Deuterated Compounds

<p>Applications D-Alanine-2-d1 (CAS# 56595-54-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Hydroxyquinoline-d6 is labelled 3-Hydroxyquinoline (H953140) which is a chemical reagent used in the preparation cyclic peptides with an antitumor functionality. Quinoline derivative as a result of the metabolism by cytochrome P 450.<br>References Riego, E. et al.: Tetrahedron, 61, 1407 (2005); Kanou, M. et al.: Fund. Clin. Pharmacol., 16, 513 (2002)<br></p>

<p>Applications N-Benzoylglycine-2,2-d2 (CAS# 208928-78-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl 2,3-Dicyanopropionate-13C2 15N2, is the labeled analogue of Ethyl 2,3-Dicyanopropionate (E915950), which is an intermediate for insecticide.<br>References Cole, L., et al.: Pestic. Biochem. Physiol., 46, 47 (1993), Cole, L., et al.: Life Sci., 56, 757 (1995), Hosie, A., et al.: Br. J. Pharmacol., 115, 909 (1995),<br></p>

<p>Applications Isotope labelled Trimethylsilyl Cyanide (T796750) is used as a reagent in the synthesis of optically active cyanohydrins. Used in the preparation of Reissert compounds, which represent reactive polyamides. Toxic to humans.<br>References Roberge, C. et al.: Tetrahedron Asymm., 18, 208 (2007); Jois, Y. et al.: Macromol., 26, 6151 (1993); Lumor, S. et al.: J. Food. Sci., 76, T16 (2011);<br></p>

<p>Applications 2-Iodopropane-2-d1 (CAS# 95927-03-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol, the novel raw material for deodorants application and is widely used as a cosmetic emollient. 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol reliably inhibits the odor-causing bacteria, yeast and fungi on the skin.<br>References Nagao, S.: Frag. J., 34, 39 (2006); Lawan, K. et al.: J. Health Sci., 23, 1 (2009); Leschke, M.: SOFW J., 136, 10 (2010);<br></p>

<p>Applications N-Suberylglycine-2,2-d2 (CAS# 1219799-02-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Fluorobenzyl-2,3,5,6-d4-amine (CAS# 1219798-96-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications (2E)-3-(Phenyl-d5)-2-propenoic Acid is labeled (2E)-3-(Phenyl)-2-propenoic Acid (P336185) which is used in the synthesis of amides and esters through coupling reactions involving carboxylic acids and amines. Also used in the N-methylation of amides and O-methylation of carboxylic acids.<br>References Kunishima, M. et al.: Tetrahedron, 55, 13159 (1999); Xia, Q. et al.: Org. Lett., 15, 3326 (2013);<br></p>

<p>Applications n-Hexadecyl-16,16,16-d3 Alcohol (CAS# 75736-52-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Dimethyl Phthalate (D477975). It is used as insect repellent.<br>References Iselin, B., et al.: Helv. Chim. Acta., 40, 373 (1957),<br></p>

<p>Applications 1-(2-Ethoxy-2-oxoethyl)pyridin-1-ium-d5 Chloride is an intermediate used in the synthesis of Girard’s Reagent P-d5 (G388502), which is a labeled girard’s reagent used in the identification and quantification of protein carbonylation as well as in the modification of nucleosides and nucleotides. Used in the preparation of potent photoactive agents.<br>References Mirzaei, H. et al.: J. Chrom. A, 1134, 122 (2007); Kanofsky, J.R. et al.: Photochem. Photobiol., 73, 349 (2001);<br></p>

<p>Applications Acetamide-d5 (CAS# 33675-83-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromooctane-3,3,4,4-d4 (CAS# 1219803-37-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazine-d2 ,13C1, is the labeled analogue of (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazine (C365935), used for the synthesis of Efavirenz (E425000), which is a nonnucleoside HIV-1 reverse transcriptase inhibitor.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>

<p>Applications 1-Chlorohexane-d13 (CAS# 1219798-45-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labeled 1,4-cyclohexanedione with high isotopic purity.<br>References Stibbe, W.; et al.: J. Labelled Compounds Radiopharmaceuticals, 16, 567 (1979),<br></p>

<p>Applications Cresyl Diphenyl Phosphate-d7 Isomer 3 is the deuterated form of Cresyl Diphenyl Phosphate (C783015), which is a phosphorus flame retardant additive.<br>References van der Veen., et al.: Chemosphere, 88, 1119 (2012);<br></p>

<p>Stability Volatile<br>Applications rac 1,2-Diaminopropane-d3 is labelled rac 1,2-Diaminopropane which was used as model precursor in the electron induced deposition of amorphous carbon nitride films. It was also used to synthesize cage peroxide, 1,6-diaza-3,4,8,9-tetraoxa-11-methylbicyclo[4.4.2]dodecane.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wnuk, J., et al.: J. Phys. Chem., 113, 12345 (2009); Edward, J., et al.: Can. J. Chem., 77, 1057 (1999)<br></p>

<p>Applications Hexadecanoic-15,15,16,16,16-d5 Acid (CAS# 285979-77-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled 2,4-Diaminobutyric Acid. 2,4-Diaminobutyric Acid is a pharmacological tool and potential chiral building block. 2,4-Diaminobutyric Acid is also used as an internal standard for amino acid analysis. 2,4-Diaminobutyric Acid is also found to inhibit GABA transaminase, thus producing an elevation of GABA level, and to have an antitumor activity in vitro and in vivo against mouse fibrosarcoma cells.<br>References Riordan, J.F. et al.: Methods Enzymol., 47, 31 (1977); Beart, P.M. et al.: Neurscience Lett., 5, 193 (1977); Ronquist, G. et al.: J. Cancer Res. Clin. Oncol., 96, 259 (1980); Solladie-Cavallo, A. et al.: Tetrahedron Lett., 30, 6011 (1989);<br></p>

<p>Applications L-2-Aminobutyric-3,3-d2 Acid (CAS# 352431-37-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3,5-Benzene-2,4,6-d3-tricarboxylic Acid (CAS# 62790-27-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phosphoric Acid-D4 Trifluoroboroane Deuterium Oxide is an intermediate in the synthesis of 3-Hydroxy Benzopyrene-d11 (H829402), which is a abelled metabolite of Benzopyrene (BaP), a carcinogenic component of tobacco smoke implicated in lung cancer.<br>References DiBiasio, K., et al.: Drug Metab. Dispos.,19, 227 (1991), Beach, J., et al.: J. Anal. Toxicol., 24, 670 (2000), Borman, S., et al.: Toxicol. Appl. Pharmacol., 167, 191 (2000), Tsai-Turton, M., et al.: Biol. Reprod., 77, 442 (2007),<br></p>

<p>Applications Hydrocinnamic-alpha,alpha-d2 Acid (CAS# 19136-97-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,5-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one-d3 is the deuterated version of 2,5-Dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one (D480165), which is an impurity of Alosetron (A575500) that is a serotonin 5HT3 receptor antagonist, used in treatment of irritable bowel syndrome.<br>References Camilleri, M., et al.: Lancet, 355, 1035 (2000); Nestorov, I., et al.: Drug Metab. Dispos., 30, 276 (2002); Lewis, D., et al.: Drug Metab. Rev., 35, 1 (2003); Tang, H., et al.: J. Pharm. Sci., 95, 1783 (2006); Gleeson, M., et al.: J. Med. Chem., 50, 101 (2007);<br></p>

<p>Applications 4-Fluoro-1,3-dioxolan-2-one-d3 is the labeled version of 4-Fluoro-1,3-dioxolan-2-one (F591523)<br></p>

<p>Applications N-Methylform-d1-amide (CAS# 26103-38-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetradecanoic-14,14,14-d3 Acid (CAS# 62217-71-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,2'-Binaphthyl-d14 (CAS# 210487-05-1) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications Phenylboronic Acid-d5 is the isotope labelled analog of Phenylboronic Acid (P319590); a compound used in the organic synthesis of various pharmaceutical goods.<br>References Ainley, A.D., et al.: J. Chem. Soc., 2171 (1930)<br></p>

<p>Applications 2-Mercaptoethanol-1,1,2,2-d4 (CAS# 284474-53-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Mercaptopropionic-2,2,3,3-d4 Acid (CAS# 1141488-67-6) is a useful isotopically labeled research compound. It is used for structural proteomics interactions.<br>References Petrotchenko, E., et.al., Mol. Cell Proteomics, 8,273-286,(2009);<br></p>

<p>Applications A is the deuterated isotope of N-Boc-Ethylenediamine (B655006). N-Boc-Ethylenediamine is used in the synthesis of Thyronamine derivatives and analogs.<br>References Anon., et al.: J. Pharmacol., 58, 53 (1936), Boissier, J., et al.: Eur. J. Pharmacol., 22, 141 (1973),<br></p>

<p>Applications n-Butyl-1,1,2,2,3,3-d6 Alcohol (CAS# 1219794-84-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl-1,1-d2-methylamine (CAS# 223459-63-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(1,1-Dimethylethyl)-4-iodo-2,5-dimethoxy-benzene-d6 is labelled 1-(1,1-Dimethylethyl)-4-iodo-2,5-dimethoxy-benzene which is an intermediate used to prepare heterocyclic tyrosine kinase inhibitors.<br>References Spada, A., et al.: PCT Int. Appl., WO 9220642 A1 19921126 (1992)<br></p>

<p>Applications Quinaldic-d6 Acid (CAS# 1219802-18-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,3’-((2-Hydroxypropane-1,3-diyl)bis(oxy))bis(2-(3-ethoxy-3-oxopropanoyl)phenolate) Disodium Salt-d5 is an intermediate used in the synthesis of Cromolyn-d5 Disodium Salt (C815002), which is a chromone complex which blocks mast cell degranulation.<br>References Ashton, M.J., et al.: Toxicol. Appl. Pharmacol., 26, 319 (1973), Friday, G.A., et al.: Am. J. Ophthalmol., 95, 169 (1983)<br></p>

<p>Applications Labelled Sarmentine (S141600). Sarmentine is used for controlling plant pests.<br>References Alecio, A., et al.: J. Na.t Prod., 61, 637 (1998), Duh, C., et al.: J. Nat. Prod., 53, 1575 (1990), Yang, Y., et al.: J. Agric. Food Chem., 50, 3765 (2002), Tsai, I., et al.: Planta Med., 71, 535 (2005),<br></p>

<p>Applications epsilon-Caprolactone-3,3,4,4,5,5-d6 (CAS# 1219802-08-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(3-Chloro-2-hydroxypropyl)-3,5-bis(2-oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione-d15 is an intermediate for the synthesis of Triglycidyl Isocyanurate-d15 (T793817). Isotope labelled Triglycidyl isocyanurate is a reagent used in the synthesis of N-Benzyl Metaxalone (B285000), which is a muscle relaxant used to relax muscles and relieve pain.<br>References Toth, P.E., et al.: Clin. Ther., 26, 1355 (2004)<br></p>

<p>Applications Isotope labelled 4-(4-Bromo-3-fluorophenyl)morpholine, used in the preparation of vascular adhesion protein inhibitors.<br></p>

<p>Applications 1-Pyrenol-d9 Acetate is a compound useful in organic synthesis.<br>References Murray, R., et al.: Carcinogen., 20, 147 (1999),<br></p>

<p>Applications 2-Chloro-N,N-diethylethylamine-d10 Hydrochloride is the isotope labelled analog of 2-Chloro-N,N-diethylethylamine Hydrochloride. 2-Chloro-N,N-diethylethylamine Hydrochloride used in the preparation of nonsteroidal antiestrogens. As well, it is used in the synthesis of novel cyanopyridine derivatives used in the design of antibacterial drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jones, C. et al.: J. Med. Chem., 27, 1057 (1984); Bogdanowicz, A. et al.: J. Hetero. Chem., 50, 544 (2013);<br></p>

<p>Applications Glyceryl Tri(hexadecanoate-d31) (CAS# 241157-04-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications rac-Mono-(4-methyloctanyl)-phthalate-D4 is the isotopically labeled analog of rac-Mono-(4-methyloctanyl)-phthalate. rac-Mono-(4-methyloctanyl)-phthalate, is similar to di-isonoyl phthalate esters (DINPs) which are used as a major plasticizer for poly(vinyl chloride) (PVC). This family of compounds (phthalate) are considered endocrine-disrupting chemicals based on biological studies.<br>References Hsu, J.F., et al.: Anal. Chem., 83, 8725 (2011)<br></p>

<p>Applications 2,4-Diamino-6-hydroxypyrimidine-15N3 (cas# 1638736-04-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,3-Propane-d6-diamine, Dihydrochloride is used in the study of trimethylsilylated di and polyamine and their isotopically labelled analogs.<br>References Smith, R. G., et al.: J. Org. Chem., 43, 2178 (1978)<br></p>

<p>Applications Pyrrole-d5 (CAS# 18430-85-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-N-(2,6-Dimethylphenyl)-1-iso-propyl-d7-2-piperidinecarboxamide (CAS# 1276197-11-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Chloro-10-[3-[[3-(dimethyl-d6-amino)propyl]methylamino]propyl]phenothiazine is the labeled analogue of 2-Chloro-10-[3-[[3-(dimethylamino)propyl]methylamino]propyl]phenothiazine (C367110), an impurity of Chlorpromazine (C424750), which is used as an antiemetic; antipsychotic. 2-Chloro-10-[3-[[3-(dimethylamino)propyl]methylamino]propyl]phenothiazine is also used in the synthesis of novel phenothiazine compounds with antimalarial activity.<br>References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970); Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990); Kalkanidis, M., et. al.: Biochem. Pharmacol., 63, 833 (2002)<br></p>

<p>Applications Labelled Maleic Anhydride. A heterocyclic compound used in the manufacture of unsaturated polyester resins. Maleic Anhydride has a wide range of other applications; it is used in synthetic tensides, insecticides, herbicides and fungicides.<br>References Hanafi, W.Z.A. et al.: Plast. Rub. Comp. Proc. Appl., 19, 175 (1993); Noma, K. et al.: Shik. Kyok., 36, 225 (1963); Augustin, M. et al.: Wissen. Zeitsch., 25, 5 (1976); Jiang, Q. et al.: Nongyao, 49, 257 (2010);<br></p>

<p>Applications N2-Methyl Trimethoprim-D3 is a labelled analogue of N2-Methyl Trimethoprim (M331190).<br></p>

<p>Applications Glyceryl Trihexadecanoate-13C2 [1,3-Di(hexadecanoate-1-13C)] (CAS# 339080-65-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-Methyl-2(1H)-pyridinone-d6 is a reagent used in the preparation of substituted N-aryl pyridinones as fibrotic inhibitors.<br></p>

<p>Applications Anteisoheneicosanoic acid-d3 is labelled Anteisoheneicosanoic acid which is used in cosmetics as it allows hair fiber to lie flat and parallel with respect to each other while its removal formed coarse tangled bundles, aligned in disorderly manner.<br>References Tanamachi, H., et al.: J. Cosmetic Sci., 61, 147 (2010); Breakspear, S., et al.: PMSE Preprints, 90, 276 (2004)<br></p>

<p>Applications A labelled major (toxic) metabolite of Styrene (S687790), catalyzed by epoxide hydrolase.<br>References Shen, S. et al.: Drug Metab. Disp., 38, 1934 (2010); Carlson, G.P. et al.: J. Toxicol. Env. Health, 73, 1689 (2010)<br></p>

<p>Applications 1,2-Dimethoxybenzene-d10 (CAS# 362049-43-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Hydroxyadamantane-d15 (CAS# 33830-11-4) is a useful isotopically labeled research compound. This compound can be used to treat viral diseases.<br>References Atkinson, J., et.al., Can., 16, (1971);<br></p>

<p>Applications m-Xylene-alpha,alpha,alpha,alpha',alpha',alpha'-d6 (CAS# 29636-65-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Butoxy-d9-acetic Acid (CAS# 669720-55-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Propyl-1,1,3,3,3-d5 Alcohol (CAS# 188894-71-5) is a useful isotopically labeled research compound.<br></p>

<p>Stability Volatile<br>Applications 1-Butan-d9-ol is the labeled form of 1-Butanol, which is used for the production of dimethylfuran for liquid fuels.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roman-Leshkov, Y. et al.: Nature, 447, 982 (2007);<br></p>

<p>Applications Isotope labelled D-galactose (G155250), A C-4 epimer of Glucose (G595000) found in milk and sugar beets as well as being synthesized by the body. Potential use in oral therapy for nephrotic syndrome in focal and segmental glomerulosclerosis.<br>References De Smet, E. et al.: Nephrol. Dial. Transplant., 24, 2938 (2009); Kivele, R. et al.: Carb. Pol., 85, 645 (2011);<br></p>

<p>Applications 2-Fluorotoluene-alpha,alpha,alpha-d3 (CAS# 25319-49-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine-d3 is the isotope analog of Methyl(4-methylnaphthalen-1-ylmethyl)amine. Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.<br>References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)<br></p>