallcross, H., et al.: Br. Med. J., 295, 1236 (1987); Yeung, P.K.F., et al.: Drug Metab. Dispos., 18, 1055 (1990); Cashman, J.R., et al.: J. Med. Chem., 34,2049 (1991); Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971); Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998); Hansson, L., et al.: Lancet, 356, 359 (2000)

Applications Diethyl-d6-amine has been used as a reactant for the analysis of the sequential oxidation of N-nitrosoalkylamines to aldehydes and carboxylic acids by human cytochrome P 450 2A6.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chowdhury, G., et. al.: J. Bio. Chem., 285, 8031 (2010)

Applications L-Leucine-3,3-d2 (CAS# 362049-59-0) is a useful isotopically labeled research compound.

Applications 1,2,3-Trichloropropane-d5 (CAS# 203578-27-2) is a useful isotopically labeled research compound.

Applications (±)-Propafenone-d7 HCl (n-propyl-d7) (CAS# 1219799-06-0) is a useful isotopically labeled research compound.

Applications Aceclofenac-d4 is deuterium labelled Aceclofenac (A130400), which is an anti-inflammatory and analgesic drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yscla, A., et al.: Drugs Exp. Clin. Res., 14, 491 (1988); Ballesteros, R., et al.: Clin. Trials J., 27, 12 (1990)

Applications Butyronitrile-d7 (CAS# 352431-11-9) is a useful isotopically labeled research compound.

Applications Ethyl (±)-2-Bromopropionate-3,3,3-d3 (CAS# 1398066-14-2) is a useful isotopically labeled research compound.

Applications 1-Bromodecane-1,1,2,2-d4 (CAS# 1219805-58-9) is a useful isotopically labeled research compound.

Applications Cyproheptadine Hydrochloride-d3 is the isotope labelled analog of Cyproheptadine (C989200, HCl,H2O); a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. Also a 5-HT2/5-HT1C serotonin receptor antagonist, H1 histamine receptor antagonist, and antipruritic.
References Marchei, E., et al.: J. Pharm. Biomed. Anal., 41, 1633 (2006); de-Benedictis, F., et al.: Allergy, 63, 1395 (2008); Feas, X., et al.: J. Pharm. Biomed. Anal., 50, 1044 (2009); Yu, C., et al.: Talanta, 2011, 83, 1376 (2011)

Applications 1,2-Dibromobenzene-d4 (CAS# 1643577-34-7) is a useful isotopically labeled research compound.

Applications Labelled Mebeverine Alcohol, a metabolite of Mebeverine (M202490), an antispasmodic.
References Greenwood, B. et al.: Eur. J. Pharmacol., 211, 143 (1992); van Outryve, M. et al.: J. Clin. Pharm. Ther., 20, 277 (1995); Kraemer, T. et al.: Drug Metab. Disp., 28, 339 (2000);

Applications Dimethyl N,N-Diisopropylphosphoramidite-d6 is an isotope labelled reagent for the efficient phosphorylation of alcohols.
References Tatsumi, S., et al.: Tetrahedron. Lett., 54, 3731 (2013);

Applications 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide-d4 is labelled 2-(1-Oxo-2(1H)-naphthalenylidene)-hydrazinecarboxamide (N359270) which is a novel anti-anflammatory agent as well as an anti-proliferative agent due to its 1,2-napthoquinone substructure.
References Marrero-Ponce, Y. et al.: Eur. J. Med. Chem., 46, 5736 (2011);

Applications Isotope labelled 1-Bromo-3-chloropropane can be used safer and equally efficient alternative to chloroform as a phase-separation agent in the 1-step method of RNA isolation from biological samples such as animal and plant tissue.
References Chomczynski, P. et al.: Anal. Biochem., 225, 163 (1995); Chey, S. et al.: Anal. Biochem., 411, 164 (2011);

Applications Estrone-2,4-d2 (CAS# 350820-16-5) is a useful isotopically labeled research compound.

Applications 8-Nitro-1-pyrenol is a urinary hydroxylated metabolites used as a biomarkers of exposure of polycyclic aromatic hydrocarbons. This is the labeled analog.
References Toriba, A., et al.: J. Health. Sci., 53; 631 (2007); Chae, Y.H., et al.: Cancer Res., 59, 1473 (1999); Sangaiah, R., et al.: Poly. Aro. Comp., 11, 283 (1996);

Applications N-Boc-(p-Aminobenzoyl)-L-glutamic Acid Dimethyl Ester-13C5 is an intermediate used in the synthesis of Folic Acid-13C5 (F680303), which is a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.
References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),

Applications 4-Bromomethcathinone-D3 hydrochloride is a labelled analogue of 4-Bromomethcathinone hydrochloride (B686080). 4-Bromomethcathinone is part of a family of synthetic cathinone compounds called aminopropiophenones (which have high potential for abuse). Aminopropiophenones have potential psychoactive effects, can lead to death, and are labelled as highly controlled substances in many countries.
References Foley, K. & Cozzi, N.: Drug Dev. Res., 60, 252 (2003); Mas-Morey, P., et al.: J. Pharm. Pract., 26, 353 (2013); Penders, T., et al.: Gen. Hosp. Psych., 34, 647 (2012); Spiller, H., et al.: Clin. Toxicol., 49, 499 (2011)

Applications 1-Bromobutane-1,1,2,2-d4 (CAS# 1219805-80-7) is a useful isotopically labeled research compound.

Applications 8,9-Dihydro-2-methyl-9-(4-methylphenyl)-8-oxo-7H-purine-6-carboxamide-d7 is a compound useful in organic synthesis.

Applications Ursodeoxycholic Acid-24-13C is the labeled compound of Ursodeoxycholic Acid (U850000). It is used as an anticholelithogenic. Epimer with Chenodiol with respect to the hydroxyl group at C7.

Applications 2-Ethyl-1-hexanol-D5 is an intermediate in the synthesis of Alexidine-d10 Dihydrochloride (A525002), which has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.
References Coburn, R.A., et al.: J. Med. Chem., 21, 8, 829 (1978), Takayama, K., et al.: J. Biol. Chem., 269, 2241 (1994), Faure, P., et al.: Biochimie, 86, 411 (2004),

Applications 3,3-Dimethyl-2-butanol-d3 is an isotopic analog of 3,3-Dimethyl-2-butanol (D471480), a reagent used in the synthesis of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists. 3,3-Dimethyl-2-butanol is also used in the preparation of dihydropyrrole derivatives containing N-sulfanyl, sulfinyl, and sulfonyl moieties which have insecticidal activity.
References Ito, M., et al.: Bioorg. Med. Chem., 11, 489 (2003); Micheli, F., et al.: Bioorg. Med. Chem., 11, 171 (2003)

Applications Pyridine-4-d1 (CAS# 10259-15-1) is a useful isotopically labeled research compound.

Applications 1,2-Bis(4-hydroxyphenyl)-2-hydroxypropane-d3 is labelled 1,2-Bis(4-hydroxyphenyl)-2-hydroxypropane (B447367) which is a metabolite of bisphenol A (B519495). It works as an endocrine disruptor.
References Krishnan, A.V., et al.: Endocrinology, 132, 2279 (1993), Steinmetz, R., et al.: Trends Endocrinol. Metab., 9, 124 (1998); Kitamura, S., et al.: Toxicol. Sci., 84, 249 (2005)

Applications 2,3-Pentanedione-1,1,1,4,4-d5 is deuterated form of 2,3-Pentanedione which is a diketone that is used as a building block in organic chemistry. It is also a volatile flavour compound found in coffee, cheese and other foods.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Engels, W., et al.: Int. Dairy J., 7, 255 (1997); Roberts, D., et al.: J. Agric. Food Chem., 48, 2430 (2000);

Applications Vinblastine-d3 Methiodide is the labeled analogue of Vinblastine Methiodide (V314015), an adduct of Vinblastine (V314000), an antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. An antineoplastic.
References Dorman, D.E., Paschal, J.W.: Org. Magnetic Resonance, 8, 413 (1976); Lu, C., et al.: Cancer Research, 39, 3575 (1979); Gobbi, P.G., et al.: J. Clin. Oncol., 14, 527 (1996); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs. Excip., 21, 611 (1992)

Applications D,L-Carnitine-d3 Chloride is the isotope labelled analog of D,L-Carnitine Chloride (C184100); a vitamin (enzyme cofactor). It is an essential cofactor of fatty acid metabolism and is required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney with the highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.
References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)

Applications Ethyl-1-d1 Alcohol (CAS# 1624-36-8) is a useful isotopically labeled research compound.

Applications 1-Bromo-2,5-difluorobenzene-d3 (CAS# 1219795-54-6) is a useful isotopically labeled research compound.

Applications Ethyl-2,2,2-d3-triphenylphosphonium Bromide (CAS# 1560-55-0) is a useful isotopically labeled research compound.

Applications 4-Aminopiperidine-3,3,4,5,5-d5 (CAS# 1219803-60-7) is a useful isotopically labeled research compound.

Applications trans-1,4-Dibromo-2-butene-d6 (CAS# 118886-18-3) is a useful isotopically labeled research compound.

Applications Isotope labelled Formamide is a compound that is used in biochemistry to prevent RNA samples from degradation due to RNAses. Formamide is also used as a plasticizer to prepare thermoplastic starch (TPS), a special type of starch that can be mixed with other synthetic polymers because of its unique ability to “flow”.
References Chomczynski, P.: Nuc. Acids Res., 20, 3791 (1992); Ma, X. & Yu, J.: Acta Polym. Sinica 2, No vol. given, 240 (2004); Rodriguez-Gonzalez, F., et al.: Polymer, 44, 1517 (2003); Shi, Q., et al.: Polym. Degrad. Stabil., 96, 175 (2011)

Applications Reagent used to make labelled Catechol.

Applications 2-Bromofluorobenzene-d4 (CAS# 50592-35-3) is a useful isotopically labeled research compound.

Applications Eicosapentaenoyl Ethanolamide-d4 is labelled Eicosapentaenoyl Ethanolamide (E477960) which inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes.
References Lucanic, M., et al.: Nature, 473, 226 (2011)

Applications Ethanol-13C2 is a labelled analogue of Ethanol, which is used in alcoholic beverages in suitable dilutions and as solvent in laboratory and industry, in the manufacture of denatured alcohol, pharmaceuticals, in perfumery, and in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wiberg, G.S., et al.: Toxicol. Appl. Pharmacol., 16, 718 (1970); Brown, N.A., et al.: Science, 206, 573 (1979);

Applications 4-tert-Butylbenzyl Bromide-D13 is the labeled form of 4-tert-Butylbenzyl Bromide (B692457), which was used as a reagent in the organic synthesis of several compounds including that of C(5)-substituted analogs of inhibitor BRP-7. Also used in the preparation of hydroxy-based sphingosine kinase inhibitors;Also, it is an intermediate used in the synthesis of Pyridaben-d13 (P991262), which is deuterium labelled Pyridaben. Pyridaben is a pyridazinone derivative used as an insecticide and acaricide. In the European Union, Pyridaben has been authorized for use as an insecticide and acaricide from 1 May 2011. In Germany, Austria and Switzerland, no plant protection products containing this active substance are authorized. Pyridaben is a colorless solid that is practically insoluble in water. Cann
References Levent, S., et al.: Eur. J. Med. Chem., 122, 510 (2016); Xi, M., et al.: Bioorgan. Med. Chem., 24, 3218 (2016);

Applications 4-(3’,6’-Dimethyl-3’-heptyl)phenol diethoxylate-13C6 (cas# 1173019-36-7) is a compound useful in organic synthesis.

Applications Oleic Acid Methyl Ester-d3 is labelled Oleic Acid Methyl Ester (M330110) which is an intermediate used to prepare cis-9,10-Epoxystearic Acid Methyl Ester, an inhibitor of soybean lipoxygenase.
References Wright, S., et al.: Bioorg. Med. Chem. Lett., 2, 1385 (1992)

Applications p-Nitrophenyl Acetate-13C,d3 (cas# 1794766-80-5) is a compound useful in organic synthesis.

Applications Acetanilide-d3 is the deuterium labelled form of Acetanilide (A168330).

Applications Thymine-alpha,alpha,alpha,6-d4 (CAS# 156054-85-2) is a useful isotopically labeled research compound.

Applications 2-(2-Aminoethoxy)anisole-d3 (cas# 1189881-28-4) is a compound useful in organic synthesis.

Applications (Z,Z)-5,11-Eicosadienoic Acid Methyl Ester-d3 is the isotope labelled analog of (Z,Z)-5,11-Eicosadienoic Acid Methyl Ester (E476810); the methyl ester derivative of (Z,Z)-5,11-Eicosadienoic Acid (E476800) which is a biomarker for trophic transfer.
References Koussoroplis, A., et al.: Lipids, 43, 461 (2008); Nguyen, J., et al.: Drug Dev. Res., 51, 233 (2000)

Applications Thiazole Orange-d3 is the isotope labelled analog of Thiazole Orange (T344135); a fluorescent DNA staining dye used for reticulocyte analysis.
References Lee, L.G., et al.: Cytometry, 7, 508 (1986); Cho, H., et al.: ACS Nano, 7, 2032 (2013)

Applications Trixylyl Phosphate-d10 is a deuterated form of Trixylyl Phosphate (T891900), which is used commercially as hydraulic fluids, flame retardants, and plasticizers. Trixylyl Phosphate inhibits the human ether-a-go-go-related gene (hERG) channel, which is a voltage-gated potassium (K+) channel involved in the repolarization of the cardiac action potential.
References Chigwada, G., et al.: Polym. Degrad. Stab. 89, 85 (2005); Xia, M., et al.: Toxicol Appl Pharmacol 252, 250 (2011)

Applications Labelled N-Nitroso-N-methyl-N-dodecylamine (N529935). N-Nitroso-N-methyl-N-dodecylamine is a nitroso compound with carcinogenic potency.
References Singer, S., et al.: J. Med. Chem., 28, 1088 (1985), Gonzalez-Mancebo, S., et al.: Mutat. Res., 558, 45 (2004), Luan, F., et al.: Chem. Res. Toxicol., 18, 198 (2005),

Applications Isotope labelled 1-Pyrenyl Potassium Sulfate is used as a biomarker of exposure to polycyclic aromatic hydrocarbons.
References Woudneh, M. et al.: J. Chrom. A., 1454, 93 (2016);

Applications Acenaphthene-d10 is an isotopic analog of Acenaphthene (1,2-Dihydro Acenaphthylene)(D448330), which is a polycyclic aromatic hydrocarbon.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hansen, B., et al.: Environ. Toxicol. Chem., 18, 772 (1999), Czub, G., et al.: Environ. Sci. Technol., 38, 2406 (2004),

Applications N,N-Diethyl-2-hydroxyacetamide-d10 is a derivative compound of N,N-Diethyl-2-hydroxyacetamide (D444580), a reactant used in the synthesis of phosphonate prodrugs to increase the oral bioavailability of an antiviral agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA).
References Starrett, J. E., et al.: J. Med. Chem., 37, 1857-64 (1994)

Applications Labelled Isobutylparaben. An antimicrobial agent used in cosmetic products.
References Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258 (1992), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998), Miller, C., et al.: J. Biol. Chem., 272, 32824 (1997), Nakagawa, Y., et al.: Biochem. Pharmacol., 55, 1907 (1998),

Applications n-Hexane-1,1,1,2,2,3,3-d7 (CAS# 32740-31-1) is a useful isotopically labeled research compound.

Applications Ethyl-d5-methylamine (CAS# 1219804-73-5) is a useful isotopically labeled research compound.

Applications 2-tert-Butyldimethylsilyloxyethanol-d4 (cas# 764650-43-3) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package