Deuterated Compounds

Applications 2-Butynol-d2 is an isotope labelled substituent in the synthesis of various pharmaceutical goods.
References Harada, A., et al.: J. Am. Chem. Soc., 136, 13932 (2014);

Applications 2,​4,​6-​Trifluorobenzenemethanamine-d4,15N Deuterium Chloride is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;

Applications 1,2,3,9-Tetrahydro-9-(methyl-d3)-4H-carbazol-4-one is used in the preparation of 5-HT3 modulators useful in the treatment and prevention of 5-HT3 receptor-mediated diseases.
References Huang, W. et al.: Zhong. Yao. Dax. Xueb., 30, 1 (1999); Kim, M. et al.: Heterocycles, 45, 2041 (1997);

Applications N-Isopropyl-N-methylamine-d7 Hydrochloride is an intermediate in the synthesis of Saflufenacil-d7 (S081802). Saflufenacil-d7 is the labeled version of Saflufenacil (S081800), which is a herbicide of the pyrimidinedione chemical class used for the preplant burndown and selective preemergence dicot weed control in different field crops. It was found to inhibit protoporphyrinogen IX oxidase (PPO) enzyme.
References Knezevic, S., et al.: Crop Prot., 29, 148 (2010); Grossmann, K., et al.: Weed Sci., 58, 1 (2010)

Applications 4-Amino-1-pentanol-d4 Hydrochloride Salt (cas# 1216414-18-4) is a compound useful in organic synthesis.

Applications Labelled Furan-3-methanol. Furan-3-methanol is used in the synthesis of potentially prebiotic RNA precursors: adenine and uracil derivatives.
References Pavey, J.B.J., et al.: Tetrahedr. Lett., 36, 2657 (1995),

Applications 2,3-Dichlorobenzoic Acid-13C (cas# 1184971-82-1) is a compound useful in organic synthesis.

Applications Benzyl 2,4-Dibromobutyrate-d5 i is a useful synthetic intermediate.

Applications A labelled reactant used in the preparation of inhibitors for treatment of neurodegenerative diseases.

Applications 4-Fluoroephedrine-d3 is the labelled analogue of 4-Fluoroephedrine.

Applications Component used in the preparation of Cyanine dyes.
References Kim, H., et al.: J. Pharm. Biomed. Anal., 27, 51 (2002), Santelli-Rouvier, C., et al.: Eur. J. Med. Chem., 39, 735 (2004),

Applications Used in the preparation of piperazine-1-carboxamide derivatives as fatty acid amide hydrolase (FAAH) inhibitors.
References Glorius, F., et al.: Org. Biomol. Chem., 3, 4171 (2005),

Applications N-tert-Boc-2-(4-hydroxy-2-methoxyphenoxy)ethylamine-d3 (cas# 1189659-07-1) is a compound useful in organic synthesis.

Applications A labelled impurity of Lansoprazole.
References Barradell, L., et al.: Drugs, 44, 225 (1992), Aydogmus, Z., et al.: Acta Pharm. Sci., 48, 45 (2006), El-Sherif, Z., et al.: Chem. Pharm. Bull., 54, 814 (2006),

Applications 2-(2-Aminothiazol-4-yl)acetic Acid-13C, 15N2 Hydrochloride is an intermediate used in the synthesis of Cefotiam Dihydrochloride-13C, 15N2 (C243007), which is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.
References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)

Applications 3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-propanol-d6 is a compound useful in organic synthesis.

Applications Cyclohexanol-d11 is the deuterated analog of cyclohexane, general organic chemical solvent. It is also used as a precursor to the synthesis of nylon.
References Hiroshi O. et al.: J. Memb. Sci., 105, 51 (1995); Rekharsky, M.V. et al.: J. Am. Chem. Soc., 124, 12361 (2002)

Applications Monomethyl Glutarate-1,5-13C2 (cas# 1189708-76-6) is a compound useful in organic synthesis.

Applications Ethyl Isobutyrylacetate-d6 (cas# 1216475-83-0) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Chloro-ethanamine-d4 Hydrochloride (cas# 172333-26-5) is a compound useful in organic synthesis.

Applications A labelled intermediate in the preparation of DOPA-decarboxylase inhibitors.

Applications 1-Bromobenzene-13C6 is the isotope labelled analog of 1-Bromobenzene, which is used as a general reagent in palladium-catalyzed reactions and in the synthesis of Grignard reagents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Miyaura, N. et al.: Synth. Commun., 11, 513 (1981); Nahm, S. et al.: Tetra. Lett., 22, 3815 (1981);

Applications Reagent used to make labelled Catechol.

Applications 5’-Deoxy-5’-iodo-2’,3’-O-isopropylidene-5-fluorouridine-13C,15N2 >95% is a compound useful in organic synthesis.

Applications rac 10-Hydroxy-1-undecen-6-one-d6 (cas# 1246818-57-4) is a compound useful in organic synthesis.

Applications Intermediate for the preparation of Isotope Labelled Tolmetin.

Applications 2-(Cyclopropylmethoxy-d4)-acetic Acid (cas# 1346602-05-8) is a compound useful in organic synthesis.

Applications 2-​(Methoxy-​d3)​-​3-​(1-​methylethyl)​pyrazine is a useful compound in the study of isotope effect in gas liquid chromatography separation of deuterated and nondeuterated compounds using ionic liquid stationary phases.
References Schmarr, H., et al.: J. Chromatogr. A., 1270, 310 (2012);

Applications 4-[[6-Chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile-d8 is an intermediate from the synthesis of Etravirine-d8 (E937003). Etravirine-d8 is a novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection.
References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008); Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008)

Applications p-Vinylguaiacol-d3 is the isotope labelled analog of p-Vinylguaiacol (V424960); an aromatic substance, one of the compounds responsible for the natural aroma of buckwheat, and also one of the major pyrolytic products of (E)-N-[(4-hydroxy-3-methoxy)-phenethyl]-3-[(3-methoxy-4-O-β-D-glucopyranosyloxy) phenyl] acrylamide; a new gycloside in tobacco.
References Janes, Damjan., et al.: Food Chem., 112(1), 120-124 (2009); Zhou, Rong., et al.: Yancao Keji, (7), 34-36, 42 (2013)

Applications N-(1,1-Dimethylethyl)-benzenemethanamine-d9 Hydrobromide (cas# 1346605-21-7) is a compound useful in organic synthesis.

Applications Balsalazide-d3 Disodium Salt is a labeled analogue of Sulfasalazine (S699084). A prodrug of 5-aminosalicylic acid where carrier molecule is 4-aminobenzoyl-β-alanine. Anti-inflammatory (gastrointestinal).
References Prakash, A., et al.: Drugs, 56, 83 (1998); Coyne, C., et al.: Mol. Biol. Cell, 13, 3218 (2002); Willemsen, L., et al.: Clin. Exp. Immunol., 142, 275 (2005)

Applications A deuterated intermediate in the synthesis of Carisoprodol.

Applications O-Benzyl-S-(methyl-d3)-3-thioacetaminophen is a useful synthetic intermediate for organic reactions.

Applications (R)-2-Hydroxy-3-(benzoyloxy)propyl-1,1-d2 4-Toluenesulfonate is an intermediate used in the synthesis of (S)-PA 824-d4 (P122502), which is a labelled novel anti-tuberculosis drug.
References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);

Applications 1,2,3,5-Tetrachlorobenzene-d2 (CAS# 2199-74-8) is a useful isotopically labeled research compound.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 1-Benzyloxy-2-propanol-d6 is an intermediate in the synthesis of Isotope labelled Propylene Glycol 2-Glucuronide which is a metabolite of propylene glycol, used in the synthesis of N-terminal kinase inhibitors with cellular activity. Acts as a solvent for various pharmaceutical compounds.
References Szczepankiewicz, B. et al.: J. Med. Chem., 49, 3563 (2006); Mateus, R. et al.: Int. J. Pharm., 444, 106 (2013);

Applications 5-Chloro-2-methoxy-benzoic Acid-13C,d3 (cas# 1346600-36-9) is a compound useful in organic synthesis.

Applications N-[2-[5-(Acetyloxy)-1H-indol-3-yl]ethyl]acetamide-D6 is an intermediate used in the synthesis of N-Acetyl-d3-5-hydroxytryptamine (A179162), which is deuterium labelled N-Acetyl-5-hydroxytryptamine (A179160), which is a metabolite of Melatonin (M215000).
References Reiter, R.J., et al.: J. Biomed. Sci., 7, 444 (2000), Chen, Z., et al.: Am. J. Physiol, 284, 1618 (2003), Barrenetxe, J., et al.: J. Physiol. Biochem., 60, 61 (2004),

Applications N,N'-Dimethyl-3,3'-dithiodipropionamide is an disulfide linked compound found in antifouling coatings and is also an intermediate in the synthesis of antimicrobial agents and biocides.
References Easton, C.J., et al.: J. Chem. Soc., 1, 153 (1985);

Applications 2,5-Dihydro-2-hydroxy-5-nitro-2-furanmethanediol-d3 Triacetate (cas# 1346604-22-5) is a compound useful in organic synthesis.

Applications Imidazol-1-yl-acetic Acid-15N2,13C2 (cas# 1184983-00-3) is a compound useful in organic synthesis.

Applications Fluorene-D10 is a labelled analogue of Fluorene (F462000). Fluorene is a polycyclic aromatic hydrocarbon that is ubiquitous in the urban environment, and is also a suspected carcinogen. Fluorene is used as a component of fluorescent probes that bind to human serum albumin, allowing researchers to study internal mechanisms more closely.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Harrison, R., et al.: Env. Sci. Tech., 30, 825 (1996); Park, K., et al.: Org. Biomol. Chem., 7, 4225 (2009); Weissenfels, W., et al.: Appl. Micro. Biotech., 32, 479 (1990)

Applications Ethyl (5-Ethyl-2-pyridinyl)-1,1-d2-acetate (cas# 1189654-25-8) is a compound useful in organic synthesis.

Applications 1,2-Dimethoxybenzene-3,4,5,6-d4 (CAS# 126840-15-1) is a useful isotopically labeled research compound.

Applications Isotope labelled analogue of tert-Pentyl Chloride, an alkyl chloride used as a starting material in various organic synthesis.

Applications 2-(Formylamino)-3-hydroxy-2-propenoic-13C2 Acid Ethyl Ester (cas# 1391062-48-8) is a compound useful in organic synthesis.

Applications α-Methyl-2-piperidinemethanol-13C2 is a labelled analogue of α-Methyl-2-piperidinemethanol (M324830), which can be used in the preparation of substances with herbicidal activity. α-Methyl-2-piperidinemethanol-13C2 is also an intermediate in synthesizing 2-Acetyl-3,4,5,6-tetrahydropyridine-13C2 Hydrochloride (A188502), which is a labelled 2-Acetyl-3,4,5,6-tetrahydropyridine (A188500), the most important bread flavor component.
References Buttery, R.G., et al.: J. Agric. Food Chem., 43, 1878 (1995)