Deuterated Compounds

Applications N-Acetyl-S-(3-hydroxypropyl-1,1,2,2,3,3-D6)cysteine Dicyclohexylammonium Salt is labelled N-Acetyl-S-(3-hydroxypropyl)cysteine Dicyclohexylammonium Salt (A179075), which is a metabolite of halopropanes.
References Barnsley, E.A.: Biochem. J., 100, 362 (1966)

Applications n-Undecyl-1,1,2,2-d4 Alcohol (CAS# 1219803-47-0) is a useful isotopically labeled research compound.

Applications N,N-Dimethylformamide-d7 is the isotope labelled analog of N,N-Dimethylformamide. N,N-Dimethylformamide-d7 is used as a cofactor for enzymic oxidation of brassinin, which allows the transformation of dithiocarbamate group into an aldehyde equivalent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pedras, M., et al.: Bioorg. Med. Chem., 19, 1390 (2011);

Stability Hygroscopic
Applications Labelled 1,4-Dinitrosopiperazine. N,N'-Dinitrosopiperazine (DNP) induces nasopharyngeal carcinoma (NPC) and shows organ specificity to the nasopharyneal epithelium.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lanier, A., et al.: Cancer, 46, 2100 (1980), Waalkes, M., et al.: Carcinogenesis, 25, 133 (2004), Toth, E., et al.: Int. J. Cancer, 121, 1744 (2007),

Applications A labelled metabolite of a mixed disulfide S-(N,N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine (AC-DDTC), an antimutagenic mixed disulfide from disulfiram.
References Madan, A., et al.: Drug Metab. Dispos., 23, 1153 (1995), Lambert, D., et al.: J. Med. Chem., 48, 5059 (2005), Tsuboi, K., et al.: J. Biol. Chem., 280, 11082 (2005),

Applications Labelled Sodium DL Lactate used as coatings in the food industry, providing antimicrobial resistance
References Zhang, H. et al.: J. Food Sci., 74, M418 (2009); Jiang, Z. et al.: J. Food Sci., 76, M22 (2011);

Applications O,O-Di(Ethyl-d5)phosphate Sodium Salt is labelled Diethyl Phosphate Sodium Salt (D444720) which is used in a cosmetic composition for treating keratin materials, for example, keratin fibers such as the hair.

Applications 1,3,5-Tribromobenzene-d3 (CAS# 52921-77-4) is a useful isotopically labeled research compound.

Applications n-Dotriacontane-d66 (CAS# 62369-68-0) is a useful isotopically labelled research compound. It has been studied as a potential generator to supply charged particles to plastic nuclear track detectors for high-energy neutrons.
References Oda, K., et al.: Radiation Measurements, 36, 119 (2003)

Applications Tetramethylsilane-d12 (CAS# 18145-38-5) is a useful isotopically labeled research compound.

Applications n-Pentyl 4-Hydroxybenzoate-2,3,5,6-d4 (CAS# 1219798-66-9) is a useful isotopically labeled research compound.

Applications Labelled Succinic Anhydride is used in the synthesis of propanoyloxy derivatives used as drug absorption modifiers. In addition it is a reagent for novel non-carboxylate inhibitors of AKR1C3
References Coufalova, L. et al.: Steroids, 78, 435 (2013); Heinrich, D. et al.: Eur. J. Med. Chem., 62, 738 (2013);

Applications Sulfoxaflor-d3 is the isotope analog of Sulfoxaflor. Sulfoxaflor, is a new insecticide which acts as an insect neurotoxin, and is the only member of class of chemicals called the sulfoximines which act on the central nervous system of insects with much lower toxicity to mammals.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Anon, IP.com J., 12, 19 (2011)

Applications Trimethyl-d9-sulfonium Iodide (CAS# 106776-17-4) is a useful isotopically labeled research compound.

Applications 1-Adamantan-d15-amine is a labeled NMDA-receptor antagonist. Antiviral; antiparkinsonian.
References Vernier, V.G., et al; Toxicol. Appl. Pharmacol., 15, 642 (1969); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 12, 1 (1983)

Applications iso-Butyl 4-Hydroxybenzoate-2,3,5,6-d4 (CAS# 1219805-33-0) is a useful isotopically labeled research compound.

Applications 2,5-Furandicarboxylic Acid-13C6 is isotopically labelled analogue of 2,5-Furandicarboxylic Acid (F863750), which is Furan (F863650) derivative that can be produced from biomass derived sugars using catalytic processes.
References Tong, X., et al.: Appl. Catal., A, 385, 1 (2010);

Applications 2,4-Dihydroxybenzophenone-d5 is deuterium labelled of 2,4-Dihydroxybenzophenone (D451780), which is a metabolite of Benzophenone (B204980). Benzophenone can be used to synthesize antihistamines, hypnotics and insecticides.
References Li, M.H., et al.: Toxicol. Environ. Chem., 94, 566 (2012); Leon, Z.. et al.: Anal. Bioanal. Chem., 398, 831 (2010); Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008)

Applications Uracil-15N2 can be used as a stable-isotopic standard to measure of post-replicative DNA metabolic and damage in brains of rodents. This compound can also be used for isotope tracing to determine the mechanism and stem-cell activity of 5-carboxycytosine decarboxylation.
References Patel, J.P., et.al., Chem. Res. Toxicol., 28, 2352-2363, (2015); Schiesser, S., et.al., Angew. Chem. Int. Ed., 51,6516-6520, (2012);

Applications A labelled metabolite of polycyclic aromatic hydrocarbons in humans.
References Jacob, J., et al.: Xenobiotica, 12, 45 (1982), Becher, G., et al.: Cancer Lett., 17, 301 (1983), Hoffmann, D., et al.: Cancer Treat. Res., 72, 1 (1995), Einolf, H., et al.: Chem. Res. Toxicol., 10, 609 (1997),

Applications Pentadecanoic-d29 Acid (CAS# 130348-95-7) is a useful isotopically labeled research compound.

Applications Trinexapac-d5, is the labeled analogue of Trinexapac (T886315), a plant growth regulator that studies have shown to have the enzymic activity of histone lysine demethylases and histone modifications during the neural stem/progenitor cell differentiation
References Vavilala, D. et al.: Toxicology Reports, Vol.1, P: 1152-1161 (2014);

Applications Labelled Tetraglyme. It is used as a solvent.

Applications Isotope labelled Diuron (D494415), which is a phenyl urea herbicide (1,2). Pre-emergent herbicide which may find its way into aquatic environments, and consumable fruit/vegetation (3,4). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Noseworthy, J. et al.: Weed. Tech. 2010 Jul:24(1) pp64-702. Armenta, S. et al.: Anal. Bioanal. Chem. 2010 May;397(1):297-308.3. Neuwoehner, J. et al.: Aquat. Toxicol. 2010 Apr 1;97(1):58-67.4. Wong, J. et al.: J. Agric. Food. Chem. 2010 May 26;58(10):5897-9034.

Stability Air sensitive, Material darkens in storage with no loss in purity
Applications Isotope labelled Aniline (A662475), which is used in the manufacture of dyes, medicinals, resins, varnishes, perfumes, as a vulcanizing rubber or even as a solvent (1,2). Hazardous and noxious substance which affects the early life stages of marine animals (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Cunha, I. et. al.: Environ. Sci. Pollut. Res. Int. 2017 Mar 10.2. Zhang, X. et al.: Synthesis. 2013 45(10): 1357-13633. Barkov, A. et al.: Russ. Chem. Bull. 2012. Aug:61(8) pp1564-9

Applications N-Acetyl-S-phenyl-d5-DL-cysteine is the deuterium labelled form of N-Acetyl-S-phenyl-DL-cysteine, which is used as a reactant in the preparation of potent HIV-1 protease inhibitors that use D-amino acids as P2/P3 ligands.
References Jungheim, L., et al.: J. Med. Chem., 39, 96 (1996);

Applications Isotope labelled Bisphenol A Bis(diphenyl phosphate) is a flame retardant. Bisphenol A Bis(diphenyl phosphate) is used in electrical wire covering and other flame resistant materials.
References Takeda, K. et al.: J. Appl. Polym. Sci., 64, 1175 (1997); Levchik, S.V. et al.: J. Vinyl Add. Technol., 7, 98 (2001);

Applications Carbon 13 Labelled analogue of Adenosine (A280400), a purine nucleoside that plays an important role in various biochemical processes.
References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010)

Applications Labelled glycerol kinase substrate specificity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Castro, C., et al.: Biochemistry, 7, 3213 (1968), Janssen, D., et al.: Eur. J. Biochem., 171, 67 (1988), Kurihara, T., et al.: J. Biochem., 117, 1317 (1995),

Stability Hygroscopic
Applications Catechol-13C6 (cas# 115881-16-8) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 17beta-Estradiol-2,4,16,16,17-d5 (CAS# 221093-45-4) is a useful isotopically labeled research compound.

Applications Labelled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.
References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),

Applications Methoxyfenozide-d9 is deuterium labelled Methoxyfenozide (M262765). It is used primarily as an insecticide, and pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zhao, Q., et al.: J. Agricul, Food Chem., 56, 10799 (2008);

Applications Labelled Norflurazon (N684500). Pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References El-Nahhal, Y., et al.: J. Agric. Food Chem., 46, 3305 (1998),

Applications Isotope labelled 5,6-Dihydrothymine is a derivative of Thymine, a nucleobase in the nucleic acid of DNA. 5,6-Dihydrothymine is a radiolysis product of DNA.
References Hubbard, K. et al.: Biochemistry, 28, 4382 (1989); Cadet, J. et al.: Int. J. Rad. Biol. Rel. Stud. Phys. Chem. Med., 39, 119 (1981);

Applications Labelled Benzylparaben. An antimicrobial agent used in cosmetic products.
References Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258 (1992), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998), Miller, C., et al.: J. Biol. Chem., 272, 32824 (1997), Nakagawa, Y., et al.: Biochem. Pharmacol., 55, 1907 (1998),

Applications Dihydro uracil-d4 is deuterium labelled dihydro uracil (D449990). Modified nucleobases are useful molecular tools to study nucleic acid structures and to probe biological systems. Dihydro uracil has also been utilized in mechanistic studies relating to the base excision repair (BER) pathway during DNA repair.
References Chawla, M., et al.: Nucleic Acids Res 43, 9573 (2015); Jian, Y., et al.: J. Am. Chem. Soc. 137, 3318 (2015); Shaul, Y. D., et al.: Cell 158, 1094 (2014)

Applications A labelled form of Catechol (C215175) and has been used in the characterization of surface inclusion of unidirectional molecular motors in hexagonal tris(o-phenylene)cyclotriphosphazene.
References Kaleta, J.; et al.: J. Am. Chem. Soc., 139, 10486 (2017).

Stability Hygroscopic
Applications Hydrochloride Salt of 2-Methyl-3-isothiazolone-d3, a pesticidal substituted 3-isothiazolinone.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Thierse, H., et al.: J. Immunol., 172, 1926 (2004), Nilsson, A., et al.: Chem. Res. Toxicol., 18, 308 (2005), Nitsche, J., eet al.: J. Pharm. Sci., 95, 649 (2006),

Applications Dodecane-d26, is the labeled analogue of Dodecane (D494625), which is used in the synthesis of triblock polymers that deliver nanoparticles to the oil/water interface and degrade non-tocxc non-aqueous liquids.
References Saleh, N. et al.: Nano. Lett., 2489, 5 (2005); Scarso, A. et al.: J. Am. Chem. Soc., 126, 13512 (2004);

Stability Volatile
Applications 2-Pentylfuran-d11 is the labeled analogue of 2-Pentylfuran (P284953), a volatile compound that is detected in meat smoke aerosol, rice aroma and tomato paste volatiles.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rogge, W., et al.: Environ. Sci. Technol., 25, 1112 (1991); Buttery, R., et al.: J. Agric. Food Chem., 36, 1006 (1988); Buttery, R., et al.: J. Agric. Food Chem., 38, 336 (1990);

Applications Norfloxacin-d5 is deuterium labeled Norfloxacin (N681000), a synthetic fluoroquinolone and an antibacterial agent. Norfloxacin can be used to treat urinary tract infections.
References Koga, H., et al.: J. Med. Chem., 23, 1358 (1980), Hirai, K., et al.: Antimicrob. Agents Chemother., 19, 188 (1981), Holmes, B., et al.: Drugs, 30, 482 (1985),

Applications N-Ethyl-2-hydroxysuccinimide-d5 is the isotope labelled analog of N-Ethyl-2-hydroxysuccinimide (E919180); a metabolite of N-ethyl-2-pyrollidone (NEP) which is a frequently used industrial solvent shown to be embryotoxic in animal experiments.
References Schindler, B.K., et al.: Anal. Chem., 84, 3787 (2012)

Applications Methionine-methyl-d3 is the labeled Methionine-methyl, a useful building block.

Applications Pentadecafluorooctanoic Acid-13C is an isotopomeric compound of Pentadecafluorooctanoic Acid (P268100). Pentadecafluorooctanoic Acid is used to produce fluoropolymers. It also exhibits a long half-life in human blood and interferes with the binding between liver-fatty acid binding protein and fatty acids.
References Biegel, L. B., et al.: Toxicol. Sci 60, 44 (2001); Luebker, D. J., et al.: Toxicology 176, 175 (2002); Butenhoff, J., et al.: Toxicol. Sci 60, 44 (2002)

Applications Ethylbenzene-d10 (cas# 25837-05-2) is a useful research chemical.

Applications Metabolite of Salicylic Acid (S088125).
References Jurkowski, W., et al.: Current Drug Metab., 10, 448 (2009), Appeldoorn, M., et al.: J. Agric. Food Chem., 57, 7693 (2009), van Oijen, M., et al.: Pharmacol., 83, 237 (2009),

Applications Acts on certain olfactory receptor cell types to reduce the activating or attracting effect of odor sources.Insect repellent.
References Boeckh, J., et al.: Pestic. Sci., 48, 359 (1996), Yap, H.H., et al.: J. Vector Ecol., 23, 62 (1998),